Tonia Vincent

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Basic FGF mediates an immediate response of articular cartilage to mechanical injury
    Tonia Vincent
    The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Proc Natl Acad Sci U S A 99:8259-64. 2002
  2. ncbi Sjögren's syndrome-associated myelopathy: response to immunosuppressive treatment
    Tonia L Vincent
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, United Kingdom
    Am J Med 114:145-8. 2003
  3. ncbi Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
    Yasunobu Sawaji
    Imperial College London, London, UK
    Arthritis Rheum 58:3498-509. 2008
  4. ncbi Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis
    Shi Lu Chia
    Imperial College London, London, UK
    Arthritis Rheum 60:2019-27. 2009
  5. ncbi Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3110-9. 2008
  6. ncbi Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded
    Tonia L Vincent
    The Kennedy Institute of Rheumatology, London, UK
    Arthritis Rheum 50:526-33. 2004
  7. ncbi Induction of interleukin-1 in articular cartilage by explantation and cutting
    Johann Gruber
    Imperial College School of Medicine, London, UK
    Arthritis Rheum 50:2539-46. 2004
  8. ncbi Is the response of cartilage to injury relevant to osteoarthritis?
    Tonia L Vincent
    Arthritis Rheum 58:1207-10. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Basic FGF mediates an immediate response of articular cartilage to mechanical injury
    Tonia Vincent
    The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Proc Natl Acad Sci U S A 99:8259-64. 2002
    ..The strong induction of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 suggests that bFGF could have a role in remodeling damaged tissue...
  2. ncbi Sjögren's syndrome-associated myelopathy: response to immunosuppressive treatment
    Tonia L Vincent
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, United Kingdom
    Am J Med 114:145-8. 2003
  3. ncbi Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
    Yasunobu Sawaji
    Imperial College London, London, UK
    Arthritis Rheum 58:3498-509. 2008
    ..Articular chondrocytes are surrounded by an extracellular pool of fibroblast growth factor 2 (FGF-2). We undertook this study to investigate the possible role of FGF-2 in aggrecan catabolism by aggrecanase in human articular cartilage...
  4. ncbi Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis
    Shi Lu Chia
    Imperial College London, London, UK
    Arthritis Rheum 60:2019-27. 2009
    ..In vitro, FGF-2 suppresses interleukin-1-driven aggrecanase activity in human cartilage explants, suggesting a chondroprotective role in vivo. We undertook this study to investigate the in vivo role of FGF-2 in murine cartilage...
  5. ncbi Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3110-9. 2008
    ..However, up to 40% of individuals with radiologic damage are asymptomatic. The purpose of this study was to assess the role of the endogenous opioid system in delaying the onset of pain in a murine model of osteoarthritis (OA)...
  6. ncbi Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded
    Tonia L Vincent
    The Kennedy Institute of Rheumatology, London, UK
    Arthritis Rheum 50:526-33. 2004
    ..To determine whether the basic fibroblast growth factor (bFGF) mediates signal transduction in articular cartilage in response to mechanical loading...
  7. ncbi Induction of interleukin-1 in articular cartilage by explantation and cutting
    Johann Gruber
    Imperial College School of Medicine, London, UK
    Arthritis Rheum 50:2539-46. 2004
    ..Biologically active IL-1alpha protein was detectable in cartilage lysates and was probably intracellular proIL-1alpha. We were unable to show that IL-1 was secreted by chondrocytes...
  8. ncbi Is the response of cartilage to injury relevant to osteoarthritis?
    Tonia L Vincent
    Arthritis Rheum 58:1207-10. 2008