Affiliation: Imperial College
- Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative ResearchM Thursz
Division of Medicine A, Imperial College, School of Medicine at St Mary s Hospital, London, UK
Lancet 354:2119-24. 1999..We aimed to confirm these associations in a cohort of European patients with different clinical outcomes...
- Genetic susceptibility in infectious diseasesM Thursz
Division of Medicine, Imperial College School of Medicine, St Mary s Campus, London W2 1NY, U K
Biotechnol Genet Eng Rev 17:253-64. 2000....
- Genetic susceptibility in chronic viral hepatitisM Thursz
Imperial College School of Medicine, St Mary s Hospital, Norfolk Place, London W2 1NY, UK
Antiviral Res 52:113-6. 2001..In particular alleles in the MHC class II loci and interleukin 10 promoter have been demonstrated to influence the outcome of these infections...
- Transmission of hepatitis B virus infection in Gambian families revealed by phylogenetic analysisU Dumpis
Department of Medicine A, Imperial College School of Medicine, London, UK
J Hepatol 35:99-104. 2001..CONCLUSIONS: Phylogenetic tree analysis of sequences obtained from family members provided strong evidence of intrafamilial transmission of HBV in at least two-thirds of the families studied from Gambia...
- Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infectionM Wright
Hepatology Section, Division of Medicine A, Imperial College School of Medicine at St Mary s Hospital, Praed St, London W2 1NY, UK
Gut 52:1206-10. 2003..We hypothesised that polymorphisms of the coagulation factors II and V affect the rate of progression to cirrhosis in HCV infected subjects...
- Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patientsA Godkin
Imperial College of Science, Technology and Medicine, St Mary s Hospital, London, GB
Eur J Immunol 31:1438-46. 2001..The frequency and phenotype of memory cells is likely to reflect the magnitude of the initial immune response, and suggests that a high frequency of IFN-gamma-secreting CD4+ T cells to multiple epitopes are important in clearance of HCV...
- Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: a multicentre randomized controlled trialM Wright
Hepatology Section, St Mary's Hospital, Imperial College London, London, UK
J Viral Hepat 12:58-66. 2005..Patients who fail to respond by 12 weeks of therapy should have their treatment curtailed early...
- Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriersU Dumpis
Department of Medicine A, Imperial College School of Medicine, London, United Kingdom
J Med Virol 65:664-70. 2001..Several of the amino acid substitutions found have been described previously been in wild-type viruses of other genotypes...
- Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal studyM Wright
Hepatology Section, Faculty of Medicine, Imperial College, London W2 1NY, UK
Gut 52:574-9. 2003..The aims of this study were: (1) to determine whether fibrosis progresses linearly through the grading scales and (2) to identify factors which influence the rate of fibrosis...
- Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infectionB J W Hennig
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK
Genes Immun 3:359-67. 2002..Our findings support a possible role for the LDLR in the modulation of disease progression by affecting immune responses, rather than functioning as receptor for HCV...
- Long-term follow-up of the hepatitis C HENCORE cohort: response to therapy and occurrence of liver-related complicationsP Pradat
Hospices Civils de Lyon, Universite Claude Bernard Lyon 1, Lyon, France
J Viral Hepat 14:556-63. 2007..The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients...
- Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infectionR Dawes
J Med Genet 43:678-84. 2006..CONCLUSIONS: Changes in CD45 isoform expression can alter immune function in human C77G variants and CD45 transgenic mice. The C77G allele may influence the outcome of HCV infection...