P C Taylor

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Rituximab in the treatment of rheumatoid arthritis
    Peter C Taylor
    Professor of Experimental Rheumatology and Honorary Consultant Rheumatologist, The Kennedy Institute Division, Imperial College School of Medicine, 1 Aspenlea Road London, W6 8LH, UK
    Expert Rev Clin Immunol 3:17-26. 2007
  2. pmc Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis
    Patricia Guyot
    Mapi Values the Netherlands, De Molen 84, 3995 AX Houten, The Netherlands
    Arthritis Res Ther 13:R204. 2011
  3. ncbi request reprint Comparison of ultrasonographic assessment of synovitis and joint vascularity with radiographic evaluation in a randomized, placebo-controlled study of infliximab therapy in early rheumatoid arthritis
    P C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, UK
    Arthritis Rheum 50:1107-16. 2004
  4. ncbi request reprint Patient perceptions concerning pain management in the treatment of rheumatoid arthritis
    P Taylor
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, UK
    J Int Med Res 38:1213-24. 2010
  5. ncbi request reprint Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W68LH, UK
    Curr Opin Biotechnol 15:557-63. 2004
  6. ncbi request reprint The importance of the patients' experience of RA compared with clinical measures of disease activity
    Peter C Taylor
    The Kennedy Institue of Rheumatology Division, Imperial College, London, UK
    Clin Exp Rheumatol 28:S28-31. 2010
  7. doi request reprint Pharmacology of TNF blockade in rheumatoid arthritis and other chronic inflammatory diseases
    Peter C Taylor
    The Kennedy Institute Division, Faculty of Medicine, Imperial College School of Medicine, 65 Aspenlea Road, London W6 8LH, United Kingdom
    Curr Opin Pharmacol 10:308-15. 2010
  8. ncbi request reprint Ultrasonographic and radiographic results from a two-year controlled trial of immediate or one-year-delayed addition of infliximab to ongoing methotrexate therapy in patients with erosive early rheumatoid arthritis
    P C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Rheum 54:47-53. 2006
  9. doi request reprint Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
    Peter C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Nat Rev Rheumatol 5:578-82. 2009
  10. ncbi request reprint Is abatacept an effective treatment for patients with RA who do not respond to other anti-TNF treatments?
    Peter C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, London, UK
    Nat Clin Pract Rheumatol 2:128-9. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Rituximab in the treatment of rheumatoid arthritis
    Peter C Taylor
    Professor of Experimental Rheumatology and Honorary Consultant Rheumatologist, The Kennedy Institute Division, Imperial College School of Medicine, 1 Aspenlea Road London, W6 8LH, UK
    Expert Rev Clin Immunol 3:17-26. 2007
    ....
  2. pmc Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis
    Patricia Guyot
    Mapi Values the Netherlands, De Molen 84, 3995 AX Houten, The Netherlands
    Arthritis Res Ther 13:R204. 2011
    ..6) between abatacept and other biologic disease modifying anti-rheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who have inadequate response to methotrexate (MTX-IR)...
  3. ncbi request reprint Comparison of ultrasonographic assessment of synovitis and joint vascularity with radiographic evaluation in a randomized, placebo-controlled study of infliximab therapy in early rheumatoid arthritis
    P C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, UK
    Arthritis Rheum 50:1107-16. 2004
    ....
  4. ncbi request reprint Patient perceptions concerning pain management in the treatment of rheumatoid arthritis
    P Taylor
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, UK
    J Int Med Res 38:1213-24. 2010
    ..Patients in the USA rated pain relief as the top required benefit from their RA medication. A comprehensive examination of patients' perspectives regarding pain could lead to better patient care and pain management strategies...
  5. ncbi request reprint Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W68LH, UK
    Curr Opin Biotechnol 15:557-63. 2004
    ..Better understanding of these pathogenic pathways will inform the development of new therapeutic approaches leading to more complete and sustained disease remissions...
  6. ncbi request reprint The importance of the patients' experience of RA compared with clinical measures of disease activity
    Peter C Taylor
    The Kennedy Institue of Rheumatology Division, Imperial College, London, UK
    Clin Exp Rheumatol 28:S28-31. 2010
    ....
  7. doi request reprint Pharmacology of TNF blockade in rheumatoid arthritis and other chronic inflammatory diseases
    Peter C Taylor
    The Kennedy Institute Division, Faculty of Medicine, Imperial College School of Medicine, 65 Aspenlea Road, London W6 8LH, United Kingdom
    Curr Opin Pharmacol 10:308-15. 2010
    ..The mode of administration of each agent, clearance and the local tissue concentrations achieved may also confer unique characteristics of relevance with respect to efficacy and safety...
  8. ncbi request reprint Ultrasonographic and radiographic results from a two-year controlled trial of immediate or one-year-delayed addition of infliximab to ongoing methotrexate therapy in patients with erosive early rheumatoid arthritis
    P C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Rheum 54:47-53. 2006
    ..To compare the impact of immediate and delayed introduction of anti-tumor necrosis factor therapy on inflammation and structural damage in methotrexate (MTX)-treated patients with early rheumatoid arthritis (RA)...
  9. doi request reprint Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
    Peter C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Nat Rev Rheumatol 5:578-82. 2009
    ..Furthermore, new approaches to blockade of signaling mediated by bioactive TNF might have the potential to generate higher-magnitude clinical responses than are currently elicited...
  10. ncbi request reprint Is abatacept an effective treatment for patients with RA who do not respond to other anti-TNF treatments?
    Peter C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, London, UK
    Nat Clin Pract Rheumatol 2:128-9. 2006
  11. ncbi request reprint How do the efficacy and safety of abatacept and infliximab compare in the treatment of active RA?
    Peter C Taylor
    Experimental Rheumatology at Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Nat Clin Pract Rheumatol 5:126-7. 2009
    ..Overall, abatacept had a relatively more-acceptable safety and tolerability profile compared to infliximab...
  12. pmc The value of sensitive imaging modalities in rheumatoid arthritis
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, UK
    Arthritis Res Ther 5:210-3. 2003
    ..However, further research using these sensitive imaging technologies is required to delineate pathophysiological correlates of imaging abnormalities and to standardise methods for assessment...
  13. pmc Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trial
    Peter C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Ann Rheum Dis 70:2119-25. 2011
    ..To evaluate the efficacy and safety of intravenous ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, active rheumatoid arthritis (RA) patients despite methotrexate treatment...
  14. ncbi request reprint Anti-cytokine therapy for rheumatoid arthritis
    R N Maini
    Kennedy Institute of Rheumatology, London, UK
    Annu Rev Med 51:207-29. 2000
    ..One anti-TNF reagent has already been approved in the United States for the treatment of RA, and other cytokine antagonists or agonists are under development...
  15. ncbi request reprint Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    R N Maini
    Kennedy Institute of Rheumatology Division, Imperial College, London, UK
    Arthritis Rheum 54:2817-29. 2006
    ....
  16. ncbi request reprint Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis
    S Ballara
    Imperial College School of Medicine, London, UK
    Arthritis Rheum 44:2055-64. 2001
    ....
  17. ncbi request reprint Anti-tumor necrosis factor therapies
    P C Taylor
    The Kennedy Institute Division, Imperial College School of Medicine, London, UK
    Curr Opin Rheumatol 13:164-9. 2001
    ..In conclusion, for patients with established and early RA, anti-TNF therapies set a new standard for symptom control and joint protection...
  18. ncbi request reprint Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapy
    P C Taylor
    Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, 1 Aspenlea Road, London W6 8LH, U K
    Rheumatology (Oxford) 44:721-8. 2005
    ..Power Doppler imaging may also have the potential to predict those patients most at risk of accelerated joint destruction. However, much work has yet to be done to standardize the use of these imaging technologies...
  19. ncbi request reprint Anti-TNF therapy for rheumatoid arthritis and other inflammatory diseases
    P C Taylor
    Kennedy Institute Division, Imperial College School of Medicine, 1 Aspenlea Road, London, W6 8LH
    Mol Biotechnol 19:153-68. 2001
    ....
  20. doi request reprint Prevalence of subjective voice impairment in rheumatoid arthritis
    Benjamin A Fisher
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Clin Rheumatol 27:1441-3. 2008
    ..RA patients with a Disease Activity Score 28 >3.2, indicating more active disease, had significantly higher VHI-10 scores. A low prevalence of self-reported voice handicap occurs in RA and associates with more active disease...
  21. pmc Towards understanding the phenotypes of myocardial involvement in the presence of self-limiting and sustained systemic inflammation: a magnetic resonance imaging study
    Valentina O Puntmann
    Department of Experimental Medicine, Imperial College London, London W12 0NN, UK
    Rheumatology (Oxford) 49:528-35. 2010
    ..To investigate the patterns of myocardial involvement in the presence of self-limiting and sustained systemic inflammation, using MRI...
  22. ncbi request reprint Antibody therapy for rheumatoid arthritis
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Curr Opin Pharmacol 3:323-8. 2003
    ..Phase III studies have yet to be undertaken for these novel biological agents, and it is unclear whether any of these agents will have true disease-modifying capabilities...
  23. ncbi request reprint Anti-TNF therapy: where have we got to in 2005?
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, 1 Aspenlea Road, London W6 8LH, UK
    J Autoimmun 25:26-8. 2005
    ..There are still many limitations, but the prospects for the future are intriguing...
  24. ncbi request reprint Monoclonal antibodies in immune and inflammatory diseases
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, W6 8LH, London, UK
    Curr Opin Biotechnol 13:615-20. 2002
    ..In the clinic, monoclonal antibodies are proving to be safe and effective for the treatment of a wide range of diseases including rheumatoid arthritis, Crohn's disease, spondyloarthropathies, psoriasis and allograft rejection...
  25. ncbi request reprint Anti-TNFalpha therapy for rheumatoid arthritis: an update
    Peter C Taylor
    Kennedy Institute Division, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, 1 Aspenlea Road, London W6 8LH
    Intern Med 42:15-20. 2003
    ..In conclusion, for patients with established and early RA, anti-TNF therapies set a new standard for symptom control and joint protection...
  26. ncbi request reprint Anti-cytokines and cytokines in the treatment of rheumatoid arthritis
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London, W6 8LH
    Curr Pharm Des 9:1095-106. 2003
    ..In this review I will also discuss the rationale and preliminary data for other potential therapeutic strategies designed to augment the activity of anti-inflammatory cytokines such as IL-4, IL-10, and IL-11 in rheumatoid disease...
  27. pmc Reproducibility of sodium MRI measures of articular cartilage of the knee in osteoarthritis
    R D Newbould
    GSK Clinical Imaging Centre, Hammersmith Hospital, Imperial College London, London, UK
    Osteoarthritis Cartilage 20:29-35. 2012
    ..To determine the stability and reproducibility of the sodium magnetic resonance imaging (MRI) signal measured in the articular cartilage of the knee in both healthy volunteers and osteoarthritis (OA) patients...
  28. ncbi request reprint Immunotherapy for rheumatoid arthritis
    P C Taylor
    The Kennedy Institute Division, Imperial College School of Medicine, 1 Aspenlea Road, W6 8LH, London, UK
    Curr Opin Immunol 13:611-6. 2001
    ..Thus, for patients with RA, anti-TNF therapies set a new standard for symptom control and joint protection...
  29. doi request reprint Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis
    Branavan Sivakumar
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Hand Surg Am 33:49-58. 2008
    ..The aim of this study was to determine whether hypoxia and angiogenesis may also play a role in RA tendon disease...
  30. doi request reprint Contemporary treatment principles for early rheumatoid arthritis: a consensus statement
    Patrick D W Kiely
    Department of Rheumatology, St Georges Healthcare NHS Trust, London, UK
    Rheumatology (Oxford) 48:765-72. 2009
    ..RA has a substantial impact on both patients and healthcare systems. Our objective is to advance the understanding of modern management principles in light of recent evidence concerning the condition's diagnosis and treatment...
  31. pmc Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1
    P C Taylor
    Kennedy Institute of Rheumatology, London, UK
    Immunology 88:315-21. 1996
    ..Our findings support the hypothesis that cells expressing Mac-1 play an important role in the induction and maintenance of joint damage in collagen-induced arthritis...
  32. pmc VEGF and imaging of vessels in rheumatoid arthritis
    Peter C Taylor
    The Kennedy Institute Division, Imperial College School of Medicine, London, UK
    Arthritis Res 4:S99-107. 2002
    ..Animal model data supports this concept. It seems likely that serological and imaging measures of vascularity in RA will become useful tools in the assessment of disease activity and response to therapy...
  33. doi request reprint Quantitative power Doppler ultrasonography is a sensitive measure of metacarpophalangeal joint synovial vascularity in rheumatoid arthritis and declines significantly following a 2-week course of oral low-dose corticosteroids
    Maggie J Larche
    Kennedy Institute of Rheumatology, London, UK
    J Rheumatol 37:2493-501. 2010
    ..And in subjects with severe disease activity, to compare the sensitivity of these measurements, acute-phase markers, and vascular endothelial growth factor to change in response to 2 weeks of oral prednisolone (7.5 mg daily)...
  34. ncbi request reprint Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response
    Betsy J Evans
    BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Blood 107:3593-9. 2006
    ..We hypothesize that LFA-1 shedding may play a role in leukocyte detachment after transendothelial migration and in regulating integrin-dependent outside-in signaling...
  35. pmc Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis
    Andrew Kinloch
    Kennedy Institute of Rheumatology, Imperial College London, Charing Cross Hospital Campus, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 7:R1421-9. 2005
    ..The presence of antibody together with expression of antigen within the joint implicates citrullinated alpha-enolase as a candidate autoantigen that could drive the chronic inflammatory response in RA...
  36. ncbi request reprint Hypoxia and angiogenesis in rheumatoid arthritis
    Peter C Taylor
    The Kennedy Institute of Rheumatology, Division Imperial College Faculty of Medicine, London, UK
    Curr Opin Rheumatol 17:293-8. 2005
    ..The purpose of this review is to discuss the role of hypoxia and angiogenesis in the pathogenesis of rheumatoid arthritis...
  37. ncbi request reprint Immune functions are maintained in healthy men with low zinc intake
    Kathryn Pinna
    Department of Nutritional Sciences, University of California, Berkeley 94720, USA
    J Nutr 132:2033-6. 2002
    ..The results suggest that changes in lymphocyte proliferation and IL-2R expression may be early markers of mild zinc deficiency...
  38. ncbi request reprint New approaches to therapeutic immunomodulation for immune-mediated inflammatory disorders
    Peter C Taylor
    Curr Opin Pharmacol 4:368-71. 2004
  39. ncbi request reprint The down-regulation of IL1alpha and IL6, in monocytes exposed to extracorporeal photopheresis (ECP)-treated lymphocytes, is not dependent on lymphocyte phosphatidylserine externalization
    John Bladon
    Haematology Department, Rotherham General Hospital, South Yorkshire, UK
    Transpl Int 19:319-24. 2006
    ..ECP-treated lymphocytes can reduce the ability of LPS-stimulated monocytes to produce some proinflammatory cytokines; however, this effect is not dependent on phosphatidylserine externalization...
  40. ncbi request reprint Lymphocytes treated by extracorporeal photopheresis can down-regulate cytokine production in untreated monocytes
    John Bladon
    Department of Haematology, Rotherham General Hospital, South Yorkshire, UK
    Photodermatol Photoimmunol Photomed 21:293-302. 2005
    ..ECP-treated cells are re-infused immediately after completion of treatment. This study attempted to determine the influence that ECP-treated cells would have on untreated cells following re-infusion...