Marios Politis

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease
    Marios Politis
    Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Brain 136:400-11. 2013
  2. ncbi Reduplicative paramnesia: a review
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Psychopathology 45:337-43. 2012
  3. ncbi In vivo imaging of the integration and function of nigral grafts in clinical trials
    Marios Politis
    Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Prog Brain Res 200:199-220. 2012
  4. ncbi Positron emission tomography imaging in neurological disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London, Cyclotron Building, London W12 0NN, UK
    J Neurol 259:1769-80. 2012
  5. ncbi Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
    Marios Politis
    Centre for Neuroscience, Hammersmith Hospital, Imperial College London, London
    Neurology 79:523-30. 2012
  6. ncbi Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 4:128ra41. 2012
  7. ncbi Serotonergic dysfunction in Parkinson's disease and its relevance to disability
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    ScientificWorldJournal 11:1726-34. 2011
  8. ncbi Clinical application of stem cell therapy in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    BMC Med 10:1. 2012
  9. ncbi Serotonergic mediated body mass index changes in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Neurobiol Dis 43:609-15. 2011
  10. ncbi Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011

Detail Information

Publications25

  1. ncbi Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease
    Marios Politis
    Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Brain 136:400-11. 2013
    ..Stimulation through exposure to sexual visual cues in patients with Parkinson's disease with hypersexuality provides a motivational impetus for seeking this reward behaviour through activations and deactivations of cerebral cortex...
  2. ncbi Reduplicative paramnesia: a review
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Psychopathology 45:337-43. 2012
    ..Our systematic review examines the research literature investigating the prevalence, symptomatology and potential neurologic mechanisms underlying RP...
  3. ncbi In vivo imaging of the integration and function of nigral grafts in clinical trials
    Marios Politis
    Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Prog Brain Res 200:199-220. 2012
    ....
  4. ncbi Positron emission tomography imaging in neurological disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London, Cyclotron Building, London W12 0NN, UK
    J Neurol 259:1769-80. 2012
    ..This review aims to explain the PET imaging technique and its applications in neurological disorders such as Parkinson’s disease, Huntington’s disease, multiple sclerosis, and dementias...
  5. ncbi Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
    Marios Politis
    Centre for Neuroscience, Hammersmith Hospital, Imperial College London, London
    Neurology 79:523-30. 2012
    ..Our objective was to evaluate microglial activation in cortical GM of patients with MS in vivo and to explore its relationship to measures of disability...
  6. ncbi Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 4:128ra41. 2012
    ....
  7. ncbi Serotonergic dysfunction in Parkinson's disease and its relevance to disability
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    ScientificWorldJournal 11:1726-34. 2011
    ..These in vivo findings indicate that agents acting on the serotonergic system could help towards alleviating these symptoms. This paper aims to review the current literature and to highlight the need for further in vivo investigations...
  8. ncbi Clinical application of stem cell therapy in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    BMC Med 10:1. 2012
    ..A successful, clinically competitive SC therapy in PD needs to produce long-lasting symptomatic relief without side effects while counteracting PD progression...
  9. ncbi Serotonergic mediated body mass index changes in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Neurobiol Dis 43:609-15. 2011
    ..The regions implicated are the rostral raphe nuclei and its connections to limbic and cognitive areas. It is conceivable that 5-HT agents could help alleviate abnormal changes in BMI in PD...
  10. ncbi Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011
    ..Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias...
  11. ncbi Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    BMC Med 9:50. 2011
    ..In this commentary we discuss how an optimized functional imaging protocol could assist new clinical trials using fetal cell transplantation in Parkinson's disease...
  12. ncbi Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study
    Marios Politis
    Department of Clinical Neurosciences and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Hum Brain Mapp 32:258-70. 2011
    ..These data suggest that pathologically activated microglia in AST and other areas related to cognitive function, maybe better predictors of clinical onset and stresses the importance of early cognitive assessment in HD...
  13. ncbi Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 2:38ra46. 2010
    ..Our observations suggest strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease with fetal tissue or stem cells...
  14. ncbi Evidence of dopamine dysfunction in the hypothalamus of patients with Parkinson's disease: an in vivo 11C-raclopride PET study
    Marios Politis
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Cyclotron Building, Hammersmith Hospital, Imperial College London, DuCane Road W12 0NN, London, UK
    Exp Neurol 214:112-6. 2008
    ..Our results provide further evidence of dopaminergic dysfunction in the hypothalamus in PD, and this may contribute to the development of sleep, endocrine and autonomic disorders...
  15. ncbi Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study
    Marios Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 40:216-21. 2010
    ..Our results suggest that progressive non-linear serotonergic dysfunction occurs in PD but it does not determine levels of disability. Additionally, chronic exposure to dopaminergic therapy does not appear to influence SERT binding...
  16. ncbi Parkinson's disease symptoms: the patient's perspective
    Marios Politis
    Department of Clinical Neurosciences, Faculty of Medicine, Hammersmith Hospital, Imperial College, London, United Kingdom
    Mov Disord 25:1646-51. 2010
    ....
  17. ncbi Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures
    M Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Imperial CollegeLondon, UK
    Neurology 75:1920-7. 2010
    ..Depression associated with Parkinson disease (PD) has a different symptom profile to endogenous depression. The etiology of depression in PD remains uncertain though abnormal serotonergic neurotransmission could play a role...
  18. ncbi Dyskinesias after neural transplantation in Parkinson's disease: what do we know and what is next?
    Marios Politis
    Centre for Neuroscience, Medical Research Council, Hammersmith Hospital, Imperial College London, UK
    BMC Med 8:80. 2010
    ..Here the implications of the recent findings for the development of new human trials testing the safety and efficacy of cell transplantation in patients with Parkinson's disease are discussed...
  19. ncbi Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers
    Nicola Pavese
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Neurobiol Dis 37:356-61. 2010
    ..It is an early event in HD pathophysiology and could contribute to the impairment in neuropsychological performance in these patients...
  20. ncbi Hypothalamic involvement in Huntington's disease: an in vivo PET study
    Marios Politis
    Division of Clinical Neurosciences and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Brain 131:2860-9. 2008
    ....
  21. ncbi The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study
    Kit Wu
    Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK
    Brain 135:2449-57. 2012
    ....
  22. ncbi Brain imaging after neural transplantation
    Marios Politis
    Centre for Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK
    Prog Brain Res 184:193-203. 2010
    ..Although functional imaging cannot currently be used as a primary endpoint in clinical transplantation trials, it can provide additional valuable information alongside clinical observations...
  23. ncbi Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation
    Lucy J Garvey
    Department of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38980. 2012
    ..The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals...
  24. ncbi Imaging of microglia in patients with neurodegenerative disorders
    Marios Politis
    Division of Experimental Medicine, Faculty of Medicine, Centre for Neuroscience, Hammersmith Hospital, Imperial College London London, UK
    Front Pharmacol 3:96. 2012
    ..In this article, we aim to review the applications of in vivo microglia imaging in neurodegenerative disorders such as Parkinson's disease, Huntington's disease, Dementias, and Multiple Sclerosis...
  25. ncbi Positron emission tomography neuroimaging in Parkinson's disease
    Clare Loane
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine Hammersmith Hospital, Imperial College London London W12 0NN, UK
    Am J Transl Res 3:323-41. 2011
    ....