Gilbert R Thompson

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint History and development of plant sterol and stanol esters for cholesterol-lowering purposes
    Gilbert R Thompson
    Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Cardiol 96:3D-9D. 2005
  2. doi request reprint The evidence-base for the efficacy of lipoprotein apheresis in combating cardiovascular disease
    Gilbert R Thompson
    Metabolic Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK Electronic address
    Atheroscler Suppl 14:67-70. 2013
  3. doi request reprint Recommendations for the use of LDL apheresis
    G R Thompson
    Imperial College, Hammersmith Hospital, London
    Atherosclerosis 198:247-55. 2008
  4. doi request reprint History of the cholesterol controversy in Britain
    G R Thompson
    Department of Metabolic Medicine, Division of Investigative Sciences, Imperial College, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    QJM 102:81-6. 2009
  5. doi request reprint Efficacy criteria and cholesterol targets for LDL apheresis
    Gilbert R Thompson
    Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
    Atherosclerosis 208:317-21. 2010
  6. doi request reprint Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe
    Gilbert R Thompson
    Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 21:492-8. 2010
  7. doi request reprint Lipoprotein apheresis
    Gilbert R Thompson
    Metabolic Medicine, Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 21:487-91. 2010
  8. ncbi request reprint Additive effects of plant sterol and stanol esters to statin therapy
    Gilbert R Thompson
    Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Cardiol 96:37D-39D. 2005
  9. ncbi request reprint Current management of severe homozygous hypercholesterolaemias
    Rossi P Naoumova
    Medical Research Council Clinical Sciences Centre Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:413-22. 2004
  10. ncbi request reprint Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies
    Frans H O'Neill
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Cardiol 96:29D-36D. 2005

Collaborators

Detail Information

Publications28

  1. ncbi request reprint History and development of plant sterol and stanol esters for cholesterol-lowering purposes
    Gilbert R Thompson
    Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Cardiol 96:3D-9D. 2005
    ..The clinical significance of these changes remains to be determined...
  2. doi request reprint The evidence-base for the efficacy of lipoprotein apheresis in combating cardiovascular disease
    Gilbert R Thompson
    Metabolic Medicine, Imperial College, Hammersmith Hospital, London W12 0NN, UK Electronic address
    Atheroscler Suppl 14:67-70. 2013
    ..To review the evidence supporting the use of lipoprotein apheresis to treat severe forms of dyslipidaemia that predispose to cardiovascular disease and are refractory to conventional therapy...
  3. doi request reprint Recommendations for the use of LDL apheresis
    G R Thompson
    Imperial College, Hammersmith Hospital, London
    Atherosclerosis 198:247-55. 2008
    ..3) LDL apheresis should also be considered for patients with aggressive progressing coronary disease and Lp(a)>60mg/l whose LDL cholesterol remains >3.2mmol/l despite maximal drug therapy...
  4. doi request reprint History of the cholesterol controversy in Britain
    G R Thompson
    Department of Metabolic Medicine, Division of Investigative Sciences, Imperial College, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    QJM 102:81-6. 2009
    ..This brief account relates why it took so long...
  5. doi request reprint Efficacy criteria and cholesterol targets for LDL apheresis
    Gilbert R Thompson
    Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
    Atherosclerosis 208:317-21. 2010
    ..Establishing a uniform approach to data collection would facilitate the setting up of national or multi-national registers and might eventually provide the information needed to formulate evidence-based guidelines for LDL apheresis...
  6. doi request reprint Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe
    Gilbert R Thompson
    Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 21:492-8. 2010
    ..On the basis of clinical experience, these patients tend to have the most severe forms of familial hypercholesterolaemia or markedly elevated LDL cholesterol (LDL-C) levels but are unable to tolerate statin therapy...
  7. doi request reprint Lipoprotein apheresis
    Gilbert R Thompson
    Metabolic Medicine, Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 21:487-91. 2010
    ..Lipoprotein apheresis is being performed with increasing frequency, but better data collection and recording of clinical outcomes are needed. Setting up registries would facilitate this process...
  8. ncbi request reprint Additive effects of plant sterol and stanol esters to statin therapy
    Gilbert R Thompson
    Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Cardiol 96:37D-39D. 2005
    ..They differ in that plasma plant sterols increase when plant sterol esters are used for this purpose, especially in patients with familial hypercholesterolemia, but decrease when plant stanol esters are used...
  9. ncbi request reprint Current management of severe homozygous hypercholesterolaemias
    Rossi P Naoumova
    Medical Research Council Clinical Sciences Centre Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:413-22. 2004
    ..This review focuses on recent advances in the management of patients with homozygous familial hypercholesterolaemia, autosomal recessive hypercholesterolaemia and familial defective apolipoprotein B...
  10. ncbi request reprint Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies
    Frans H O'Neill
    Department of Metabolic Medicine, Division of Investigative Science, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Cardiol 96:29D-36D. 2005
    ..We conclude that plant stanol esters are preferable for the long-term management of hypercholesterolemia...
  11. ncbi request reprint Goals of statin therapy: three viewpoints
    Gilbert R Thompson
    Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Curr Atheroscler Rep 4:26-33. 2002
    ..We asked three investigators, Drs. Gilbert Thompson, Christopher Packard, and Neil Stone, who have all been integrally involved in the accumulation of our present database, to argue three different possible answers...
  12. ncbi request reprint Why some patients respond poorly to statins and how this might be remedied
    G R Thompson
    Department of Investigative Science, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Eur Heart J 23:200-6. 2002
  13. ncbi request reprint Coronary calcification and predicted risk of coronary heart disease in asymptomatic men with hypercholesterolaemia
    Robert S Elkeles
    Department of Medicine, St Mary s, London, UK
    J Cardiovasc Risk 9:349-53. 2002
    ..To document the relationship between coronary calcification and coronary risk assessed clinically in asymptomatic patients with hypercholesterolaemia...
  14. ncbi request reprint Measurement of the reflectivity of the intima-medial layer of the common carotid artery improves the discriminatory value of intima-medial thickness measurement as a predictor of risk of atherosclerotic disease
    Stephen M Ellis
    Department of Radiology, King s College Hospital, Denmark Hill, London, UK
    Ultrasound Med Biol 33:1029-38. 2007
    ....
  15. pmc Management of dyslipidaemia
    Gilbert R Thompson
    Metabolic Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Heart 90:949-55. 2004
  16. ncbi request reprint Familial Hypercholesterolaemia Regression Study: a randomised trial of low-density-lipoprotein apheresis
    G R Thompson
    Department of Cardiology, Hammersmith Hospital, London
    Lancet 345:811-6. 1995
    ..Decreasing lipoprotein(a) seems to be unnecessary if LDL cholesterol is reduced to 3.4 mmol/L or less...
  17. pmc Screening relatives of patients with premature coronary heart disease
    Gilbert R Thompson
    Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Heart 87:390-4. 2002
  18. ncbi request reprint Combined bezafibrate and simvastatin treatment for mixed hyperlipidaemia
    A Kehely
    MRC Lipoprotein Team, Hammersmith Hospital, London, UK
    QJM 88:421-7. 1995
    ..The combination of bezafibrate and simvastatin was more effective in controlling mixed hyperlipidaemia than either drug alone and did not provoke more adverse events...
  19. ncbi request reprint Effect of enprostil on glucose and lipid metabolism in type 2 diabetes
    T M Davis
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Diabet Med 6:400-5. 1989
    ..14 +/- 0.25 and 7.35 +/- 0.46 mmol l-1, p = 0.031 and p = 0.002, respectively), the latter effect being primarily due to reduced LDL-cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint Serum lipoprotein(a) level is related to thrombin generation and spontaneous intermittent coronary occlusion in patients with acute myocardial infarction
    A W Haider
    Division of Clinical Cardiology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England
    Circulation 94:2072-6. 1996
    ....
  21. ncbi request reprint Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom
    J C Webb
    MRC Lipoprotein Team, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Lipid Res 37:368-81. 1996
    ..These observations confirm the striking heterogeneity underlying FH in most populations and demonstrate the variability in phenotype between patients with the same mutation...
  22. ncbi request reprint Cholesterol synthesis is increased in mixed hyperlipidaemia
    R P Naoumova
    MRC Lipoprotein Team, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W2 ONN, UK
    Biochim Biophys Acta 1394:146-52. 1998
    ..21, P=0.014). These results are in accordance with previous observations that VLDL-apolipoprotein B secretion and cholesterol synthesis are linked and demonstrate that the latter is increased in mixed hyperlipidaemia...
  23. ncbi request reprint Effect of inhibiting HMG-CoA reductase on 7 alpha-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathway
    R P Naoumova
    Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Eur J Clin Invest 29:404-12. 1999
    ..The objectives of the study were to determine the effect of atorvastatin on bile acid synthesis in patients in whom this process had not been or had been previously up-regulated by pharmacological or surgical means...
  24. ncbi request reprint Novel lipid-regulating drugs
    G R Thompson
    Division of Investigative Science, Imperial College School of Medicine and MRC Molecular Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Expert Opin Investig Drugs 9:2619-28. 2000
    ....
  25. ncbi request reprint Coronary calcification score: the coronary-risk impact factor
    G R Thompson
    Metabolic Medicine, Division of Investigative Science, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, UK
    Lancet 363:557-9. 2004
    ..It would also be worth investigating the relation between coronary calcification and risk factors not quantified in Framingham-based estimates, including familial and racial predisposition to premature coronary heart disease...
  26. ncbi request reprint Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome
    Dick C Chan
    University Department of Medicine, University of Western Australia, Western Australian Institute for Medical Research, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia
    Clin Sci (Lond) 104:383-8. 2003
    ..Our findings suggest that in subjects with the MS alterations in cholesterol absorption and synthesis may be closely linked with the kinetic defects in TRL metabolism...
  27. ncbi request reprint Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome
    Dick C Chan
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Obes Res 11:591-6. 2003
    ..The metabolic syndrome is characterized by defective hepatic apolipoprotein B-100 (apoB) metabolism. Hepato-intestinal cholesterol metabolism may contribute to this abnormality...
  28. ncbi request reprint New developments in pharmacotherapy
    Gilbert R Thompson
    Cardiovasc J S Afr 15:56-8. 2004