Research Topics
| Basant K PuriSummaryAffiliation: Imperial College Country: UK Publications
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Detail Information
Publications
A human in vivo study of the extent to which 31-phosphorus neurospectroscopy phosphomonoesters index cerebral cell membrane phospholipid anabolismB K Puri
MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
Prostaglandins Leukot Essent Fatty Acids 81:307-8. 2009..404, P<0.005). These results are consistent with the hypothesis that the phosphomonoester narrow resonance does indeed index cell membrane phospholipid anabolism in brain studies...
Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI studyB K Puri
Department of Imaging, Hammersmith Hospital, London, UK
Br J Radiol 85:e270-3. 2012..The aim of this study was to investigate this by conducting the largest voxel-based morphometry study to date in CFS...- Indexation of cerebral cell membrane phospholipid catabolism by the non-invasively determined cerebral 31-phosphorus neurospectroscopic phosphodiester peakB K Puri
Department of Surgery and Cancer, Imperial College London, London, UK
Med Hypotheses 78:312-4. 2012..509, P<0.0001). This result is consistent with the hypothesis that the phosphodiester narrow resonance does index cell membrane phospholipid catabolism in non-invasive human neuropsychiatric studies... - An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome)B K Puri
MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
Prostaglandins Leukot Essent Fatty Acids 81:303-5. 2009..At the present time, based on the results of this study, there is no evidence to support the suggestion that, by taking glutathione supplements, an improvement in the brain-related symptomatology of myalgic encephalomyelitis may occur... - Progressive structural brain changes in schizophreniaBasant K Puri
Imperial College London, MRI Unit, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK
Expert Rev Neurother 10:33-42. 2010..The rate of decline in the sizes of the putamen and corpus callosum is greater in patients with a poor outcome compared to those with a good-outcome. In addition to describing these phenomena, their potential causes are discussed... 
Reduction in left supplementary motor area grey matter in adult female fibromyalgia sufferers with marked fatigue and without affective disorder: a pilot controlled 3-T magnetic resonance imaging voxel-based morphometry studyB K Puri
Imaging Department, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
J Int Med Res 38:1468-72. 2010..This brain region plays an important role in cognitive or executive control and in the translation of painful cognition; these functions are impaired in fibromyalgia associated with marked fatigue...- Increased tenderness in the left third intercostal space in adult patients with myalgic encephalomyelitis: a controlled studyB K Puri
Imaging Department, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
J Int Med Res 39:212-4. 2011..This finding may be related to changes in lymphatic function and to the descending course of the thoracic duct. Further studies, preferably blinded and combined with appropriate imaging, are required... - Brain tissue changes and antipsychotic medicationBasant K Puri
Department of Imaging, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK and Imperial College London, London, UK
Expert Rev Neurother 11:943-6. 2011..The study and its implications are discussed in the context of the current state of knowledge regarding the pathophysiology of schizophrenia... - Evidence from in vivo 31-phosphorus magnetic resonance spectroscopy phosphodiesters that exhaled ethane is a biomarker of cerebral n-3 polyunsaturated fatty acid peroxidation in humansBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
BMC Psychiatry 8:S2. 2008..Schizophrenia patients were chosen because of evidence of increased free radical-mediated damage and cerebral lipid peroxidation in this disorder... - A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidationBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
BMC Psychiatry 8:S4. 2008..The aim was to carry out the first study of the relationship of smoking in humans to the level of n-3 lipid peroxidation indexed by the level of ethane in exhaled breath... - Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexiaBasant K Puri
MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
Int Rev Psychiatry 18:145-7. 2006..The application of these techniques to the investigation of membrane phospholipid metabolism in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis or M.E.) and dyslexia is described... - Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brain structure of patients who have seriously and violently offended with that of patients who have notBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
BMC Psychiatry 8:S6. 2008..The aim was to carry out the first voxel-based morphometry study of grey matter changes in the whole brain in schizophrenia associated with a history of seriously and violently offending... - High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in Basant K Puri
MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
Int Rev Psychiatry 18:149-54. 2006.... - Brain cell membrane motion-restricted phospholipids in patients with schizophrenia who have seriously and dangerously violently offendedBasant K Puri
MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, England, W12 0HS, UK
Prog Neuropsychopharmacol Biol Psychiatry 32:751-4. 2008..These results suggest that patients with schizophrenia who have predominantly positive symptoms may not show neuroimaging-based signs compatible with the membrane phospholipid hypothesis of schizophrenia... - Changes in brain size with treatment in patients with hyper- or hypothyroidismAngela Oatridge
Robert Steiner Magnetic Resonance Unit, Imaging Sciences Department, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, London W12 0HS, England, UK
AJNR Am J Neuroradiol 23:1539-44. 2002..The mechanism of these changes is uncertain, but it may involve osmolyte regulation, the sodium and water balance, and alterations in cerebral hemodynamics... - MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatmentBasant K Puri
Magnetic Resonance Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London UK
Neuroreport 13:123-6. 2002..We conclude that treatment with ethyl-EPA is associated with beneficial motor and MRI changes... - Increased levels of ethane, a non-invasive, quantitative, direct marker of n-3 lipid peroxidation, in the breath of patients with schizophreniaBasant K Puri
MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, England, W12 0HS, UK
Prog Neuropsychopharmacol Biol Psychiatry 32:858-62. 2008..These results suggest that the measurement of exhaled ethane levels may offer a non-invasive direct biomarker of increased n-3 lipid peroxidation in schizophrenia... - What insights can we gain from studying early-onset schizophrenia? The neurodevelopmental pathway and beyondNora S Vyas
Department of Imaging, Imperial College Healthcare Trust, London, W12 OHS, UK
Expert Rev Neurother 10:1243-7. 2010 - Hypothermia and amiloride preserve energetics in a neonatal brain slice modelNicola J Robertson
Department of Paediatrics, Division of Paediatrics, Obstetrics and Gynaecology, Division of Clinical Sciences, Hammersmith Hospital, Imperial College London, London W12 ONN, UK
Pediatr Res 58:288-96. 2005..81 +/- 0.05; these parameters were not significantly different at 5 h. Our interpretation of these findings is that the brain slice model underwent secondary energy failure, which was delayed with hypothermia or amiloride... - In vitro 1H-magnetic resonance spectroscopy of Barrett's esophageal mucosa using magic angle spinning techniquesUmakant Dave
Division of Medicine A, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
Eur J Gastroenterol Hepatol 16:1199-205. 2004..Although MAS does affect the histological architecture in Barrett's epithelium, compared with squamous epithelium, direct histological assessment was possible in the majority of samples... - Magnetic resonance imaging of the liver with ultrashort TE (UTE) pulse sequencesKaryn E Chappell
Imaging Sciences Department, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, England
J Magn Reson Imaging 18:709-13. 2003..T(2)* was specifically correlated with the presence of hemochromatosis, cirrhosis, and functional grade. Imaging of short T(2) relaxation components may provide useful information in disease... - Normal phospholipid-related signal transduction in autismBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
Prog Neuropsychopharmacol Biol Psychiatry 26:1405-7. 2002..Furthermore, since the VNR is reduced in a related disorder, schizophrenia, these results suggest fatty acid abnormalities in autism are likely to differ from those in schizophrenia... - A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophreniaBasant K Puri
MRI Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College School of Medicine, London, England, UK
Prog Neuropsychopharmacol Biol Psychiatry 26:49-52. 2002.... - The human mirror system: a motor resonance theory of mind-readingZarinah K Agnew
MRC Clinical Sciences Center, Imperial College London, UK
Brain Res Rev 54:286-93. 2007..Preliminary evidence indicates that mirror neurons may be involved in theory of mind; however, these data by their very nature are reliant on the presence, and precise characterization, of the human mirror system... - The clinical advantages of cold-pressed non-raffinated evening primrose oil over refined preparationsBasant K Puri
Department of Imaging Sciences, MRI Unit, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK
Med Hypotheses 62:116-8. 2004.... - Change in brain size during and after pregnancy: study in healthy women and women with preeclampsiaAngela Oatridge
Robert Steiner Magnetic Resonance Unit, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England
AJNR Am J Neuroradiol 23:19-26. 2002..The changes follow a consistent time course in each woman. The mechanism and physiologic importance of these findings are speculative at the present time... - Positron emission tomography in schizophrenia: a new perspectiveNeva H Patel
Radiological Sciences Unit, Imperial College Healthcare NHS Trust, London, United Kingdom
J Nucl Med 51:511-20. 2010..PET is increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia...