D A van Heel
Affiliation: Imperial College
- Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's diseaseDavid A van Heel
Gastroenterology Section, Imperial College London Hammersmith Campus, UK
Eur J Immunol 36:1629-35. 2006..Responses to specific NOD1 agonists are unaffected by NOD2 genotype, suggesting independent action of the NOD1 and NOD2 pathways...
- Interleukin 15: its role in intestinal inflammationD A van Heel
Gastroenterology Section, Imperial College London Hammersmith Campus, Du Cane Road, London W12 0NN, UK
Gut 55:444-5. 2006
- Synergistic enhancement of Toll-like receptor responses by NOD1 activationDavid A van Heel
Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London Hammersmith Campus, London, UK
Eur J Immunol 35:2471-6. 2005..Cross-talk between cytosolic NOD1 and membrane-bound TLR enhances responses to the multiple antigens simultaneously presented by a microbe...
- Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's diseaseD A van Heel
Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
Gut 54:1553-7. 2005..TLR9 is functional in the intestinal epithelium where it is most strongly expressed in Paneth cells...
- Genetics in coeliac diseaseDavid A van Heel
Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK
Best Pract Res Clin Gastroenterol 19:323-39. 2005..Identification of coeliac disease genes may improve diagnostic/prognostic markers, basic understanding of disease aetiology, permit development of novel therapeutics and provide insight into other autoimmune disorders...
- Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's diseaseDavid A van Heel
Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
Lancet 365:1794-6. 2005....
- Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairsDavid A van Heel
Department of Gastoenterology, Imperial College London, UK
Hum Mol Genet 13:763-70. 2004..Clustering of adjacent bins was observed for chromosomes 6p, 16, 19p. The meta-analysis has identified novel loci and prioritized genomic regions for further gene identification studies...
- Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac diseaseP C Dubois
Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
Clin Exp Immunol 153:162-73. 2008..Overlap with autoimmune diseases is striking with several of these regions being shown to confer susceptibility to other chronic immune-mediated diseases, particularly type 1 diabetes...
- Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitisM C Wapenaar
Genetics Department, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Gut 57:463-7. 2008..Previous studies showed the association of both diseases with variants in MYO9B, presumably involved in epithelial permeability...
- Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease familiesS Adamovic
Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
Genes Immun 9:364-7. 2008..001 and 0.002, respectively). However, we found no association with the FcgammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region...
- Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac diseaseR P Anderson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, Department of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
Gut 55:485-91. 2006....
- Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's diseaseK Negoro
Wellcome Trust Centre for Human Genetics, University of Oxford, UK Tohoku University Graduate School of Medicine, Sendai, Japan Oxagen Ltd, Abingdon, UK Gastroenterology Unit, University of Oxford, UK
Gut 52:541-6. 2003..Complex interactions between susceptibility loci have been shown in animal models, and we tested for potential gene-gene interactions between the three CD associated loci...
- T cells in peripheral blood after gluten challenge in coeliac diseaseR P Anderson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, c o Post Office RMH, Victoria, Australia 3050
Gut 54:1217-23. 2005..T cell clones allow identification of gluten peptides that stimulate T cells but do not quantify their contribution to the overall gluten specific T cell response in individuals with CD when exposed to gluten in vivo...
- Association of TNF-alpha-857C with inflammatory bowel disease in the Australian populationN J O'Callaghan
John Curtin School of Medical Research, ANU, Canberra, Australia
Scand J Gastroenterol 38:533-4. 2003..A candidate in that region, TNF-alpha, contains polymorphisms in the promoter region that appear to be associated with disease...
- Lack of association of MYO9B genetic variants with coeliac disease in a British cohortK A Hunt
Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner St, London E1 2AD, USA
Gut 55:969-72. 2006..MYO9B is a Rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation...
- Recent advances in coeliac diseaseD A van Heel
Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner St, London E1 2AD, UK
Gut 55:1037-46. 2006
- Detecting the risks of osteoporotic fractures in coeliac diseaseJ R F Walters
Gut 52:1229-30. 2003
- Novel presentation of coeliac disease after following the Atkins' low carbohydrate dietD A van Heel
Gut 54:1342. 2005