Patrick J W Venables
Affiliation: Imperial College
- Mixed connective tissue diseaseP J W Venables
Kennedy Institute, Imperial College, London, UK
Lupus 15:132-7. 2006..Whether it can be credited with the term 'disease' awaits the demonstration of common etiopathological events underlying the development of antibodies to U1 RNP and their associated clinical features...
- Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fireBenjamin Ac Fisher
Department of Rheumatology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK
Arthritis Res Ther 14:108. 2012..Recent findings indicate that citrullination closely correlates with inflammation, and that glucocorticoids decrease peptidylarginine deiminase expression independent of their other anti-inflammatory effects...
- Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritisAndrew Kinloch
Kennedy Institute of Rheumatology, Imperial College London, Charing Cross Hospital Campus, 1 Aspenlea Road, London W6 8LH, UK
Arthritis Res Ther 7:R1421-9. 2005..The presence of antibody together with expression of antigen within the joint implicates citrullinated alpha-enolase as a candidate autoantigen that could drive the chronic inflammatory response in RA...
- Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?Pamela Mangat
The Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Road, London, W6 8LH, UK
Arthritis Res Ther 12:209. 2010..Blockades of bacterial and human PADs may act as powerful novel therapies by inhibiting the generation of the antigens that trigger and sustain autoimmunity in rheumatoid arthritis...
- Sjögren's syndromePatrick J W Venables
Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, UK
Best Pract Res Clin Rheumatol 18:313-29. 2004..Hypofunction rather than destruction of these cells is now regarded as the main mechanism of secretory failure in Sjögren's syndrome...
- Management of patients presenting with Sjogren's syndromeP J Venables
Kennedy Institute Division, Imperial College, London, UK
Best Pract Res Clin Rheumatol 20:791-807. 2006..In spite of intensive research in other systemic treatments including biologic therapies, there is limited evidence to support their use in routine clinical practice...
- Sjögren's syndrome-associated myelopathy: response to immunosuppressive treatmentTonia L Vincent
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, United Kingdom
Am J Med 114:145-8. 2003