James Scott

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
  2. ncbi request reprint Pathophysiology and biochemistry of cardiovascular disease
    James Scott
    Imperial College London, South Kensington, London SW7 2AZ, UK
    Curr Opin Genet Dev 14:271-9. 2004
  3. doi request reprint Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
  4. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
  5. doi request reprint Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
  6. pmc Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Nat Genet 41:1170-2. 2009
  7. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
  8. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009
  9. pmc Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat
    Xinzhong Li
    National Heart and Lung Institute, Medicine Department, Imperial College London, South Kensington, Exhibition Road, London SW7 2AZ, UK
    BMC Syst Biol 4:175. 2010
  10. ncbi request reprint Lipoproteins, inflammation, and atherosclerosis
    James Scott
    Arterioscler Thromb Vasc Biol 23:528. 2003

Detail Information

Publications19

  1. doi request reprint Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
  2. ncbi request reprint Pathophysiology and biochemistry of cardiovascular disease
    James Scott
    Imperial College London, South Kensington, London SW7 2AZ, UK
    Curr Opin Genet Dev 14:271-9. 2004
    ..Although in humans cardiac damage produces permanent loss of cells, because the heart cannot regenerate, developments in stem cell technology suggest that help is at hand...
  3. doi request reprint Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance...
  4. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
    ..001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D...
  5. doi request reprint Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
    ..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
  6. pmc Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Nat Genet 41:1170-2. 2009
    ..13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance...
  7. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
    ..Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function...
  8. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009
    ..Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain...
  9. pmc Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat
    Xinzhong Li
    National Heart and Lung Institute, Medicine Department, Imperial College London, South Kensington, Exhibition Road, London SW7 2AZ, UK
    BMC Syst Biol 4:175. 2010
    ....
  10. ncbi request reprint Lipoproteins, inflammation, and atherosclerosis
    James Scott
    Arterioscler Thromb Vasc Biol 23:528. 2003
  11. ncbi request reprint Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
    Bethan Jones
    Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
    Nat Genet 34:29-31. 2003
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell...
  12. ncbi request reprint Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia
    Rossitza P Naoumova
    Genomic and Molecular Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Arterioscler Thromb Vasc Biol 23:2070-7. 2003
    ..The etiology of the lipid abnormalities (increased serum cholesterol and triglyceride or either lipid alone) is unknown...
  13. ncbi request reprint The influence of pharmacogenetics on fatty liver disease in the wistar and kyoto rats: a combined transcriptomic and metabonomic study
    Julian L Griffin
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK
    J Proteome Res 6:54-61. 2007
    ..This emphasizes the need to understand how strain background interacts with a given toxic lesion or genetic modification...
  14. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    ..The specific associations with ALP levels may point to genes for bone or intestinal diseases...
  15. doi request reprint Physical aggression during admission to a child and adolescent inpatient unit: predictors and impact on clinical outcomes
    Angela J Dean
    Kids in Mind Research, Mater Child and Youth Mental Health Service, South Brisbane, QLD, Australia
    Aust N Z J Psychiatry 42:536-43. 2008
    ..The aim of the present study was to identify predictors of aggression in a child and adolescent inpatient unit and examine differences in clinical outcomes between aggressive and non-aggressive patients...
  16. pmc Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia
    Sophie Eichenbaum-Voline
    Genomic and Molecular Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Arterioscler Thromb Vasc Biol 24:167-74. 2004
    ....
  17. ncbi request reprint An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver
    Julian L Griffin
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom
    Physiol Genomics 17:140-9. 2004
    ..The results suggest that the integration of 1H-NMR and gene expression data sets represents a robust method for identifying a focused line of research in a complex system...
  18. pmc Coarse particulate matter (PM2.5-10) affects heart rate variability, blood lipids, and circulating eosinophils in adults with asthma
    Karin Yeatts
    Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7310, USA
    Environ Health Perspect 115:709-14. 2007
    ..5-10 microm (PM(2.5-10))] and fine (PM(2.5)) size range...
  19. ncbi request reprint An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22
    Adam Jarmuz
    RNA Editing Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 ONN, UK
    Genomics 79:285-96. 2002
    ..Tissue-specific expression of these genes in a variety of cell lines, along with other evidence, suggests a role for these enzymes in growth or cell cycle control...