Mark Thursz

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc The importance of baseline viral load when assessing relative efficacy in treatment-naïve HBeAg-positive chronic hepatitis B: a systematic review and network meta-analysis
    Stuart Mealing
    Oxford Outcomes Ltd, Seacourt Tower, West Way, Oxford OX2 0JJ, UK
    Syst Rev 3:21. 2014
  2. pmc Steroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial
    Ewan Forrest
    Hepatology Section, Imperial College, Norfolk Place, London, Paddington W2 1NY, UK
    Trials 14:262. 2013
  3. pmc Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection
    Mark Thursz
    Gastroenterology and Hepatology Research, Imperial College St Mary s Hospital Campus, Norfolk Place, London W2 1NY, UK
    Gut 56:613-4. 2007
  4. ncbi request reprint Understanding the host genetics of chronic hepatitis B and C
    Mark Thursz
    Hepatology and Gastroenterology Section, Department of Medicine, Imperial College, London, United Kingdom
    Semin Liver Dis 31:115-27. 2011
  5. ncbi request reprint Natural NS3 resistance polymorphisms occur frequently prior to treatment in HIV-positive patients with acute hepatitis C
    Mayke Leggewie
    aMRC Centre for Virus Research, University of Glasgow, Glasgow bDepartment of Virology, Imperial College NHS Trust cDepartment of Medicine, Imperial College London, London, UK
    AIDS 27:2485-8. 2013
  6. ncbi request reprint The diversity and management of chronic hepatitis B virus infections in the United Kingdom: a wake-up call
    Richard S Tedder
    Microbiology Services Colindale, Health Protection Agency, London, UK
    Clin Infect Dis 56:951-60. 2013
  7. ncbi request reprint Blunted increase in serum hepcidin as response to oral iron in HFE-hemochromatosis
    Arvind Sangwaiya
    Department of Gastroenterology, Ealing Hospital NHS Trust, London, UK
    Eur J Gastroenterol Hepatol 23:721-4. 2011
  8. ncbi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
  9. ncbi request reprint NICE guidelines and a treatment algorithm for the management of chronic hepatitis B: a review of 12 years experience in west London
    Patrick T F Kennedy
    Department of Hepatology, Imperial College London at St Mary s Hospital, London, UK
    Antivir Ther 13:1067-76. 2008
  10. ncbi request reprint Quantitative versus morphological assessment of liver fibrosis: semi-quantitative scores are more robust than digital image fibrosis area estimation
    Mark Wright
    Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
    Liver Int 23:28-34. 2003

Collaborators

Detail Information

Publications12

  1. pmc The importance of baseline viral load when assessing relative efficacy in treatment-naïve HBeAg-positive chronic hepatitis B: a systematic review and network meta-analysis
    Stuart Mealing
    Oxford Outcomes Ltd, Seacourt Tower, West Way, Oxford OX2 0JJ, UK
    Syst Rev 3:21. 2014
    ..We undertook baseline-adjusted and unadjusted analyses using the same data to explore the impact of baseline viral load (BVL) on CHB treatment response...
  2. pmc Steroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial
    Ewan Forrest
    Hepatology Section, Imperial College, Norfolk Place, London, Paddington W2 1NY, UK
    Trials 14:262. 2013
    ..The role of corticosteroids is controversial as trial results have been inconsistent, whereas the role of pentoxifylline requires confirmation as only one previous placebo-controlled trial has been published...
  3. pmc Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection
    Mark Thursz
    Gastroenterology and Hepatology Research, Imperial College St Mary s Hospital Campus, Norfolk Place, London W2 1NY, UK
    Gut 56:613-4. 2007
  4. ncbi request reprint Understanding the host genetics of chronic hepatitis B and C
    Mark Thursz
    Hepatology and Gastroenterology Section, Department of Medicine, Imperial College, London, United Kingdom
    Semin Liver Dis 31:115-27. 2011
    ..Indeed, stratification of clinical trial populations based on IL-28B genotype is already considered mandatory...
  5. ncbi request reprint Natural NS3 resistance polymorphisms occur frequently prior to treatment in HIV-positive patients with acute hepatitis C
    Mayke Leggewie
    aMRC Centre for Virus Research, University of Glasgow, Glasgow bDepartment of Virology, Imperial College NHS Trust cDepartment of Medicine, Imperial College London, London, UK
    AIDS 27:2485-8. 2013
    ..Low-frequency mutations were detected in all samples. Further studies are required to determine threshold levels associated with treatment failure. ..
  6. ncbi request reprint The diversity and management of chronic hepatitis B virus infections in the United Kingdom: a wake-up call
    Richard S Tedder
    Microbiology Services Colindale, Health Protection Agency, London, UK
    Clin Infect Dis 56:951-60. 2013
    ..Through migration, diversity of chronic hepatitis B virus (HBV) infection has changed, affecting disease burden and control. We describe clinical and viral characteristics of chronic HBV in the United Kingdom...
  7. ncbi request reprint Blunted increase in serum hepcidin as response to oral iron in HFE-hemochromatosis
    Arvind Sangwaiya
    Department of Gastroenterology, Ealing Hospital NHS Trust, London, UK
    Eur J Gastroenterol Hepatol 23:721-4. 2011
    ..However, the precise link between hepcidin levels and iron absorption in HFE-H patients has been poorly understood...
  8. ncbi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
    ..Culture of healthy monocytes with AALF liver homogenates, plasma, or rhSLPI induced monocytes with strikingly similar anti-inflammatory characteristics which were reversed by inhibiting the activity of SLPI...
  9. ncbi request reprint NICE guidelines and a treatment algorithm for the management of chronic hepatitis B: a review of 12 years experience in west London
    Patrick T F Kennedy
    Department of Hepatology, Imperial College London at St Mary s Hospital, London, UK
    Antivir Ther 13:1067-76. 2008
    ....
  10. ncbi request reprint Quantitative versus morphological assessment of liver fibrosis: semi-quantitative scores are more robust than digital image fibrosis area estimation
    Mark Wright
    Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
    Liver Int 23:28-34. 2003
    ..Accurate determination of a threshold greyscale level representing fibrous tissue is critical. This method has not been fully evaluated in clinical practice...
  11. ncbi request reprint Autoregulatory role of interleukin-10 in hepatitis C patients treated with IFN-alpha
    Armin Luik
    University of Mainz, Department of Medicine, 55101 Mainz, Germany
    J Interferon Cytokine Res 24:585-93. 2004
    ..This suggests an autoregulatory role of IL-10 in IFN therapy...
  12. ncbi request reprint Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection
    Simon Hellier
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Hepatology 38:1468-76. 2003
    ..018, OR: 2.29, 95% CI: 1.14-4.58). In conclusion, our study suggests a possible role of the polymorphisms CCR5-delta32, RANTES -403, and MCP-2 Q46K in the outcome of HCV infection...