D A van Heel

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease
    David A van Heel
    Gastroenterology Section, Imperial College London Hammersmith Campus, UK
    Eur J Immunol 36:1629-35. 2006
  2. pmc Interleukin 15: its role in intestinal inflammation
    D A van Heel
    Gastroenterology Section, Imperial College London Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Gut 55:444-5. 2006
  3. ncbi Synergistic enhancement of Toll-like receptor responses by NOD1 activation
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London Hammersmith Campus, London, UK
    Eur J Immunol 35:2471-6. 2005
  4. pmc Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
    D A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Gut 54:1553-7. 2005
  5. ncbi Genetics in coeliac disease
    David A van Heel
    Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Best Pract Res Clin Gastroenterol 19:323-39. 2005
  6. ncbi Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
    Lancet 365:1794-6. 2005
  7. ncbi Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    David A van Heel
    Department of Gastoenterology, Imperial College London, UK
    Hum Mol Genet 13:763-70. 2004
  8. pmc Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease
    P C Dubois
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Clin Exp Immunol 153:162-73. 2008
  9. ncbi Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis
    M C Wapenaar
    Genetics Department, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Gut 57:463-7. 2008
  10. doi Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    S Adamovic
    Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Genes Immun 9:364-7. 2008

Detail Information

Publications18

  1. ncbi Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease
    David A van Heel
    Gastroenterology Section, Imperial College London Hammersmith Campus, UK
    Eur J Immunol 36:1629-35. 2006
    ..Responses to specific NOD1 agonists are unaffected by NOD2 genotype, suggesting independent action of the NOD1 and NOD2 pathways...
  2. pmc Interleukin 15: its role in intestinal inflammation
    D A van Heel
    Gastroenterology Section, Imperial College London Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Gut 55:444-5. 2006
  3. ncbi Synergistic enhancement of Toll-like receptor responses by NOD1 activation
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London Hammersmith Campus, London, UK
    Eur J Immunol 35:2471-6. 2005
    ..Cross-talk between cytosolic NOD1 and membrane-bound TLR enhances responses to the multiple antigens simultaneously presented by a microbe...
  4. pmc Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
    D A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Gut 54:1553-7. 2005
    ..TLR9 is functional in the intestinal epithelium where it is most strongly expressed in Paneth cells...
  5. ncbi Genetics in coeliac disease
    David A van Heel
    Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Best Pract Res Clin Gastroenterol 19:323-39. 2005
    ..Identification of coeliac disease genes may improve diagnostic/prognostic markers, basic understanding of disease aetiology, permit development of novel therapeutics and provide insight into other autoimmune disorders...
  6. ncbi Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
    Lancet 365:1794-6. 2005
    ....
  7. ncbi Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    David A van Heel
    Department of Gastoenterology, Imperial College London, UK
    Hum Mol Genet 13:763-70. 2004
    ..Clustering of adjacent bins was observed for chromosomes 6p, 16, 19p. The meta-analysis has identified novel loci and prioritized genomic regions for further gene identification studies...
  8. pmc Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease
    P C Dubois
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Clin Exp Immunol 153:162-73. 2008
    ..Overlap with autoimmune diseases is striking with several of these regions being shown to confer susceptibility to other chronic immune-mediated diseases, particularly type 1 diabetes...
  9. ncbi Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis
    M C Wapenaar
    Genetics Department, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Gut 57:463-7. 2008
    ..Previous studies showed the association of both diseases with variants in MYO9B, presumably involved in epithelial permeability...
  10. doi Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    S Adamovic
    Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Genes Immun 9:364-7. 2008
    ..001 and 0.002, respectively). However, we found no association with the FcgammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region...
  11. pmc Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease
    R P Anderson
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, Department of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Gut 55:485-91. 2006
    ....
  12. pmc Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease
    K Negoro
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK Tohoku University Graduate School of Medicine, Sendai, Japan Oxagen Ltd, Abingdon, UK Gastroenterology Unit, University of Oxford, UK
    Gut 52:541-6. 2003
    ..Complex interactions between susceptibility loci have been shown in animal models, and we tested for potential gene-gene interactions between the three CD associated loci...
  13. pmc T cells in peripheral blood after gluten challenge in coeliac disease
    R P Anderson
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, c o Post Office RMH, Victoria, Australia 3050
    Gut 54:1217-23. 2005
    ..T cell clones allow identification of gluten peptides that stimulate T cells but do not quantify their contribution to the overall gluten specific T cell response in individuals with CD when exposed to gluten in vivo...
  14. ncbi Association of TNF-alpha-857C with inflammatory bowel disease in the Australian population
    N J O'Callaghan
    John Curtin School of Medical Research, ANU, Canberra, Australia
    Scand J Gastroenterol 38:533-4. 2003
    ..A candidate in that region, TNF-alpha, contains polymorphisms in the promoter region that appear to be associated with disease...
  15. pmc Lack of association of MYO9B genetic variants with coeliac disease in a British cohort
    K A Hunt
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner St, London E1 2AD, USA
    Gut 55:969-72. 2006
    ..MYO9B is a Rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation...
  16. pmc Recent advances in coeliac disease
    D A van Heel
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner St, London E1 2AD, UK
    Gut 55:1037-46. 2006
  17. pmc Detecting the risks of osteoporotic fractures in coeliac disease
    J R F Walters
    Gut 52:1229-30. 2003
  18. pmc Novel presentation of coeliac disease after following the Atkins' low carbohydrate diet
    D A van Heel
    Gut 54:1342. 2005