Robert D Sanders

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery
    Mark Coburn
    Department of Anaesthesiology, University Hospital Aachen, RWTH, Aachen, Germany
    Trials 13:180. 2012
  2. doi Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice
    Robert D Sanders
    Department of Leukocyte Biology, Imperial College, London, UK
    Crit Care Med 41:1627-36. 2013
  3. ncbi Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial
    R D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK
    Br J Anaesth 109:361-7. 2012
  4. doi Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation
    Robert D Sanders
    Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Ann Surg 255:901-7. 2012
  5. pmc Unresponsiveness ≠ unconsciousness
    Robert D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, United Kingdom
    Anesthesiology 116:946-59. 2012
  6. pmc Sedation improves early outcome in severely septic Sprague Dawley rats
    Hong Qiao
    Department of Anesthesiology, First Hospital, Peking University, NO, 8 Xishiku St, Beijing 100034, PR China
    Crit Care 13:R136. 2009
  7. doi Sedation & immunomodulation
    Robert D Sanders
    Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, SW10 9NH, London, UK
    Crit Care Clin 25:551-70, ix. 2009
  8. doi Hypothesis for the pathophysiology of delirium: role of baseline brain network connectivity and changes in inhibitory tone
    Robert D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Med Hypotheses 77:140-3. 2011
  9. ncbi Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
    Daqing Ma
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, London, United Kingdom
    Ann Neurol 58:182-93. 2005
  10. ncbi Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models
    Nishanthan Rajakumaraswamy
    Departments of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 409:128-33. 2006

Collaborators

Detail Information

Publications35

  1. pmc The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery
    Mark Coburn
    Department of Anaesthesiology, University Hospital Aachen, RWTH, Aachen, Germany
    Trials 13:180. 2012
    ....
  2. doi Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice
    Robert D Sanders
    Department of Leukocyte Biology, Imperial College, London, UK
    Crit Care Med 41:1627-36. 2013
    ..Herein we sought to elucidate the impact and mechanism of benzodiazepine-induced susceptibility to infection at anxiolytic doses in mice...
  3. ncbi Nitrous oxide exposure does not seem to be associated with increased mortality, stroke, and myocardial infarction: a non-randomized subgroup analysis of the General Anaesthesia compared with Local Anaesthesia for carotid surgery (GALA) trial
    R D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK
    Br J Anaesth 109:361-7. 2012
    ..Here, we conducted a secondary analysis of the GALA trial to ascertain the impact of nitrous oxide on outcomes after carotid surgery under general anaesthesia (GA)...
  4. doi Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation
    Robert D Sanders
    Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Ann Surg 255:901-7. 2012
    ....
  5. pmc Unresponsiveness ≠ unconsciousness
    Robert D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, United Kingdom
    Anesthesiology 116:946-59. 2012
    ..These concepts emphasize the need for developing anesthetic regimens and depth of anesthesia monitors that specifically target mechanisms of consciousness, connectedness, and responsiveness...
  6. pmc Sedation improves early outcome in severely septic Sprague Dawley rats
    Hong Qiao
    Department of Anesthesiology, First Hospital, Peking University, NO, 8 Xishiku St, Beijing 100034, PR China
    Crit Care 13:R136. 2009
    ..We sought to compare the effects of dexmedetomidine and midazolam, at equi-sedative doses, on inflammation and apoptosis in an animal model of severe sepsis...
  7. doi Sedation & immunomodulation
    Robert D Sanders
    Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, SW10 9NH, London, UK
    Crit Care Clin 25:551-70, ix. 2009
    ..Given the burden of sepsis and secondary infections in critical care, choice of sedation may need to be carefully considered to preserve immune responses in critically ill patients...
  8. doi Hypothesis for the pathophysiology of delirium: role of baseline brain network connectivity and changes in inhibitory tone
    Robert D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Med Hypotheses 77:140-3. 2011
    ..The form of delirium that ensues will depend upon how and which networks breakdown (dependent on both the individual's baseline network connectivity and the degree change in inhibitory tone produced)...
  9. ncbi Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
    Daqing Ma
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, London, United Kingdom
    Ann Neurol 58:182-93. 2005
    ..If applied to humans, these data suggest that low (subanesthetic) concentrations of xenon in combination with mild hypothermia may provide a safe and effective therapy for perinatal asphyxia...
  10. ncbi Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models
    Nishanthan Rajakumaraswamy
    Departments of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 409:128-33. 2006
    ..The long-term neurological function data corroborated these morphological data. Our study demonstrates that the combination of xenon and Dex offers neuroprotection additively in vitro and synergistically in vivo...
  11. doi Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model
    Yan Luo
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Anesthesiology 109:782-9. 2008
    ..Xenon and sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated the potential application of these agents independently and in combination to attenuate perinatal injury...
  12. doi Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
    Anesthesiology 110:1077-85. 2009
    ....
  13. pmc Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia
    Ting Yang
    Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    PLoS ONE 7:e37020. 2012
    ..These data suggest that anesthetic agents with neuroprotective properties may be effective in preventing HIE and should be tested in clinical trials in the future...
  14. ncbi Xenon preconditioning reduces brain damage from neonatal asphyxia in rats
    Daqing Ma
    Department of Anaesthetics, Intensive Care and Pain Medicine, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    J Cereb Blood Flow Metab 26:199-208. 2006
    ..These studies provide evidence for xenon's preconditioning effect, which might be caused by a pCREB-regulated synthesis of proteins that promote survival against neuronal injury...
  15. doi Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain
    Yi Shu
    Anesthetics, Pain Medicine and Intensive Care, Division of Surgery, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Neurobiol Dis 45:743-50. 2012
    ..Nociceptive stimulation and prolonged anesthesia produced significantly more apoptosis than prolonged anesthesia alone when administered to neonates during the synaptogenic period...
  16. doi Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term
    Robert D Sanders
    Departments of Anaesthetics, Medical Research Council Clinical Sciences Centre, Queen Charlotte s and Chelsea Hospital, Imperial College London, London, United Kingdom
    Anesthesiology 113:233-49. 2010
    ..Although most of these neuroprotective strategies have not yet entered clinical practice, there is a significant hope that further developments will enhance hypothermic neuroprotection...
  17. doi General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westerminster Hospital, London, UK
    Anesth Analg 106:1708-11. 2008
    ..Exposure to anesthetics triggers apoptotic neurodegeneration in the neonatal rat brain; whether neuronal apoptosis also occurs in the spinal cord, a crucial target for analgesic and anesthetic drugs, is unknown...
  18. doi Preoperative stroke and outcomes after coronary artery bypass graft surgery
    Alex Bottle
    School of Public Health, Imperial College London, UK
    Anesthesiology 118:885-93. 2013
    ..The authors investigated the preoperative predictors of adverse outcomes in patients undergoing CABG, with a focus on the importance of the time interval between prior stroke and CABG...
  19. pmc Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway
    Robert D Sanders
    Department of Anesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK
    Can J Anaesth 58:149-56. 2011
    ..To review the mechanisms of sedative-hypnotic action with respect to the risk of delirium imparted by drugs that act on γ-amino-butyric-acid type A receptors or α(2) adrenoceptors...
  20. ncbi Xenon: elemental anaesthesia in clinical practice
    Robert D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK
    Br Med Bull 71:115-35. 2004
    ..Furthermore, we highlight specific areas where xenon demonstrates advantages over other anaesthetics, including safety, beneficial pharmacokinetics, cardiovascular stability, analgesia and neuroprotection...
  21. doi Biologic effects of nitrous oxide: a mechanistic and toxicologic review
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    Anesthesiology 109:707-22. 2008
    ..Although it would seem prudent to avoid nitrous oxide in certain vulnerable populations, current evidence in support of a more widespread prescription from clinical practice is unconvincing...
  22. ncbi Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats
    Robert D Sanders
    Sir Ivan Magill Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Anesth Analg 100:1295-302, table of contents. 2005
    ..05), whereas Dex 10 microg/kg had little effect. Neonatal rats showed the greatest hypnotic sensitivity to Dex (P < 0.05)...
  23. ncbi Alpha2-adrenoceptor agonists
    Robert D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Curr Opin Investig Drugs 8:25-33. 2007
    ..The ability of these agents to provide renal, cardiac and neurocognitive protection is only just being realized and requires further study...
  24. doi Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice
    Robert D Sanders
    Department of Leukocyte Biology, Imperial College London, London, UK Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, London, UK Wellcome Department of Imaging Neuroscience, University College, London, UK
    Influenza Other Respir Viruses 7:895-9. 2013
    ..Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal. ..
  25. doi A xenon recirculating ventilator for the newborn piglet: developing clinical applications of xenon for neonates
    Stuart D Faulkner
    Institute for Women s Health, University College London, London, UK
    Eur J Anaesthesiol 29:577-85. 2012
    ..However, due to the limited natural availability of xenon, special equipment is required to administer and recapture the gas to develop xenon as a therapeutic agent...
  26. pmc Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice
    Jianteng Gu
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Campus, 369 Fulham Rd, London SW10 9NH, UK
    Crit Care 15:R153. 2011
    ..We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) provides protection against ischemia-reperfusion induced kidney injury in vitro and in vivo...
  27. ncbi Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype
    Daqing Ma
    Department of Anaesthetics, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Eur J Pharmacol 502:87-97. 2004
    ..Our data suggest that the neuroprotective effect of dexmedetomidine is mediated by activation of the alpha2A adrenergic receptor subtype...
  28. ncbi Anaesthesia induced neuroprotection
    Robert D Sanders
    Department of Anaesthetics and Intensive Care Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    Best Pract Res Clin Anaesthesiol 19:461-74. 2005
    ..In particular the application of isoflurane and/or xenon as inhalational neuroprotectants is advocated and evidence for the neuroprotection provided by barbiturates and suppression of cerebral metabolic rate is discussed...
  29. doi Provider profiling models for acute coronary syndrome mortality using administrative data
    Alex Bottle
    Dr Foster Unit at Imperial, School of Public Health, Imperial College London, London, UK
    Int J Cardiol 168:338-43. 2013
    ..We assess the impact on risk model performance and hospital-level mortality rate ratios (SMRs) of three key issues: comorbidity measurement methods, inter-hospital transfers and post-discharge deaths...
  30. doi The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats
    Lei Zhuang
    Department of Anesthesiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Crit Care Med 40:1724-30. 2012
    ..Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and helium neuroprotection in a neonatal asphyxia model in rats...
  31. doi Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery
    Robert D Sanders
    Surgical Outcomes Research Centre and Department of Anaesthesia, University College London Hospital and Wellcome Departmentof Imaging Neuroscience, University College London, London, UK
    Cochrane Database Syst Rev 7:CD009971. 2013
    ..Evidence is accumulating that patients taking statins at the time of surgery are protected against a range of perioperative complications, but the specific benefits for patients undergoing noncardiac vascular surgery are not clear...
  32. doi Transient regional hypothermia applied to a traumatic limb attenuates distant lung injury following blast limb trauma
    Jiaolin Ning
    1Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, China 2Department of Nephrology, People s Liberation Army Chengdu Military Area Command General Hospital, Chengdu, Sichuan, China 3Department of Hepatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China 4State Key Laboratory of Trauma and Burns, Surgery Research Institute, Department of Traumatic Surgery, Daping Hospital, Third Military Medical University, Chongqing, China 5Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom 6Surgical Outcomes Research Centre, University College London Hospital and Wellcome Department of Imaging Neuroscience, University College London, London, United Kingdom
    Crit Care Med 42:e68-78. 2014
    ..Furthermore, the optimal duration of regional traumatic limb hypothermic treatment was also evaluated...
  33. doi Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia
    Stuart Faulkner
    Institute for Women s Health, University College London, London, UK
    Ann Neurol 70:133-50. 2011
    ....
  34. ncbi Xenon exerts age-independent antinociception in Fischer rats
    Daqing Ma
    Department of Anesthetics and Intensive Care, Imperial College London, London, United Kingdom
    Anesthesiology 100:1313-8. 2004
  35. ncbi Sedation & immunomodulation
    Robert D Sanders
    Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, SW10 9NH, London, UK National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, SW7 2AZ, London, UK
    Anesthesiol Clin 29:687-706. 2011
    ..Given the burden of sepsis and secondary infections in critical care, choice of sedation may need to be carefully considered to preserve immune responses in critically ill patients...