Douglas S Robinson

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint CD34(+)/interleukin-5Ralpha messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors
    D S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Cell Mol Biol 20:9-13. 1999
  2. ncbi request reprint T-cell cytokines: what we have learned from human studies
    Douglas S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Paediatr Respir Rev 5:S53-8. 2004
  3. ncbi request reprint Asthma: T-bet--a master controller?
    Douglas S Robinson
    Department of Allergy, National Heart and Lung Institute, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Curr Biol 12:R322-4. 2002
  4. ncbi request reprint Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial
    D S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, London SW3 6LY, UK
    Lancet 357:2007-11. 2001
  5. ncbi request reprint Eosinophil development and bone marrow and tissue eosinophils in atopic asthma
    D S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Int Arch Allergy Immunol 118:98-100. 1999
  6. doi request reprint Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 124:454-62. 2009
  7. pmc CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 122:617-24.e6. 2008
  8. ncbi request reprint Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London
    J Allergy Clin Immunol 111:714-9. 2003
  9. pmc Tregs and allergic disease
    Douglas S Robinson
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Clin Invest 114:1389-97. 2004
  10. doi request reprint Basal expression of bone morphogenetic protein receptor is reduced in mild asthma
    Harsha H Kariyawasam
    Emeritus Professor of Allergy and Clinical Immunology, Sir Alexander Fleming Building, Leukocyte Biology Section, Imperial College, South Kensington Campus, London, SW7 2AZ UK
    Am J Respir Crit Care Med 177:1074-81. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint CD34(+)/interleukin-5Ralpha messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors
    D S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Cell Mol Biol 20:9-13. 1999
    ..Airway numbers of CD34(+)/IL-5Ralpha mRNA+ cells were correlated to airway caliber in asthmatic subjects and to eosinophil numbers. These findings support the concept that eosinophils may differentiate locally in the airway in asthma...
  2. ncbi request reprint T-cell cytokines: what we have learned from human studies
    Douglas S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Paediatr Respir Rev 5:S53-8. 2004
  3. ncbi request reprint Asthma: T-bet--a master controller?
    Douglas S Robinson
    Department of Allergy, National Heart and Lung Institute, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London SW7 2AZ, UK
    Curr Biol 12:R322-4. 2002
    ..The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma...
  4. ncbi request reprint Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial
    D S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, London SW3 6LY, UK
    Lancet 357:2007-11. 2001
    ..We aimed to assess whether montelukast, a leukotriene receptor antagonist, can improve symptoms or lung function in patients with chronic asthma with symptoms already taking corticosteroids...
  5. ncbi request reprint Eosinophil development and bone marrow and tissue eosinophils in atopic asthma
    D S Robinson
    Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Int Arch Allergy Immunol 118:98-100. 1999
    ..Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma...
  6. doi request reprint Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 124:454-62. 2009
    ..Both transforming growth factor (TGF)-beta(1) and activin-A have been implicated in airway remodeling in asthma, but the modulation of their specific signaling pathways after disease activation remains undefined...
  7. pmc CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 122:617-24.e6. 2008
    ..We have previously demonstrated that prophylactic administration of CD4(+)CD25(+) regulatory T cells suppresses the development of acute allergen-induced airway inflammation in vivo...
  8. ncbi request reprint Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London
    J Allergy Clin Immunol 111:714-9. 2003
    ..We have previously reported that anti-IL-5 monoclonal antibody treatment decreases total bone marrow and bronchial mucosal eosinophil numbers in asthma...
  9. pmc Tregs and allergic disease
    Douglas S Robinson
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Clin Invest 114:1389-97. 2004
    ..Improvements in allergen immunotherapy, such as peptide therapy, and greater understanding of the biology of Tregs hold great promise for the treatment and prevention of allergic disease...
  10. doi request reprint Basal expression of bone morphogenetic protein receptor is reduced in mild asthma
    Harsha H Kariyawasam
    Emeritus Professor of Allergy and Clinical Immunology, Sir Alexander Fleming Building, Leukocyte Biology Section, Imperial College, South Kensington Campus, London, SW7 2AZ UK
    Am J Respir Crit Care Med 177:1074-81. 2008
    ..Despite increasing recognition of bone morphogenetic protein (BMP) signaling in tissue remodeling, the expression pattern of ligands and signaling pathways remain undefined in the asthmatic airway...
  11. pmc Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent
    Jennifer Kearley
    Leukocyte Biology Section, Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, SW7 2AZ London, England, UK
    J Exp Med 202:1539-47. 2005
    ..These data suggest that CD4+CD25+ T cells can suppress the Th2 cell-driven response to allergen in vivo by an IL-10-dependent mechanism but that IL-10 production by the regulatory T cells themselves is not required for such suppression...
  12. ncbi request reprint Acute allergen-induced airway remodeling in atopic asthma
    Simon Phipps
    Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Cell Mol Biol 31:626-32. 2004
    ..Airway remodeling in asthma may, in part, result from repeated acute activation of the EMTU by allergen exposure...
  13. ncbi request reprint Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    Eleanor M Ling
    Department of Allergy, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Lancet 363:608-15. 2004
    ..We aimed to investigate whether the amount of inhibition of allergic responses by CD4+CD25+ T cells was related to atopy and allergic disease...
  14. pmc Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients
    Emmanuel Xystrakis
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma at King s College London, Strand, London, United Kingdom
    J Clin Invest 116:146-55. 2006
    ..This strongly suggests that vitamin D3 could potentially increase the therapeutic response to glucocorticoids in SR patients...
  15. ncbi request reprint Regulatory T cells as a target for induction of immune tolerance in allergy
    David J Ahern
    National Heart and Lung Institute, Imperial College London, London, UK
    Curr Opin Allergy Clin Immunol 5:531-6. 2005
    ..This concept of an alteration in the balance between the suppression and activation of harmful T helper type 2 immunity in allergy has important potential implications for strategies to prevent and control disease...
  16. ncbi request reprint A role for eosinophils in airway remodelling in asthma
    A Barry Kay
    Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London, UK
    Trends Immunol 25:477-82. 2004
    ..However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established...
  17. ncbi request reprint Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    Patrick T Flood-Page
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 167:199-204. 2003
    ..Anti-IL-5 treatment reduces but does not deplete airway or bone marrow eosinophils. The role of the eosinophil remains uncertain. Further clinical studies in asthma with more effective antieosinophil strategies are required...
  18. ncbi request reprint The role of regulatory T lymphocytes in asthma pathogenesis
    Douglas S Robinson
    Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, England
    Curr Allergy Asthma Rep 5:136-41. 2005
    ..If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma...
  19. ncbi request reprint The role of eosinophils in airway tissue remodelling in asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology Section, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Curr Opin Immunol 19:681-6. 2007
    ..The current studies that support a role for eosinophils in airway remodelling are reviewed in article...
  20. ncbi request reprint Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma
    Harsha H Kariyawasam
    Allergy and Clinical Immunology, Leukocyte Biology Section, Sir Alexander Fleming Building, Imperial College London, London, UK
    Am J Respir Crit Care Med 175:896-904. 2007
    ..Cellular inflammation and airway remodeling are increased 24 hours after allergen challenge...
  21. ncbi request reprint Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism
    X Dao Nguyen
    Leukocyte Biology Section, Division of Biomedical Sciences and Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 114:296-301. 2004
    ..We previously reported that CD4+CD25+ T cells from atopic donors suppressed allergen-stimulated T cells less than those from nonatopic donors...
  22. ncbi request reprint Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor alpha expr
    Bernard Gregory
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 170:5359-66. 2003
    ....
  23. doi request reprint The role of the T cell in asthma
    Douglas S Robinson
    Leukocyte Biology Section, NHLI, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 126:1081-91; quiz 1092-3. 2010
    ..Strategies directed specifically at the T cells are currently being evaluated, including novel forms of allergen immunotherapy. T cells remain an exciting potential target for new treatments in patients with asthma...
  24. ncbi request reprint Adenoid-derived TH2 cells reactive to allergen and recall antigen express CC chemokine receptor 4
    Miles E Banwell
    Leukocyte Biology Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 112:1155-61. 2003
    ..However, whether selective recruitment of allergen-specific T(H)2 cells to the airways occurs through CCR4 or other chemokine receptors remains controversial...
  25. ncbi request reprint The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle?
    Douglas S Robinson
    Allergy and Clinical Immunology, National Heart and Lung Institute Division, and Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, United Kingdom
    J Allergy Clin Immunol 114:58-65. 2004
    ..The recent data on interactions of mast cells and ASM suggest that this could be an important contributor to airway hyperresponsiveness in asthma. Why this occurs in asthma and how it is sustained remain to be established...
  26. ncbi request reprint Eosinophils, eosinophilic cytokines (interleukin-5), and antieosinophilic therapy in asthma
    Andrew Menzies-Gow
    Department of Allergy and Clinical Immunology, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Curr Opin Pulm Med 8:33-8. 2002
    ..After publication of these studies, some commentators questioned the role of eosinophils in allergic inflammation. Current evidence for and against eosinophils as effector cells in asthma is reviewed...
  27. ncbi request reprint The role of T lymphocytes in the pathogenesis of asthma
    Mark Larché
    Department of Allergy and Clinical Immunology, Faculty of Medicine, Imperial College London, National Heart and Lung Institute, London, United Kingdom
    J Allergy Clin Immunol 111:450-63; quiz 464. 2003
    ....
  28. ncbi request reprint The eosinophil: the cell and its weapons, the cytokines, its locations
    Harsha H Kariyawasam
    Allergy and Clinical Immunology, National Heart and Lung Institute, London, United Kingdom
    Semin Respir Crit Care Med 27:117-27. 2006
    ..This is essential to prevent injury to tissue during migration. Therapy is still limited for eosinophil-driven diseases, but intervention at the key events that govern eosinophil recruitment and effector function may be the way forward...
  29. ncbi request reprint New therapies for asthma: where next?
    Douglas S Robinson
    Department of Allergy, National Heart and Lung Institute and Basic Medical Sciences Division, Faculty of Medicine, Imperial College London, London, UK
    Pediatr Pulmonol 36:369-75. 2003
  30. ncbi request reprint Eosinophils
    Douglas S Robinson
    Imperial College School of Medicine, National Heart and Lung Institute, London, England
    Clin Allergy Immunol 16:43-75. 2002
  31. pmc Regulatory T cells in human disease and their potential for therapeutic manipulation
    Leonie S Taams
    Division of Infection, Immunity and Inflammatory Diseases, Guy s Hospital, King s College London, London, UK
    Immunology 118:1-9. 2006
    ..The purpose of this review was to summarize current knowledge on regulatory T-cell function in human disease, and to assess critically how this can be tailored to suit the therapeutic manipulation of immunity...
  32. ncbi request reprint Cost advantages of combination asthma therapy
    Debbie A Campbell
    Royal Brompton and Harefield NHS Trust, London, UK
    Treat Respir Med 3:133-7. 2004
    ..Overall, these devices have been priced at less than the two drugs given separately, but prospective studies evaluating costs in clinical settings are required...
  33. doi request reprint Mepolizumab treatment for asthma
    Douglas S Robinson
    Imperial College London, Leukocyte Biology, Sir Alexander Fleming Building, London, SW7 2AZ, UK
    Expert Opin Biol Ther 13:295-302. 2013
    ..Mepolizumab is a humanized monoclonal antibody that blocks binding of the key cytokine implicated specifically in eosinophil maturation and survival, interleukin-5, to its receptor...
  34. ncbi request reprint Further checkpoints in Th1 development
    Douglas S Robinson
    Allergy and Clinical Immunology and Leukocyte Biology, Faculty of Medicine, Imperial College, SW7 2AK, London, United Kingdom
    Immunity 16:755-8. 2002
    ..In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function...
  35. pmc Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation
    Roma Sehmi
    Firestone Institute of Respiratory Health, Asthma Research Group, St Joseph s Healthcare, Divisions of Clinical Immunology, McMaster University, Hamilton, Ontario, Canada
    Immunology 109:536-46. 2003
    ....
  36. ncbi request reprint Severe asthma treatment: need for characterising patients
    Liam G Heaney
    Regional Respiratory Centre, Belfast City Hospital, Belfast, UK
    Lancet 365:974-6. 2005
    ..However, difficult-to-control asthma is complex and multifactorial, and is often not due to severe or therapy-resistant asthma...