Omar S Usmani

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols
    Omar S Usmani
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    J Appl Physiol 95:2106-12. 2003
  2. doi request reprint Treating the small airways
    Omar S Usmani
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, and Royal Brompton Hospital, London, UK
    Respiration 84:441-53. 2012
  3. doi request reprint Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease
    Omar S Usmani
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Ann Med 44:146-56. 2012
  4. doi request reprint Clinical posters discussion: summary
    Omar S Usmani
    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, Airway Disease Section, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:341-3. 2011
  5. ncbi request reprint Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size
    Omar S Usmani
    Department of Thoracic Medicine, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:1497-504. 2005
  6. ncbi request reprint Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top aerosol generator
    Omar S Usmani
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Nucl Med 45:69-73. 2004
  7. pmc Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease
    Kittipong Maneechotesuwan
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS Med 6:e1000076. 2009
  8. ncbi request reprint Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator
    Martyn F Biddiscombe
    Nuclear Medicine, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Aerosol Med 19:245-53. 2006
  9. doi request reprint Comparing lung regions of interest in gamma scintigraphy for assessing inhaled therapeutic aerosol deposition
    Martyn F Biddiscombe
    Nuclear Medicine Department, Royal Brompton Hospital, Sydney Street, London, United Kingdom
    J Aerosol Med Pulm Drug Deliv 24:165-73. 2011
  10. pmc Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma
    Nicolas Mercado
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 7:e41582. 2012

Detail Information

Publications19

  1. ncbi request reprint Effects of bronchodilator particle size in asthmatic patients using monodisperse aerosols
    Omar S Usmani
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    J Appl Physiol 95:2106-12. 2003
    ..Aerosols delivered in monodisperse form can enable large reductions of the inhaled dose without loss of clinical efficacy...
  2. doi request reprint Treating the small airways
    Omar S Usmani
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, and Royal Brompton Hospital, London, UK
    Respiration 84:441-53. 2012
    ....
  3. doi request reprint Assessing and treating small airways disease in asthma and chronic obstructive pulmonary disease
    Omar S Usmani
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Ann Med 44:146-56. 2012
    ..Large studies are needed to determine whether better distal lung deposition leads to improvements in small airways function that are translated into clinically significant patient outcomes...
  4. doi request reprint Clinical posters discussion: summary
    Omar S Usmani
    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, Airway Disease Section, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:341-3. 2011
    ..At the Sixth International Cough Symposium, eleven clinical posters were presented at the podium in a formal symposium session. Here we summarize the posters and the discussions...
  5. ncbi request reprint Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size
    Omar S Usmani
    Department of Thoracic Medicine, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:1497-504. 2005
    ..Aerosol particle size influences the extent, distribution, and site of inhaled drug deposition within the airways...
  6. ncbi request reprint Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top aerosol generator
    Omar S Usmani
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Nucl Med 45:69-73. 2004
    ..Here, we report our methodology for radiolabeling and imaging monodisperse pharmacologic aerosols in order to study basic aerosol science concepts of drug delivery within the human airways...
  7. pmc Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease
    Kittipong Maneechotesuwan
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS Med 6:e1000076. 2009
    ..We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo...
  8. ncbi request reprint Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator
    Martyn F Biddiscombe
    Nuclear Medicine, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Aerosol Med 19:245-53. 2006
    ..The aerosols generated by the STAG can allow investigators to study the scientific principles of inhaled drug deposition and lung physiology for a range of therapeutic agents...
  9. doi request reprint Comparing lung regions of interest in gamma scintigraphy for assessing inhaled therapeutic aerosol deposition
    Martyn F Biddiscombe
    Nuclear Medicine Department, Royal Brompton Hospital, Sydney Street, London, United Kingdom
    J Aerosol Med Pulm Drug Deliv 24:165-73. 2011
    ..Our primary intention was to assess the ability of different regional lung templates to discriminate between central and peripheral airway deposition patterns generated by inhaling aerosols of different particle sizes...
  10. pmc Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma
    Nicolas Mercado
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 7:e41582. 2012
    ..We investigated the effects of a p38MAPK inhibitor in corticosteroid sensitivity in peripheral blood mononuclear cells (PBMCs) from severe asthmatics and the profile of its responders...
  11. ncbi request reprint Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy
    Omar S Usmani
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:704-12. 2005
    ..Together, our data confirm that GR nuclear translocation may underlie the complementary interactions between LABAs and corticosteroids, although the precise signal transduction mechanisms remain to be determined...
  12. ncbi request reprint The importance of imaging and physiology measurements in assessing the delivery of peripherally targeted aerosolized drugs
    Martyn F Biddiscombe
    Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Ther Deliv 3:1329-45. 2012
    ....
  13. ncbi request reprint Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3
    Kittipong Maneechotesuwan
    Section of Airway Disease, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 178:2491-8. 2007
    ..This provides a means whereby allergen exposure leads to the expression of Th2 cytokines, and this novel mechanism may provide new approaches to treating allergic diseases...
  14. doi request reprint Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease
    Paolo Paredi
    Airway Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 65:263-7. 2010
    ..Large inspiratory-expiratory variations in Xrs at 5 Hz (DeltaX5) in an individual have been used as a surrogate marker of expiratory flow limitation...
  15. ncbi request reprint Chronic cough and Holmes-Adie syndrome
    Paul A Ford
    Cough Clinic, Royal Brompton Hospital, Sydney Street, London SW3 6LY, UK
    Lancet 369:342. 2007
  16. doi request reprint Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction
    Amir Hakim
    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK
    Drugs 72:1299-312. 2012
    ..Combinations of these drugs with corticosteroids may have additional benefits...
  17. ncbi request reprint Chronic idiopathic cough: a discrete clinical entity?
    Rubaiyat A Haque
    Airways Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse St, London, SW3 6LY, UK
    Chest 127:1710-3. 2005
    ....
  18. ncbi request reprint Theobromine inhibits sensory nerve activation and cough
    Omar S Usmani
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    FASEB J 19:231-3. 2005
    ..These data indicate the actions of theobromine appear to be peripherally mediated. We conclude theobromine is a novel and promising treatment, which may form the basis for a new class of antitussive drugs...
  19. ncbi request reprint A system for the production and delivery of monodisperse salbutamol aerosols to the lungs
    Martyn F Biddiscombe
    Department of Nuclear Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Int J Pharm 254:243-53. 2003
    ..The application and validation of the system with the bronchodilator drug salbutamol sulphate is described, and its potential use in the study of aerosol particle size effects is discussed...