Andrew J Stagg

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Vaccines against Chlamydia: approaches and progress
    A J Stagg
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Hospital, Harrow, Middlesex, UK
    Mol Med Today 4:166-73. 1998
  2. pmc Protection against ascending infection of the genital tract by Chlamydia trachomatis is associated with recruitment of major histocompatibility complex class II antigen-presenting cells into uterine tissue
    A J Stagg
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    Infect Immun 66:3535-44. 1998
  3. ncbi Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin
    Andrew J Stagg
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Harrow, GB
    Eur J Immunol 32:1445-54. 2002
  4. pmc Dendritic cells derived from bone marrow cells fail to acquire and present major histocompatibility complex antigens from other dendritic cells
    Penelope A Bedford
    Antigen Presentation Research Group, Imperial College London, North West London Hospitals campus, Harrow, London, UK
    Immunology 124:542-52. 2008
  5. doi Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment
    Elizabeth R Mann
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Harrow, UK
    Inflamm Bowel Dis 18:1275-86. 2012
  6. doi Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis
    Siew C Ng
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Inflamm Bowel Dis 16:1286-98. 2010
  7. doi Human gut dendritic cells drive aberrant gut-specific t-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ
    Elizabeth R Mann
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Harrow, United Kingdom Gastrointestinal Division, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom Department of Gastroenterology, St Mark s Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom Yakult UK Ltd, South Ruislip, United Kingdom and Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Inflamm Bowel Dis 20:2299-307. 2014
  8. ncbi IL-10-producing B220+CD11c- APC in mouse spleen
    Fiona Burke
    Antigen Presentation Research Group, Faculty of Medicine Imperial College London, Harrow, United Kingdom
    J Immunol 173:2362-72. 2004
  9. pmc Methylglyoxal modulates immune responses: relevance to diabetes
    Claire L Price
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Marks Campus, Harrow, Middlesex, UK
    J Cell Mol Med 14:1806-15. 2010
  10. ncbi Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity
    Andrew J Stagg
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College, Northwick Park Campus, Watford Road, Harrow HA1 3UJ, Middlesex, UK
    Best Pract Res Clin Gastroenterol 18:255-70. 2004

Collaborators

  • Stella C Knight
  • Michael A Kamm
  • Borja Sanchez
  • Abelardo Margolles
  • T T MacDonald
  • Ailsa L Hart
  • G Monteleone
  • Heather Jebbari
  • John N Gordon
  • Elizabeth R Mann
  • Nicholas R English
  • Hafid O Al-Hassi
  • David Bernardo
  • Siew C Ng
  • Penelope A Bedford
  • Simon T C Peake
  • Fiona Burke
  • Hafid Omar Al-Hassi
  • Claire L Price
  • Antonio Di Sabatino
  • Rebecca J Critchley-Thorne
  • M Ruth Mason
  • Rachael J Rigby
  • Jose A Garrote
  • Jon Landy
  • Ripple Man
  • Maria Urdaci
  • Jonathan Landy
  • Henning Spranger
  • Linda V Thomas
  • Luis Fernández-Salazar
  • Eduardo Arranz
  • Gui Han Lee
  • Andrew N Milestone
  • Stella A Cochrane
  • Susan K Clark
  • Neil E McCarthy
  • Alexandra I F Blakemore
  • Thomas Guenther
  • Sophie Plamondon
  • Hafid O S Al Hassi
  • Nicholas M Croft
  • Virginia Salvati
  • Nicholas A B Leakey
  • Anna Vossenkaemper
  • Giuseppe Mazzarella
  • Karen M Pickard
  • Gino R Corazza
  • Laura Rovedatti
  • Riccardo Troncone
  • Robert M Beattie
  • Georges Vassaux
  • Ronald F Lamont
  • Nicholas English

Detail Information

Publications16

  1. ncbi Vaccines against Chlamydia: approaches and progress
    A J Stagg
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Hospital, Harrow, Middlesex, UK
    Mol Med Today 4:166-73. 1998
    ..Progress has been made in understanding protective and pathological immune mechanisms in these infections, and a number of potential vaccine candidates have been developed...
  2. pmc Protection against ascending infection of the genital tract by Chlamydia trachomatis is associated with recruitment of major histocompatibility complex class II antigen-presenting cells into uterine tissue
    A J Stagg
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    Infect Immun 66:3535-44. 1998
    ..An additional level of immunological control may thus exist in genital chlamydial infection...
  3. ncbi Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin
    Andrew J Stagg
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Harrow, GB
    Eur J Immunol 32:1445-54. 2002
    ..Therefore, in addition to their other immunoregulatory roles, DC have the potential to shape immune responses by influencing the homing of the lymphocytes they activate...
  4. pmc Dendritic cells derived from bone marrow cells fail to acquire and present major histocompatibility complex antigens from other dendritic cells
    Penelope A Bedford
    Antigen Presentation Research Group, Imperial College London, North West London Hospitals campus, Harrow, London, UK
    Immunology 124:542-52. 2008
    ..The evidence suggests that T-cell activation may be blocked by the presence of dendritic cells that have not matured through lymphoid tissues which are unable to acquire and present antigens pre-processed by other dendritic cells...
  5. doi Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment
    Elizabeth R Mann
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Harrow, UK
    Inflamm Bowel Dis 18:1275-86. 2012
    ..In humans, we characterized normal human gut DC and tested whether gut-specific homeostatic DC could be generated from blood precursors by factors in the gut microenvironment...
  6. doi Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis
    Siew C Ng
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Inflamm Bowel Dis 16:1286-98. 2010
    ..The probiotic mixture, VSL#3, increases interleukin (IL)-10 and downregulates IL-12p40 production by DC in vitro. We evaluated in vivo effects of oral VSL#3 and steroids on colonic DC in patients with acute UC...
  7. doi Human gut dendritic cells drive aberrant gut-specific t-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ
    Elizabeth R Mann
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Harrow, United Kingdom Gastrointestinal Division, Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom Department of Gastroenterology, St Mark s Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom Yakult UK Ltd, South Ruislip, United Kingdom and Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Inflamm Bowel Dis 20:2299-307. 2014
    ..Manipulation of DC to allow generation of DC-specific therapy may be beneficial in inflammatory bowel disease. ..
  8. ncbi IL-10-producing B220+CD11c- APC in mouse spleen
    Fiona Burke
    Antigen Presentation Research Group, Faculty of Medicine Imperial College London, Harrow, United Kingdom
    J Immunol 173:2362-72. 2004
    ..B220(+) APC in mouse spleen that stimulate naive T cells and preferentially produce IL-10 may be involved in activating regulatory immune responses...
  9. pmc Methylglyoxal modulates immune responses: relevance to diabetes
    Claire L Price
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Marks Campus, Harrow, Middlesex, UK
    J Cell Mol Med 14:1806-15. 2010
    ..We conclude that MG is a potent suppressor of myeloid and T-cell immune function and may be a major player in diabetes-associated susceptibility to infection...
  10. ncbi Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity
    Andrew J Stagg
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College, Northwick Park Campus, Watford Road, Harrow HA1 3UJ, Middlesex, UK
    Best Pract Res Clin Gastroenterol 18:255-70. 2004
    ..Here, we review current knowledge on gut DCs, suggest models for interactions between DCs and the commensal microflora in health and disease, and discuss gut DCs as targets for probiotic therapies...
  11. pmc Leishmania major promastigotes inhibit dendritic cell motility in vitro
    Heather Jebbari
    Antigen Presentation Research Group, Department of Immunology, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom
    Infect Immun 70:1023-6. 2002
    ..Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis...
  12. doi Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp
    Hafid O Al-Hassi
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Harrow, UK
    Mol Nutr Food Res 58:1132-43. 2014
    ....
  13. ncbi Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Gastroenterology 133:1175-87. 2007
    ..We examined mucosal DCs in celiac disease in terms of phenotype, activation/maturation state, cytokine production, and function...
  14. ncbi Characteristics of intestinal dendritic cells in inflammatory bowel diseases
    Ailsa L Hart
    Antigen Presentation Research Group, Imperial College London, England
    Gastroenterology 129:50-65. 2005
    ..We aimed to identify changes in intestinal DCs that may underlie the dysregulated immune response to enteric bacteria that occurs in patients with inflammatory bowel disease (IBD)...
  15. ncbi The measurement of dendritic cells in umbilical cord blood: a novel technique using small volumes of whole blood
    M Ruth Mason
    Department of Obstetrics and Gynaecology, Northwick Park and St Mark s NHS Trust, Imperial College, London, United Kingdom
    J Soc Gynecol Investig 12:246-52. 2005
    ..To develop a technique that would permit the identification of dendritic cells (DC) in small volumes of preterm neonatal cord blood in order to investigate neonatal immune response in relation to infection and preterm labor...
  16. ncbi Recombinant Escherichia coli expressing invasin targets the Peyer's patches: the basis for a bacterial formulation for oral vaccination
    Rebecca J Critchley-Thorne
    Centre for Molecular Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    Mol Ther 14:183-91. 2006
    ..These data demonstrate the selectivity of invasin-mediated invasion to the Peyer's patches and indicate the potential of nonpathogenic, invasive E. coli as an oral vaccine with applications in immunotherapy...