R D Sanders

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity
    R D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, London, UK
    Br J Anaesth 101:597-609. 2008
  2. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
  3. ncbi request reprint Anaesthesia induced neuroprotection
    Robert D Sanders
    Department of Anaesthetics and Intensive Care Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    Best Pract Res Clin Anaesthesiol 19:461-74. 2005
  4. ncbi request reprint Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat
    J L Martin
    Department of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, London, UK
    Br J Anaesth 98:236-40. 2007
  5. doi request reprint Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain
    R D Sanders
    Magill Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Acta Anaesthesiol Scand 54:710-6. 2010
  6. ncbi request reprint Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats
    R D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College, London, UK
    Br J Anaesth 95:393-9. 2005
  7. ncbi request reprint Xenon: no stranger to anaesthesia
    R D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK
    Br J Anaesth 91:709-17. 2003
  8. ncbi request reprint Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model
    M Ezzati
    Institute for Women s Health, University College London, London, UK
    Acta Anaesthesiol Scand 58:733-42. 2014
  9. pmc Impact of anaesthetics and surgery on neurodevelopment: an update
    R D Sanders
    Wellcome Department of Imaging Neuroscience, Institute for Women s Health, University College London, London, UK
    Br J Anaesth 110:i53-72. 2013
  10. ncbi request reprint Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models
    Nishanthan Rajakumaraswamy
    Departments of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 409:128-33. 2006

Collaborators

Detail Information

Publications21

  1. doi request reprint Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity
    R D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, London, UK
    Br J Anaesth 101:597-609. 2008
    ..We review the current state of preclinical research in paediatric anaesthesia and identify areas which require further exploration in order to provide the foundations for well-conducted clinical trials...
  2. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
    ....
  3. ncbi request reprint Anaesthesia induced neuroprotection
    Robert D Sanders
    Department of Anaesthetics and Intensive Care Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK
    Best Pract Res Clin Anaesthesiol 19:461-74. 2005
    ..In particular the application of isoflurane and/or xenon as inhalational neuroprotectants is advocated and evidence for the neuroprotection provided by barbiturates and suppression of cerebral metabolic rate is discussed...
  4. ncbi request reprint Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat
    J L Martin
    Department of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, London, UK
    Br J Anaesth 98:236-40. 2007
    ..This study sought to investigate whether asynchronous administration of xenon and hypothermia is capable of combining synergistically to provide neuroprotection...
  5. doi request reprint Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain
    R D Sanders
    Magill Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Acta Anaesthesiol Scand 54:710-6. 2010
    ..Recent evidence has demonstrated the anti-apoptotic of dexmedetomidine in different brain injury models. Herein, we investigated whether dexmedetomidine could directly protect against cortical injury in vitro and in vivo...
  6. ncbi request reprint Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats
    R D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College, London, UK
    Br J Anaesth 95:393-9. 2005
    ..We investigated whether a similar time dependency existed for the responses to the volatile anaesthetic isoflurane...
  7. ncbi request reprint Xenon: no stranger to anaesthesia
    R D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK
    Br J Anaesth 91:709-17. 2003
  8. ncbi request reprint Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model
    M Ezzati
    Institute for Women s Health, University College London, London, UK
    Acta Anaesthesiol Scand 58:733-42. 2014
    ..The optimal safe dose for pre-clinical newborn neuroprotection studies is unknown...
  9. pmc Impact of anaesthetics and surgery on neurodevelopment: an update
    R D Sanders
    Wellcome Department of Imaging Neuroscience, Institute for Women s Health, University College London, London, UK
    Br J Anaesth 110:i53-72. 2013
    ..This places even greater emphasis on prospective approaches to this problem, such as the ongoing GAS trial and PANDA study...
  10. ncbi request reprint Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models
    Nishanthan Rajakumaraswamy
    Departments of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 409:128-33. 2006
    ..The long-term neurological function data corroborated these morphological data. Our study demonstrates that the combination of xenon and Dex offers neuroprotection additively in vitro and synergistically in vivo...
  11. ncbi request reprint Xenon: elemental anaesthesia in clinical practice
    Robert D Sanders
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK
    Br Med Bull 71:115-35. 2004
    ..Furthermore, we highlight specific areas where xenon demonstrates advantages over other anaesthetics, including safety, beneficial pharmacokinetics, cardiovascular stability, analgesia and neuroprotection...
  12. doi request reprint Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term
    Robert D Sanders
    Departments of Anaesthetics, Medical Research Council Clinical Sciences Centre, Queen Charlotte s and Chelsea Hospital, Imperial College London, London, United Kingdom
    Anesthesiology 113:233-49. 2010
    ..Although most of these neuroprotective strategies have not yet entered clinical practice, there is a significant hope that further developments will enhance hypothermic neuroprotection...
  13. ncbi request reprint Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype
    Daqing Ma
    Department of Anaesthetics, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Eur J Pharmacol 502:87-97. 2004
    ..Our data suggest that the neuroprotective effect of dexmedetomidine is mediated by activation of the alpha2A adrenergic receptor subtype...
  14. doi request reprint Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK
    Anesthesiology 110:1077-85. 2009
    ....
  15. doi request reprint Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model
    Yan Luo
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Anesthesiology 109:782-9. 2008
    ..Xenon and sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated the potential application of these agents independently and in combination to attenuate perinatal injury...
  16. doi request reprint Biologic effects of nitrous oxide: a mechanistic and toxicologic review
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    Anesthesiology 109:707-22. 2008
    ..Although it would seem prudent to avoid nitrous oxide in certain vulnerable populations, current evidence in support of a more widespread prescription from clinical practice is unconvincing...
  17. ncbi request reprint Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
    Daqing Ma
    Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, London, United Kingdom
    Ann Neurol 58:182-93. 2005
    ..If applied to humans, these data suggest that low (subanesthetic) concentrations of xenon in combination with mild hypothermia may provide a safe and effective therapy for perinatal asphyxia...
  18. doi request reprint General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord
    Robert D Sanders
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westerminster Hospital, London, UK
    Anesth Analg 106:1708-11. 2008
    ..Exposure to anesthetics triggers apoptotic neurodegeneration in the neonatal rat brain; whether neuronal apoptosis also occurs in the spinal cord, a crucial target for analgesic and anesthetic drugs, is unknown...
  19. ncbi request reprint Alpha2-adrenoceptor agonists
    Robert D Sanders
    Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Curr Opin Investig Drugs 8:25-33. 2007
    ..The ability of these agents to provide renal, cardiac and neurocognitive protection is only just being realized and requires further study...
  20. ncbi request reprint Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon
    Benedikt Preckel
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Anesthesiology 105:187-97. 2006
    ....
  21. ncbi request reprint Translational research: addressing problems facing the anesthesiologist
    Robert D Sanders
    Anesth Analg 105:899-901. 2007