F E Turkheimer

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Multi-resolution Bayesian regression in PET dynamic studies using wavelets
    F E Turkheimer
    Hammersmith Imanet, Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Neuroimage 32:111-21. 2006
  2. pmc Executive functions and prefrontal cortex: a matter of persistence?
    Gareth Ball
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital London, UK
    Front Syst Neurosci 5:3. 2011
  3. pmc Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example
    Federico E Turkheimer
    MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 32:70-80. 2012
  4. pmc Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas
    Federico E Turkheimer
    Department of Clinical Neuroscience, Division of Neuroscience, Imperial College London, UK
    BMC Bioinformatics 7:526. 2006
  5. ncbi request reprint On the logic of hypothesis testing in functional imaging
    Federico E Turkheimer
    Department of Neuropathology, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, UK
    Eur J Nucl Med Mol Imaging 31:725-32. 2004
  6. doi request reprint PET image denoising using a synergistic multiresolution analysis of structural (MRI/CT) and functional datasets
    Federico E Turkheimer
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College, London, United Kingdom
    J Nucl Med 49:657-66. 2008
  7. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
  8. pmc Microglial activation and amyloid deposition in mild cognitive impairment: a PET study
    A Okello
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK
    Neurology 72:56-62. 2009
  9. doi request reprint Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
    P Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College, London, UK
    Neuroimage 60:1716-23. 2012
  10. ncbi request reprint In-vivo measurement of activated microglia in dementia
    A Cagnin
    MRC Cyclotron Unit, Imperial College, Faculty of Medicine, Division of Neuroscience and Psychological Medicince, Hammersmith Hospital, London, UK
    Lancet 358:461-7. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Multi-resolution Bayesian regression in PET dynamic studies using wavelets
    F E Turkheimer
    Hammersmith Imanet, Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Neuroimage 32:111-21. 2006
    ..Significance of the methodology and extension of the procedure to other data (fMRI) and models are discussed...
  2. pmc Executive functions and prefrontal cortex: a matter of persistence?
    Gareth Ball
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital London, UK
    Front Syst Neurosci 5:3. 2011
    ..We propose that persistence within the PFC reflects dynamic network formation and these findings underline the importance of frequency analysis of fMRI time-series in the study of executive functions...
  3. pmc Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example
    Federico E Turkheimer
    MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 32:70-80. 2012
    ..Test-retest results demonstrated a tight linear relationship between BP(D) calculated either with plasma or with a reference input and high reproducibility...
  4. pmc Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas
    Federico E Turkheimer
    Department of Clinical Neuroscience, Division of Neuroscience, Imperial College London, UK
    BMC Bioinformatics 7:526. 2006
    ....
  5. ncbi request reprint On the logic of hypothesis testing in functional imaging
    Federico E Turkheimer
    Department of Neuropathology, Imperial College London, Charing Cross Hospital, St Dunstan s Road, London, W6 8RP, UK
    Eur J Nucl Med Mol Imaging 31:725-32. 2004
    ..The (smaller) set of likely spatial patterns generated is then tested with newer data and a more rigorous multiple hypothesis testing technique (deductive step)...
  6. doi request reprint PET image denoising using a synergistic multiresolution analysis of structural (MRI/CT) and functional datasets
    Federico E Turkheimer
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College, London, United Kingdom
    J Nucl Med 49:657-66. 2008
    ..The method can be naturally extended to other functional imaging modalities (SPECT, functional MRI)...
  7. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
    ....
  8. pmc Microglial activation and amyloid deposition in mild cognitive impairment: a PET study
    A Okello
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK
    Neurology 72:56-62. 2009
    ..They are, therefore, a potential therapeutic target in both AD and its prodrome amnestic mild cognitive impairment (MCI)...
  9. doi request reprint Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
    P Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College, London, UK
    Neuroimage 60:1716-23. 2012
    ..3) Determine the test-retest reliability in AD subjects. 4) Demonstrate the application of target-to-pons ratio in subjects with elevated cerebellar [(11)C]PIB binding...
  10. ncbi request reprint In-vivo measurement of activated microglia in dementia
    A Cagnin
    MRC Cyclotron Unit, Imperial College, Faculty of Medicine, Division of Neuroscience and Psychological Medicince, Hammersmith Hospital, London, UK
    Lancet 358:461-7. 2001
    ..INTERPRETATION: In-vivo detection of increased [11C](R)-PK11195 binding in Alzheimer-type dementia, including mild and early forms, suggests that microglial activation is an early event in the pathogenesis of the disease...
  11. ncbi request reprint Microglia in culture: what genes do they express?
    D C Duke
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, London, UK
    Dev Neurosci 26:30-7. 2004
    ..Furthermore, the data reported here add to our understanding of microglia biology and allow projections as to what functions microglia may exert in vivo, as well as in vitro...
  12. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
    ..The reference-to-target ratio and the Logan graphical approach were significantly less reliable and less sensitive...
  13. ncbi request reprint A linear wavelet filter for parametric imaging with dynamic PET
    Federico E Turkheimer
    IRSL, Cyclotron Building, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    IEEE Trans Med Imaging 22:289-301. 2003
    ..Finally, the formal framework is interpreted for the practitioner's point of view and advantages and limitations of the method are discussed...
  14. ncbi request reprint Balancing bias, reliability, noise properties and the need for parametric maps in quantitative ligand PET: [(11)C]diprenorphine test-retest data
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:82-94. 2007
    ..86) but unacceptably low for VOI-derived VD estimates at the low doses of injected radioactivity (0.24/0.04). Our data can inform the choice of methodology for a given biological problem...
  15. pmc Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study
    A Okello
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, UK
    Neurology 73:754-60. 2009
    ..Patients with amnestic mild cognitive impairment (MCI) represent an important clinical group as they are at increased risk of developing Alzheimer disease (AD). (11)C-PIB PET is an in vivo marker of brain amyloid load...
  16. doi request reprint Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures
    M Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Imperial CollegeLondon, UK
    Neurology 75:1920-7. 2010
    ..Depression associated with Parkinson disease (PD) has a different symptom profile to endogenous depression. The etiology of depression in PD remains uncertain though abnormal serotonergic neurotransmission could play a role...
  17. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    ..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
  18. ncbi request reprint Study of direct and indirect parametric estimation methods of linear models in dynamic positron emission tomography
    Charalampos Tsoumpas
    Hammersmith Imanet, part of GE Healthcare, London, United Kingdom
    Med Phys 35:1299-309. 2008
    ..However, some regions may converge slowly. The FBP and ordered subsets expectation maximization (OSEM) indirect estimations have a similar level of bias after matching their resolutions, but OSEM has smaller standard deviation...
  19. doi request reprint Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College London, UK
    Neuroimage 48:329-38. 2009
    ..Patlak analysis of [11C]PIB binding was the least reproducible...
  20. doi request reprint A new model for prediction of drug distribution in tumor and normal tissues: pharmacokinetics of temozolomide in glioma patients
    Lula Rosso
    Clinical Sciences Centre, Imperial College, Faculty of Medicine, Hammersmith Hospital Campus, London, UK
    Cancer Res 69:120-7. 2009
    ..Overall, the method is considered a robust tool to analyze and predict tissue drug concentrations to help select the most rational dosing schedules...
  21. ncbi request reprint [11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 28:207-16. 2008
    ..Full quantification with an image-independent input should ideally be used in the evaluation of FMZ PET; at least in TLE, intrasubject correlations do not predict equivalent clinical usefulness...
  22. ncbi request reprint Increased frontoparietal integration after stroke and cognitive recovery
    David J Sharp
    Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital Campus, London, UK
    Ann Neurol 68:753-6. 2010
    ..This change reflects greater top-down control of speech comprehension and provides a mechanism by which language impairments after stroke may be compensated for...
  23. ncbi request reprint Rank-shaping regularization of exponential spectral analysis for application to functional parametric mapping
    Federico E Turkheimer
    Hammersmith Imanet, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Phys Med Biol 48:3819-41. 2003
    ..Through application to simulated and real datasets, it is shown that RS ameliorates and extends SA properties in the case of the production of functional parametric maps from PET studies...
  24. ncbi request reprint Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
    M R Turner
    Department of Neurology, Institute of Psychiatry, King s College, London, UK
    Neurobiol Dis 15:601-9. 2004
    ..They also argue for the development of therapeutic strategies aimed at inflammatory pathways...
  25. ncbi request reprint On the undecidability among kinetic models: from model selection to model averaging
    Federico E Turkheimer
    Imaging Research Solutions Ltd, Cyclotron Building, Hammersmith Hospital, London, United Kingdom
    J Cereb Blood Flow Metab 23:490-8. 2003
    ..The new method is illustrated and epitomized by a case example on the modeling of [11C]flumazenil kinetics in the brain, containing both real and simulated data...
  26. doi request reprint Kinetic filtering of [(18)F]Fluorothymidine in positron emission tomography studies
    Katherine R Gray
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Phys Med Biol 55:695-709. 2010
    ..A scan acquisition time of 60 min has been shown to be sufficient to obtain the necessary kinetic data. The algorithm extends utility of FLT-PET imaging in oncology research...
  27. ncbi request reprint Chromosomal profiles of gene expression in Huntington's disease
    Alexander N Anderson
    MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Brain 131:381-8. 2008
    ..These findings support the notion of a common genome-wide mechanism of disruption of RNA transcription in the brain and periphery of Huntington's disease patients...
  28. doi request reprint Quantification of intra-tumour cell proliferation heterogeneity using imaging descriptors of 18F fluorothymidine-positron emission tomography
    J M Y Willaime
    Comprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, London, UK
    Phys Med Biol 58:187-203. 2013
    ..A number of textural features derived from FLT-PET are altered following chemotherapy in breast cancer, and should be evaluated in larger clinical trials for clinical relevance...
  29. ncbi request reprint Towards a transcriptome definition of microglial cells
    L B Moran
    University Department of Neuropathology, Neurosciences Division, Faculty of Medicine, Imperial College London, London, UK
    Neurogenetics 5:95-108. 2004
    ....
  30. pmc Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson disease
    A F Ramlackhansingh
    Room 244, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    Neurology 76:1811-6. 2011
    ..A2A antagonists have antiparkinsonian activity by boosting levodopa efficacy. We aimed to study A2A receptor availability in patients with PD with and without LIDs using PET and [¹¹C]SCH442416, an A2A antagonist...
  31. doi request reprint Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging
    Subrata K Bose
    MRC Clinical Sciences Centre, Imperial College London, United Kingdom
    Schizophr Res 106:148-55. 2008
    ..Overall, these analyses have shown the potential utility of pattern recognition tools in the classification of psychiatric patients based upon molecular imaging of a single target...
  32. ncbi request reprint A survey of approaches for direct parametric image reconstruction in emission tomography
    Charalampos Tsoumpas
    Hammersmith Imanet, London, United Kingdom
    Med Phys 35:3963-71. 2008
    ..This review highlights some aspects of the methods that have been proposed for such direct estimation of pharmacokinetic information from raw emission data...
  33. doi request reprint Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformity
    Alice Egerton
    Institute of Psychiatry, King s College London, London, UK
    Neuroimage 53:777-81. 2010
    ..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
  34. ncbi request reprint A common system for the comprehension and production of narrative speech
    Malaka Awad
    Division of Neuroscience and Mental Health and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Neurosci 27:11455-64. 2007
    ....
  35. ncbi request reprint Wavelet variance components in image space for spatiotemporal neuroimaging data
    John A D Aston
    Institute of Statistical Science, Academia Sinica, 128 Academia Road, Sec 2, Taipei 11529, Taiwan
    Neuroimage 25:159-68. 2005
    ..The techniques are demonstrated for both functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) data sets...
  36. doi request reprint Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease
    Giampaolo Tomasi
    Department of Information Engineering, University of Padova, Padova, Italy
    J Nucl Med 49:1249-56. 2008
    ....
  37. ncbi request reprint The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas
    Shigetoshi Takaya
    Radioisotope Research Centre, Kyoto University, Kyoto, Japan
    J Neurooncol 85:95-103. 2007
    ..Our results demonstrated PBR suppression in glioma-infiltrating microglia and suggested that PBR may have a relevant role in modulating the anti-tumour inflammatory response in astrocytic tumours...
  38. ncbi request reprint Volumes, spatial extents and a probabilistic atlas of the human basal ganglia and thalamus
    R Laila Ahsan
    Division of Neuroscience, Faculty of Medicine, Imperial College, and MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London, UK
    Neuroimage 38:261-70. 2007
    ..We present a comprehensive assessment of thalamic and basal ganglia volumetric and geometric data in both native and stereotaxic spaces. Probabilistic maps in MNI/ICBM152 space will allow accurate localization in group analyses...
  39. ncbi request reprint HBM functional imaging analysis contest data analysis in wavelet space
    John A D Aston
    Institute of Statistical Science, Academia Sinica, Taiwan
    Hum Brain Mapp 27:372-9. 2006
    ..The combination of small- and large-scale effects detected in the FIAC data would be easy to miss using conventional single filter analysis...
  40. ncbi request reprint Positron emission tomography compartmental models: a basis pursuit strategy for kinetic modeling
    Roger N Gunn
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 22:1425-39. 2002
    ..Although the method is presented in the context of PET neuroreceptor binding studies, it has general applicability to the quantification of PET/SPECT radiotracer studies in neurology, oncology, and cardiology...