N Poulter

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Measures of global risk: old versus new methods
    Neil R Poulter
    NHLI, Faculty of Medicine, Imperial College London, London, UK
    Clin Exp Hypertens 26:653-62. 2004
  2. ncbi request reprint Modulating the design of clinical trials to address the question of mechanisms of disease
    Neil R Poulter
    NHLI, Faculty of Medicine, Imperial College London, London, UK
    Clin Exp Hypertens 26:727-30. 2004
  3. doi request reprint A new dimension in hypertension management with the amlodipine/perindopril combination
    Neil R Poulter
    International Centre for Circulatory Health ICCH, Imperial College London, London, United Kingdom
    J Hypertens 29:S15-21. 2011
  4. doi request reprint Blood pressure and glucose control in subjects with diabetes: new analyses from ADVANCE
    Neil R Poulter
    International Centre for Circulatory Health, Imperial College London, UK
    J Hypertens Suppl 27:S3-8. 2009
  5. doi request reprint Baseline heart rate, antihypertensive treatment, and prevention of cardiovascular outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial)
    Neil R Poulter
    Imperial College London, United Kingdom
    J Am Coll Cardiol 54:1154-61. 2009
  6. ncbi request reprint Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)
    Neil R Poulter
    Imperial College London, London, UK
    Lancet 366:907-13. 2005
  7. pmc Global risk of cardiovascular disease
    N Poulter
    Cardiovascular Studies Unit, Department of Clinical Pharmacology, Imperial College London, NHLI, Faculty of Medicine, St Mary s Campus, London W2 1PG, UK
    Heart 89:ii2-5; discussion ii35-7. 2003
  8. ncbi request reprint Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Drugs 64:43-60. 2004
  9. ncbi request reprint Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Lancet 361:1149-58. 2003
  10. ncbi request reprint Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial--lipid-lowering arm (ASCOT-LLA)
    Peter S Sever
    International Centre for Circulatory Health, NHLI, Faculty of Medicine, Imperial College London, St Mary s Campus, 59 N Wharf Road, London W2 1PG, U K
    Diabetes Care 28:1151-7. 2005

Detail Information

Publications43

  1. ncbi request reprint Measures of global risk: old versus new methods
    Neil R Poulter
    NHLI, Faculty of Medicine, Imperial College London, London, UK
    Clin Exp Hypertens 26:653-62. 2004
    ..It must be acknowledged however that all risk scores have limitations and hence whichever method is used should be used to guide rather than rule practice...
  2. ncbi request reprint Modulating the design of clinical trials to address the question of mechanisms of disease
    Neil R Poulter
    NHLI, Faculty of Medicine, Imperial College London, London, UK
    Clin Exp Hypertens 26:727-30. 2004
    ....
  3. doi request reprint A new dimension in hypertension management with the amlodipine/perindopril combination
    Neil R Poulter
    International Centre for Circulatory Health ICCH, Imperial College London, London, United Kingdom
    J Hypertens 29:S15-21. 2011
    ..Thus, the combination of perindopril and amlodipine seems an ideal logical evidence-based pair of antihypertensive agents to select...
  4. doi request reprint Blood pressure and glucose control in subjects with diabetes: new analyses from ADVANCE
    Neil R Poulter
    International Centre for Circulatory Health, Imperial College London, UK
    J Hypertens Suppl 27:S3-8. 2009
    ..5%) with a gliclazide MR-based regimen, compared with usual care...
  5. doi request reprint Baseline heart rate, antihypertensive treatment, and prevention of cardiovascular outcomes in ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial)
    Neil R Poulter
    Imperial College London, United Kingdom
    J Am Coll Cardiol 54:1154-61. 2009
    ....
  6. ncbi request reprint Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA)
    Neil R Poulter
    Imperial College London, London, UK
    Lancet 366:907-13. 2005
    ..86 and 0.77, respectively). Our aim was to assess to what extent these differences were due to significant differences in blood pressures and in other variables noted after randomisation...
  7. pmc Global risk of cardiovascular disease
    N Poulter
    Cardiovascular Studies Unit, Department of Clinical Pharmacology, Imperial College London, NHLI, Faculty of Medicine, St Mary s Campus, London W2 1PG, UK
    Heart 89:ii2-5; discussion ii35-7. 2003
    ..However, an over reliance on short term absolute risk may result in under treatment of young people (particularly women) at high relative risk and over treatment of older people (particularly men) at low relative risk...
  8. ncbi request reprint Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Drugs 64:43-60. 2004
    ..No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemic...
  9. ncbi request reprint Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomis
    Peter S Sever
    Imperial College, London, UK
    Lancet 361:1149-58. 2003
    ..No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemic...
  10. ncbi request reprint Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial--lipid-lowering arm (ASCOT-LLA)
    Peter S Sever
    International Centre for Circulatory Health, NHLI, Faculty of Medicine, Imperial College London, St Mary s Campus, 59 N Wharf Road, London W2 1PG, U K
    Diabetes Care 28:1151-7. 2005
    ..This study aims to establish the benefits of lowering cholesterol in diabetic patients with well-controlled hypertension and average/below-average cholesterol concentrations, but without established coronary disease...
  11. doi request reprint The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure
    Peter S Sever
    International Centre for Circulatory Health, Imperial College London, 59 North Wharf Road, London W2 1PG, UK
    Eur Heart J 29:499-508. 2008
    ..To determine the cardiovascular benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-2.2 years after closure of the lipid-lowering arm of the trial (ASCOT-LLA)...
  12. ncbi request reprint The effect of non-steroidal anti-inflammatory drugs and other commonly used non-narcotic analgesics on blood pressure level in adults
    Sarah L Wilson
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, St Mary s Campus, London, W2 1PG UK
    J Hypertens 24:1457-69. 2006
    ....
  13. ncbi request reprint Blood pressure reduction is not the only determinant of outcome
    Peter S Sever
    International Centre for Circulatory Health, Imperial College London, 59 N Wharf Rd, London, W2 1PG, UK
    Circulation 113:2754-72; discussion 2773-4. 2006
  14. doi request reprint Coronary heart disease benefits from blood pressure and lipid-lowering
    Peter S Sever
    Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, London, UK
    Int J Cardiol 135:218-22. 2009
    ..We report further analyses on the combined benefits of these interventions...
  15. doi request reprint Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial
    Neil Chapman
    International Centre for Circulatory Health, Imperial College London, 59 N Wharf Rd, London W2 1PG, United Kingdom
    Circulation 118:42-8. 2008
    ..The role of doxazosin in treatment of hypertension remains controversial...
  16. doi request reprint Antihypertensive therapy and the benefits of atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial: lipid-lowering arm extension
    Peter S Sever
    Imperial College London, International Centre for Circulatory Health, London, UK
    J Hypertens 27:947-54. 2009
    ..To determine the cardiovascular benefits of atorvastatin stratified by blood pressure-lowering regimen, 2.2 years after closure of the lipid-lowering arm (LLA) of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA)...
  17. doi request reprint Hypertension and its identification among current, past and never smokers in an English population sample
    Lion Shahab
    Department of Epidemiology and Public Health, University College London, London, UK
    Eur J Cardiovasc Prev Rehabil 17:63-70. 2010
    ..This study aimed to determine the prevalence of hypertension awareness in hypertensive smokers and its association with receiving and acting on advice to stop smoking...
  18. doi request reprint Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy
    Robyn J Tapp
    International Centre for Circulatory Health, NHLI, St Mary s Hospital and Imperial College London, St Mary sCampus, London, United Kingdom
    J Am Coll Cardiol 55:1875-81. 2010
    ..We hypothesized that an amlodipine-based regimen would have more favorable effects on left ventricular (LV) diastolic function...
  19. pmc Metabolic syndrome, independent of its components, is a risk factor for stroke and death but not for coronary heart disease among hypertensive patients in the ASCOT-BPLA
    Ajay K Gupta
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, U K
    Diabetes Care 33:1647-51. 2010
    ..To evaluate whether in hypertensive patients the risk of cardiovascular disease is greater in association with the metabolic syndrome (MetS) or the sum of its individual components...
  20. doi request reprint Ethnic differences in blood pressure response to first and second-line antihypertensive therapies in patients randomized in the ASCOT Trial
    Ajay K Gupta
    ICCH, Imperial College London, London, UK
    Am J Hypertens 23:1023-30. 2010
    ..Some studies suggest that blood pressure (BP)-lowering effects of commonly used antihypertensive drugs differ among ethnic groups. However, differences in the response to second-line therapy have not been studied extensively...
  21. ncbi request reprint Levels of dyslipidaemia and improvement in its management in England: results from the Health Survey for England 2003
    Paola Primatesta
    Department of Epidemiology and Public Health, University College London Medical School, London, UK
    Clin Endocrinol (Oxf) 64:292-8. 2006
    ..To evaluate blood lipid levels in the adult English population and to report changes in the use and efficacy of lipid-lowering treatment between 1998 and 2003...
  22. doi request reprint Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis
    Ajay K Gupta
    International Centre for Circulatory Health, Imperial College London, London, United Kingdom
    Hypertension 55:399-407. 2010
    ..In conclusion, compared with free-drug combinations, FDCs of antihypertensive agents are associated with a significant improvement in compliance and with nonsignificant beneficial trends in BP and adverse effects...
  23. ncbi request reprint Different time course for prevention of coronary and stroke events by atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA)
    Peter S Sever
    International Center for Circulatory Health, Imperial College London, London, United Kingdom
    Am J Cardiol 96:39F-44F. 2005
    ..These observations support the hypothesis that non-lipid-lowering actions of atorvastatin may have contributed to early protection against CAD in ASCOT-LLA...
  24. ncbi request reprint Coronary heart disease is a multifactorial disease
    N Poulter
    Department of Clinical Pharmacology, Imperial College School of Medicine, Paddington, London, United Kingdom
    Am J Hypertens 12:92S-95S. 1999
    ..The current trend towards a more holistic approach in CHD risk evaluation and preventive management appears logical based on evidence from animal-experimental, observational, and clinical trial evidence...
  25. doi request reprint Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy
    Andrew Sharp
    International Centre for Circulatory Health, St Mary s Hospital and Imperial College London, London, United Kingdom
    J Am Coll Cardiol 52:1015-21. 2008
    ..We investigated whether diastolic function differs between hypertensive patients of African-Caribbean or white European origin and established whether differences could be explained by confounding variables...
  26. ncbi request reprint Hypertension management and control among English adults aged 65 years and older in 2000 and 2001
    Paola Primatesta
    Department of Epidemiology and Public Health, University College London Medical School, London, UK
    J Hypertens 22:1093-8. 2004
    ..To describe blood pressures, and hypertension and its management among older people...
  27. doi request reprint Wave reflection predicts cardiovascular events in hypertensive individuals independent of blood pressure and other cardiovascular risk factors: an ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) substudy
    Charlotte Manisty
    International Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom
    J Am Coll Cardiol 56:24-30. 2010
    ....
  28. ncbi request reprint The influence of economic development on the association between education and the risk of acute myocardial infarction and stroke
    Choon Lan Chang
    Cardiovascular Studies Unit, Department of Clinical Pharmacology, Imperial College of Science, Technology and Medicine, St Mary s Campus, London W2 1PG, UK
    J Clin Epidemiol 55:741-7. 2002
    ..Low education was associated with increased risk of AMI in Eastern Europe but not in the other three regions combined. Educationally related stroke risk was positively correlated with national life expectancy...
  29. ncbi request reprint Effect of spironolactone on blood pressure in subjects with resistant hypertension
    Neil Chapman
    International Centre for Circulatory Health, Imperial College London, 59 North Wharf Rd, London W2 1PG, United Kingdom
    Hypertension 49:839-45. 2007
    ..Although nonrandomized and not placebo controlled, these data support the use of spironolactone in uncontrolled hypertension...
  30. ncbi request reprint Improvement in hypertension management in England: results from the Health Survey for England 2003
    Paola Primatesta
    Department of Epidemiology and Public Health, University College London Medical School, London, UK
    J Hypertens 24:1187-92. 2006
    ....
  31. ncbi request reprint Ethnic and gender differences in electrocardiographic QT length and QT dispersion in hypertensive subjects
    N Chapman
    The Peart Rose Clinic and Departments of Clinical Pharmacology, Imperial College School of Medicine at St Mary s, St Mary s Hospital, London, UK
    J Hum Hypertens 14:403-5. 2000
    ..Among normotensives, compared with whites, QTc is reported to be shorter in African-Americans and longer in Chinese. We looked for ethnic and gender differences in QT parameters in hypertensive subjects...
  32. ncbi request reprint Can cardiovascular risk factors explain the association between education and cardiovascular disease in young women?
    Choon Lan Chang
    Cardiovascular Studies Unit, Department of Clinical Pharmacology, Imperial College of Science, Technology and Medicine, St Mary s Campus, London W2 1PG, UK
    J Clin Epidemiol 55:749-55. 2002
    ..These data suggest that standard risk factors explain a substantial proportion if not all of the difference in AMI risk associated with education but a lesser proportion of educationally linked stroke risk...
  33. ncbi request reprint Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?
    Sarah Wilson
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 M 6BQ, UK
    J Cardiovasc Risk 10:137-41. 2003
    ..It is important to quantify the impact of this advice if risk assessments are to be sufficiently accurate to guide treatment decisions...
  34. pmc British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester
    BMJ 328:634-40. 2004
  35. ncbi request reprint Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B
    Bjorn Dahlof
    Department of Medicine, Sahlgrenska University Hospital Ostra, SE 416 85 Goteborg, Sweden
    Lancet 366:895-906. 2005
    ..Our aim, therefore, was to compare the effect on non-fatal myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril...
  36. doi request reprint The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes
    Jan Ostergren
    Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    J Hypertens 26:2103-11. 2008
    ....
  37. ncbi request reprint Cost-effectiveness of atorvastatin for the prevention of coronary and stroke events: an economic analysis of the Anglo-Scandinavian Cardiac Outcomes Trial--lipid-lowering arm (ASCOT-LLA)
    Peter Lindgren
    Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden
    Eur J Cardiovasc Prev Rehabil 12:29-36. 2005
    ....
  38. ncbi request reprint Antihypertensive-associated incident diabetes: controversy persists
    Ajay K Gupta
    Arch Intern Med 167:1433; author reply 1434-5. 2007
  39. ncbi request reprint Angiotensin receptor blockers: therapeutic targets and cardiovascular protection
    Luis M Ruilope
    Hypertension Unit, Hospital 12 de Octobre, Madrid, Spain, and Division of Internal Medicine, Ospedali Civili, University of Brescia, Italy
    Blood Press 14:196-209. 2005
    ..Furthermore, evidence in favour of combining an ACE inhibitor and an ARB in certain circumstances is continuously growing...
  40. ncbi request reprint Influence of hormone replacement therapy on C-reactive protein: population-based data
    Paola Primatesta
    Department of Epidemiology and Public Health, Royal Free and University College Medical School, London WC1E 6BT, UK
    J Cardiovasc Risk 10:57-60. 2003
    ..One possible explanation for the trial findings is that adverse effects of HRT-- such as an elevation of C-reactive protein (CRP)--might counterbalance other benefits of HRT...
  41. ncbi request reprint Birth weight and blood pressure in childhood: results from the Health Survey for England
    Paola Primatesta
    Department of Epidemiology and Public Health, University College London Medical School, Gower Street Campus, 1 19 Torrington Place, London WC1E 6BT, UK
    Hypertension 45:75-9. 2005
    ..Reducing the prevalence of overweight among children may reduce their systolic blood pressure importantly and, particularly among children with lower birth weight, the prevalence of hypertension later in life...
  42. ncbi request reprint Independent effects of smoking on risk of hypertension: small, if present
    Neil R Poulter
    J Hypertens 20:171-2. 2002
  43. pmc NICE and BHS guidelines on hypertension differ importantly
    Neil R Poulter
    BMJ 329:1289. 2004