Marios Politis

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Imaging of microglia in patients with neurodegenerative disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London London, UK
    Front Pharmacol 3:96. 2012
  2. doi request reprint Ambient particulate matter and its potential neurological consequences
    Clare Loane
    Imperial College, London, UK
    Rev Neurosci 24:323-35. 2013
  3. ncbi request reprint Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease
    Marios Politis
    Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Brain 136:400-11. 2013
  4. doi request reprint Reduplicative paramnesia: a review
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Psychopathology 45:337-43. 2012
  5. doi request reprint In vivo imaging of the integration and function of nigral grafts in clinical trials
    Marios Politis
    Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Prog Brain Res 200:199-220. 2012
  6. ncbi request reprint Positron emission tomography imaging in neurological disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London, Cyclotron Building, London W12 0NN, UK
    J Neurol 259:1769-80. 2012
  7. pmc Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
    Marios Politis
    Centre for Neuroscience, Hammersmith Hospital, Imperial College London, London
    Neurology 79:523-30. 2012
  8. doi request reprint Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 4:128ra41. 2012
  9. pmc Serotonergic dysfunction in Parkinson's disease and its relevance to disability
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    ScientificWorldJournal 11:1726-34. 2011
  10. pmc Clinical application of stem cell therapy in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    BMC Med 10:1. 2012

Collaborators

Detail Information

Publications30

  1. pmc Imaging of microglia in patients with neurodegenerative disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London London, UK
    Front Pharmacol 3:96. 2012
    ..In this article, we aim to review the applications of in vivo microglia imaging in neurodegenerative disorders such as Parkinson's disease, Huntington's disease, Dementias, and Multiple Sclerosis...
  2. doi request reprint Ambient particulate matter and its potential neurological consequences
    Clare Loane
    Imperial College, London, UK
    Rev Neurosci 24:323-35. 2013
    ..This article aimed to review the literature in relation to translocation routes of PM and UFP and their potential role in neurological disease processes...
  3. ncbi request reprint Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease
    Marios Politis
    Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Brain 136:400-11. 2013
    ..Stimulation through exposure to sexual visual cues in patients with Parkinson's disease with hypersexuality provides a motivational impetus for seeking this reward behaviour through activations and deactivations of cerebral cortex...
  4. doi request reprint Reduplicative paramnesia: a review
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Psychopathology 45:337-43. 2012
    ..Our systematic review examines the research literature investigating the prevalence, symptomatology and potential neurologic mechanisms underlying RP...
  5. doi request reprint In vivo imaging of the integration and function of nigral grafts in clinical trials
    Marios Politis
    Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Prog Brain Res 200:199-220. 2012
    ....
  6. ncbi request reprint Positron emission tomography imaging in neurological disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London, Cyclotron Building, London W12 0NN, UK
    J Neurol 259:1769-80. 2012
    ..This review aims to explain the PET imaging technique and its applications in neurological disorders such as Parkinson’s disease, Huntington’s disease, multiple sclerosis, and dementias...
  7. pmc Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
    Marios Politis
    Centre for Neuroscience, Hammersmith Hospital, Imperial College London, London
    Neurology 79:523-30. 2012
    ..Our objective was to evaluate microglial activation in cortical GM of patients with MS in vivo and to explore its relationship to measures of disability...
  8. doi request reprint Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 4:128ra41. 2012
    ....
  9. pmc Serotonergic dysfunction in Parkinson's disease and its relevance to disability
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    ScientificWorldJournal 11:1726-34. 2011
    ..These in vivo findings indicate that agents acting on the serotonergic system could help towards alleviating these symptoms. This paper aims to review the current literature and to highlight the need for further in vivo investigations...
  10. pmc Clinical application of stem cell therapy in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    BMC Med 10:1. 2012
    ..A successful, clinically competitive SC therapy in PD needs to produce long-lasting symptomatic relief without side effects while counteracting PD progression...
  11. doi request reprint Evidence of dopamine dysfunction in the hypothalamus of patients with Parkinson's disease: an in vivo 11C-raclopride PET study
    Marios Politis
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Cyclotron Building, Hammersmith Hospital, Imperial College London, DuCane Road W12 0NN, London, UK
    Exp Neurol 214:112-6. 2008
    ..Our results provide further evidence of dopaminergic dysfunction in the hypothalamus in PD, and this may contribute to the development of sleep, endocrine and autonomic disorders...
  12. doi request reprint Serotonergic mediated body mass index changes in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Neurobiol Dis 43:609-15. 2011
    ..The regions implicated are the rostral raphe nuclei and its connections to limbic and cognitive areas. It is conceivable that 5-HT agents could help alleviate abnormal changes in BMI in PD...
  13. doi request reprint Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011
    ..Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias...
  14. doi request reprint Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 2:38ra46. 2010
    ..Our observations suggest strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease with fetal tissue or stem cells...
  15. doi request reprint Parkinson's disease symptoms: the patient's perspective
    Marios Politis
    Department of Clinical Neurosciences, Faculty of Medicine, Hammersmith Hospital, Imperial College, London, United Kingdom
    Mov Disord 25:1646-51. 2010
    ....
  16. doi request reprint Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures
    M Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Imperial CollegeLondon, UK
    Neurology 75:1920-7. 2010
    ..Depression associated with Parkinson disease (PD) has a different symptom profile to endogenous depression. The etiology of depression in PD remains uncertain though abnormal serotonergic neurotransmission could play a role...
  17. pmc Dyskinesias after neural transplantation in Parkinson's disease: what do we know and what is next?
    Marios Politis
    Centre for Neuroscience, Medical Research Council, Hammersmith Hospital, Imperial College London, UK
    BMC Med 8:80. 2010
    ..Here the implications of the recent findings for the development of new human trials testing the safety and efficacy of cell transplantation in patients with Parkinson's disease are discussed...
  18. doi request reprint Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study
    Marios Politis
    Department of Clinical Neurosciences and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Hum Brain Mapp 32:258-70. 2011
    ..These data suggest that pathologically activated microglia in AST and other areas related to cognitive function, maybe better predictors of clinical onset and stresses the importance of early cognitive assessment in HD...
  19. pmc Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    BMC Med 9:50. 2011
    ..In this commentary we discuss how an optimized functional imaging protocol could assist new clinical trials using fetal cell transplantation in Parkinson's disease...
  20. doi request reprint Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study
    Marios Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 40:216-21. 2010
    ..Our results suggest that progressive non-linear serotonergic dysfunction occurs in PD but it does not determine levels of disability. Additionally, chronic exposure to dopaminergic therapy does not appear to influence SERT binding...
  21. doi request reprint Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers
    Nicola Pavese
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Neurobiol Dis 37:356-61. 2010
    ..It is an early event in HD pathophysiology and could contribute to the impairment in neuropsychological performance in these patients...
  22. doi request reprint Hypothalamic involvement in Huntington's disease: an in vivo PET study
    Marios Politis
    Division of Clinical Neurosciences and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Brain 131:2860-9. 2008
    ....
  23. doi request reprint Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: an in vivo [(11)C](R)-PK11195-PET pilot study
    Paolo Giannetti
    Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK Electronic address
    Neurobiol Dis 65:203-10. 2014
    ..The significant association between PKBPND, neurological impairment and outcome in progressive subjects supports a role for activated microglia in disability progression. ..
  24. ncbi request reprint The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study
    Kit Wu
    Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK
    Brain 135:2449-57. 2012
    ....
  25. doi request reprint Brain imaging after neural transplantation
    Marios Politis
    Centre for Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK
    Prog Brain Res 184:193-203. 2010
    ..Although functional imaging cannot currently be used as a primary endpoint in clinical transplantation trials, it can provide additional valuable information alongside clinical observations...
  26. doi request reprint Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD
    Clare Loane
    Department of Medicine, Division of Brain Sciences, Hammersmith Hospital, Imperial College London, UK
    Neurology 80:1850-5. 2013
    ..It is suggested that serotonergic dysfunction could have a role in tremor development...
  27. pmc Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation
    Lucy J Garvey
    Department of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38980. 2012
    ..The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals...
  28. doi request reprint Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART
    Lucy J Garvey
    aDepartment of Medicine, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, Norfolk Place bDepartment of HIV and GU Medicine, Imperial College Healthcare NHS Trust cDivision of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK
    AIDS 28:67-72. 2014
    ..We imaged microglial activation, the hallmark of neuroinflammation, in asymptomatic HIV-infected patients on effective combination ART...
  29. ncbi request reprint Problematic Internet use in Parkinson's disease
    Kit Wu
    Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK Electronic address
    Parkinsonism Relat Disord 20:482-7. 2014
    ..However, Internet use has not been previously systematically studied in Parkinson's disease...
  30. pmc Positron emission tomography neuroimaging in Parkinson's disease
    Clare Loane
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine Hammersmith Hospital, Imperial College London London W12 0NN, UK
    Am J Transl Res 3:323-41. 2011
    ....