Claire Thornton

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Molecular mechanisms of neonatal brain injury
    Claire Thornton
    Centre for the Developing Brain, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Neurol Res Int 2012:506320. 2012
  2. doi AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure
    Claire Thornton
    Cellular Stress Group, MRC Clinical Sciences Centre, London, UK
    Biochem J 434:503-12. 2011
  3. ncbi Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression
    Claire Thornton
    Medical Research Council MRC Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, United Kingdom
    J Biol Chem 283:17116-22. 2008
  4. doi Mitochondria: hub of injury responses in the developing brain
    Henrik Hagberg
    Centre for the Developing Brain, Perinatal Imaging and Health, King s College London, St Thomas Hospital, London, UK Perinatal Center, Departments of Clinical Sciences and Physiology and Neurosciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden Electronic address
    Lancet Neurol 13:217-32. 2014
  5. pmc Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation
    Nicola J Bright
    Medical Research Council Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London, United Kingdom
    J Biol Chem 283:14946-54. 2008
  6. doi Mitochondria and perinatal brain injury
    Catherine I Rousset
    Centre for the Developing Brain, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College, Hammersmith Campus, London, UK
    J Matern Fetal Neonatal Med 25:35-8. 2012
  7. doi AMP-activated protein kinase: new regulation, new roles?
    David Carling
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
    Biochem J 445:11-27. 2012
  8. pmc Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner
    Rachel Jurd
    Gallo Research Center, Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
    J Biol Chem 283:301-10. 2008
  9. pmc H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity
    Claire Thornton
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:23823-9. 2003
  10. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002

Collaborators

Detail Information

Publications10

  1. pmc Molecular mechanisms of neonatal brain injury
    Claire Thornton
    Centre for the Developing Brain, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Neurol Res Int 2012:506320. 2012
    ..We review some of the critical molecular events related to mitochondrial dysfunction and apoptosis during the secondary phase and report some recent evidence that intervention may be feasible also days-weeks after the insult...
  2. doi AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure
    Claire Thornton
    Cellular Stress Group, MRC Clinical Sciences Centre, London, UK
    Biochem J 434:503-12. 2011
    ..These findings identify a pathway in which Aβ-(1-42) activates CaMKKβ and AMPK via the NMDA receptor, suggesting the possibility that AMPK plays a role in the pathophysiological phosphorylation of tau...
  3. ncbi Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression
    Claire Thornton
    Medical Research Council MRC Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, United Kingdom
    J Biol Chem 283:17116-22. 2008
    ..These data support a hypothesis that modulating basal AMPK activity in the hypothalamus is essential for maintaining tight regulation of pathways contributing to food intake...
  4. doi Mitochondria: hub of injury responses in the developing brain
    Henrik Hagberg
    Centre for the Developing Brain, Perinatal Imaging and Health, King s College London, St Thomas Hospital, London, UK Perinatal Center, Departments of Clinical Sciences and Physiology and Neurosciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden Electronic address
    Lancet Neurol 13:217-32. 2014
    ..Understanding of these new aspects of mitochondrial function will provide insights into brain development and neurological disease, and enable discovery and development of new strategies for treatment. ..
  5. pmc Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation
    Nicola J Bright
    Medical Research Council Cellular Stress Group, MRC Clinical Sciences Centre, Du Cane Road, London, United Kingdom
    J Biol Chem 283:14946-54. 2008
    ..Furthermore, stimuli that activate AMPK had no effect on BRSK1/2. Finally, we provide evidence suggesting that protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2...
  6. doi Mitochondria and perinatal brain injury
    Catherine I Rousset
    Centre for the Developing Brain, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College, Hammersmith Campus, London, UK
    J Matern Fetal Neonatal Med 25:35-8. 2012
    ..In this brief review, we update the critical role of mitochondria in brain development and the decision of cell fate after hypoxia-ischemia in the immature CNS...
  7. doi AMP-activated protein kinase: new regulation, new roles?
    David Carling
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
    Biochem J 445:11-27. 2012
    ....
  8. pmc Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner
    Rachel Jurd
    Gallo Research Center, Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
    J Biol Chem 283:301-10. 2008
    ..These results identify a specific E3 ubiquitin ligase as a novel interactant with the NR2B subunit and suggest a possible mechanism for the regulation of NMDAR function involving both phosphorylation and ubiquitination...
  9. pmc H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity
    Claire Thornton
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:23823-9. 2003
    ..This mechanism is specific for Src and NR2A and has implications for studies in which regulation of NMDA receptor-mediated LTP is important, such as synaptic plasticity, learning, and memory and addiction...
  10. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002
    ..Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory...