Affiliation: Imperial College
- BGX: a Bioconductor package for the Bayesian integrated analysis of Affymetrix GeneChipsErnest Turro
Centre for Biostatistics, Imperial College London, UK
BMC Bioinformatics 8:439. 2007..They principally provide a point estimate of gene expression and, in contrast to BGX, do not fully integrate the uncertainty arising from potentially heterogeneous responses of the probes...
- MMBGX: a method for estimating expression at the isoform level and detecting differential splicing using whole-transcript Affymetrix arraysErnest Turro
Department of Epidemiology and Public Health, Imperial College London, London, UK
Nucleic Acids Res 38:e4. 2010..Finally, we show that our method for detecting differential splicing has a lower error rate than standard exon-level approaches on a previously validated colon cancer data set...
- Haplotype and isoform specific expression estimation using multi-mapping RNA-seq readsErnest Turro
Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK
Genome Biol 12:R13. 2011..A new statistical method, MMSEQ, deconvolves the mapping of reads to multiple transcripts (isoforms or haplotype-specific isoforms). Our software can take into account non-uniform read generation and works with paired-end reads...
- Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell linesLenka Skalska
Section of Virology, Department of Medicine, Imperial College London, St Mary s Campus, London, United Kingdom
PLoS Pathog 9:e1003187. 2013..If cells are p16(INK4a)-null, functional EBNA3C is dispensable for the outgrowth of LCLs...
- Extensive co-operation between the Epstein-Barr virus EBNA3 proteins in the manipulation of host gene expression and epigenetic chromatin modificationRobert E White
Section of Virology, Imperial College London, London, United Kingdom
PLoS ONE 5:e13979. 2010..Together, this shows the complexity of the interaction between EBV and its host, whereby multiple EBNA3 proteins co-operate to modulate the behaviour of the host cell...