M Thursz

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research
    M Thursz
    Division of Medicine A, Imperial College, School of Medicine at St Mary s Hospital, London, UK
    Lancet 354:2119-24. 1999
  2. ncbi request reprint Genetic susceptibility in infectious diseases
    M Thursz
    Division of Medicine, Imperial College School of Medicine, St Mary s Campus, London W2 1NY, U K
    Biotechnol Genet Eng Rev 17:253-64. 2000
  3. ncbi request reprint Genetic susceptibility in chronic viral hepatitis
    M Thursz
    Imperial College School of Medicine, St Mary s Hospital, Norfolk Place, London W2 1NY, UK
    Antiviral Res 52:113-6. 2001
  4. ncbi request reprint Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Hepatol 35:99-104. 2001
  5. pmc Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    M Wright
    Hepatology Section, Division of Medicine A, Imperial College School of Medicine at St Mary s Hospital, Praed St, London W2 1NY, UK
    Gut 52:1206-10. 2003
  6. ncbi request reprint Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients
    A Godkin
    Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, GB
    Eur J Immunol 31:1438-46. 2001
  7. ncbi request reprint Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trial
    M Wright
    Hepatology Section, St Mary s Hospital, Imperial College London, London, UK
    J Viral Hepat 12:58-66. 2005
  8. ncbi request reprint Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
    J Med Virol 65:664-70. 2001
  9. pmc Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study
    M Wright
    Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
    Gut 52:574-9. 2003
  10. ncbi request reprint Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection
    B J W Hennig
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
    Genes Immun 3:359-67. 2002

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research
    M Thursz
    Division of Medicine A, Imperial College, School of Medicine at St Mary s Hospital, London, UK
    Lancet 354:2119-24. 1999
    ..We aimed to confirm these associations in a cohort of European patients with different clinical outcomes...
  2. ncbi request reprint Genetic susceptibility in infectious diseases
    M Thursz
    Division of Medicine, Imperial College School of Medicine, St Mary s Campus, London W2 1NY, U K
    Biotechnol Genet Eng Rev 17:253-64. 2000
    ....
  3. ncbi request reprint Genetic susceptibility in chronic viral hepatitis
    M Thursz
    Imperial College School of Medicine, St Mary s Hospital, Norfolk Place, London W2 1NY, UK
    Antiviral Res 52:113-6. 2001
    ..In particular alleles in the MHC class II loci and interleukin 10 promoter have been demonstrated to influence the outcome of these infections...
  4. ncbi request reprint Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysis
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, UK
    J Hepatol 35:99-104. 2001
    ..CONCLUSIONS: Phylogenetic tree analysis of sequences obtained from family members provided strong evidence of intrafamilial transmission of HBV in at least two-thirds of the families studied from Gambia...
  5. pmc Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection
    M Wright
    Hepatology Section, Division of Medicine A, Imperial College School of Medicine at St Mary s Hospital, Praed St, London W2 1NY, UK
    Gut 52:1206-10. 2003
    ..We hypothesised that polymorphisms of the coagulation factors II and V affect the rate of progression to cirrhosis in HCV infected subjects...
  6. ncbi request reprint Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients
    A Godkin
    Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, GB
    Eur J Immunol 31:1438-46. 2001
    ..The frequency and phenotype of memory cells is likely to reflect the magnitude of the initial immune response, and suggests that a high frequency of IFN-gamma-secreting CD4+ T cells to multiple epitopes are important in clearance of HCV...
  7. ncbi request reprint Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trial
    M Wright
    Hepatology Section, St Mary s Hospital, Imperial College London, London, UK
    J Viral Hepat 12:58-66. 2005
    ..Patients who fail to respond by 12 weeks of therapy should have their treatment curtailed early...
  8. ncbi request reprint Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers
    U Dumpis
    Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
    J Med Virol 65:664-70. 2001
    ..Several of the amino acid substitutions found have been described previously been in wild-type viruses of other genotypes...
  9. pmc Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study
    M Wright
    Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
    Gut 52:574-9. 2003
    ..The aims of this study were: (1) to determine whether fibrosis progresses linearly through the grading scales and (2) to identify factors which influence the rate of fibrosis...
  10. ncbi request reprint Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection
    B J W Hennig
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
    Genes Immun 3:359-67. 2002
    ..Our findings support a possible role for the LDLR in the modulation of disease progression by affecting immune responses, rather than functioning as receptor for HCV...
  11. ncbi request reprint Long-term follow-up of the hepatitis C HENCORE cohort: response to therapy and occurrence of liver-related complications
    P Pradat
    Hospices Civils de Lyon, Universite Claude Bernard Lyon 1, Lyon, France
    J Viral Hepat 14:556-63. 2007
    ..The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients...
  12. pmc Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection
    R Dawes
    J Med Genet 43:678-84. 2006
    ..A polymorphism in exon 4 (C77G) of CD45 that alters CD45 splicing has been associated with autoimmune and infectious diseases in humans...