Research Topics
| Robert D SandersSummaryAffiliation: Imperial College Country: UK Publications
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Publications
Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trialR D Sanders
Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK
Br J Anaesth 109:361-7. 2012..Here, we conducted a secondary analysis of the GALA trial to ascertain the impact of nitrous oxide on outcomes after carotid surgery under general anaesthesia (GA)...
Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operationRobert D Sanders
Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
Ann Surg 255:901-7. 2012....
Unresponsiveness ≠ unconsciousnessRobert D Sanders
Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, United Kingdom
Anesthesiology 116:946-59. 2012..These concepts emphasize the need for developing anesthetic regimens and depth of anesthesia monitors that specifically target mechanisms of consciousness, connectedness, and responsiveness...- Sedation improves early outcome in severely septic Sprague Dawley ratsHong Qiao
Department of Anesthesiology, First Hospital, Peking University, NO, 8 Xishiku St, Beijing 100034, PR China
Crit Care 13:R136. 2009..We sought to compare the effects of dexmedetomidine and midazolam, at equi-sedative doses, on inflammation and apoptosis in an animal model of severe sepsis... - Sedation & immunomodulationRobert D Sanders
Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, SW10 9NH, London, UK
Crit Care Clin 25:551-70, ix. 2009..Given the burden of sepsis and secondary infections in critical care, choice of sedation may need to be carefully considered to preserve immune responses in critically ill patients... - Hypothesis for the pathophysiology of delirium: role of baseline brain network connectivity and changes in inhibitory toneRobert D Sanders
Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
Med Hypotheses 77:140-3. 2011..The form of delirium that ensues will depend upon how and which networks breakdown (dependent on both the individual's baseline network connectivity and the degree change in inhibitory tone produced)... - Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxiaDaqing Ma
Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, London, United Kingdom
Ann Neurol 58:182-93. 2005..If applied to humans, these data suggest that low (subanesthetic) concentrations of xenon in combination with mild hypothermia may provide a safe and effective therapy for perinatal asphyxia... - Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury modelsNishanthan Rajakumaraswamy
Departments of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
Neurosci Lett 409:128-33. 2006..The long-term neurological function data corroborated these morphological data. Our study demonstrates that the combination of xenon and Dex offers neuroprotection additively in vitro and synergistically in vivo... - Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal ratsRobert D Sanders
Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
Anesthesiology 110:1077-85. 2009.... - Xenon and sevoflurane protect against brain injury in a neonatal asphyxia modelYan Luo
Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
Anesthesiology 109:782-9. 2008..Xenon and sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated the potential application of these agents independently and in combination to attenuate perinatal injury... - Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemiaTing Yang
Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
PLoS ONE 7:e37020. 2012..These data suggest that anesthetic agents with neuroprotective properties may be effective in preventing HIE and should be tested in clinical trials in the future... - Xenon preconditioning reduces brain damage from neonatal asphyxia in ratsDaqing Ma
Department of Anaesthetics, Intensive Care and Pain Medicine, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
J Cereb Blood Flow Metab 26:199-208. 2006..These studies provide evidence for xenon's preconditioning effect, which might be caused by a pCREB-regulated synthesis of proteins that promote survival against neuronal injury... - Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brainYi Shu
Anesthetics, Pain Medicine and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
Neurobiol Dis 45:743-50. 2012..Nociceptive stimulation and prolonged anesthesia produced significantly more apoptosis than prolonged anesthesia alone when administered to neonates during the synaptogenic period... - General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cordRobert D Sanders
Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westerminster Hospital, London, UK
Anesth Analg 106:1708-11. 2008..Exposure to anesthetics triggers apoptotic neurodegeneration in the neonatal rat brain; whether neuronal apoptosis also occurs in the spinal cord, a crucial target for analgesic and anesthetic drugs, is unknown... - Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at termRobert D Sanders
Departments of Anaesthetics, Medical Research Council Clinical Sciences Centre, Queen Charlotte s and Chelsea Hospital, Imperial College London, London, United Kingdom
Anesthesiology 113:233-49. 2010..Although most of these neuroprotective strategies have not yet entered clinical practice, there is a significant hope that further developments will enhance hypothermic neuroprotection... - Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathwayRobert D Sanders
Department of Anesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK
Can J Anaesth 58:149-56. 2011..To review the mechanisms of sedative-hypnotic action with respect to the risk of delirium imparted by drugs that act on γ-amino-butyric-acid type A receptors or α(2) adrenoceptors... - Xenon: elemental anaesthesia in clinical practiceRobert D Sanders
Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK
Br Med Bull 71:115-35. 2004..Furthermore, we highlight specific areas where xenon demonstrates advantages over other anaesthetics, including safety, beneficial pharmacokinetics, cardiovascular stability, analgesia and neuroprotection... - Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer ratsRobert D Sanders
Sir Ivan Magill Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Anesth Analg 100:1295-302, table of contents. 2005..05), whereas Dex 10 microg/kg had little effect. Neonatal rats showed the greatest hypnotic sensitivity to Dex (P < 0.05)... - Biologic effects of nitrous oxide: a mechanistic and toxicologic reviewRobert D Sanders
Department of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
Anesthesiology 109:707-22. 2008..Although it would seem prudent to avoid nitrous oxide in certain vulnerable populations, current evidence in support of a more widespread prescription from clinical practice is unconvincing... - Alpha2-adrenoceptor agonistsRobert D Sanders
Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Curr Opin Investig Drugs 8:25-33. 2007..The ability of these agents to provide renal, cardiac and neurocognitive protection is only just being realized and requires further study... - Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in miceJianteng Gu
Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Rd, London SW10 9NH, UK
Crit Care 15:R153. 2011..We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) provides protection against ischemia-reperfusion induced kidney injury in vitro and in vivo... - Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtypeDaqing Ma
Department of Anaesthetics, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Eur J Pharmacol 502:87-97. 2004..Our data suggest that the neuroprotective effect of dexmedetomidine is mediated by activation of the alpha2A adrenergic receptor subtype... - Anaesthesia induced neuroprotectionRobert D Sanders
Department of Anaesthetics and Intensive Care Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
Best Pract Res Clin Anaesthesiol 19:461-74. 2005..In particular the application of isoflurane and/or xenon as inhalational neuroprotectants is advocated and evidence for the neuroprotection provided by barbiturates and suppression of cerebral metabolic rate is discussed... - The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in ratsLei Zhuang
Department of Anesthesiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Crit Care Med 40:1724-30. 2012..Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and helium neuroprotection in a neonatal asphyxia model in rats... - Xenon exerts age-independent antinociception in Fischer ratsDaqing Ma
Department of Anesthetics and Intensive Care, Imperial College London, London, United Kingdom
Anesthesiology 100:1313-8. 2004 - Sedation & immunomodulationRobert D Sanders
Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, SW10 9NH, London, UK National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, SW7 2AZ, London, UK
Anesthesiol Clin 29:687-706. 2011..Given the burden of sepsis and secondary infections in critical care, choice of sedation may need to be carefully considered to preserve immune responses in critically ill patients... - A xenon recirculating ventilator for the newborn piglet: developing clinical applications of xenon for neonatesStuart D Faulkner
Institute for Women s Health, University College London, London, UK
Eur J Anaesthesiol 29:577-85. 2012..However, due to the limited natural availability of xenon, special equipment is required to administer and recapture the gas to develop xenon as a therapeutic agent... - Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxiaStuart Faulkner
Institute for Women s Health, University College London, London, UK
Ann Neurol 70:133-50. 2011....