Janet T Powell

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Should the Frequency of Surveillance for Small Abdominal Aortic Aneurysms be Reduced?
    J T Powell
    Vascular Surgery Research Group, Imperial College at Charing Cross, St Dunstan s Road, London W6 8RP, UK Electronic address
    Eur J Vasc Endovasc Surg 46:171-2. 2013
  2. doi request reprint Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms
    J T Powell
    Vascular Surgery Research Group, Imperial College London, Charing Cross Campus, London, UK
    Br J Surg 98:609-18. 2011
  3. ncbi request reprint Final 12-year follow-up of surgery versus surveillance in the UK Small Aneurysm Trial
    J T Powell
    Vascular Surgery Research Group, Imperial College, Charing Cross Hospital, London, UK
    Br J Surg 94:702-8. 2007
  4. ncbi request reprint Genes predisposing to rapid aneurysm growth
    J T Powell
    Imperial College, Charing Cross Campus, St Dunstan s Rd, London W6 8RP, UK
    Ann N Y Acad Sci 1085:236-41. 2006
  5. ncbi request reprint Intermittent claudication: a plea for guidelines for medical management
    J T Powell
    Imperial College at Charing Cross Campus, Vascular Surgery Research Group, St Dunstan s Road, London W6 8RP, UK
    Eur J Vasc Endovasc Surg 33:451-2. 2007
  6. ncbi request reprint The rupture rate of large abdominal aortic aneurysms: is this modified by anatomical suitability for endovascular repair?
    Janet T Powell
    Department of Vascular Surgery, Imperial College at Charing Cross, London, United Kingdom
    Ann Surg 247:173-9. 2008
  7. ncbi request reprint Non-operative or medical management of abdominal aortic aneurysm
    J T Powell
    Vascular Surgery Research Group, Imperial College at Charing Cross, London, UK
    Scand J Surg 97:121-4. 2008
  8. doi request reprint Rupture rates of small abdominal aortic aneurysms: a systematic review of the literature
    J T Powell
    Vascular Surgery Research Group, Imperial College London, Charing Cross Campus, St Dunstan s Road, London W6 8RP, UK
    Eur J Vasc Endovasc Surg 41:2-10. 2011
  9. doi request reprint Fit patients with small abdominal aortic aneurysms (AAAs) do not benefit from early intervention
    Louise C Brown
    Department of Vascular Surgery Research Group, Imperial College, London, United Kingdom
    J Vasc Surg 48:1375-81. 2008
  10. doi request reprint Rate and predictability of graft rupture after endovascular and open abdominal aortic aneurysm repair: data from the EVAR Trials
    Thomas R Wyss
    Vascular Surgery Research Group, Imperial College, London, United Kingdom
    Ann Surg 252:805-12. 2010

Detail Information

Publications53

  1. doi request reprint Should the Frequency of Surveillance for Small Abdominal Aortic Aneurysms be Reduced?
    J T Powell
    Vascular Surgery Research Group, Imperial College at Charing Cross, St Dunstan s Road, London W6 8RP, UK Electronic address
    Eur J Vasc Endovasc Surg 46:171-2. 2013
    ..In many screening programmes the number of surveillance visits for men could be reduced by up to half. The higher rate of aneurysm rupture in women leads to different recommendation for women. ..
  2. doi request reprint Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms
    J T Powell
    Vascular Surgery Research Group, Imperial College London, Charing Cross Campus, London, UK
    Br J Surg 98:609-18. 2011
    ..The aim of this study was to synthesize systematically the published data on growth rates for small aneurysms to investigate the evidence basis for surveillance intervals...
  3. ncbi request reprint Final 12-year follow-up of surgery versus surveillance in the UK Small Aneurysm Trial
    J T Powell
    Vascular Surgery Research Group, Imperial College, Charing Cross Hospital, London, UK
    Br J Surg 94:702-8. 2007
    ..The aim was to determine whether early open surgical repair would benefit patients with small abdominal aortic aneurysm compared with surveillance on long-term follow-up...
  4. ncbi request reprint Genes predisposing to rapid aneurysm growth
    J T Powell
    Imperial College, Charing Cross Campus, St Dunstan s Rd, London W6 8RP, UK
    Ann N Y Acad Sci 1085:236-41. 2006
    ..There was no evidence that any specific MMP polymorphism had a clinically significant effect on aneurysm growth. However the plasminogen system (via PAI-1) appears to have a small, but clinically significant, role in aneurysm growth...
  5. ncbi request reprint Intermittent claudication: a plea for guidelines for medical management
    J T Powell
    Imperial College at Charing Cross Campus, Vascular Surgery Research Group, St Dunstan s Road, London W6 8RP, UK
    Eur J Vasc Endovasc Surg 33:451-2. 2007
  6. ncbi request reprint The rupture rate of large abdominal aortic aneurysms: is this modified by anatomical suitability for endovascular repair?
    Janet T Powell
    Department of Vascular Surgery, Imperial College at Charing Cross, London, United Kingdom
    Ann Surg 247:173-9. 2008
    ..There are no precise estimates of the rate of rupture of large abdominal aortic aneurysms (AAA). There is recent suspicion that anatomic suitability for endovascular repair may be associated with a decreased risk of AAA rupture...
  7. ncbi request reprint Non-operative or medical management of abdominal aortic aneurysm
    J T Powell
    Vascular Surgery Research Group, Imperial College at Charing Cross, London, UK
    Scand J Surg 97:121-4. 2008
    ..Medical management also is required to reduce peri-operative risks, stabilise endovascular aneurysm repair and minimise the risk of rupture in those with large AAA unfit for aneurysm repair...
  8. doi request reprint Rupture rates of small abdominal aortic aneurysms: a systematic review of the literature
    J T Powell
    Vascular Surgery Research Group, Imperial College London, Charing Cross Campus, St Dunstan s Road, London W6 8RP, UK
    Eur J Vasc Endovasc Surg 41:2-10. 2011
    ..The risk of small aneurysm rupture is considered to be low. The purpose of this review is to summarise the reported estimates of small aneurysm rupture rates...
  9. doi request reprint Fit patients with small abdominal aortic aneurysms (AAAs) do not benefit from early intervention
    Louise C Brown
    Department of Vascular Surgery Research Group, Imperial College, London, United Kingdom
    J Vasc Surg 48:1375-81. 2008
    ..Here we investigate whether the fittest patients from the UKSAT might have benefited from early intervention...
  10. doi request reprint Rate and predictability of graft rupture after endovascular and open abdominal aortic aneurysm repair: data from the EVAR Trials
    Thomas R Wyss
    Vascular Surgery Research Group, Imperial College, London, United Kingdom
    Ann Surg 252:805-12. 2010
    ..To assess the rate and factors associated with rupture after endovascular aneurysm repair (EVAR) or open repair (OR) of abdominal aortic aneurysm...
  11. ncbi request reprint Secondary interventions and mortality following endovascular aortic aneurysm repair: device-specific results from the UK EVAR trials
    L C Brown
    Vascular Surgery Research Group, Imperial College London, Charing Cross Hospital, London, UK
    Eur J Vasc Endovasc Surg 34:281-90. 2007
    ....
  12. doi request reprint Endovascular repair of ruptured abdominal aortic aneurysm: A strategy in need of definitive evidence
    Robert J Hinchliffe
    St George s Vascular Institute, London, United Kingdom
    J Vasc Surg 49:1077-80. 2009
    ..Endovascular strategies have been increasingly used to manage patients with ruptured abdominal aortic aneurysm (AAA) in an attempt to improve patient survival. We analyzed the evidence to support such an approach...
  13. doi request reprint Renal function and abdominal aortic aneurysm (AAA): the impact of different management strategies on long-term renal function in the UK EndoVascular Aneurysm Repair (EVAR) Trials
    Louise C Brown
    Vascular Surgery Research Group, Charing Cross Hospital, Imperial College, London, United Kingdom
    Ann Surg 251:966-75. 2010
    ..To investigate the impact of different management policies on renal function in patients with abdominal aortic aneurysm...
  14. ncbi request reprint Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms
    K G Jones
    Department of Vascular Surgery, Imperial College at Charing Cross Hospital, Rayne Institute, London, UK
    Circulation 103:2260-5. 2001
    ..In explant culture, aneurysm biopsies secrete large amounts of interleukin-6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased...
  15. ncbi request reprint The UK Endovascular Aneurysm Repair (EVAR) trials: design, methodology and progress
    L C Brown
    Imperial College of Science, Technology and Medicine, London, UK
    Eur J Vasc Endovasc Surg 27:372-81. 2004
    ..When recruitment closes in December 2003 patients will need to be followed for at least 1 year from their operation. Publication of full results for both trials is expected in mid 2005...
  16. ncbi request reprint Color duplex ultrasonography is insensitive for the detection of endoleak after aortic endografting: a systematic review
    Roy Ashoke
    Department of Vascular Surgery, Imperial College, London, UK
    J Endovasc Ther 12:297-305. 2005
    ....
  17. doi request reprint Use of baseline factors to predict complications and reinterventions after endovascular repair of abdominal aortic aneurysm
    L C Brown
    Vascular Surgery Research Group, Imperial College, Charing Cross Hospital, London, UK
    Br J Surg 97:1207-17. 2010
    ..It is uncertain which baseline factors are associated with graft-related complications and reinterventions after endovascular aneurysm repair (EVAR) in patients with a large abdominal aortic aneurysm...
  18. doi request reprint Do abdominal aortic aneurysm necks increase in size faster after endovascular than open repair?
    A D Rodway
    Vascular Surgical Research Group, Imperial College at Charing Cross Hospital, St Dunstan s Road, London W6 8RP, UK
    Eur J Vasc Endovasc Surg 35:685-93. 2008
    ..We tested the hypothesis that 2 years after AAA repair the size of the aortic neck increased more after endovascular (EVAR) than open repair...
  19. doi request reprint Does EVAR alter the rate of cardiovascular events in patients with abdominal aortic aneurysm considered unfit for open repair? Results from the randomised EVAR trial 2
    L C Brown
    Vascular Surgery Research Group, Imperial College, 4th Floor, Charing Cross Hospital, Fulham Palace Road, London, UK
    Eur J Vasc Endovasc Surg 39:396-402. 2010
    ..To investigate whether endovascular aneurysm repair (EVAR) influences the rate of cardiovascular events (fatal or non-fatal myocardial infarction or stroke) in patients with abdominal aortic aneurysm (AAA) considered unfit for open repair...
  20. ncbi request reprint High risk and unfit for open repair are not the same
    R M Greenhalgh
    Vascular Surgical Research Group, Imperial College at Charing Cross, St Dunstan s Road, London W6 8RP, UK
    Eur J Vasc Endovasc Surg 34:154-5. 2007
  21. ncbi request reprint Patient fitness and survival after abdominal aortic aneurysm repair in patients from the UK EVAR trials
    L C Brown
    Vascular Surgery Research Group, Imperial College, London, UK
    Br J Surg 94:709-16. 2007
    ..The aim was to use a validated fitness score to determine whether fitter patients with a large abdominal aortic aneurysm (AAA) benefited from having open rather than endovascular repair...
  22. ncbi request reprint Interaction between fibrillin genotype and blood pressure and the development of aneurysmal disease
    J T Powell
    Charing Cross and Westminster Medical School, London, United Kingdom
    Ann N Y Acad Sci 800:198-207. 1996
    ..003. We suggest that a strong interaction occurs between fibrillin genotype and blood pressure which contributes to the development of aneurysmal disease...
  23. doi request reprint The adjuvant benefit of angioplasty in patients with mild to moderate intermittent claudication (MIMIC) managed by supervised exercise, smoking cessation advice and best medical therapy: results from two randomised trials for stenotic femoropopliteal and
    R M Greenhalgh
    Imperial College London, Vascular Surgery Research Group, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    Eur J Vasc Endovasc Surg 36:680-8. 2008
    ..Uncertainty exists on whether there is adjuvant benefit of percutaneous transluminal angioplasty (PTA) over supervised exercise and best medical therapy in the treatment of intermittent claudication...
  24. ncbi request reprint Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance
    Anthony R Brady
    MRC Clinical Trials Unit, London, UK
    Circulation 110:16-21. 2004
    ..The aim of this study was to characterize AAA growth in a national cohort of patients with AAA both overall and by cardiovascular risk factors...
  25. doi request reprint Endovascular repair of abdominal aortic aneurysm
    Roger M Greenhalgh
    Imperial College London Vascular Surgery Research Group, Imperial College London, Charing Cross Hospital, London, United Kingdom
    N Engl J Med 358:494-501. 2008
  26. ncbi request reprint Appraisal era for endovascular repair of abdominal aortic aneurysms
    F Dick
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Charing Cross Hospital, London, UK
    Acta Chir Belg 108:288-91. 2008
  27. ncbi request reprint The Immediate Management of the Patient with Rupture: Open Versus Endovascular repair (IMPROVE) aneurysm trial--ISRCTN 48334791 IMPROVE trialists
    J T Powell
    Imperial College, Charing Cross, London, UK
    Acta Chir Belg 109:678-80. 2009
    ..Systematic reviews have suggested a survival advantage for patients with ruptured abdominal aortic aneurysm (AAA), who are managed by endovascular repair. These reviews are based on single centre experiences of selected patients...
  28. ncbi request reprint Are we ignoring the importance of ankle pressures in patients with abdominal aortic aneurysm?
    J T Powell
    Department of Vascular Surgery, Imperial College at Charing Cross, St Dunstans Road, London W6 8RF, U K
    Eur J Vasc Endovasc Surg 21:65-9. 2001
    ..the ankle/brachial pressure index (ABPI) has been shown to be a reliable marker of cardiovascular risk in population studies. We investigated whether the ABPI was a useful prognostic index for patients with abdominal aortic aneurysm...
  29. pmc Transfer of patients with ruptured abdominal aortic aneurysm from general hospitals to specialist vascular centres: results of a Delphi consensus study
    Robert J Hinchliffe
    St George s Vascular Institute, St George s Healthcare NHS Trust, London, UK
    Emerg Med J 30:483-6. 2013
    ..To explore areas of consensus and disagreement concerning the interhospital transfer of patients with a clinical diagnosis of ruptured abdominal aortic aneurysm...
  30. ncbi request reprint Current interpretation of the UK EVAR Trials
    R M Greenhalgh
    Charing Cross Hospital, London W6 8RF, UK
    Acta Chir Belg 106:137-8. 2006
  31. ncbi request reprint Does nibbling or grazing protect the peripheral arteries from atherosclerosis?
    J T Powell
    Department of Vascular Surgery, Charing Cross Hospital, London, UK
    J Cardiovasc Risk 6:19-22. 1999
    ..It has been suggested that frequent food intake is metabolically advantageous. We investigated whether meal frequency was associated with the development of peripheral arterial disease among smokers...
  32. ncbi request reprint The natural history of abdominal aortic aneurysms and their risk of rupture
    J T Powell
    Department of Vascular Surgery, Imperial College at Charing Cross, St Dunstan s Road, London W6 8RP
    Acta Chir Belg 101:11-6. 2001
    ..Effective control of blood pressure and cessation of smoking are two simple measures that are likely to diminish the risk of aneurysm rupture and improve the cardiovascular health of patients with abdominal aortic aneurysm...
  33. doi request reprint Endovascular versus conventional medical treatment for uncomplicated chronic type B aortic dissection
    Pinar Ulug
    Vascular Surgery Research Group, Imperial College London, London, UK
    Cochrane Database Syst Rev 11:CD006512. 2012
    ..It has traditionally been treated by blood pressure control (medical treatment) or open surgery, both with high mortality rates. More recently stent-graft repair has been suggested as an alternative...
  34. ncbi request reprint Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomised controlled trial
    R M Greenhalgh
    Charing Cross Hospital, London
    Lancet 364:843-8. 2004
    ..Uncertainty exists about how endovascular repair compares with conventional open surgery. EVAR trial 1 was instigated to compare these treatments in patients judged fit for open AAA repair...
  35. ncbi request reprint Provocation of experimental aortic inflammation and dilatation by inflammatory mediators and Chlamydia pneumoniae
    J Tambiah
    Department of Vascular Surgery, Imperial College at Charing Cross, London, UK
    Br J Surg 88:935-40. 2001
    ..C. pneumoniae antigens appeared to stimulate aortic dilatation, probably by specific activation of macrophages...
  36. ncbi request reprint Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial
    A R Brady
    Department of Vascular Surgery, Imperial College, Charing Cross Campus, London, UK
    J Vasc Surg 41:602-9. 2005
    ....
  37. doi request reprint Patient preference for surgical method of abdominal aortic aneurysm repair: postal survey
    J A Reise
    Imperial College London, London, UK
    Eur J Vasc Endovasc Surg 39:55-61. 2010
    ..To determine whether men with small abdominal aortic aneurysm have a preference between either endovascular or open aneurysm repair for future treatment...
  38. ncbi request reprint Cadmium accumulation in aortas of smokers
    S Abu-Hayyeh
    Department of Vascular Surgery, Imperial College at Charing Cross, London, UK
    Arterioscler Thromb Vasc Biol 21:863-7. 2001
    ..In smokers, the level of cadmium accumulation is probably sufficient to impair the viability of cultured smooth muscle cells. Similar mechanisms could underlie the development of degenerative aortic disease in smokers...
  39. ncbi request reprint Aortic aneurysm diameter and risk of cardiovascular mortality
    A R Brady
    MRC Clinical Trials Unit, London, UK
    Arterioscler Thromb Vasc Biol 21:1203-7. 2001
    ..The significant association between aortic diameter and cardiovascular mortality, excluding aneurysm-related deaths, suggests that aneurysm diameter is an independent marker of cardiovascular disease risk...
  40. ncbi request reprint Detection, management, and prospects for the medical treatment of small abdominal aortic aneurysms
    Janet T Powell
    Department of Vascular Surgery, Imperial College, London, UK
    Arterioscler Thromb Vasc Biol 24:241-5. 2004
    ..Any proposed treatments, including statins, will need to be tested in clinical trials...
  41. ncbi request reprint Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways
    Emma McGregor
    Department of Vascular Surgery, Imperial College at Charing Cross Hospital, St Dunstan s Road, London W6 8RP, UK
    Cardiovasc Res 53:219-26. 2002
    ..Surgical preparation and/or pulsatile arterial perfusion of saphenous vein increases the sensitivity of vein rings to calcium mobilising agonists such as phenylephrine. We have investigated the mechanism(s) underlying this effect...
  42. ncbi request reprint Chlamydia pneumoniae antigens facilitate experimental aortic dilatation: prevention with azithromycin
    Jeymi Tambiah
    Imperial College at Charing Cross, London, United Kingdom
    J Vasc Surg 36:1011-7. 2002
    ..The purpose of this study was to investigate whether Chlamydia pneumoniae (live, antigens, or polysaccharide) cause abdominal aortic aneurysm in a susceptible animal host with appropriate drug reversal...
  43. ncbi request reprint Prostaglandin E2 receptors in abdominal aortic aneurysm and human aortic smooth muscle cells
    T Bayston
    Imperial College, London, UK
    J Vasc Surg 38:354-9. 2003
    ..These actions are mediated by cellular receptors for PGE(2) EP receptors...
  44. ncbi request reprint Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease
    F Gerald R Fowkes
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 43:474-80. 2006
    ..The aim of this study was to determine if these factors accounted for the link between aneurysms and pulmonary disease...
  45. ncbi request reprint Clinical practice. Small abdominal aortic aneurysms
    Janet T Powell
    University Hospitals of Coventry and Warwickshire, National Health Service Trust, Coventry, United Kingdom
    N Engl J Med 348:1895-901. 2003
  46. doi request reprint Abdominal aortic aneurysm events in postmenopausal women
    Janet T Powell
    BMJ 337:a1894. 2008
  47. ncbi request reprint Repair of small abdominal aortic aneurysms
    Frank A Lederle
    N Engl J Med 354:1537-8. 2006
  48. ncbi request reprint Familial abdominal aortic aneurysms: collection of 233 multiplex families
    Helena Kuivaniemi
    Center for Molecular Medicine and Genetics and Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Vasc Surg 37:340-5. 2003
    ..genetics.wayne.edu/ags)...
  49. pmc Screening men for aortic aneurysm
    Roger M Greenhalgh
    BMJ 325:1123-4. 2002
  50. doi request reprint The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
    ..These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases...
  51. doi request reprint Registries and RCTs for new interventional procedures
    Roger M Greenhalgh
    Lancet 372:891-2. 2008
  52. ncbi request reprint Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium
    Sabena Sultan
    Department of Vascular Surgery Charing Cross site, Imperial College London, St Dunstan s Road, London W6 8RP, UK
    FEBS Lett 564:161-5. 2004
    ..sICAM-1 was processed distal to Arg441, indicating that MMP-9, docking to ICAM-1, contributes to sICAM-1 shedding and attenuation of the shear stress-induced upregulation of ICAM-1...