A J Stagg

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
    A J Stagg
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, UK
    Gut 52:1522-9. 2003
  2. pmc A novel population of human CD56+ human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis
    S C Ng
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Clin Exp Immunol 158:205-18. 2009
  3. pmc A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease
    H O Al-Hassi
    Antigen Presentation Research Group, Department of Medicine, Imperial College London, Northwick Park and St Mark s Hospitals, Harrow, UK
    Mucosal Immunol 6:751-61. 2013
  4. doi Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease
    S C Ng
    Antigen Presentation Research Group, Imperial College London, St Mark s Hospital, London, UK
    Inflamm Bowel Dis 17:2027-37. 2011
  5. pmc Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli
    R J Rigby
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Clin Exp Immunol 139:245-56. 2005
  6. doi Mechanisms of action of probiotics: recent advances
    S C Ng
    Antigen Presentation Research Group, Imperial College London, London, UK
    Inflamm Bowel Dis 15:300-10. 2009
  7. doi Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation
    S C Ng
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Harrow, UK
    Inflamm Bowel Dis 16:1787-807. 2010
  8. ncbi Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma
    N E McCarthy
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Middlesex, UK
    Clin Exp Allergy 37:72-82. 2007
  9. pmc Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease
    E R Mann
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Level 7W, St Mark s Hospital, Watford Road, Harrow HA1 3UJ, UK
    Clin Exp Immunol 170:122-30. 2012
  10. pmc Modulation of human dendritic cell phenotype and function by probiotic bacteria
    A L Hart
    Antigen Presentation Research Group, Faculty of Medicine Imperial College London, Northwick Park Campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 53:1602-9. 2004

Collaborators

Detail Information

Publications15

  1. pmc The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
    A J Stagg
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, UK
    Gut 52:1522-9. 2003
    ..The concept that interactions between dendritic cells and commensal organisms may be responsible for maintaining intestinal immune homeostasis is also explored...
  2. pmc A novel population of human CD56+ human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis
    S C Ng
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Clin Exp Immunol 158:205-18. 2009
    ..This novel population of human colonic CD56(+) HLA-DR(+) cells may play a role in immune regulation or tissue repair. Their increase in quiescent UC may be a marker of subclinical inflammation...
  3. pmc A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease
    H O Al-Hassi
    Antigen Presentation Research Group, Department of Medicine, Imperial College London, Northwick Park and St Mark s Hospitals, Harrow, UK
    Mucosal Immunol 6:751-61. 2013
    ..In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation...
  4. doi Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease
    S C Ng
    Antigen Presentation Research Group, Imperial College London, St Mark s Hospital, London, UK
    Inflamm Bowel Dis 17:2027-37. 2011
    ..We assessed the relationship between DC function with disease activity and intestinal microbiota in patients with CD...
  5. pmc Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli
    R J Rigby
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Watford Road, Harrow, UK
    Clin Exp Immunol 139:245-56. 2005
    ..longum. Thus, colonic DC can produce both IL-12 and IL-10 following bacterial stimulation. Cell wall components from different bacteria stimulate distinct responses and may direct immune responses differentially in the gut...
  6. doi Mechanisms of action of probiotics: recent advances
    S C Ng
    Antigen Presentation Research Group, Imperial College London, London, UK
    Inflamm Bowel Dis 15:300-10. 2009
    ..These effects are discussed with an emphasis on those organisms that have been used to treat human inflammatory bowel diseases in controlled clinical trials...
  7. doi Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation
    S C Ng
    Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, Northwick Park and St Mark s Campus, Harrow, UK
    Inflamm Bowel Dis 16:1787-807. 2010
    ..Lastly, we describe how DC functions are altered in intestinal inflammation and their emerging potential as a therapeutic target in inflammatory bowel disease...
  8. ncbi Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma
    N E McCarthy
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Middlesex, UK
    Clin Exp Allergy 37:72-82. 2007
    ..Recent data suggest that CD1 antigen presentation by hRTDC may contribute to asthma pathogenesis...
  9. pmc Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease
    E R Mann
    Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark s Campus, Level 7W, St Mark s Hospital, Watford Road, Harrow HA1 3UJ, UK
    Clin Exp Immunol 170:122-30. 2012
    ..Enhanced expression of gut-homing molecules on circulating γδ T cells in IBD and skin-homing molecules in cutaneous manifestations of IBD may be of clinical relevance...
  10. pmc Modulation of human dendritic cell phenotype and function by probiotic bacteria
    A L Hart
    Antigen Presentation Research Group, Faculty of Medicine Imperial College London, Northwick Park Campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 53:1602-9. 2004
    ..Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in mediating the effects of these bacteria...
  11. ncbi Vaccines against Chlamydia: approaches and progress
    A J Stagg
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Hospital, Harrow, Middlesex, UK
    Mol Med Today 4:166-73. 1998
    ..Progress has been made in understanding protective and pathological immune mechanisms in these infections, and a number of potential vaccine candidates have been developed...
  12. ncbi Prospective evaluation of intestinal homing memory T cells in ulcerative colitis
    A L Hart
    St Mark s Hospital, Harrow, United Kingdom
    Inflamm Bowel Dis 10:496-503. 2004
    ....
  13. pmc Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls
    A L Hart
    St Mark s Hospital, Watford Road, Harrow, UK
    Clin Exp Immunol 135:137-45. 2004
    ..Furthermore, there was a selective loss of IL-10 and increase in TGF-beta in both beta7+ and beta7- memory T cell subsets which may contribute to the pathogenesis of the inflammatory process in Crohn's disease...
  14. ncbi Migration and maturation of human colonic dendritic cells
    S J Bell
    Antigen Presentation Research Group, Imperial College School of Medicine, Northwick Park Institute for Medical Research, and St. Marks Hospital, Harrow, Middlesex, United Kingdom
    J Immunol 166:4958-67. 2001
    ..This study presents the first analysis of the phenotype, maturational status, and migratory activity of human gut DC...
  15. pmc Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease
    J O Lindsay
    St Mark s Hospital, Harrow, UK
    Gut 55:348-55. 2006
    ..The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease...