J Stebbing

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint An open-label assessment of TMC 125--a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance
    Brian G Gazzard
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    AIDS 17:F49-54. 2003
  2. pmc CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions
    Georgios Giamas
    Department of Medical Oncology, Imperial College London, Hammersmith Hospital Campus, London, UK
    Nucleic Acids Res 37:3110-23. 2009
  3. pmc Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment
    M J Slade
    1Department of Oncology, Imperial College, MRC Cyclotron Building, London W12 0NN, UK
    Br J Cancer 100:160-6. 2009
  4. ncbi request reprint Host pharmacogenetics in the treatment of HIV and cancer
    Alan Winston
    The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Curr Drug Saf 1:107-16. 2006
  5. pmc A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study)
    J Stebbing
    Imperial College, Imperial Healthcare, NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Br J Cancer 98:716-9. 2008
  6. pmc The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer
    C Horlock
    Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    Br J Cancer 100:1061-7. 2009
  7. doi request reprint Genomic instability in pre-neoplastic colonic lesions
    J A Shaw
    Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Oncogene 32:5331-2. 2013
  8. ncbi request reprint Molecular basis of 5-fluorouracil-related toxicity: lessons from clinical practice
    Panagiotis Papanastasopoulos
    Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Rd, London, W6 8RF, U K
    Anticancer Res 34:1531-5. 2014
  9. pmc The efficacy of lapatinib in metastatic breast cancer with HER2 non-amplified primary tumors and EGFR positive circulating tumor cells: a proof-of-concept study
    Justin Stebbing
    Department of Oncology, Imperial College Healthcare National Health Service Trust, Charing Cross Hospital, London, United Kingdom
    PLoS ONE 8:e62543. 2013
  10. pmc The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?
    Jonathan Krell
    Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    BMC Cancer 12:135. 2012

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. ncbi request reprint An open-label assessment of TMC 125--a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance
    Brian G Gazzard
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    AIDS 17:F49-54. 2003
    ..TMC 125 was studied in HIV-1 infected patients with high-level phenotypic NNRTI resistance in an open-label phase IIa trial...
  2. pmc CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions
    Georgios Giamas
    Department of Medical Oncology, Imperial College London, Hammersmith Hospital Campus, London, UK
    Nucleic Acids Res 37:3110-23. 2009
    ....
  3. pmc Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment
    M J Slade
    1Department of Oncology, Imperial College, MRC Cyclotron Building, London W12 0NN, UK
    Br J Cancer 100:160-6. 2009
    ....
  4. ncbi request reprint Host pharmacogenetics in the treatment of HIV and cancer
    Alan Winston
    The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Curr Drug Saf 1:107-16. 2006
    ....
  5. pmc A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study)
    J Stebbing
    Imperial College, Imperial Healthcare, NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Br J Cancer 98:716-9. 2008
    ..Gefitinib does not sensitise patients with fluoropyrimidine refractory metastatic colorectal cancer to 5-FU chemotherapy...
  6. pmc The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer
    C Horlock
    Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    Br J Cancer 100:1061-7. 2009
    ..The change in balance of the T(reg) : Th17 ratio appears to characterise the cancer state, and furthermore, is disrupted by trastuzumab therapy...
  7. doi request reprint Genomic instability in pre-neoplastic colonic lesions
    J A Shaw
    Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Oncogene 32:5331-2. 2013
    ....
  8. ncbi request reprint Molecular basis of 5-fluorouracil-related toxicity: lessons from clinical practice
    Panagiotis Papanastasopoulos
    Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Rd, London, W6 8RF, U K
    Anticancer Res 34:1531-5. 2014
    ..Pharmacogenetics is expected to further identify and clarify the mechanisms associated with 5-FU-related toxicity, thus aiding the oncology societies to formulate specific guidance on pre-treatment testing. ..
  9. pmc The efficacy of lapatinib in metastatic breast cancer with HER2 non-amplified primary tumors and EGFR positive circulating tumor cells: a proof-of-concept study
    Justin Stebbing
    Department of Oncology, Imperial College Healthcare National Health Service Trust, Charing Cross Hospital, London, United Kingdom
    PLoS ONE 8:e62543. 2013
    ..We examined whether lapatinib which binds both HER2 and EGFR could induce depletion of the EGFR-positive pool of CTCs, which may in turn lead to clinical benefits...
  10. pmc The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?
    Jonathan Krell
    Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    BMC Cancer 12:135. 2012
    ..The importance of TILs appears to be subtype-specific and varies depending on the histologic characteristics of the tumor. As our understanding of tumorigenesis is increasing the relevance of immunobiology will become apparent...
  11. doi request reprint An intra-patient placebo-controlled phase I trial to evaluate the safety and tolerability of intradermal IMM-101 in melanoma
    J Stebbing
    Department of Oncology, Imperial College and Imperial College Healthcare NHS Trust, London, UK
    Ann Oncol 23:1314-9. 2012
    ..IMM-101 is a heat-killed innate and adaptive immune-activating mycobacterial product; a phase I study aimed to determine its safety and tolerability in individuals with melanoma...
  12. doi request reprint A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy
    J Stebbing
    Section of Oncology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK
    Ann Oncol 23:860-6. 2012
    ..To study this further, we examined the relationship between serum metabolite levels and the components of metabolic syndrome with treatment outcomes in breast cancer...
  13. doi request reprint LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome
    Justin Stebbing
    Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Breast Cancer Res Treat 132:537-44. 2012
    ..006). In summary, higher LMTK3 expression is associated with more aggressive cancers. These data support our previous findings and suggest LMTK3 expression may be a reliable new biomarker in breast cancer...
  14. pmc The successful treatment of haemophagocytic syndrome in patients with human immunodeficiency virus-associated multi-centric Castleman's disease
    J Stebbing
    Department of Oncology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London UK
    Clin Exp Immunol 154:399-405. 2008
    ..Systemic activation of cytokines was limited, suggesting that immunosuppressive therapy with steroids is not indicated in HHV-8-driven HPS...
  15. ncbi request reprint The rationale and development of new drugs to treat HIV infection
    Justin Stebbing
    St Bartholomew s Hospital, The Bodley Scott Unit, W Smithfield, London EC1A, London, UK
    Med Chem 1:635-42. 2005
    ..The replacement of older therapies with newer drugs that avoid cross resistance even within the same class of antiretroviral, represents a new hope in retroviral targeting...
  16. ncbi request reprint Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients
    Justin Stebbing
    The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cell Res 14:251-6. 2004
    ..These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals...
  17. pmc Assessment of the efficacy of total lymphocyte counts as predictors of AIDS defining infections in HIV-1 infected people
    J Stebbing
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 81:586-8. 2005
    ..This study assessed the utility of the total lymphocyte count (TLC) in place of the CD4 count to predict the development of AIDS defining opportunistic infections (ADOI)...
  18. doi request reprint A meta-analysis of transient elastography for the detection of hepatic fibrosis
    Justin Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, St Stephen s Centre, Imperial College School of Medicine, London, UK
    J Clin Gastroenterol 44:214-9. 2010
    ..We performed a meta-analysis to further assess its use in comparison with liver biopsy...
  19. pmc A questionnaire survey of stress and bullying in doctors undertaking research
    J Stebbing
    Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 80:93-6. 2004
    ..Research is an increasingly important aspect of higher medical training for many doctors. Studies investigating sources of stress, isolation, and workplace bullying have not previously sought information in this setting...
  20. pmc Highly active anti-retroviral therapy (HAART)-induced maintenance of adaptive but not innate immune parameters is associated with protection from HIV-induced mortality
    J Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Clin Exp Immunol 145:271-6. 2006
    ..001). Effective HAART-induced maintenance of the adaptive immune system (CD4, CD8 and CD19 counts) protects from HIV-related mortality...
  21. doi request reprint FLEX data, KRAS and ERCC1 testing in oncology
    Justin Stebbing
    Imperial College Imperial Healthcare NHS Trust, Charing Cross Hospital, Department of Medical Oncology, Fulham Palace Road, London W6 8RF, UK
    Future Oncol 4:471-3. 2008
  22. doi request reprint The efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma
    Justin Stebbing
    Department of Medical Oncology, St Bartholomew s Hospital, West Smithfield, London EC1A 7BE, UK
    Lung Cancer 63:94-7. 2009
    ..Its use should be prospectively evaluated in a randomised trial in the first or second-line therapy of MPM...
  23. ncbi request reprint Hepatitis C virus infection in HIV type 1-infected individuals does not accelerate a decrease in the CD4+ cell count but does increase the likelihood of AIDS-defining events
    Justin Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Clin Infect Dis 41:906-11. 2005
    ..In conclusion, there was an increased number of adverse events in coinfected individuals, compared with individuals infected with HIV-1 alone...
  24. doi request reprint Cancer vaccines: clinical development challenges and proposed regulatory approaches for patient access to promising treatments
    Justin Stebbing
    Imperial College School of Science, Medicine, and Technology, The Hammersmith Hospitals National Health Service Trust, London, UK
    Cancer 112:955-61. 2008
    ..All of these solutions aim to balance a complex equation of biologic rationale, weight of the evidence for efficacy and safety, regulatory expectations, and cost and timeline of clinical development...
  25. doi request reprint Cardiotoxicity and anthracyclines
    Justin Stebbing
    Imperial College, School of Medicine, Imperial Healthcare NHS Trust, Charing Cross Hospital, London, UK
    Breast Cancer Res Treat 107:451-3. 2008
  26. ncbi request reprint Prognostic significance of immune subset measurement in individuals with AIDS-associated Kaposi's sarcoma
    Justin Stebbing
    Imperial College of Science, Medicine, and Technology, Department of Oncology, The Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 25:2230-5. 2007
    ..Because immune subset measurement is often performed in HIV-positive individuals, we examined whether these were predictive of mortality independently of the prognostic index, or could predict time to progression of KS...
  27. ncbi request reprint A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART)
    Justin Stebbing
    The St Stephen s Centre, The Chelsea and Westminster Hospital, London, UK
    J Antimicrob Chemother 53:501-5. 2004
    ....
  28. ncbi request reprint Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor
    Justin Stebbing
    Department of Immunology, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 102:1806-14. 2003
    ..These results have important implications for the etiopathogenesis of KS and for the development and design of any compounds, including vaccines, derived from cellular lysates...
  29. doi request reprint Plasma HHV8 DNA predicts relapse in individuals with HIV-associated multicentric Castleman disease
    Justin Stebbing
    Department of HIV Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
    Blood 118:271-5. 2011
    ..Rising levels predicted an attack (hazard ratio = 2.9; 95% confidence interval, 1.3-6.7), and maintenance therapy with rituximab should be considered in these individuals...
  30. doi request reprint No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer
    Justin Stebbing
    Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    AIDS 24:1221-3. 2010
    ..Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer...
  31. ncbi request reprint Nadir B cell counts are significantly correlated with the risk of Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 108:473-4. 2004
    ..015). These data highlight a potential role for B cells and therefore the humoral immune system in KS aetiopathogenesis...
  32. ncbi request reprint All for CD91 and CD91 for all
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Antimicrob Chemother 53:1-3. 2004
    ..The abundance of heat shock proteins in tumours and their presence in virion coats makes them attractive propositions for use in antitumour and antiviral strategies...
  33. doi request reprint Epidermal growth factor receptor status in early stage breast cancer is associated with cellular proliferation but not cross-talk
    Justin Stebbing
    Departments of Oncology, Surgery and Histopathology, Imperial College, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
    J Clin Pathol 64:829-31. 2011
    ..1; 95% CI 12.7 to 46.00, p=0.0001). EGFR expression may play a role in breast cancer proliferation, but appears unlikely to modify tumour pathology via postulated mechanisms of oestrogen receptor/EGFR-mediated cross-talk...
  34. doi request reprint Primary esophageal carcinoma in the era of highly active antiretroviral therapy
    Justin Stebbing
    Department of Medical Oncology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, First Floor, East Wing, Fulham Palace Road, London W6 8RF, England
    Arch Intern Med 170:203-7. 2010
    ..Primary esophageal tumors in people living with HIV have seldom been reported. We sought to document patient, virologic, and tumor characteristics and clinical outcomes in this patient group...
  35. ncbi request reprint A comparison of the CD4 response to antiretroviral regimens in patients commencing therapy with low CD4 counts
    L Waters
    St Stephen s Centre, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Antimicrob Chemother 54:503-7. 2004
    ..To compare the immunological response to highly active antiretroviral therapy (HAART) in treatment-naive patients with a baseline CD4 count of <200 cells/mm(3)...
  36. ncbi request reprint Impact of antiretroviral choice on hypercholesterolaemia events: the role of the nucleoside reverse transcriptase inhibitor backbone
    R Jones
    Department of HIV and GU Medicine, The Chelsea and Westminster Hospital, London, UK
    HIV Med 6:396-402. 2005
    ..Metabolic abnormalities associated with antiretrovirals and cumulative exposure to combination antiretroviral therapy, including dyslipidaemia and insulin resistance, have been linked to an increased risk of myocardial infarction...
  37. pmc Outcome of patients with HIV-related germ cell tumours: a case-control study
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
    Br J Cancer 90:1526-30. 2004
    ..78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population...
  38. pmc The common heat shock protein receptor CD91 is up-regulated on monocytes of advanced melanoma slow progressors
    J Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 138:312-6. 2004
    ....
  39. doi request reprint The role of immune suppression and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman's disease
    T Powles
    Department of Medical Oncology, Barts and the London Medical School, London, UK
    Ann Oncol 20:775-9. 2009
    ..In HIV cohorts with access to highly active antiretroviral therapy (HAART), the incidence of Kaposi's sarcoma (KS) is falling; however, the incidence of multicentric Castleman's disease (MCD) in HIV has not previously been described...
  40. ncbi request reprint Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations
    J Stebbing
    Departments of Oncology and HIV Medicine, Chelsea and Westminster Hospital, London, UK
    Ann Oncol 14:1660-6. 2003
    ..Cytokines measured included tumour necrosis factor-alpha (TNF-alpha), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and the interleukins IL-2, -6 and -12...
  41. pmc A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia
    T Powles
    Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Hammersmith Hospitals Campus of Imperial College London, London, UK
    Br J Cancer 96:732-7. 2007
    ..01)). The outcome of patients with relapsed GTN is good. However, patients with primary chemo-refractory disease do poorly and novel therapies are required for this group of patients...
  42. ncbi request reprint Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    J Clin Oncol 23:5224-8. 2005
    ..This clinical response, known as the immune reconstitution inflammatory syndrome (IRIS), occurs secondary to an immune response against previously diagnosed pathogens...
  43. ncbi request reprint Treatment of primary HIV-1 infection with nonnucleoside reverse transcriptase inhibitor-based therapy is effective and well tolerated
    S Portsmouth
    Chelsea and Westminster Hospital, London, UK
    HIV Med 5:26-9. 2004
    ..Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection. We investigated the use of a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen in this setting...
  44. pmc A single centre cohort experience with a new once daily antiretroviral drug
    J Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 82:343-6. 2006
    ..Unboosted atazanavir is also used in highly active antiretroviral therapy (HAART) naive patients...
  45. ncbi request reprint Multicenter study of human immunodeficiency virus-related germ cell tumors
    T Powles
    Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 21:1922-7. 2003
    ..Testicular germ cell tumors (GCT) occur at increased frequency in men with human immunodeficiency virus (HIV). This multicenter study addresses the characteristics of these tumors...
  46. pmc GAMEC--a new intensive protocol for untreated poor prognosis and relapsed or refractory germ cell tumours
    J Shamash
    Department of Medical Oncology, St Bartholomew s Hospital, London, UK
    Br J Cancer 97:308-14. 2007
    ..GAMEC is a novel intensive regimen for this group of patients producing encouraging responses, although with significant toxicity. For those in whom it fails, further therapy is still possible with durable responses being seen...
  47. pmc Pneumonia due to antibiotic resistant Streptococcus pneumoniae and Pseudomonas aeruginosa in the HAART era
    S H Allen
    Department of Microbiology, Chelsea and Westminster Hospital, London
    Postgrad Med J 79:691-4. 2003
    ..These findings have implications for the treatment of individuals presenting with serious infections in which antibiotic therapy needs to be instituted before identification and sensitivities are known...
  48. ncbi request reprint An open-label study of tenofovir in HIV-1 and Hepatitis B virus co-infected individuals
    M Nelson
    Chelsea and Westminster Hospital, London, UK
    AIDS 17:F7-10. 2003
    ..Recent data suggest an effect on Hepatitis B virus (HBV) replication. We therefore investigated the use of tenofovir in HIV-1 and HBV co-infected individuals...
  49. ncbi request reprint The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Blood 101:4000-4. 2003
    ..The ability of CD91 to internalize alpha-defensins and to cross-present exogenous antigen to cytotoxic T lymphocytes through major histocompatibility complex (MHC) class 1 may maintain CD8(+) responses in these patients...
  50. ncbi request reprint A phase II study using a topoisomerase I-based approach in patients with multiply relapsed germ-cell tumours
    J Shamash
    The Department of Medical Oncology, St Bartholomew s Hospital, London, UK
    Ann Oncol 18:925-30. 2007
    ..We investigated the role of irinotecan, paclitaxel and oxaliplatin (IPO) followed by topotecan-based high-dose therapy in responding patients, in this patient population...
  51. doi request reprint The frequency and reasons for antiretroviral switching with specific antiretroviral associations: the SWITCH study
    I Davidson
    St Stephen s Centre, Chelsea and Westminster Hospital Trust, United Kingdom
    Antiviral Res 86:227-9. 2010
    ..We investigated the reasons for switching antiretroviral regimens, an issue rarely addressed in cohort studies...
  52. ncbi request reprint Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects
    Anthony Kebba
    Department of Immunology, Imperial College, Chelsea and Westminster Hospital, London, UK
    J Leukoc Biol 78:37-42. 2005
    ..7, P = 0.015). Increased surface expression of CD91 on CD14(+) monocytes is associated with the apparent HIV-1 resistance that is observed in ESN subjects...
  53. ncbi request reprint Recurrent locally advanced breast cancer: the treatment of chest wall disease with further chemotherapy
    Y Saunders
    The Royal Marsden NHS Trust, London, UK
    Clin Oncol (R Coll Radiol) 13:195-9. 2001
    ..A prospective database will now be established to collect further information on this group of patients, including their quality of life...
  54. ncbi request reprint Outcome in AIDS-related systemic non-Hodgkin lymphoma and leptomeningeal disease is not predicted by a CT brain scan
    C L Davies
    Department of Oncology, Imperial College School of Science, Medicine and Technology, Chelsea and Westminster Hospital, London, United Kingdom
    AJNR Am J Neuroradiol 28:1988-90. 2007
    ..We investigated the utility of brain CT in determining the outcome of leptomeningeal disease, despite MR imaging being the gold standard...
  55. ncbi request reprint The presentation and survival of patients with non-cutaneous AIDS-associated Kaposi's sarcoma
    J Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, UK
    Ann Oncol 17:503-6. 2006
    ..We describe for the first time a proportion of patients with AIDS-KS who presented with no evidence of cutaneous disease...
  56. doi request reprint LMTK3 is implicated in endocrine resistance via multiple signaling pathways
    J Stebbing
    Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
    Oncogene 32:3371-80. 2013
    ..In aggregate, these data support a role for LMTK3 in both innate (intrinsic) and acquired (adaptive) endocrine resistance in breast cancer. ..
  57. pmc Prospective cohort study showing changes in the monthly incidence of Pneumocystis carinii pneumonia
    N Lubis
    Imperial College School of Medicine, London
    Postgrad Med J 79:164-6. 2003
    ..These data are consistent with an influence of climatic conditions on the presentation of PCP. The diagnosis of PCP is more common in winter months suggesting that this is a transmissible infection...
  58. ncbi request reprint Antiretroviral treatment regimens and immune parameters in the prevention of systemic AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    J Clin Oncol 22:2177-83. 2004
    ..As there are no data demonstrating that specific antiretroviral regimens are effective at protecting from NHL, we compared different HAART regimens...
  59. ncbi request reprint Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels
    Tom Newsom-Davis
    Departments of Oncology and HIV Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Leuk Lymphoma 45:1939-41. 2004
    ..This highlights the close association between circulating cytokines such as IL-6 and virally-induced malignancy...
  60. ncbi request reprint The evidence-based treatment of AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    Medical Day Unit, Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cancer Treat Rev 30:249-53. 2004
    ..In this review, we discuss the evidence for choosing particular therapies in patients with AIDS-related NHL...
  61. pmc SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1
    H Zhang
    Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 ONN, UK
    Br J Cancer 109:2675-84. 2013
    ..Although efforts have been made to study the role of KSR1 in certain tumour types, its involvement in breast cancer remains unknown...
  62. ncbi request reprint A prognostic index for AIDS-associated Kaposi's sarcoma in the era of highly active antiretroviral therapy
    Justin Stebbing
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Lancet 367:1495-502. 2006
    ..We developed a simple model for predicting mortality on the basis of clinical characteristics present at the time of diagnosis of Kaposi's sarcoma...
  63. ncbi request reprint A comparison of regimens based on non-nucleoside reverse transcriptase inhibitors or protease inhibitors in preventing Kaposi's sarcoma
    Simon Portsmouth
    Department of Immunology, Chelsea and Westminster Hospital, London, UK
    AIDS 17:F17-22. 2003
    ....
  64. ncbi request reprint Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and a decreased cholesterol
    Victoria Latham
    The St Stephen s Centre, The Chelsea and Westminster Hospital, London, UK
    J Antimicrob Chemother 56:186-9. 2005
    ..Trizivir (zidovudine/lamivudine/abacavir) and tenofovir disoproxil fumarate may improve adherence and enhance virological suppression in individuals who have failed previous regimens...
  65. ncbi request reprint Should cervical cancer be an acquired immunodeficiency syndrome-defining cancer?
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 24:2417-9. 2006
  66. ncbi request reprint Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer
    D J Pinato
    Division of Experimental Medicine, Hammersmith Campus of Imperial College London, Du Cane Road, W120HS London, UK
    Br J Cancer 110:1930-5. 2014
    ..We aimed to establish whether inflammation-based scores offer an improved prognostic ability in terms of estimating overall (OS) and recurrence-free survival (RFS) in a cohort of operable, early-stage NSCLC patients...
  67. doi request reprint The regulatory roles of phosphatases in cancer
    J Stebbing
    Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK
    Oncogene 33:939-53. 2014
    ..In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies. ..
  68. doi request reprint The efficacy of tacrolimus and sirolimus in heavily pre-treated unresectable thymic malignancies
    S J L Payne
    Barts Cancer Centre, St Bartholomew s Hospital, 7th Floor Gloucester House, West Smithfield, London, UK
    Lung Cancer 80:228-9. 2013
    ..Systemic chemotherapy is the mainstay of treatment for inoperable or recurrent disease, but immunosuppressive therapy may provide an alternative treatment strategy...
  69. pmc The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy
    R E Payne
    Division of Cancer, Imperial College, MRC Cyclotron Building, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Br J Cancer 106:375-82. 2012
    ..The aim of this study was to gain insight into breast cancer dormancy by examining different measures of minimal residual disease (MRD) over time in relation to known prognostic factors...
  70. pmc The clinical significance of radiologically detected silent pulmonary nodules in early breast cancer
    B Lee
    Department of Medical Oncology, Imperial College, The Hammersmith Hospitals NHS Trust, Charing Cross Hospital, London, UK
    Ann Oncol 19:2001-6. 2008
    ..Those in whom indeterminate pulmonary nodules are visualized without the presence of other metastatic lesions represent a clinical dilemma regarding their management as early breast cancer or metastatic disease...
  71. doi request reprint Use of antidepressants and risk of cancer in individuals infected with HIV
    Justin Stebbing
    Imperial College, Imperial Healthcare NHS Trust, Charing Cross Hospital, Department of Medical Oncology, London, UK
    J Clin Oncol 26:2305-10. 2008
    ..We aimed to assess whether different classes of antidepressants were associated with changes in cancer incidence in a population of HIV-1 infected individuals, based on duration of exposure...
  72. doi request reprint Kinetic filtering of [(18)F]Fluorothymidine in positron emission tomography studies
    Katherine R Gray
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Phys Med Biol 55:695-709. 2010
    ..A scan acquisition time of 60 min has been shown to be sufficient to obtain the necessary kinetic data. The algorithm extends utility of FLT-PET imaging in oncology research...
  73. doi request reprint The phosphorylated membrane estrogen receptor and cytoplasmic signaling and apoptosis proteins in human breast cancer
    Paul J Mintz
    Department of Biosurgery and Surgical Technology, Faculty of Medicine, Imperial College London, London, United Kingdom
    Cancer 113:1489-95. 2008
    ..Therefore, it is crucial to elucidate pathways that may contribute to ER signaling in clinical specimens...
  74. doi request reprint Kinases as targets in the treatment of solid tumors
    Georgios Giamas
    Department of Cancer and Surgery, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 ONN, UK
    Cell Signal 22:984-1002. 2010
    ..In this review we focus on protein kinases involved in different signaling pathways and their alterations in solid tumors...
  75. doi request reprint Serum molecular signatures of weight change during early breast cancer chemotherapy
    Hector C Keun
    Department of Biomolecular Medicine, Imperial College, London, United Kingdom
    Clin Cancer Res 15:6716-23. 2009
    ..Weight gain in women receiving chemotherapy for breast cancer is associated with a higher risk of recurrence but its mechanisms are poorly understood...
  76. pmc The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response
    Leandro Castellano
    Department of Oncology, Cyclotron Building, Hammersmith Hospital Campus, Imperial College, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 106:15732-7. 2009
    ..We propose that ERalpha, c-MYC, and miRNA transcriptional programs invoke a sophisticated network of interactions able to provide the wide range of coordinated cellular responses to estrogen...
  77. doi request reprint Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection
    Thomas Powles
    Department of Medical Oncology, St Bartholomew s Hospital, Little Brittain, London EC1A7BE, United Kingdom
    J Clin Oncol 27:884-90. 2009
    ..The effect of highly active antiretroviral therapy (HAART) on the incidence of non-AIDS-defining cancers (NADCs) is unclear...
  78. doi request reprint Cytokine changes during rituximab therapy in HIV-associated multicentric Castleman disease
    Mark Bower
    Department of Oncology, HIV Medicine and Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Blood 113:4521-4. 2009
    ..Therapies that reduce the inflammatory cytokine response are likely to be successful in a range of diseases, including HIV-MCD, and in the future may be used to guide therapeutic strategies...
  79. ncbi request reprint Antigen presentation and the role of dendritic cells in HIV
    Heather Donaghy
    Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, UK
    Curr Opin Infect Dis 17:1-6. 2004
    ..We review recent publications regarding the effect of HIV-1 infection on the numbers and function of dendritic cells, as well as progress in the use of dendritic cells in immunotherapeutic protocols...
  80. ncbi request reprint A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study)
    Chloe Orkin
    The St Stephen s Centre, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH
    J Antimicrob Chemother 55:246-51. 2005
    ..Research is required on the effectiveness of quadruple therapy in comparison to this and the relative effectiveness of specific highly active antiretroviral therapy (HAART) combinations...
  81. ncbi request reprint Recent advances in the systemic management of colorectal cancer
    Danish Mazhar
    Charing Cross Hospital, Department of Medical Oncology, London, W6 8RF, UK
    Future Oncol 2:643-50. 2006
    ..These novel agents are now being incorporated into treatment schedules for colorectal cancer. This review assesses recent improvements in the systemic management of large bowel cancer and highlights future challenges...
  82. doi request reprint Immunologic recovery in survivors following chemotherapy for AIDS-related non-Hodgkin lymphoma
    Mark Bower
    Department of Oncology, Imperial College School of Medicine, London, UK
    Blood 111:3986-90. 2008
    ..Chemotherapy and concomitant HAART for AIDS-related NHL does not cause prolonged suppression of lymphocyte subsets. These data should provide reassurance regarding the long-term consequences of chemotherapy in these individuals...
  83. ncbi request reprint A prognostic index for systemic AIDS-related non-Hodgkin lymphoma treated in the era of highly active antiretroviral therapy
    Mark Bower
    The Chelsea and Westminster Hospital, London, United Kingdom
    Ann Intern Med 143:265-73. 2005
    ..The established International Prognostic Index for lymphomas has not included patients with systemic AIDS-related non-Hodgkin lymphoma...
  84. ncbi request reprint Chemotherapy for advanced cholangiocarcinoma: what is standard treatment?
    Danish Mazhar
    Chelsea and Westminster Hospital, Department of Oncology, 369 Fulham Road, London SW10 9NH, UK
    Future Oncol 2:509-14. 2006
    ..This review examines this data and assesses whether a new standard of care for advanced cholangiocarcinoma can be found...
  85. ncbi request reprint Efficacy and safety of first- or second-line irinotecan, cisplatin, and mitomycin in mesothelioma
    Dean A Fennell
    Lung and Mesothelioma Unit, Department of Medical Oncology, St Bartholomew s Hospital, West Smithfield, London, UK
    Cancer 109:93-9. 2007
    ..Malignant pleural mesothelioma (MPM) is a rapidly progressive lethal tumor. Treatment options remain limited and the outcome in recurrent disease is poor...
  86. ncbi request reprint How does HAART lead to the resolution of Kaposi's sarcoma?
    Justin Stebbing
    Department of Immunology, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Antimicrob Chemother 51:1095-8. 2003
  87. ncbi request reprint Current treatment of HIV infection
    Simon Portsmouth
    St Stephen s Centre, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Curr Top Med Chem 3:1458-66. 2003
    ..Future progress in antiretroviral therapy will bring more choices for physicians and patients and will make an already complex field both more challenging and more rewarding...
  88. ncbi request reprint The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 108:631-3. 2004
    ..This is consistent with data suggesting that regression of KS is mediated by an overall improvement in immune function and not by the effects of specific antiretrovirals...
  89. ncbi request reprint Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study
    Laura Waters
    Department of HIV Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 116:161-3. 2005
    ..1 of 10(4) patient years during HIV alone (p = 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma...
  90. ncbi request reprint Protease inhibitors potentiate chemotherapy-induced neutropenia
    Mark Bower
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 104:2943-6. 2004
    ..PI-based HAART appears to significantly potentiate the myelotoxicity of CDE chemotherapy. This potentiation may be a consequence of microsomal enzyme inhibition reducing the metabolism of cytotoxics in this regimen...
  91. ncbi request reprint AIDS-associated malignancies
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Cancer Chemother Biol Response Modif 22:687-706. 2005
  92. doi request reprint Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer
    Dmitri Pchejetski
    Department of Surgery and Cancer, Imperial College, London, UK
    Breast Cancer Res Treat 124:543-9. 2010
    ..These data provide evidence for an association between serum S1P and weight gain during chemotherapy cycles in women with breast cancer. Lipid second messengers have a role in chemotherapy-induced weight gain in breast cancer...
  93. doi request reprint Trastuzumab: unusual responses and toxicities
    Eliyaz Ahamed
    Department of Medical Oncology, First Floor, Charing Cross Hospital, Fulham Palace Road, London, UK
    Future Oncol 5:779-84. 2009
    ..While cardiotoxicity is well recognized with trastuzumab, unusual pulmonary toxicities are becoming apparent. Cases that reflect the unusual efficacy and unusual toxicity of trastuzumab are reported...
  94. doi request reprint An open-label study of lapatinib in women with HER-2-negative early breast cancer: the lapatinib pre-surgical study (LPS study)
    R C Coombes
    Division of Cancer, Department of Surgery and Cancer, Imperial College London, 1st Floor ICTEM, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Ann Oncol 24:924-30. 2013
    ..This phase II, open-label, multicentre study aimed to evaluate changes in cell proliferation and biomarkers, as well as efficacy of lapatinib in treatment-naïve patients with HER-2-negative primary breast cancer...
  95. pmc The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours
    T Powles
    Charing Cross Gestational Trophoblastic Centre, London, UK
    Br J Cancer 95:1145-7. 2006
    ..The interval between antecedent pregnancy and diagnosis in high-risk GTT is of prognostic significance. This gives some insight into the pathogenesis of the disease...
  96. doi request reprint Clinical outcome in resistant HIV-2 infection treated with raltegravir and maraviroc
    Darius Armstrong-James
    Imperial College, St Stephens AIDS Trust, Chelsea and Westminster Hospital, London, UK
    Antiviral Res 86:224-6. 2010
    ..Further studies are required to assess the clinical efficacy of maraviroc in HIV-2 infection...
  97. ncbi request reprint What can oncologists learn from HIV?
    Justin Stebbing
    Chelsea and Westminster Hospital, London, UK
    Lancet Oncol 4:438-45. 2003
    ..In this review, we discuss what oncologists can learn from the HIV epidemic...
  98. ncbi request reprint The clades of HIV: their origins and clinical significance
    Justin Stebbing
    The St Stephen s Centre, The Chelsea and Westminster Hospital, London, United Kingdom
    AIDS Rev 5:205-13. 2003
    ..Efficient targeting of the extreme genetic diversity of HIV-1, and an understanding of the processes underlying this, represents one of the major challenges in the control of this ongoing pandemic...
  99. ncbi request reprint Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma
    Mark Bower
    Department of Oncology and HIV Medicine, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    J Natl Cancer Inst 98:1088-91. 2006
    ..013), and patients were more likely to have the diagnosis of PCL confirmed histologically or by polymerase chain reaction (77% versus 26%; P<.001). Exposure to specific antiretroviral agents was not associated with risk for PCL...