M C Seabra

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Rab GTPases, intracellular traffic and disease
    Miguel C Seabra
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Exhibition Road, London, UK SW7 2AZ
    Trends Mol Med 8:23-30. 2002
  2. pmc Rab27a regulates the peripheral distribution of melanosomes in melanocytes
    A N Hume
    Cell and Molecular Biology Section, Division of Biomedical Sciences, London, United Kingdom
    J Cell Biol 152:795-808. 2001
  3. pmc Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models
    Jose S Ramalho
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, Exhibition Road, London, SW7 2AZ, UK
    BMC Cell Biol 3:26. 2002
  4. ncbi request reprint Membrane association and targeting of prenylated Ras-like GTPases
    M C Seabra
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell Signal 10:167-72. 1998
  5. ncbi request reprint cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
    D A Andres
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 73:1091-9. 1993
  6. ncbi request reprint Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex
    J S Anant
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Biochemistry 37:12559-68. 1998
  7. pmc Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene
    J S Ramalho
    Cell and Molecular Biology, Division of Biomedical Sciences, Imperial College School of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, UK
    BMC Genet 2:2. 2001
  8. ncbi request reprint Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease
    J B Pereira-Leal
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, SW7 2AZ, London, UK
    FEBS Lett 498:197-200. 2001
  9. ncbi request reprint cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase
    S A Armstrong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046
    J Biol Chem 268:12221-9. 1993
  10. ncbi request reprint Cloning, mapping and characterization of the human RAB27A gene
    T Tolmachova
    Molecular Genetics, Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
    Gene 239:109-16. 1999

Collaborators

  • M S Brown
  • T C Sudhof
  • J C Hansen
  • C Huxley
  • Alistair N Hume
  • J Deisenhofer
  • Graca Raposo
  • Clare E Futter
  • Jean Bennett
  • L Desnoyers
  • Wendy Westbroek
  • F P Cremers
  • Dylan M Owen
  • Michael Harris-Love
  • Mark C Field
  • D A Andres
  • Daniel M Davis
  • L Bugeon
  • Pierre Guermonprez
  • Tanya Tolmachova
  • Christina Wasmeier
  • Jose S Ramalho
  • Duarte C Barral
  • Vanda S Lopes
  • Ka Fai Leung
  • Bassam R Ali
  • Ross Anders
  • Molly Strom
  • Carolina Jancic
  • Magnus Abrink
  • Jose B Pereira-Leal
  • Ariel Savina
  • J B Pereira-Leal
  • Abul K Tarafder
  • Ana C Figueiredo
  • Kouichi Mizuno
  • Maryse Romao
  • Sebastian Amigorena
  • Rudi Baron
  • Björn Önfelt
  • J S Ramalho
  • Ying Chen
  • Jennifer L Johnson
  • B R Ali
  • Kalwant S Authi
  • T Tolmachova
  • Mathias W Seeliger
  • Sanjay Tiwari
  • Vibha Anand
  • Banafshe Larijani
  • Matthew J Hannah
  • J S Anant
  • Rudi A Baron
  • Olaf Strauss
  • Jamel El-Benna
  • Maire Anne Gougerot-Pocidalo
  • Michael A Ferenczi
  • Anthony I Magee
  • Pham My Chan Dang
  • Mike O Karl
  • Dmitry S Ushakov
  • Steve Pascolo
  • Margaret J Dallman
  • Lynn Plowright
  • Ivan Cruz Moura
  • Felix Tonagel
  • Marco A Purbhoo
  • Richard K P Benninger
  • Shlomo Nedvetzki
  • Stefanie Sowinski
  • Paul M W French
  • Stephanie Hugues
  • Mark A A Neil
  • Dorothy C Bennett
  • Naoyuki Tanimoto
  • Pablo Vargas
  • Ana Maria Lennon-Dumenil
  • William P Bellamy
  • Beverly A Ellis
  • Sergio D Catz
  • Deborah Noack
  • Gillian M Griffiths
  • Giovanna Bossi
  • Lynn Lamoreux
  • Jane Stinchcombe
  • Edward K Novak
  • Yong Zeng
  • Joseph E Italiano
  • Richard F Godfrey
  • Albert M Maguire

Detail Information

Publications47

  1. ncbi request reprint Rab GTPases, intracellular traffic and disease
    Miguel C Seabra
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Exhibition Road, London, UK SW7 2AZ
    Trends Mol Med 8:23-30. 2002
    ..The human genome is predicted to contain 60 RAB genes, suggesting that future work could reveal further links between Rab dysfunction and disease...
  2. pmc Rab27a regulates the peripheral distribution of melanosomes in melanocytes
    A N Hume
    Cell and Molecular Biology Section, Division of Biomedical Sciences, London, United Kingdom
    J Cell Biol 152:795-808. 2001
    ..These results, together with recent data implicating myosinVa in the peripheral capture of melanosomes, suggest that Rab27a is necessary for the recruitment of myosinVa, so allowing the peripheral retention of melanosomes in melanocytes...
  3. pmc Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models
    Jose S Ramalho
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, Exhibition Road, London, SW7 2AZ, UK
    BMC Cell Biol 3:26. 2002
    ....
  4. ncbi request reprint Membrane association and targeting of prenylated Ras-like GTPases
    M C Seabra
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell Signal 10:167-72. 1998
    ..The detailed understanding of these targeting mechanisms may allow future development of specific therapeutic agents that interfere with the function of each one of these proteins...
  5. ncbi request reprint cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
    D A Andres
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 73:1091-9. 1993
    ..A genetic defect in REP underlies human choroideremia, a disease of retinal degeneration...
  6. ncbi request reprint Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex
    J S Anant
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Biochemistry 37:12559-68. 1998
    ..Our data suggest a model whereby REP behaves kinetically as an essential activator of the reaction...
  7. pmc Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene
    J S Ramalho
    Cell and Molecular Biology, Division of Biomedical Sciences, Imperial College School of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, UK
    BMC Genet 2:2. 2001
    ..Rab27a plays a key role in the function of lysosomal-like organelles such as melanosomes in melanocytes and lytic granules in cytotoxic T lymphocytes. Little is known about Rab27b...
  8. ncbi request reprint Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease
    J B Pereira-Leal
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, SW7 2AZ, London, UK
    FEBS Lett 498:197-200. 2001
    ..Here we discuss recent insights into Rab prenylation and advances towards our understanding of both diseases...
  9. ncbi request reprint cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase
    S A Armstrong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046
    J Biol Chem 268:12221-9. 1993
    ..Comparisons of the amino acid sequences suggest that the proteins encoded by the Saccharomyces cerevisiae genes MAD2 and BET2 are the yeast counterparts of the mammalian Rab GG transferase alpha and beta subunits, respectively...
  10. ncbi request reprint Cloning, mapping and characterization of the human RAB27A gene
    T Tolmachova
    Molecular Genetics, Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
    Gene 239:109-16. 1999
    ..The gene is located on chromosome 15q15-21.1, as determined by fluorescent in situ hybridization, and between markers D15S209 and AFM321ZD5 by radiation hybrid mapping...
  11. ncbi request reprint Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase
    M C Seabra
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Science 259:377-81. 1993
    ..The data imply the existence of multiple component A proteins, one of which is missing in choroideremia...
  12. ncbi request reprint Evolution of the Rab family of small GTP-binding proteins
    J B Pereira-Leal
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK
    J Mol Biol 313:889-901. 2001
    ..Rab functional groups can help the understanding of the functional evolution of the Rab family in particular and vesicular transport in general, and may be used to predict general functions for novel Rab sequences...
  13. ncbi request reprint Deficient geranylgeranylation of Ram/Rab27 in choroideremia
    M C Seabra
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Biol Chem 270:24420-7. 1995
    ..These results raise the possibility that the retinal degeneration in choroideremia results from the deficient geranylgeranylation of Ram/Rab27 or a closely related protein...
  14. ncbi request reprint Targeting of Rab GTPases to cellular membranes
    B R Ali
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Biochem Soc Trans 33:652-6. 2005
    ..Recent results indicate that Rab cellular targeting might be Rab-dependent, and this paper briefly reviews our current knowledge of this process...
  15. ncbi request reprint Expression of the VLDL receptor in endothelial cells
    K L Wyne
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75235 9046, USA
    Arterioscler Thromb Vasc Biol 16:407-15. 1996
    ..This tissue and cell pattern of expression suggests that the VLDLR plays a role in the transport of VLDL or another plasma constituent from the vascular compartment to adjacent tissues...
  16. ncbi request reprint Rab GTPases and myosin motors in organelle motility
    Miguel C Seabra
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Traffic 5:393-9. 2004
    ..Furthermore, the molecular switch property of Rabs may enable them to regulate the timing of the myosin association with the target organelle...
  17. ncbi request reprint The melanosome as a model to study organelle motility in mammals
    Duarte C Barral
    Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, UK
    Pigment Cell Res 17:111-8. 2004
    ..Unraveling regulatory mechanisms responsible for melanosome motility in pigmented cells will provide general insights into organelles dynamics within eukaryotic cells...
  18. pmc The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium
    Vanda S Lopes
    Molecular and Cellular Medicine, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Traffic 8:486-99. 2007
    ....
  19. pmc Rab27b regulates mast cell granule dynamics and secretion
    Kouichi Mizuno
    Molecular and Cellular Medicine, National Heart and Lung Institute, Imperial College London SW7 2AZ, UK
    Traffic 8:883-92. 2007
    ..These results suggest that Rab27 proteins, particularly Rab27b, play a crucial role in mast cell degranulation and that their action regulates the transition from microtubule to actin-based motility...
  20. ncbi request reprint A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport
    Molly Strom
    Department of Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom
    J Biol Chem 277:25423-30. 2002
    ..Thus, melanophilin can associate simultaneously with activated Rab27a and myosin Va via distinct regions, and serve as a linker between these proteins...
  21. ncbi request reprint Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts
    Wendy Westbroek
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, Gent, Belgium
    Pigment Cell Res 17:498-505. 2004
    ..Our data suggest that up-regulated Rab27b in melanocytes of the Griscelli patient can partially take over the function of Rab27a, which could explain the fact that this patient had an evenly pigmented skin and was able to tan...
  22. ncbi request reprint Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes
    Alistair N Hume
    Molecular and Cellular Medicine, National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK
    J Cell Sci 120:3111-22. 2007
    ..EB1 appears to be non-essential to this process in cultured melanocytes, which suggests that it plays a redundant role and/or is required for melanocyte/keratinocyte contacts and melanosome transfer...
  23. ncbi request reprint The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes
    Alistair N Hume
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Traffic 3:193-202. 2002
    ..These results suggest that Rab27a interacts with different classes of effector proteins in melanocytes and cytotoxic T lymphocytes...
  24. ncbi request reprint NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells
    Ariel Savina
    Institut Curie, INSERM U653, Immunité et Cancer, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    Cell 126:205-18. 2006
    ..Therefore, NOX2 plays a critical role in conferring DCs the ability to function as specialized phagocytes adapted to process antigens rather than kill pathogens...
  25. pmc A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes
    Alistair N Hume
    Molecular and Cellular Medicine, Division of Biomedical Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 17:4720-35. 2006
    ..Our results highlight the importance of the coiled-coil region together with R27BD and EFBD regions of Mlph in the formation of the active melanosomal Rab27a-Mlph-MyoVa complex...
  26. pmc Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes
    Christina Wasmeier
    Molecular and Cellular Medicine, Division of Biomedical Sciences, Imperial College London, London SW7 2AZ, England, UK
    J Cell Biol 175:271-81. 2006
    ..This work identifies a key role for the Rab38/Rab32 subfamily of Rab proteins in the biogenesis of melanosomes and potentially other lysosome-related organelles...
  27. ncbi request reprint Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation
    Ka Fai Leung
    Molecular and Cellular Medicine Section, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 282:1487-97. 2007
    ..Our findings also imply that those Rabs that undergo post-prenylation processing follow an indirect targeting pathway requiring initial endoplasmic reticulum membrane association prior to specific organelle targeting...
  28. pmc Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis
    Vanda S Lopes
    Molecular and Cellular Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 18:3914-27. 2007
    ..Together with the high levels of cathepsin D in immature melanosomes of the RPE, our results suggest that melanin deposition may protect the maturing melanosome from the activity of lumenal acid hydrolases...
  29. pmc Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes
    Ana C Figueiredo
    Molecular Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 283:23209-16. 2008
    ..Our results indicate promiscuity in Rab GEF action and suggest that members of related but functionally distinct Rab subfamilies can be controlled by common activators...
  30. ncbi request reprint Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria
    Björn Önfelt
    Division of Cell and Molecular Biology, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK
    J Immunol 177:8476-83. 2006
    ..Thus, membrane nanotubes between macrophages are more complex than unvarying ubiquitous membrane tethers and facilitate several means for distal interactions between immune cells...
  31. ncbi request reprint Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
    Carolina Jancic
    Institut Curie, INSERM U653, Immunité et Cancer, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    Nat Cell Biol 9:367-78. 2007
    ..The Rab27a-dependent recruitment of these "inhibitory lysosome-related organelles" to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation...
  32. pmc Rab27b regulates number and secretion of platelet dense granules
    Tanya Tolmachova
    Molecular and Cellular Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 104:5872-7. 2007
    ..The morphology and function of platelet alpha-granules were unaffected. Our data suggest that Rab27b is a key regulator of dense granule secretion in platelets and thus a candidate gene for delta-storage pool deficiency in humans...
  33. pmc Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia
    Tanya Tolmachova
    Molecular and Cellular Medicine Section, Division of Biomedical Sciences, Imperial College London, London, United Kingdom
    J Clin Invest 116:386-94. 2006
    ....
  34. ncbi request reprint Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases
    Ka Fai Leung
    Molecular and Cellular Medicine, Division of Biomedical Sciences, Imperial College London, London SW7 2AZ, UK
    J Lipid Res 47:467-75. 2006
    ..The postprenylation events, including the specific targeting of Rabs to target membranes and the requirement for single versus double geranylgeranylation by different Rabs, remain obscure and should be the subject of future studies...
  35. ncbi request reprint ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome
    Ying Chen
    Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Hum Mol Genet 14:2559-69. 2005
    ..These data both uncover a major pathogenic factor for RRS and indicate that misfolding of secretory proteins is likely to significantly contribute to human disease and morbidity...
  36. pmc Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome
    Duarte C Barral
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, United Kingdom
    J Clin Invest 110:247-57. 2002
    ..Our data suggest that Rab27b is functionally redundant with Rab27a and that the pathogenesis of GS is determined by the relative expression of Rab27a and Rab27b in specialized cell types...
  37. ncbi request reprint Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus
    Vibha Anand
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6069, USA
    Vision Res 43:919-26. 2003
    ..Adenovirus-mediated delivery of REP-1 rescued the defective cells as assessed through protein and enzymatic assays. Ultimately, it may be possible to use virus-mediated delivery of REP-1 to evaluate disease intervention in vivo...
  38. ncbi request reprint A role for Rab27b in NF-E2-dependent pathways of platelet formation
    Sanjay Tiwari
    Dana Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Blood 102:3970-9. 2003
    ..These results establish a role for Rab27 in platelet synthesis and suggest that Rab27b in particular may coordinate proplatelet formation with granule transport, possibly by recruiting specific effector pathways...
  39. ncbi request reprint Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type
    Matthew J Hannah
    MRC Laboratory of Molecular Cell Biology, Cell Biology Unit, University College London, Gower St, London WC1E 6BT, UK
    J Cell Sci 116:3939-48. 2003
    ..We conclude that a lumenal cargo protein drives the recruitment of Rab27a to the organelle membrane by a novel mechanism that is indirect, maturation-dependent and cell-type independent...
  40. ncbi request reprint Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases
    Banafshe Larijani
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, U K
    J Biol Chem 278:46798-804. 2003
    ..We suggest that the restricted phenotypes observed in these diseases result from multiple contributing factors...
  41. pmc A general role for Rab27a in secretory cells
    Tanya Tolmachova
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 15:332-44. 2004
    ..The present strategy represents one way in which the complex pattern of expression and function of proteins involved in specialized cell types may be unraveled...
  42. pmc The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells
    Clare E Futter
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Mol Biol Cell 15:2264-75. 2004
    ..Rab27a and myosin VIIa are likely to be required for association with and movement through the apical actin cytoskeleton, which is a prerequisite for entry into the apical processes...
  43. ncbi request reprint Controlling the location and activation of Rab GTPases
    Miguel C Seabra
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Curr Opin Cell Biol 16:451-7. 2004
    ..The diversity of cellular processes regulated by Rab family members is made possible, not only by the wide range of effectors they recruit, but also by the different mechanisms regulating their own targeting and activation...
  44. ncbi request reprint Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface
    Jose B Pereira-Leal
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Biochem Biophys Res Commun 301:92-7. 2003
    ..These results support the hypothesis that Rabs bind REP via conserved RabF motifs and provide a molecular explanation for the preferential recognition of the GDP-bound conformation of Rab by REP...
  45. ncbi request reprint Multiple regions contribute to membrane targeting of Rab GTPases
    Bassam R Ali
    Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    J Cell Sci 117:6401-12. 2004
    ....
  46. pmc The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase
    Jennifer L Johnson
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 391:699-710. 2005
    ..In conclusion, we present evidence that JFC1 differentially regulates the secretion of PSAP and PSA, and that Rab27a and PI3K play a central role in the exocytosis of prostate-specific markers...
  47. ncbi request reprint Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase
    Jose B Pereira-Leal
    Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
    Methods Mol Biol 189:157-65. 2002