Peter H Sugden

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines
    Timothy E Cullingford
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Biochim Biophys Acta 1783:1229-36. 2008
  2. ncbi Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes
    Peter H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom
    Antioxid Redox Signal 8:2111-24. 2006
  3. ncbi Endothelin signalling in the cardiac myocyte and its pathophysiological relevance
    Peter H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Curr Vasc Pharmacol 3:343-51. 2005
  4. pmc Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
    P H Sugden
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 153:S137-53. 2008
  5. ncbi An overview of endothelin signaling in the cardiac myocyte
    Peter H Sugden
    Cardiac Medicine, Faculty of Medicine NHLI Division, Imperial College of Science, Technology and Medicine, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    J Mol Cell Cardiol 35:871-86. 2003
  6. ncbi Ras, Akt, and mechanotransduction in the cardiac myocyte
    Peter H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Circ Res 93:1179-92. 2003
  7. pmc Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes
    Timothy E Cullingford
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Armstrong Road, London SW7 2AZ, UK
    Genome Biol 9:R32. 2008
  8. ncbi Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition
    Thomais Markou
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Cell Signal 20:206-18. 2008
  9. doi Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors
    Stephen J Fuller
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Cell Signal 20:1564-77. 2008
  10. pmc Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes
    Sampsa Pikkarainen
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 284:27195-210. 2009

Collaborators

Detail Information

Publications36

  1. pmc Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines
    Timothy E Cullingford
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Biochim Biophys Acta 1783:1229-36. 2008
    ..The dynamic regulation of expression of multiple Klf family members in cardiac myocytes suggests that, as a family, they are actively involved in regulating phenotypic responses (hypertrophy and apoptosis) to extracellular stimuli...
  2. ncbi Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes
    Peter H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom
    Antioxid Redox Signal 8:2111-24. 2006
    ....
  3. ncbi Endothelin signalling in the cardiac myocyte and its pathophysiological relevance
    Peter H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Curr Vasc Pharmacol 3:343-51. 2005
    ..These changes in c-Jun expression and phosphorylation are likely to be important in the regulation of gene transcription...
  4. pmc Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
    P H Sugden
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 153:S137-53. 2008
    ..We discuss whether cardiac pathologies could be treated by therapeutic intervention at the GSK3 level but conclude that any intervention would be premature without greater understanding of the precise role of GSK3 in cardiac processes...
  5. ncbi An overview of endothelin signaling in the cardiac myocyte
    Peter H Sugden
    Cardiac Medicine, Faculty of Medicine NHLI Division, Imperial College of Science, Technology and Medicine, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    J Mol Cell Cardiol 35:871-86. 2003
    ..g. 90-kDa ribosomal protein S6 kinase, MAPK-activated protein kinase 2), and ion exchangers/channels (e.g. the Na(+)/H(+) exchanger 1). These changes are responsible for the overall biological effects of ET isopeptides on the myocyte...
  6. ncbi Ras, Akt, and mechanotransduction in the cardiac myocyte
    Peter H Sugden
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Circ Res 93:1179-92. 2003
    ..The overall conclusion is that although an involvement of Ras and Akt in mechanotransduction is likely, more work (particularly focusing on mechanoreception) needs to be undertaken before it is unequivocally established...
  7. pmc Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes
    Timothy E Cullingford
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Armstrong Road, London SW7 2AZ, UK
    Genome Biol 9:R32. 2008
    ..Hypertrophy is associated with changes in mRNA/protein expression, presumably consequent to protein kinase signaling, but the connections between early, transient signaling events and developed hypertrophy are unknown...
  8. ncbi Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition
    Thomais Markou
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Cell Signal 20:206-18. 2008
    ....
  9. doi Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors
    Stephen J Fuller
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Cell Signal 20:1564-77. 2008
    ..From a pathological viewpoint, we conclude that activities of NDR1 and NDR2 are responsive to cytotoxic stresses in heart preparations and this may represent a previously-unidentified response to myocardial ischaemia in vivo...
  10. pmc Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes
    Sampsa Pikkarainen
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 284:27195-210. 2009
    ..Thus, increased Mdm2 expression is associated with transactivation at the P2 AP-1 RE (rather than the p53 or Ets REs), and Mdm2 induction potentially represents a cardioprotective response to oxidative stress...
  11. ncbi Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes
    Robert A Kennedy
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building Floor 4, UK
    J Mol Cell Cardiol 41:236-47. 2006
    ..Our data suggest that the majority of changes in gene expression induced by endothelin-1 are mediated by the ERK1/2 cascade...
  12. pmc Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin
    Thomais Markou
    National Heart and Lung Institute Cardiovascular Sciences, Faculty of Medicine, Imperial College London, London, UK
    BMC Genomics 11:343. 2010
    ..Here, we used microarrays to compare the effects of endothelin-1 and insulin on the global transcriptome of neonatal rat cardiomyocytes, and on mRNA recruitment to polysomes (i.e. the translatome)...
  13. ncbi Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses
    Angela Clerk
    NHLI Division, Faculty of Medicine, Imperial College London, London, UK
    J Cell Physiol 212:311-22. 2007
    ..Finally, we discuss how intracellular signaling and gene expression may be integrated to elicit the overall change in cellular phenotype...
  14. doi Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1
    Arne Yndestad
    National Heart and Lung Institute Division Cardiovascular Sciences, Faculty of Medicine, Imperial College London, Guy Scadding Building, Dovehouse Street, London, UK
    Int J Biochem Cell Biol 42:263-72. 2010
    ..Coupled with the general decrease in p38-MAPK signalling, we conclude that endothelin-1 attenuates the cardiac myocyte inflammatory response, potentially to confer cardioprotection...
  15. ncbi Chemotherapeutic agents and gene expression in cardiac myocytes
    Angela Clerk
    NHLI Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Adv Enzyme Regul 47:140-53. 2007
  16. ncbi Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes
    Timothy J Kemp
    NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    J Mol Cell Cardiol 37:603-6. 2004
    ..By increasing the expression of CTGF in cardiac myocytes, hypertrophic agonists such as phenylephrine and endothelin-1 may promote fibrosis. CTGF may also propagate the hypertrophic response initiated by these agonists...
  17. ncbi Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes
    Thomais Markou
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 281:8321-31. 2006
    ..We concluded that, with this physiological agonist, PKCdelta becomes activated in the particulate fraction but retains activity following its retrotranslocation, presumably to phosphorylate substrates elsewhere...
  18. ncbi Cardiac myocyte gene expression profiling during H2O2-induced apoptosis
    Angela Clerk
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom
    Physiol Genomics 29:118-27. 2007
    ..Thus, H2O2-induced cardiac myocyte apoptosis is associated with dynamic changes in gene expression. The expression of these genes and their protein products potentially influences the progression of the apoptotic response...
  19. ncbi Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes
    Angela Clerk
    NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Cell Signal 18:225-35. 2006
    ..Our data provide clear evidence for differential coupling of PDGF and EGF receptors to the ERK1/2 cascade, and indicate that a minimum threshold/duration of ERK1/2 signaling is required for the development of cardiomyocyte hypertrophy...
  20. pmc ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes
    Andrew K Marshall
    National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 5:e10027. 2010
    ..Our aim was to establish the significance of ERK1/2 and/or RhoA in the early cardiomyocyte transcriptomic response to endothelin-1...
  21. doi The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes
    Oliver P T Barrett
    Department of Life Sciences, Imperial College London, London, UK
    Cytokine 61:340-4. 2013
    ..Quantitatively different responses in production of receptor agonists and transcription factors may contribute to qualitative differences at later times resulting in different phenotypic cellular responses...
  22. ncbi Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins
    Tim E Cullingford
    National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building Floor 4, Armstrong Road, London SW7 2AZ, UK
    J Mol Cell Cardiol 40:157-72. 2006
    ..These changes may be potentially useful diagnostically. In the short term, oxidative stress causes few detectable changes in global protein abundance as assessed by silver-staining...
  23. ncbi Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases
    Angela Clerk
    Imperial College of Science, Technology and Medicine, NHLI Division Cardiac Medicine Section, Faculty of Medicine, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Adv Enzyme Regul 44:233-48. 2004
  24. pmc Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein
    Angela Clerk
    Cardiac Medicine Section, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Biochem J 368:101-10. 2002
    ..Thus whereas ERKs are the principal MAPKs required for c- jun transcription, JNKs are necessary to stabilize c-Jun for efficient up-regulation of the protein...
  25. doi ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium
    Stephen J Fuller
    NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    J Mol Cell Cardiol 44:831-54. 2008
    ..Here, we review the basic biochemistry of ErbB receptors/ligands, and emphasise their particular roles in the myocardium...
  26. ncbi Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression
    Joanne G Harrison
    NHLI Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, South Kensington, London SW7 2AZ, UK
    Biochim Biophys Acta 1644:17-25. 2004
    ..Thus, phosphorylation and activation of CREB in cardiac myocytes may be effected by a range of different stimuli to influence the expression of immediate early genes such as c-jun...
  27. ncbi Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis
    Angela Clerk
    NHLI Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Adv Enzyme Regul 45:94-111. 2005
    ....
  28. doi Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?
    Stuart A Cook
    NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    J Mol Cell Cardiol 46:118-29. 2009
    ..We believe that the transgenic approach should not be viewed in an empyreal light and, depending on the questions asked, we suggest that other experimental systems provide equal (or even more) valuable outcomes...
  29. ncbi Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes
    Angela Clerk
    NHLI Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Biochem Cell Biol 82:603-9. 2004
    ..Signaling to the nucleus and the regulation of transcription factor activity associated with ERK1/2 activation in cardiac myocytes are also discussed...
  30. ncbi Signaling pathways activated by vasoactive peptides in the cardiac myocyte and their role in myocardial pathologies
    Peter H Sugden
    National Heart and Lung Institute Division Cardiac Medicine Section, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, London, UK
    J Card Fail 8:S359-69. 2002
    ..The actions of 2 other vasoactive peptides, angiotensin II and bradykinin, on the heart or cardiac myocyte in relation to cardiac hypertrophy are also discussed...
  31. ncbi Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A
    Donna M Valks
    Division of Biomedical Sciences Cell and Molecular Biology Section, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK
    J Mol Cell Cardiol 34:749-63. 2002
    ..These phosphorylations potentially diminish the pro-apoptotic activity of Bad and contribute to the cytoprotective effects of phenylephrine and 8-(4-chlorophenylthio)-cAMP...
  32. doi Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC
    Ralph Knoll
    Myocardial Genetics, British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial College London, Flowers Building, 4th Floor, South Kensington Campus, London SW7 2AZ, UK
    Eur J Heart Fail 13:811-9. 2011
    ..We believe that this effort is the first step towards a much auspicated unification of the terminology between the experimental and the clinical cardiologists...
  33. ncbi Ras: the stress and the strain
    Angela Clerk
    J Mol Cell Cardiol 41:595-600. 2006
  34. ncbi Inflame my heart (by p38-MAPK)
    Angela Clerk
    Circ Res 99:455-8. 2006
  35. ncbi Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants
    Sonia Caroline Sorli
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Oncogene 24:90-100. 2005
    ..Taken together, our findings suggest that regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells...
  36. ncbi Phenotyping hypertrophy: eschew obfuscation
    Gerald W Dorn
    Circ Res 92:1171-5. 2003