Paul R A Stokes
Affiliation: Imperial College
- Acute increases in synaptic GABA detectable in the living human brain: a [Â¹Â¹C]Ro15-4513 PET studyPaul R A Stokes
Centre for Neuropsychopharmacology, Division of Brain Sciences, Burlington Danes Building, Imperial College London, W12 0NN, UK Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, UK Electronic address
Neuroimage 99:158-65. 2014..These findings have potentially major implications for the investigation of GABA function in brain disorders and in the development of new treatments targeting this neurotransmitter system...
- History of cigarette smoking is associated with higher limbic GABAA receptor availabilityPaul R A Stokes
Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
Neuroimage 69:70-7. 2013....
- Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET studyPaul R A Stokes
Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
Neuropsychopharmacology 38:485-91. 2013....
- History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availabilityPaul R A Stokes
Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
J Psychopharmacol 26:144-9. 2012..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability...
- Can recreational doses of THC produce significant dopamine release in the human striatum?Paul R A Stokes
Psychiatry Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK
Neuroimage 48:186-90. 2009..In animals, Delta9-tetrahydrocannabinol (THC) increases the rate of dopamine neuronal firing and release in the striatum. Thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis...
- The effects of the COMT Val108/158Met polymorphism on BOLD activation during working memory, planning, and response inhibition: a role for the posterior cingulate cortex?Paul R A Stokes
Psychiatry Group, MRC Clinical Science Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
Neuropsychopharmacology 36:763-71. 2011....
- Significant decreases in frontal and temporal [11C]-raclopride binding after THC challengePaul R A Stokes
MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
Neuroimage 52:1521-7. 2010..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
- Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulatorsSuzanne J Reeves
Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London, UK
Psychiatry Res 202:60-4. 2012..Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function...
- Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformityAlice Egerton
Institute of Psychiatry, King s College London, London, UK
Neuroimage 53:777-81. 2010..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
- Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET studyAlice Egerton
Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Neuroimage 50:260-6. 2010..These findings have important implications for understanding the mechanism of action underlying bupropions' therapeutic efficacy and for the development of novel treatments for addiction and depression...
- Does human presynaptic striatal dopamine function predict social conformity?Paul R A Stokes
1Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
J Psychopharmacol 28:237-43. 2014....
- Amphetamine induced endogenous opioid release in the human brain detected with [Â¹Â¹C]carfentanil PET: replication in an independent cohortInge Mick
Division of Brain Science, Faculty of Medicine, Centre for Neuropsychopharmacology, Imperial College London, UK
Int J Neuropsychopharmacol 17:2069-74. 2014..11C]carfentanil PET is able to detect changes in binding following an oral amphetamine challenge that reflects endogenous opioid release and is suitable to characterize the opioid system in neuropsychiatric disorders...