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Genomes and Genes | T TodaSummaryAffiliation: Imperial Cancer Research Fund Country: UK Publications
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Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycleT Toda
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London, UK
Philos Trans R Soc Lond B Biol Sci 354:1551-7. 1999..We propose that dual downregulation of CDK, one via the APC/cyclosome and the other via the CDK inhibitor, is a universal mechanism that is used to arrest the cell cycle at G1...- The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathwayT Toda
Cell Regulation Laboratory, Imperial Cancer Research Fund, London, United Kingdom
Mol Cell Biol 16:6752-64. 1996..pombe, Pmk1 may not act in a linear manner with respect to fission yeast protein kinase C homologs. Interestingly, however, these two pathways are not independent; instead, they regulate cell integrity in a coordinate manner... 
The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligasesH Yamano
Laboratory of Cell Cycle Control, Imperial Cancer Research Fund, South Mimms, Herts EN6 3LD, United Kingdom
Mol Cell 6:1377-87. 2000..These data indicate that the APC/C and SCF control Cig2 levels differentially at different stages of the cell cycle...- Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeastK Kitamura
Laboratory of Cell Regulation, Imperial Cancer Research Fund, United Kingdom
Dev Cell 1:389-99. 2001..Overall, therefore, these results show that Pat1 coordinates concerted molecular mechanisms that govern the sexual differentiation developmental decision... - A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeastP A Radcliffe
Laboratory of Cell Regulation, Imperial Cancer Research Fund, P O Box 123, 44 Lincoln s Inn Fields, London, UK
FEBS Lett 468:84-8. 2000..Genetic analysis indicates that Alp41 plays a crucial role in the cofactor-dependent pathway, in which it functions upstream of the cofactor D homologue Alp1(D) and possibly in concert with Alp21(E)... - Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligaseK Kominami
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London, UK
Genes Cells 3:721-35. 1998..In fission yeast, F-box/WD-repeat protein Pop1 regulates the level of the CDK (cyclin-dependent kinase) inhibitor Rum1 and the S phase regulator Cdc18... - The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpointL Vardy
Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO J 19:6098-111. 2000..Furthermore, alp4mad2 double mutants show an exaggerated multiple septation phenotype in TBZ. These results indicate that Alp4 and Alp6 may play a crucial role in the spindle pole-mediated checkpoint pathway... - Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeastP A Radcliffe
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
Mol Biol Cell 10:2987-3001. 1999..Finally, the alp1 mutant is not complemented by either alp11(+) or alp21(+). The results suggest that cofactors operate in a linear pathway (Alp11(B)-Alp21(E)-Alp1(D)), each with distinct roles... - Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpointM A Garcia
Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO J 20:3389-401. 2001..These results indicate that the TOG/XMAP215 family may play a central role as a bridge between the kinetochores and the plus end of pole to chromosome microtubules... - Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturationI L Ochotorena
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London, UK
J Cell Sci 114:2911-20. 2001..The results suggest that Wat1 plays a role in mRNA maturation as a coupling protein between splicing and synthesis and/or stabilisation... - Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeastK Kominami
Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO J 17:5388-99. 1998..The results suggest that dual downregulation of CDK, one via the APC and the other via the CDK inhibitor, is a universal mechanism that is used to arrest cell cycle progression at G1... - Characterisation of fission yeast alp11 mutants defines three functional domains within tubulin-folding cofactor BP A Radcliffe
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London, UK
Mol Gen Genet 263:752-60. 2000.... - The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeastM G Wilkinson
Division of Yeast Genetics, National Institute for Medical Research, London, UK
Genes Dev 10:2289-301. 1996..These findings highlight a remarkable level of conservation in transcriptional control by stress-activated MAP kinase pathways between fission yeast and mammalian cells... - The cofactor-dependent pathways for alpha- and beta-tubulins in microtubule biogenesis are functionally different in fission yeastP A Radcliffe
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
Genetics 156:93-103. 2000..We conclude that the cofactor-dependent biogenesis of microtubules comprises an essential and a nonessential pathway, both of which are required for microtubule integrity... - Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutantsP Radcliffe
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
Mol Biol Cell 9:1757-71. 1998..Therefore, it appears that the ts nda3 mutant becomes temperature lethal because of irreversible progression through the cell cycle in the absence of activating the spindle assembly checkpoint pathway... - Rho-dependence of Schizosaccharomyces pombe Pck2L G Sayers
Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, London, UK
Genes Cells 5:17-27. 2000..The structural similarity between the Schizosaccaromyces pombe Pck proteins and the mammalian Rho-dependent protein kinase C-related family, has led us to investigate the relationship between the function of Rho and that of Pck1/2... - Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeastD Hirata
Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
EMBO J 17:658-66. 1998..Our results suggest that, in addition to a function in the folding of beta-tubulin, cofactor D may play a vital role in microtubule-dependent processes as a microtubule-associated protein... - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathwayT Toda
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London, UK
J Cell Sci 109:2331-42. 1996.... - Caffeine can override the S-M checkpoint in fission yeastS W Wang
Imperial Cancer Research Fund, Cell Regulation Laboratory, PO Box 123, Lincoln s Inn Fields, London WC2 A3P, UK
J Cell Sci 112:927-37. 1999..These findings should allow further molecular investigation of the regulation of S phase arrest, and may provide a useful system with which to identify novel drugs that specifically abrogate the checkpoint control... - Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18K Kominami
Laboratory of Cell Regulation, Imperial Cancer Research Fund ICRF, London, UK
Genes Dev 11:1548-60. 1997..Finally we show that Pop1 binds Cdc18 in vivo. We propose that Pop1 functions as a recognition factor for Rum1 and Cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation... - Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombeA Goodwin
Imperial Cancer Research Fund Laboratories, London, UK
Nucleic Acids Res 27:4050-8. 1999..Our data are consistent with a model in which the association of a RecQ helicase and topoisomerase III is important for facilitating decatenation of late stage replicons to permit faithful chromosome segregation during anaphase... 
Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C functionS Katayama
Laboratory of Cell Regulation, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
J Cell Biol 144:1173-86. 1999..These results indicate that Mok1 plays a crucial role in cell morphogenesis interdependently of the actin cytoskeleton and works as one of downstream effectors for Pck1/2...- Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phaseT Takeda
Laboratory of Gene Regulation, Imperial Cancer Research Fund, London, UK
EMBO J 14:6193-208. 1995..Thus Atf1 is a transcription factor that plays an important role in the response of cells to adverse environmental conditions, which is to exit the mitotic cell cycle and either sexually differentiate or enter a resting state... - pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeastR Sugiura
Department of Pharmacology, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650, Japan
EMBO J 17:140-8. 1998..Consistently, the deletion of pmk1(+) suppresses the Cl--sensitive growth defect of ppb1 null. Thus, calcineurin and the Pmk1 MAP kinase pathway may play antagonistic functional roles in the Cl- homeostasis... - Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinasesN Bone
School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Curr Biol 8:135-44. 1998..We have investigated the involvement of S. pombe MAP kinase pathways in signalling a newly described response to osmotic stress - that of vacuole fusion and fission... - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1W M Toone
Laboratory of Gene Regulation, Imperial Cancer Research Fund ICRF, London WC2A 3PX
Genes Dev 12:1453-63. 1998..This relocalization is the result of regulated protein export, rather than import, and involves the Crm1 (exportin) nuclear export factor and the dcd1+/pim1+ gene that encodes an Ran nucleotide exchange factor... - The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switchR Sugiura
Department of Pharmacology, Kobe University School of Medicine, Japan
Nature 399:479-83. 1999..This switch-like mechanism could contribute to the all-or-none physiological response mediated by the MAPK signalling pathway... - Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonismY Li
Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
Neurology 64:1955-7. 2005..Clinically, the patients with the deletion had dementia. Thus, early-onset PD with dementia may be considered PINK1-linked parkinsonism. Furthermore, patients with PINK1 mutations form 8.9% of parkin- and DJ-1-negative ARPD families... - The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of schizosaccharomyces Crm1S Collier
Department of Genetics, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Genetics 155:1799-807. 2000..We see a nuclear accumulation of endogenous actin in the intestinal epithelial cells of the emb mutant larvae, consistent with a role for the emb gene product in nuclear export of actin protein... - Schizosaccharomyces pombe rho2p GTPase regulates cell wall alpha-glucan biosynthesis through the protein kinase pck2pT M Calonge
Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genetica, Consejo Superior de Investigaciones CientÃficas CSIC Universidad de Salamanca, Edificio Departamental, 37007 Salamanca, Spain
Mol Biol Cell 11:4393-401. 2000..Taken together, all of these results indicate the presence of a signaling pathway regulating alpha-glucan biosynthesis in which the Rho2p GTPase activates Pck2p, and this kinase in turn controls Mok1p... - Sequence of Crm1/exportin 1 mutant alleles reveals critical sites associated with multidrug resistanceS Carobbio
Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona
Curr Genet 39:2-9. 2001.... - Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunitV Spataro
Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
J Biol Chem 272:30470-5. 1997..Hence, Poh1 is part of a conserved mechanism that determines cellular susceptibility to cytotoxic agents, perhaps by influencing the ubiquitin-dependent proteolysis of transcription factors... - Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivatedS W Wang
Imperial Cancer Research Fund Molecular Oncology Laboratory, University of Oxford Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
Mol Cell Biol 20:3234-44. 2000..Genetic data suggest that Cid1 acts in association with Crb2/Rhp9 and through the checkpoint-signaling kinase Chk1 to inhibit unscheduled mitosis specifically when DNA polymerase delta or epsilon is inhibited... - Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compoundsK Umesono
J Mol Biol 168:271-84. 1983..Thus, the products of genes nda2 and nda3 (ben1) interact directly or indirectly with the drugs and control, in different ways, microtubular organization in the cells of S. pombe... - The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathwayD Broek
Cell 48:789-99. 1987..We propose that CDC25 regulates adenylate cyclase by regulating the guanine nucleotide bound to RAS proteins... - Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiaeT Toda
Mol Cell Biol 7:1371-7. 1987..Strains of S. cerevisiae with disrupted BCY1 genes do not display a cyclic AMP-dependent protein kinase in vitro, fail to grow on many carbon sources, and are exquisitely sensitive to heat shock and starvation... - In yeast, RAS proteins are controlling elements of adenylate cyclaseT Toda
Cell 40:27-36. 1985..Mixing membranes from ras1- ras2- yeast with membranes from adenylate cyclase deficient yeast reconstitutes a GTP-dependent adenylate cyclase... - The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatasesH Ohkura
Department of Biophysics, Faculty of Science, Kyoto University, Japan
Cell 57:997-1007. 1989..These dis2+ and similar polypeptides of yeasts and mouse are found to be highly homologous (75%-90% identical) to rabbit protein phosphatase 1. The implications of these findings are discussed with regard to mitotic control... - Essential roles of the RNA polymerase I largest subunit and DNA topoisomerases in the formation of fission yeast nucleolusT Hirano
Department of Biophysics, Faculty of Science, Kyoto University, Japan
J Cell Biol 108:243-53. 1989.... - Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinasesT Toda
Department of Biophysics, Faculty of Science, Kyoto University, Japan
Genes Dev 5:60-73. 1991..The pap1+ gene is required for spk1(+)-conferred staurosporine resistance. These two genes appear to function as a part of the fission yeast growth control pathway... - Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1T Toda
Department of Biophysics, Faculty of Science, Kyoto University, Japan
Mol Cell Biol 12:5474-84. 1992..These results suggest the functional importance of chromosome structure on the regulation of gene expression through the pap1 transcription factor... - Fission yeast TPR-family protein nuc2 is required for G1-arrest upon nitrogen starvation and is an inhibitor of septum formationK Kumada
Department of Biophysics, Faculty of Science, Kyoto University, Japan
J Cell Sci 108:895-905. 1995.... - A novel protein kinase gene ssp1+ is required for alteration of growth polarity and actin localization in fission yeastT Matsusaka
Department of Biophysics, Faculty of Science, Kyoto University, Japan
EMBO J 14:3325-38. 1995..These results show that the dynamics of actin-based growth polarity during the cell cycle are regulated, at least in part, by a novel set of protein kinases and phosphatases... - A novel essential fission yeast gene pad1+ positively regulates pap1(+)-dependent transcription and is implicated in the maintenance of chromosome structureM Shimanuki
Department of Biophysics, Faculty of Science, Kyoto University, Japan
J Cell Sci 108:569-79. 1995..Taken concurrently with our previous results, two essential genes pad1+ and crm1+ regulate pap1-dependent transcription; pad1+ and crm1+ are positive and negative regulators, respectively... - Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+K Ishii
Department of Biophysics, Faculty of Science, Kyoto University, Sakyo ku, Japan
EMBO J 15:6629-40. 1996..These results demonstrate functions other than promoting anaphase for the components of the 20S cyclosome/APC and also a close functional relationship of Sds23 with PP1 and 20S cyclosome/APC... - A new group of conserved coactivators that increase the specificity of AP-1 transcription factorsF X Claret
Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California, San Diego, La Jolla 92093 0636, USA
Nature 383:453-7. 1996..JAB1 and Pad1 are also functionally interchangeable. They define a new group of coactivators that increase the specificity of target gene activation by AP-1 proteins... - Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+K Kumada
Department of Biophysics, Faculty of Science, Kyoto University, Japan
Mol Gen Genet 250:59-68. 1996..These results show that the crm1+ gene is a major locus for caffeine resistance, which arises from Pap1-dependent transcriptional activation... - Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape controlT Toda
Department of Biophysics, Faculty of Science, Kyoto University, Japan
EMBO J 12:1987-95. 1993..1991) Genes Dev., 5, 60-73]. In addition, the lethal overexpression of pck2+ can be suppressed by staurosporine, indicating that fission yeast pck1 and pck2 are molecular targets of this inhibitor... - Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosisM Shimanuki
Department of Biophysics, Faculty of Science, Kyoto University, Japan
Mol Biol Cell 4:303-13. 1993..Consistent with this hypothesis, double mutants ppe1-ppa2 and ppe1-pck1 are lethal at the permissive temperature... - Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulationM Shimanuki
Department of Biophysics, Faculty of Science, Kyoto University, Japan
Mol Biol Cell 3:263-73. 1992..Disruption of the sts1+ gene does not lead to a sensitivity to thiabendazole or hydroxyurea... - Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 familyS Miyake
Laboratory of Molecular Genetics, University of Tokyo, Japan
Mol Biol Cell 4:1003-15. 1993..The central domains of these proteins are conserved, whereas the NH2- and COOH- domains are distinct. Results of the disruption of the nda1+ and nda4+ genes demonstrates that they are essential for viability... - Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)T Toda
Department of Biochemistry, Cancer Institute, Tokyo, Japan
Hum Mol Genet 3:465-70. 1994..These data suggest that ZFM1 might be a candidate for mutations that cause MEN1... - A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioningT Yoshida
Department of Biophysics, Faculty of Science, Kyoto University, Japan
J Cell Sci 107:1725-35. 1994..Thus the ppb1+ gene appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape... - SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunitsT Toda
Cold Spring Harbor Laboratory, New York 11724
Genes Dev 2:517-27. 1988..This defect is suppressed by activation of the cAMP effector pathway. We propose that SCH9 encodes a protein kinase that is part of a growth control pathway which is at least partially redundant with the cAMP pathway... - Deletion analysis of the enolase gene (enoA) promoter from the filamentous fungus Aspegillus oryzaeT Toda
Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
Curr Genet 40:260-7. 2001..oryzae cellular factors specifically bind. These results suggest that the 15-bp element between -195 nt and -181 nt includes the sequence essential for the transcription regulation of the A. oryzae enoA gene... - Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombeT Toda
Cell 37:233-42. 1984..S. pombe tubulin was isolated by cycles of assembly and disassembly. Presumed alpha- and beta-tubulin polypeptide bands reacted with monoclonal antibodies specific for chicken alpha- and beta-tubulins... - The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosisY Hiraoka
Cell 39:349-58. 1984..6 kb Hind III genomic DNA that complemented the nda3 mutations had only one coding frame split with five short introns. The predicted amino acid sequence contained 448 residues, and was 75% homologous to that of chicken beta-tubulin... - Analysis of microsatellite instability and loss of heterozygosity in uterine endometrial adenocarcinomaT Toda
Department of Clinical Laboratory Medicine, University of the Ryukyus Hospital, School of Medicine, Nishihara-cho, Aza Uehara 207, 903-0125, Okinawa, Japan
Cancer Genet Cytogenet 126:120-7. 2001..However, the TGF-beta type II receptor gene was considered a minor target of genetic instability in endometrial carcinogenesis... - Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinaseT Toda
Cell 50:277-87. 1987..The amino-terminal regions show no homology to each other and are heterogeneous in length. The TPK1 gene carried on a multicopy plasmid can suppress both a temperature-sensitive ras2 gene and adenylate cyclase gene... - Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosisH Ohkura
Department of Biophysics, Faculty of Science, Kyoto University, Japan
EMBO J 7:1465-73. 1988..We cloned, in addition to the dis2+ and dis3+ genes, multicopy extragenic suppressor sequences which complement dis1 and dis2 mutations. A complex regulatory system may exist for the execution of the dis+ gene functions... - Haplotype-phenotype correlation in Fukuyama congenital muscular dystrophyK Saito
Department of Pediatrics, Tokyo Women s Medical University, School of Medicine, Japan
Am J Med Genet 92:184-90. 2000..005). Severe FCMD patients appeared to be compound heterozygotes for the founder mutation and another mutation. Thus, the present study yielded molecular genetic evidence of a broad clinical spectrum in FCMD... - Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiaeT Toda
Cold Spring Harbor Laboratory, New York 11724
Princess Takamatsu Symp 17:253-60. 1986..RAS proteins are themselves probably controlled by growth regulatory proteins... - Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiaeP Sass
Proc Natl Acad Sci U S A 83:9303-7. 1986..These results therefore imply that the effects of RAS2Val19 are mediated through its changes in cAMP concentration...