Andrew J Stagg
Affiliation: Imperial College
- Vaccines against Chlamydia: approaches and progressA J Stagg
Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Hospital, Harrow, Middlesex, UK
Mol Med Today 4:166-73. 1998..Progress has been made in understanding protective and pathological immune mechanisms in these infections, and a number of potential vaccine candidates have been developed...
- Protection against ascending infection of the genital tract by Chlamydia trachomatis is associated with recruitment of major histocompatibility complex class II antigen-presenting cells into uterine tissueA J Stagg
Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
Infect Immun 66:3535-44. 1998..An additional level of immunological control may thus exist in genital chlamydial infection...
- Intestinal dendritic cells increase T cell expression of alpha4beta7 integrinAndrew J Stagg
Antigen Presentation Research Group, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Harrow, GB
Eur J Immunol 32:1445-54. 2002..Therefore, in addition to their other immunoregulatory roles, DC have the potential to shape immune responses by influencing the homing of the lymphocytes they activate...
- Dendritic cells derived from bone marrow cells fail to acquire and present major histocompatibility complex antigens from other dendritic cellsPenelope A Bedford
Antigen Presentation Research Group, Imperial College London, North West London Hospitals campus, Harrow, London, UK
Immunology 124:542-52. 2008..The evidence suggests that T-cell activation may be blocked by the presence of dendritic cells that have not matured through lymphoid tissues which are unable to acquire and present antigens pre-processed by other dendritic cells...
- Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironmentElizabeth R Mann
Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Harrow, UK
Inflamm Bowel Dis 18:1275-86. 2012..In humans, we characterized normal human gut DC and tested whether gut-specific homeostatic DC could be generated from blood precursors by factors in the gut microenvironment...
- Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitisSiew C Ng
Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
Inflamm Bowel Dis 16:1286-98. 2010..The probiotic mixture, VSL#3, increases interleukin (IL)-10 and downregulates IL-12p40 production by DC in vitro. We evaluated in vivo effects of oral VSL#3 and steroids on colonic DC in patients with acute UC...
- IL-10-producing B220+CD11c- APC in mouse spleenFiona Burke
Antigen Presentation Research Group, Faculty of Medicine Imperial College London, Harrow, United Kingdom
J Immunol 173:2362-72. 2004..B220(+) APC in mouse spleen that stimulate naive T cells and preferentially produce IL-10 may be involved in activating regulatory immune responses...
- Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunityAndrew J Stagg
Antigen Presentation Research Group, Faculty of Medicine, Imperial College, Northwick Park Campus, Watford Road, Harrow HA1 3UJ, Middlesex, UK
Best Pract Res Clin Gastroenterol 18:255-70. 2004..Here, we review current knowledge on gut DCs, suggest models for interactions between DCs and the commensal microflora in health and disease, and discuss gut DCs as targets for probiotic therapies...
- Leishmania major promastigotes inhibit dendritic cell motility in vitroHeather Jebbari
Antigen Presentation Research Group, Department of Immunology, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom
Infect Immun 70:1023-6. 2002..Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis...
- Methylglyoxal modulates immune responses: relevance to diabetesClaire L Price
Antigen Presentation Research Group, Imperial College London, Northwick Park and St Marks Campus, Harrow, Middlesex, UK
J Cell Mol Med 14:1806-15. 2010..We conclude that MG is a potent suppressor of myeloid and T-cell immune function and may be a major player in diabetes-associated susceptibility to infection...
- Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac diseaseAntonio Di Sabatino
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Gastroenterology 133:1175-87. 2007..We examined mucosal DCs in celiac disease in terms of phenotype, activation/maturation state, cytokine production, and function...
- The measurement of dendritic cells in umbilical cord blood: a novel technique using small volumes of whole bloodM Ruth Mason
Department of Obstetrics and Gynaecology, Northwick Park and St Mark s NHS Trust, Imperial College, London, United Kingdom
J Soc Gynecol Investig 12:246-52. 2005..To develop a technique that would permit the identification of dendritic cells (DC) in small volumes of preterm neonatal cord blood in order to investigate neonatal immune response in relation to infection and preterm labor...
- Recombinant Escherichia coli expressing invasin targets the Peyer's patches: the basis for a bacterial formulation for oral vaccinationRebecca J Critchley-Thorne
Centre for Molecular Oncology, Institute of Cancer and CR UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
Mol Ther 14:183-91. 2006..These data demonstrate the selectivity of invasin-mediated invasion to the Peyer's patches and indicate the potential of nonpathogenic, invasive E. coli as an oral vaccine with applications in immunotherapy...
- Characteristics of intestinal dendritic cells in inflammatory bowel diseasesAilsa L Hart
Antigen Presentation Research Group, Imperial College London, England
Gastroenterology 129:50-65. 2005..We aimed to identify changes in intestinal DCs that may underlie the dysregulated immune response to enteric bacteria that occurs in patients with inflammatory bowel disease (IBD)...