M Thursz

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research
    M Thursz
    Division of Medicine A, Imperial College, School of Medicine at St Mary s Hospital, London, UK
    Lancet 354:2119-24. 1999
  2. ncbi Genetic susceptibility in infectious diseases
    M Thursz
    Division of Medicine, Imperial College School of Medicine, St Mary s Campus, London W2 1NY, U K
    Biotechnol Genet Eng Rev 17:253-64. 2000
  3. ncbi Genetic susceptibility in chronic viral hepatitis
    M Thursz
    Imperial College School of Medicine, St Mary s Hospital, Norfolk Place, London W2 1NY, UK
    Antiviral Res 52:113-6. 2001
  4. ncbi Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Hepatol 35:99-104. 2001
  5. ncbi Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    M Wright
    Hepatology Section, Division of Medicine A, Imperial College School of Medicine at St Mary s Hospital, Praed St, London W2 1NY, UK
    Gut 52:1206-10. 2003
  6. ncbi Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients
    A Godkin
    Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, GB
    Eur J Immunol 31:1438-46. 2001
  7. ncbi Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trial
    M Wright
    Hepatology Section, St Mary's Hospital, Imperial College London, London, UK
    J Viral Hepat 12:58-66. 2005
  8. ncbi Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
    J Med Virol 65:664-70. 2001
  9. ncbi Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study
    M Wright
    Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
    Gut 52:574-9. 2003
  10. ncbi Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection
    B J W Hennig
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
    Genes Immun 3:359-67. 2002

Collaborators

Detail Information

Publications12

  1. ncbi Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research
    M Thursz
    Division of Medicine A, Imperial College, School of Medicine at St Mary s Hospital, London, UK
    Lancet 354:2119-24. 1999
    ..We aimed to confirm these associations in a cohort of European patients with different clinical outcomes...
  2. ncbi Genetic susceptibility in infectious diseases
    M Thursz
    Division of Medicine, Imperial College School of Medicine, St Mary s Campus, London W2 1NY, U K
    Biotechnol Genet Eng Rev 17:253-64. 2000
    ....
  3. ncbi Genetic susceptibility in chronic viral hepatitis
    M Thursz
    Imperial College School of Medicine, St Mary s Hospital, Norfolk Place, London W2 1NY, UK
    Antiviral Res 52:113-6. 2001
    ..In particular alleles in the MHC class II loci and interleukin 10 promoter have been demonstrated to influence the outcome of these infections...
  4. ncbi Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Hepatol 35:99-104. 2001
    ..CONCLUSIONS: Phylogenetic tree analysis of sequences obtained from family members provided strong evidence of intrafamilial transmission of HBV in at least two-thirds of the families studied from Gambia...
  5. ncbi Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    M Wright
    Hepatology Section, Division of Medicine A, Imperial College School of Medicine at St Mary s Hospital, Praed St, London W2 1NY, UK
    Gut 52:1206-10. 2003
    ..We hypothesised that polymorphisms of the coagulation factors II and V affect the rate of progression to cirrhosis in HCV infected subjects...
  6. ncbi Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients
    A Godkin
    Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, GB
    Eur J Immunol 31:1438-46. 2001
    ..The frequency and phenotype of memory cells is likely to reflect the magnitude of the initial immune response, and suggests that a high frequency of IFN-gamma-secreting CD4+ T cells to multiple epitopes are important in clearance of HCV...
  7. ncbi Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trial
    M Wright
    Hepatology Section, St Mary's Hospital, Imperial College London, London, UK
    J Viral Hepat 12:58-66. 2005
    ..Patients who fail to respond by 12 weeks of therapy should have their treatment curtailed early...
  8. ncbi Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
    J Med Virol 65:664-70. 2001
    ..Several of the amino acid substitutions found have been described previously been in wild-type viruses of other genotypes...
  9. ncbi Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study
    M Wright
    Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
    Gut 52:574-9. 2003
    ..The aims of this study were: (1) to determine whether fibrosis progresses linearly through the grading scales and (2) to identify factors which influence the rate of fibrosis...
  10. ncbi Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection
    B J W Hennig
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
    Genes Immun 3:359-67. 2002
    ..Our findings support a possible role for the LDLR in the modulation of disease progression by affecting immune responses, rather than functioning as receptor for HCV...
  11. ncbi Long-term follow-up of the hepatitis C HENCORE cohort: response to therapy and occurrence of liver-related complications
    P Pradat
    Hospices Civils de Lyon, Universite Claude Bernard Lyon 1, Lyon, France
    J Viral Hepat 14:556-63. 2007
    ..The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients...
  12. ncbi Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection
    R Dawes
    J Med Genet 43:678-84. 2006
    ..CONCLUSIONS: Changes in CD45 isoform expression can alter immune function in human C77G variants and CD45 transgenic mice. The C77G allele may influence the outcome of HCV infection...