Paul R A Stokes

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Burlington Danes Building, Imperial College London, W12 0NN, UK Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, UK Electronic address
    Neuroimage 99:158-65. 2014
  2. ncbi request reprint History of cigarette smoking is associated with higher limbic GABAA receptor availability
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neuroimage 69:70-7. 2013
  3. pmc Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Neuropsychopharmacology 38:485-91. 2013
  4. ncbi request reprint History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
  5. ncbi request reprint Can recreational doses of THC produce significant dopamine release in the human striatum?
    Paul R A Stokes
    Psychiatry Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK
    Neuroimage 48:186-90. 2009
  6. pmc The effects of the COMT Val108/158Met polymorphism on BOLD activation during working memory, planning, and response inhibition: a role for the posterior cingulate cortex?
    Paul R A Stokes
    Psychiatry Group, MRC Clinical Science Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Neuropsychopharmacology 36:763-71. 2011
  7. ncbi request reprint Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
  8. ncbi request reprint Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators
    Suzanne J Reeves
    Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London, UK
    Psychiatry Res 202:60-4. 2012
  9. ncbi request reprint Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformity
    Alice Egerton
    Institute of Psychiatry, King s College London, London, UK
    Neuroimage 53:777-81. 2010
  10. pmc Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study
    Alice Egerton
    Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroimage 50:260-6. 2010

Detail Information

Publications12

  1. ncbi request reprint Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Burlington Danes Building, Imperial College London, W12 0NN, UK Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, UK Electronic address
    Neuroimage 99:158-65. 2014
    ..These findings have potentially major implications for the investigation of GABA function in brain disorders and in the development of new treatments targeting this neurotransmitter system...
  2. ncbi request reprint History of cigarette smoking is associated with higher limbic GABAA receptor availability
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neuroimage 69:70-7. 2013
    ....
  3. pmc Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Neuropsychopharmacology 38:485-91. 2013
    ....
  4. ncbi request reprint History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
    ..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability...
  5. ncbi request reprint Can recreational doses of THC produce significant dopamine release in the human striatum?
    Paul R A Stokes
    Psychiatry Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK
    Neuroimage 48:186-90. 2009
    ..In animals, Delta9-tetrahydrocannabinol (THC) increases the rate of dopamine neuronal firing and release in the striatum. Thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis...
  6. pmc The effects of the COMT Val108/158Met polymorphism on BOLD activation during working memory, planning, and response inhibition: a role for the posterior cingulate cortex?
    Paul R A Stokes
    Psychiatry Group, MRC Clinical Science Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Neuropsychopharmacology 36:763-71. 2011
    ....
  7. ncbi request reprint Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
  8. ncbi request reprint Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators
    Suzanne J Reeves
    Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London, UK
    Psychiatry Res 202:60-4. 2012
    ..Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function...
  9. ncbi request reprint Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformity
    Alice Egerton
    Institute of Psychiatry, King s College London, London, UK
    Neuroimage 53:777-81. 2010
    ..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
  10. pmc Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study
    Alice Egerton
    Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroimage 50:260-6. 2010
    ..These findings have important implications for understanding the mechanism of action underlying bupropions' therapeutic efficacy and for the development of novel treatments for addiction and depression...
  11. ncbi request reprint Does human presynaptic striatal dopamine function predict social conformity?
    Paul R A Stokes
    1Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    J Psychopharmacol 28:237-43. 2014
    ....
  12. ncbi request reprint Amphetamine induced endogenous opioid release in the human brain detected with [¹¹C]carfentanil PET: replication in an independent cohort
    Inge Mick
    Division of Brain Science, Faculty of Medicine, Centre for Neuropsychopharmacology, Imperial College London, UK
    Int J Neuropsychopharmacol 17:2069-74. 2014
    ..11C]carfentanil PET is able to detect changes in binding following an oral amphetamine challenge that reflects endogenous opioid release and is suitable to characterize the opioid system in neuropsychiatric disorders...