Stephen J Till

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Mechanisms of immunotherapy
    Stephen J Till
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Doverhouse Street, London SW3 6LY, United Kingdom
    J Allergy Clin Immunol 113:1025-34; quiz 1035. 2004
  2. doi request reprint Mechanisms of immunotherapy and surrogate markers
    S Till
    Section of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Allergy 66:25-7. 2011
  3. ncbi request reprint Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Immunol 172:3252-9. 2004
  4. ncbi request reprint CXCR1+CD4+ T cells in human allergic disease
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom
    J Immunol 172:268-73. 2004
  5. doi request reprint Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies
    Louisa K James
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, part of the Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, UK
    J Allergy Clin Immunol 127:509-516.e1-5. 2011
  6. ncbi request reprint Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    J Allergy Clin Immunol 111:1255-61. 2003
  7. doi request reprint Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
    James N Francis
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 121:1120-1125.e2. 2008
  8. ncbi request reprint Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy
    Petra A Wachholz
    Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    J Allergy Clin Immunol 112:915-22. 2003
  9. doi request reprint Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses
    Giuseppina Rotiroti
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 130:918-24.e1. 2012
  10. ncbi request reprint CCR4 in human allergen-induced late responses in the skin and lung
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:1933-8. 2002

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Mechanisms of immunotherapy
    Stephen J Till
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Doverhouse Street, London SW3 6LY, United Kingdom
    J Allergy Clin Immunol 113:1025-34; quiz 1035. 2004
    ....
  2. doi request reprint Mechanisms of immunotherapy and surrogate markers
    S Till
    Section of Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Allergy 66:25-7. 2011
    ..There is a continuing unmet need for biomarkers that will allow prediction of treatment efficacy and assist in monitoring the response after starting therapy or postwithdrawal...
  3. ncbi request reprint Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Immunol 172:3252-9. 2004
    ..Thus, grass pollen immunotherapy may induce allergen-specific, IL-10-dependent "protective" IgG4 responses...
  4. ncbi request reprint CXCR1+CD4+ T cells in human allergic disease
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom
    J Immunol 172:268-73. 2004
    ..Phenotypic analysis reveals that IFN-gamma expression was lower in the CXCR1+CD4+ cells. The identification of CXCR1 as a marker of allergic rhinitis reveals a possible target for therapeutic intervention in atopic disease...
  5. doi request reprint Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies
    Louisa K James
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, part of the Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, UK
    J Allergy Clin Immunol 127:509-516.e1-5. 2011
    ..Active treatment is associated with generation of inhibitory grass pollen-specific IgG antibodies capable of blocking allergen-IgE interactions...
  6. ncbi request reprint Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    J Allergy Clin Immunol 111:1255-61. 2003
    ..IL-10-producing CD4+CD25+ regulatory T cells have emerged as potential mediators of immune tolerance in numerous murine models of immunopathology...
  7. doi request reprint Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
    James N Francis
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 121:1120-1125.e2. 2008
    ..Grass pollen immunotherapy is an effective treatment for seasonal allergic rhinitis that provides the opportunity to study the induction and maintenance of allergen-specific immune tolerance...
  8. ncbi request reprint Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy
    Petra A Wachholz
    Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    J Allergy Clin Immunol 112:915-22. 2003
    ..These observations have led to proposals that allergen-specific IgG antibodies might have protective properties in atopic individuals...
  9. doi request reprint Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses
    Giuseppina Rotiroti
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 130:918-24.e1. 2012
    ..Uncontrolled reports from the early 20th century describe low-dose allergen inoculation directly into the dermis, an immunologically active area containing abundant dendritic cells and lymphatics...
  10. ncbi request reprint CCR4 in human allergen-induced late responses in the skin and lung
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:1933-8. 2002
    ..CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner...
  11. doi request reprint Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation
    Stephen J Till
    Department of Asthma, Allergy and Respiratory Science, Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, UK
    Thorax 69:335-45. 2014
    ..T-cell targeted peptide epitope tolerogens from grass pollen allergens may be useful in treating seasonal allergic rhinitis, but there is urgent need for optimisation of approaches from improved understanding of mechanism...
  12. pmc Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios
    Petra A Wachholz
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Immunology 105:56-62. 2002
    ....
  13. ncbi request reprint Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics
    Duncan R Wilson
    Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 165:22-6. 2002
    ..These data indicate that allergen provocation results in a selective local accumulation of isotype-specific and allergen-specific IgE antibody within the bronchi, independent of alterations in circulating IgE...
  14. ncbi request reprint Immunological responses to allergen immunotherapy
    Stephen J Till
    Imperial College, London, England
    Clin Allergy Immunol 18:85-104. 2004
  15. ncbi request reprint Immunomodulatory treatment strategies for allergic diseases
    Eva Maria Varga
    Division of Respiratory and Allergic Diseases, Department of Pediatrics, University of Graz, A 8036 Graz, Auenbruggerplatz 30, Austria
    Curr Drug Targets Inflamm Allergy 2:31-46. 2003
    ..Although, immunomodulatory strategies provide a promising outlook for the treatment of allergic patients, more studies are needed in the future to address issues of efficacy, safety and long-term effects of altered immune responses...