Gilbert R Thompson
Affiliation: Imperial College
- History and development of plant sterol and stanol esters for cholesterol-lowering purposesGilbert R Thompson
Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Am J Cardiol 96:3D-9D. 2005..The clinical significance of these changes remains to be determined...
- The evidence-base for the efficacy of lipoprotein apheresis in combating cardiovascular diseaseGilbert R Thompson
Metabolic Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK Electronic address
Atheroscler Suppl 14:67-70. 2013..To review the evidence supporting the use of lipoprotein apheresis to treat severe forms of dyslipidaemia that predispose to cardiovascular disease and are refractory to conventional therapy...
- Recommendations for the use of LDL apheresisG R Thompson
Imperial College, Hammersmith Hospital, London
Atherosclerosis 198:247-55. 2008..3) LDL apheresis should also be considered for patients with aggressive progressing coronary disease and Lp(a)>60mg/l whose LDL cholesterol remains >3.2mmol/l despite maximal drug therapy...
- History of the cholesterol controversy in BritainG R Thompson
Department of Metabolic Medicine, Division of Investigative Sciences, Imperial College, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
QJM 102:81-6. 2009..This brief account relates why it took so long...
- Efficacy criteria and cholesterol targets for LDL apheresisGilbert R Thompson
Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
Atherosclerosis 208:317-21. 2010..Establishing a uniform approach to data collection would facilitate the setting up of national or multi-national registers and might eventually provide the information needed to formulate evidence-based guidelines for LDL apheresis...
- Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in EuropeGilbert R Thompson
Imperial College, Hammersmith Hospital, London, UK
Curr Opin Lipidol 21:492-8. 2010..On the basis of clinical experience, these patients tend to have the most severe forms of familial hypercholesterolaemia or markedly elevated LDL cholesterol (LDL-C) levels but are unable to tolerate statin therapy...
- Lipoprotein apheresisGilbert R Thompson
Metabolic Medicine, Imperial College, Hammersmith Hospital, London, UK
Curr Opin Lipidol 21:487-91. 2010..Lipoprotein apheresis is being performed with increasing frequency, but better data collection and recording of clinical outcomes are needed. Setting up registries would facilitate this process...
- Additive effects of plant sterol and stanol esters to statin therapyGilbert R Thompson
Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Am J Cardiol 96:37D-39D. 2005..They differ in that plasma plant sterols increase when plant sterol esters are used for this purpose, especially in patients with familial hypercholesterolemia, but decrease when plant stanol esters are used...
- Current management of severe homozygous hypercholesterolaemiasRossi P Naoumova
Medical Research Council Clinical Sciences Centre Imperial College, Hammersmith Hospital, London, UK
Curr Opin Lipidol 15:413-22. 2004..This review focuses on recent advances in the management of patients with homozygous familial hypercholesterolaemia, autosomal recessive hypercholesterolaemia and familial defective apolipoprotein B...
- Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studiesFrans H O'Neill
Department of Metabolic Medicine, Division of Investigative Science, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Am J Cardiol 96:29D-36D. 2005..We conclude that plant stanol esters are preferable for the long-term management of hypercholesterolemia...
- Goals of statin therapy: three viewpointsGilbert R Thompson
Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
Curr Atheroscler Rep 4:26-33. 2002..We asked three investigators, Drs. Gilbert Thompson, Christopher Packard, and Neil Stone, who have all been integrally involved in the accumulation of our present database, to argue three different possible answers...
- Why some patients respond poorly to statins and how this might be remediedG R Thompson
Department of Investigative Science, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Eur Heart J 23:200-6. 2002
- Coronary calcification and predicted risk of coronary heart disease in asymptomatic men with hypercholesterolaemiaRobert S Elkeles
Department of Medicine, St Mary s, London, UK
J Cardiovasc Risk 9:349-53. 2002..To document the relationship between coronary calcification and coronary risk assessed clinically in asymptomatic patients with hypercholesterolaemia...
- Measurement of the reflectivity of the intima-medial layer of the common carotid artery improves the discriminatory value of intima-medial thickness measurement as a predictor of risk of atherosclerotic diseaseStephen M Ellis
Department of Radiology, King s College Hospital, Denmark Hill, London, UK
Ultrasound Med Biol 33:1029-38. 2007....
- Management of dyslipidaemiaGilbert R Thompson
Metabolic Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Heart 90:949-55. 2004
- Familial Hypercholesterolaemia Regression Study: a randomised trial of low-density-lipoprotein apheresisG R Thompson
Department of Cardiology, Hammersmith Hospital, London
Lancet 345:811-6. 1995..Decreasing lipoprotein(a) seems to be unnecessary if LDL cholesterol is reduced to 3.4 mmol/L or less...
- Screening relatives of patients with premature coronary heart diseaseGilbert R Thompson
Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
Heart 87:390-4. 2002
- Combined bezafibrate and simvastatin treatment for mixed hyperlipidaemiaA Kehely
MRC Lipoprotein Team, Hammersmith Hospital, London, UK
QJM 88:421-7. 1995..The combination of bezafibrate and simvastatin was more effective in controlling mixed hyperlipidaemia than either drug alone and did not provoke more adverse events...
- Effect of enprostil on glucose and lipid metabolism in type 2 diabetesT M Davis
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Diabet Med 6:400-5. 1989..14 +/- 0.25 and 7.35 +/- 0.46 mmol l-1, p = 0.031 and p = 0.002, respectively), the latter effect being primarily due to reduced LDL-cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Serum lipoprotein(a) level is related to thrombin generation and spontaneous intermittent coronary occlusion in patients with acute myocardial infarctionA W Haider
Division of Clinical Cardiology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England
Circulation 94:2072-6. 1996....
- Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United KingdomJ C Webb
MRC Lipoprotein Team, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
J Lipid Res 37:368-81. 1996..These observations confirm the striking heterogeneity underlying FH in most populations and demonstrate the variability in phenotype between patients with the same mutation...
- Cholesterol synthesis is increased in mixed hyperlipidaemiaR P Naoumova
MRC Lipoprotein Team, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W2 ONN, UK
Biochim Biophys Acta 1394:146-52. 1998..21, P=0.014). These results are in accordance with previous observations that VLDL-apolipoprotein B secretion and cholesterol synthesis are linked and demonstrate that the latter is increased in mixed hyperlipidaemia...
- Effect of inhibiting HMG-CoA reductase on 7 alpha-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathwayR P Naoumova
Clinical Sciences Centre, Hammersmith Hospital, London, UK
Eur J Clin Invest 29:404-12. 1999..The objectives of the study were to determine the effect of atorvastatin on bile acid synthesis in patients in whom this process had not been or had been previously up-regulated by pharmacological or surgical means...
- Novel lipid-regulating drugsG R Thompson
Division of Investigative Science, Imperial College School of Medicine and MRC Molecular Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
Expert Opin Investig Drugs 9:2619-28. 2000....
- Coronary calcification score: the coronary-risk impact factorG R Thompson
Metabolic Medicine, Division of Investigative Science, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, UK
Lancet 363:557-9. 2004..It would also be worth investigating the relation between coronary calcification and risk factors not quantified in Framingham-based estimates, including familial and racial predisposition to premature coronary heart disease...
- Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndromeDick C Chan
University Department of Medicine, University of Western Australia, Western Australian Institute for Medical Research, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia
Clin Sci (Lond) 104:383-8. 2003..Our findings suggest that in subjects with the MS alterations in cholesterol absorption and synthesis may be closely linked with the kinetic defects in TRL metabolism...
- Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndromeDick C Chan
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
Obes Res 11:591-6. 2003..The metabolic syndrome is characterized by defective hepatic apolipoprotein B-100 (apoB) metabolism. Hepato-intestinal cholesterol metabolism may contribute to this abnormality...
- New developments in pharmacotherapyGilbert R Thompson
Cardiovasc J S Afr 15:56-8. 2004