James S Ware

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Next generation diagnostics in inherited arrhythmia syndromes : a comparison of two approaches
    James S Ware
    MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Cardiovasc Transl Res 6:94-103. 2013
  2. doi Paralogous annotation of disease-causing variants in long QT syndrome genes
    James S Ware
    Medical Research Council Clinical Sciences Centre, Imperial College London, London, United Kingdom
    Hum Mutat 33:1188-91. 2012
  3. ncbi Republished review: Next generation sequencing for clinical diagnostics and personalised medicine: implications for the next generation cardiologist
    James S Ware
    Molecular Cardiology, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK
    Postgrad Med J 88:234-9. 2012
  4. ncbi Next generation sequencing for clinical diagnostics and personalised medicine: implications for the next generation cardiologist
    James S Ware
    Molecular Cardiology, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK
    Heart 98:276-81. 2012
  5. pmc Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia
    Roddy Walsh
    NIHR Royal Brompton Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK
    J Med Genet 51:35-44. 2014
  6. pmc NECTAR: a database of codon-centric missense variant annotations
    Sungsam Gong
    NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK, National Heart Centre Singapore, Singapore 168752, Singapore and Cardiovascular and Metabolic Disorders, Duke National University of Singapore, Singapore 169857, Singapore
    Nucleic Acids Res 42:D1013-9. 2014
  7. pmc Towards clinical molecular diagnosis of inherited cardiac conditions: a comparison of bench-top genome DNA sequencers
    Xinzhong Li
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 8:e67744. 2013
  8. pmc Integrative genomics in cardiovascular medicine
    James S Ware
    MRC Clinical Sciences Centre, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK
    Cardiovasc Res 97:623-30. 2013

Detail Information

Publications8

  1. pmc Next generation diagnostics in inherited arrhythmia syndromes : a comparison of two approaches
    James S Ware
    MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Cardiovasc Transl Res 6:94-103. 2013
    ..In the next iteration of these assays we anticipate sensitivity above 97 % for all LQT genes. NGS assays will soon replace conventional sequencing for LQT diagnostics and molecular pathology...
  2. doi Paralogous annotation of disease-causing variants in long QT syndrome genes
    James S Ware
    Medical Research Council Clinical Sciences Centre, Imperial College London, London, United Kingdom
    Hum Mutat 33:1188-91. 2012
    ..org/Paralogue_Annotation/), based on newly created Locus Reference Genomic sequences (http://www.lrg-sequence.org/). We propose that paralogous annotation is widely applicable for Mendelian human disease genes...
  3. ncbi Republished review: Next generation sequencing for clinical diagnostics and personalised medicine: implications for the next generation cardiologist
    James S Ware
    Molecular Cardiology, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK
    Postgrad Med J 88:234-9. 2012
    ..This paper presents an overview of the implications of next generation sequencing for clinical diagnostics and personalised medicine in the cardiology clinic...
  4. ncbi Next generation sequencing for clinical diagnostics and personalised medicine: implications for the next generation cardiologist
    James S Ware
    Molecular Cardiology, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK
    Heart 98:276-81. 2012
    ..This paper presents an overview of the implications of next generation sequencing for clinical diagnostics and personalised medicine in the cardiology clinic...
  5. pmc Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia
    Roddy Walsh
    NIHR Royal Brompton Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK
    J Med Genet 51:35-44. 2014
    ....
  6. pmc NECTAR: a database of codon-centric missense variant annotations
    Sungsam Gong
    NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK, National Heart Centre Singapore, Singapore 168752, Singapore and Cardiovascular and Metabolic Disorders, Duke National University of Singapore, Singapore 169857, Singapore
    Nucleic Acids Res 42:D1013-9. 2014
    ..The database is freely available to download from the ftp site: ftp://ftp.nectarmutation.org. ..
  7. pmc Towards clinical molecular diagnosis of inherited cardiac conditions: a comparison of bench-top genome DNA sequencers
    Xinzhong Li
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 8:e67744. 2013
    ..Recently introduced high-throughput bench-top DNA sequencing platforms have the potential to overcome these limitations...
  8. pmc Integrative genomics in cardiovascular medicine
    James S Ware
    MRC Clinical Sciences Centre, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK
    Cardiovasc Res 97:623-30. 2013
    ....