Affiliation: Imperial College
- Evolution of vertebrate immunity: sequence and functional analysis of the SEFIR domain family member Act1Grigory Ryzhakov
Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology and Medicine, Hammersmith, London, UK
J Mol Evol 72:521-30. 2011..We propose a model of evolutionary changes in Act1-mediated signalling, which contributes to a better understanding of evolution of the vertebrate immunity...
- IRF5 is required for late-phase TNF secretion by human dendritic cellsThomas Krausgruber
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
Blood 115:4421-30. 2010..This study provides new insights into diverse molecular mechanisms employed by IRF5 to regulate gene expression and implicates RelA-IRF5 interactions as a putative target for cell-specific modulation of TNF expression...