Affiliation: Imperial College
- ABCA1 and atherosclerosisS Soumian
Department of Vascular Surgery, Faculty of Medicine, Imperial College, Charing Cross Hospital, London, UK
Vasc Med 10:109-19. 2005..Therapeutic manipulation of the ABCA1 transporter is feasible using PPAR and LXR agonists. PPAR agonists like glitazones and ABCA1 protein stabilization could potentially modify the clinical progression of atherosclerotic lesions...
- mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic diseaseS Soumian
Department of Vascular Surgery, Imperial College, Charing Cross Hospital, Fulham Palace Road, London W68RF, UK
J Clin Pathol 58:1255-60. 2005..PPARgamma promotes lipid efflux through the liver X receptor alpha (LXRalpha) and the ATP binding cassette transporter A1 (ABCA1). Matrix metalloproteinase 9 (MMP-9) and cyclooxygenase 2 (COX-2) are implicated in plaque instability...
- ABCA1 expression in carotid atherosclerotic plaquesC Albrecht
MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK
Stroke 35:2801-6. 2004..Whereas previous investigations focused on mutations causing impaired ABCA1 function, we assessed the role of ABCA1 in human carotid atherosclerotic disease...
- Placental ABCA1 expression is reduced in primary antiphospholipid syndrome compared to pre-eclampsia and controlsC Albrecht
MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
Placenta 28:701-8. 2007..The decrease in ABCA1 protein in APS may reflect reduced cholesterol transport to the fetus affecting the formation of cell membranes and decreasing the level of substrate available for steroidogenesis...