E Simpson

Summary

Affiliation: Imperial College School of Medicine
Country: UK

Publications

  1. ncbi The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning
    E Simpson
    Medical Research Council Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Annu Rev Immunol 15:39-61. 1997
  2. ncbi Minor H antigens: genes and peptides
    E Simpson
    MRC Clinical Sciences Centre, Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Eur J Immunogenet 28:505-13. 2001
  3. ncbi Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis
    M Millrain
    Transplantation Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Immunol 167:3756-64. 2001
  4. ncbi Minor H antigens: genes and peptides
    E Simpson
    MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Transpl Immunol 10:115-23. 2002
  5. ncbi Identification of a mouse male-specific transplantation antigen, H-Y
    D M Scott
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 376:695-8. 1995
  6. ncbi The case of the midwife scientist
    E Simpson
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Int J Dev Biol 45:513-8. 2001
  7. ncbi Acceptance of skin grafts between mice bearing different allelic forms of beta 2-microglobulin
    R A Hederer
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Transplantation 61:299-304. 1996
  8. pmc Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells
    P Chandler
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Immunology 85:531-7. 1995
  9. ncbi Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice
    M B Hogarth
    Rheumatology Section, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Immunol 161:2753-61. 1998
  10. ncbi Minor histocompatibility antigens
    E Simpson
    Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Curr Opin Immunol 9:655-61. 1997

Collaborators

Detail Information

Publications32

  1. ncbi The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning
    E Simpson
    Medical Research Council Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Annu Rev Immunol 15:39-61. 1997
    ..Each of the Hya genes in mice is ubiquitously expressed but of unknown function. Their X chromosome homologues do not undergo X inactivation...
  2. ncbi Minor H antigens: genes and peptides
    E Simpson
    MRC Clinical Sciences Centre, Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Eur J Immunogenet 28:505-13. 2001
    ....
  3. ncbi Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis
    M Millrain
    Transplantation Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Immunol 167:3756-64. 2001
    ..Immunization with female spleen or DCs coated with the full complement of defined HY peptides, including the A(b)-restricted CD4+ Th cell determinant, failed to induce tetramer-reactive cells...
  4. ncbi Minor H antigens: genes and peptides
    E Simpson
    MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Transpl Immunol 10:115-23. 2002
    ....
  5. ncbi Identification of a mouse male-specific transplantation antigen, H-Y
    D M Scott
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 376:695-8. 1995
    ..These findings provide a genetic basis for the antigenic difference between males and females that contributes towards a tissue transplant rejection response...
  6. ncbi The case of the midwife scientist
    E Simpson
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England
    Int J Dev Biol 45:513-8. 2001
    ..Knowledge of the peptide identity of HY epitopes allows monitoring of immune responses following BMT, using fluorescent tetramers, and also offers the possibility of inducing immunological tolerance...
  7. ncbi Acceptance of skin grafts between mice bearing different allelic forms of beta 2-microglobulin
    R A Hederer
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Transplantation 61:299-304. 1996
    ....
  8. pmc Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells
    P Chandler
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Immunology 85:531-7. 1995
    ....
  9. ncbi Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice
    M B Hogarth
    Rheumatology Section, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Immunol 161:2753-61. 1998
    ..This implies that, though some loci may be common to a number of mouse models of lupus, different clusters of disease genes confer disease susceptibility in different strains of mice...
  10. ncbi Minor histocompatibility antigens
    E Simpson
    Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Curr Opin Immunol 9:655-61. 1997
    ....
  11. ncbi The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen
    E H Warren
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 164:2807-14. 2000
    ..Identification of this CTL-defined H-Y epitope should facilitate analysis of its contribution to graft/host interactions following sex-mismatched organ and bone marrow transplantation...
  12. ncbi An H-YDb epitope is encoded by a novel mouse Y chromosome gene
    A Greenfield
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Nat Genet 14:474-8. 1996
    ..We identify the peptide WMHHNMDLI derived from the UTY protein as an H-Y epitope, H-YDb. Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome...
  13. ncbi Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution
    I E Ehrmann
    Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Hum Mol Genet 7:1725-37. 1998
    ..These results shed light on the evolution of X-Y homologous genes...
  14. ncbi Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus
    T R King
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 24:159-68. 1994
    ..The analysis also suggests that at least two and up to five distinct loci encode H-Y antigens...
  15. ncbi Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism
    S D Husbands
    Division of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, GB
    Eur J Immunol 22:2655-61. 1992
    ..These data reveal that extremely low levels of self-antigen expression in the thymus are sufficient to induce tolerance via non-deletional mechanisms...
  16. pmc Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome
    A McLaren
    Medical Research Council Mammalian Development Unit, University College London, United Kingdom
    Proc Natl Acad Sci U S A 85:6442-5. 1988
    ..We therefore conclude that the two linked genes Tdy and Hya, controlling testis determination and H-Y antigen expression, respectively, are located on the short arm of the mouse Y chromosome...
  17. ncbi Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells
    D Zelenika
    Therapeutic Immunology Group, Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 161:1868-74. 1998
    ..Surprisingly, the transfer of either Th1 or Th2 CD4+ T cell lines from these mice into T cell-depleted recipients was sufficient to cause a specific rejection of male skin...
  18. ncbi Minor histocompatibility antigens and stem cell transplantation
    R Laylor
    Imperial College London, UK
    Vox Sang 87:11-4. 2004
  19. ncbi Genetic analysis of a new mouse model for non-insulin-dependent diabetes
    J H Kim
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 74:273-86. 2001
    ..The overt hyperglycemia in TH mice is, therefore, likely due to a mutation in a major diabetes susceptibility locus on Chr 19, which interacts with additional genes to lead to an observable phenotype...
  20. ncbi Immune-response gene control of cytotoxic T-cell responses to H-Y
    R D Gordon
    Transplant Proc 9:885-8. 1977
  21. pmc Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen
    C Mamalaki
    Laboratory of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, U K
    Dev Immunol 3:159-74. 1993
    ..This is true even following backcrossing of the F5 TcR transgene to H-2d scid/scid mice, in which functional rearrangement of endogenous TcR alpha- and beta-chain genes is impaired...
  22. pmc In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice
    R D Gordon
    J Exp Med 142:1108-20. 1975
    ..We conclude that secondary in vitro cytotoxic responses against the H-Y antigen are mediated by cytotoxic T lymphocytes, and that the H-Y target cell antigen may be specified by the H-2 complex...
  23. ncbi Toward identification of minor histocompatibility antigens in mouse and man
    G A Fowlis
    Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Transplant Proc 24:1689-91. 1992
  24. ncbi PCR-analyzed microsatellites of the mouse genome--additional polymorphisms among ten inbred mouse strains
    G A Fowlis
    Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, UK
    Mamm Genome 3:192-6. 1992
    ..This simple approach will, therefore, continue to be useful in genome mapping studies, leading eventually to high-resolution maps of both the mouse and human genomes; this should allow for physical mapping and cloning of specific genes...
  25. ncbi Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes
    P J Dyson
    Clinical Research Centre, Harrow, Middlesex, UK
    Nature 349:531-2. 1991
    ..abstract truncated at 250 words)..
  26. ncbi Mapping H-1 with the distal break point of chromosome 7 in Cattanach's insertion
    B E Loveland
    Immunogenetics 22:503-10. 1985
  27. ncbi The H-Y antigen and sex reversal
    E Simpson
    Cell 44:813-4. 1986
  28. ncbi H-Y typing of karyotypically abnormal mice
    E Simpson
    Clinical Research Centre, England, U K
    Differentiation 23:S116-20. 1983
    ..We conclude that H-Y is not the sole Y-linked testis determining gene...
  29. ncbi Male sexual differentiation in mice lacking H-Y antigen
    A McLaren
    Nature 312:552-5. 1984
    ..11). We report here that H-Y is absent from certain mice that develop testes and are of indisputably male phenotype, hence this transplantation antigen is unlikely to be responsible for testis determination...
  30. ncbi Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4
    N R Rodrigues
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK
    Mamm Genome 5:167-70. 1994
  31. ncbi Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal
    B Capel
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nat Genet 5:301-7. 1993
    ..Each deletion involved a repeat sequence, Sx1, located at a distance from Sry. Since expression of Sry was affected these results suggest that long range position effects have disrupted Sry action...
  32. pmc Mapping a new genetic locus for X linked retinitis pigmentosa to Xq28
    A Melamud
    J Med Genet 43:e27. 2006
    ..06, 2.17, and 2.20, respectively. Haplotype analysis revealed segregation of the disease phenotype with markers at Xq28...