Ray J Playford

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Cytokines and growth factor modulators in intestinal inflammation and repair
    R J Playford
    Imperial College, London, UK
    J Pathol 205:417-25. 2005
  2. ncbi request reprint Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Peptides 25:793-801. 2004
  3. pmc Effects of growth factors and receptor blockade on gastrointestinal cancer
    R J Playford
    Gastroenterology Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Gut 53:1059-63. 2004
  4. ncbi request reprint Growth factors and trefoil peptides in gastrointestinal health and disease
    Raymond J Playford
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Curr Opin Pharmacol 4:567-71. 2004
  5. ncbi request reprint The challenges of Barrett's -- suppression, symptoms or surveillance
    Ray J Playford
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Best Pract Res Clin Gastroenterol 18:47-53. 2004
  6. pmc Reparative properties of a commercial fish protein hydrolysate preparation
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 54:775-81. 2005
  7. ncbi request reprint The value of surveillance and other unresolved issues in the management of Barrett's esophagus
    Raymond J Playford
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospitals NHS Trust, London, UK
    Nat Clin Pract Gastroenterol Hepatol 2:60-1. 2005
  8. pmc New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett's oesophagus
    R J Playford
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:442. 2006
  9. ncbi request reprint Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice
    T Marchbank
    Department of Gastroenterology, Hammersmith Hospital, Imperial College School of Medicine, London W12 0NN, United Kingdom
    J Biol Chem 276:24088-96. 2001
  10. ncbi request reprint Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease
    David A van Heel
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Inflamm Bowel Dis 12:598-605. 2006

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Cytokines and growth factor modulators in intestinal inflammation and repair
    R J Playford
    Imperial College, London, UK
    J Pathol 205:417-25. 2005
    ..This review summarizes current thoughts on the use of these factors in general, but with particular emphasis on inflammatory bowel disease...
  2. ncbi request reprint Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Peptides 25:793-801. 2004
    ....
  3. pmc Effects of growth factors and receptor blockade on gastrointestinal cancer
    R J Playford
    Gastroenterology Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Gut 53:1059-63. 2004
    ..Similarly, peptide and non-peptide antagonists of growth factor receptors show great potential as novel antichemotherapy agents. However, their actual place in clinical practice has yet to be established...
  4. ncbi request reprint Growth factors and trefoil peptides in gastrointestinal health and disease
    Raymond J Playford
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Curr Opin Pharmacol 4:567-71. 2004
    ....
  5. ncbi request reprint The challenges of Barrett's -- suppression, symptoms or surveillance
    Ray J Playford
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Best Pract Res Clin Gastroenterol 18:47-53. 2004
    ..This document considers the sort of information that should be discussed with patients to allow them to make their own choices regarding therapeutic strategies...
  6. pmc Reparative properties of a commercial fish protein hydrolysate preparation
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 54:775-81. 2005
    ..However, there has been only limited scientific study regarding its true biological activity...
  7. ncbi request reprint The value of surveillance and other unresolved issues in the management of Barrett's esophagus
    Raymond J Playford
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospitals NHS Trust, London, UK
    Nat Clin Pract Gastroenterol Hepatol 2:60-1. 2005
  8. pmc New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett's oesophagus
    R J Playford
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:442. 2006
  9. ncbi request reprint Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice
    T Marchbank
    Department of Gastroenterology, Hammersmith Hospital, Imperial College School of Medicine, London W12 0NN, United Kingdom
    J Biol Chem 276:24088-96. 2001
    ..01). Overexpression of TFF3 stabilizes the mucosa against noxious agents, supporting its role in mucosal protection/repair. It may therefore provide a novel approach to the prevention and/or treatment of intestinal ulceration...
  10. ncbi request reprint Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease
    David A van Heel
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Inflamm Bowel Dis 12:598-605. 2006
    ..Rare NOD2 variants occur, but it is difficult to both identify them and assess their functional effect. We assessed the true frequency of defective muramyl dipeptide sensing in Crohn's disease and developed a rapid diagnostic assay...
  11. pmc Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents
    Tania Marchbank
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Am J Pathol 171:1462-73. 2007
    ..We conclude that administration of PSTI may provide a novel method of stabilizing intestinal mucosa against noxious agents and stimulating repair after injury...
  12. ncbi request reprint Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair
    Raymond J Playford
    Centre for Gastroenterology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Gastroenterology 131:809-17. 2006
    ..Their potential role in maintaining gastrointestinal mucosal integrity and repair is, however, unclear...
  13. ncbi request reprint Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice
    O Bashir
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Clin Sci (Lond) 105:323-30. 2003
    ..EGF did not initiate polyp formation in control or Min mice. However, as polyp size is an important determinant for subsequent risk of malignant change in human colon cancer, further studies appear justified...
  14. ncbi request reprint Dietary microparticles implicated in Crohn's disease can impair macrophage phagocytic activity and act as adjuvants in the presence of bacterial stimuli
    M Butler
    Department of Gastroenterology, Imperial College London, Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Inflamm Res 56:353-61. 2007
    ..These are taken up by M cells, accumulate in gut macrophages, and may influence the aetiology of inflammatory bowel diseases (IBD)...
  15. pmc Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
    A Mahmood
    Department of Gastroenterology, Imperial College London, UK
    Gut 56:168-75. 2007
    ..Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited...
  16. pmc Probiotics in inflammatory bowel disease: is it all gut flora modulation?
    S Ghosh
    Gastroentrology Section, Division of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Gut 53:620-2. 2004
  17. pmc Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
    D A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Gut 54:1553-7. 2005
    ..TLR9 is functional in the intestinal epithelium where it is most strongly expressed in Paneth cells...
  18. pmc Is thiopurine therapy in ulcerative colitis as effective as in Crohn's disease?
    S Ghosh
    Imperial College London, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:6-8. 2006
  19. ncbi request reprint Synergistic enhancement of Toll-like receptor responses by NOD1 activation
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London Hammersmith Campus, London, UK
    Eur J Immunol 35:2471-6. 2005
    ..Cross-talk between cytosolic NOD1 and membrane-bound TLR enhances responses to the multiple antigens simultaneously presented by a microbe...
  20. ncbi request reprint Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure
    Danay Cibrian
    Center for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190 Playa 10600, Havana, Cuba
    Clin Sci (Lond) 110:563-73. 2006
    ..In view of these findings, further studies appear justified...
  21. ncbi request reprint Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease
    David A van Heel
    Gastroenterology Section, Imperial College London Hammersmith Campus, UK
    Eur J Immunol 36:1629-35. 2006
    ..Responses to specific NOD1 agonists are unaffected by NOD2 genotype, suggesting independent action of the NOD1 and NOD2 pathways...
  22. ncbi request reprint Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    David A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
    Lancet 365:1794-6. 2005
    ....
  23. ncbi request reprint Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis
    A Mahmood
    Department of Gastroenterology, Imperial College, Hammersmith Hospital Campus, London, UK
    Aliment Pharmacol Ther 21:1357-64. 2005
    ..Current treatment of ulcerative colitis is imperfect. Trefoil peptides are known to stimulate repair in many models of injury, including animal models of colitis...
  24. pmc Gastroprotective effects of oral nucleotide administration
    A Belo
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:165-71. 2006
    ..However, there has been only limited scientific study regarding the true biological activity of orally administered nucleotides. We therefore tested their efficacy in a variety of models of epithelial injury and repair...
  25. ncbi request reprint Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor
    Paul A Kitchen
    St Mark s Hospital, Imperial College London, Harrow, United Kingdom
    JPEN J Parenter Enteral Nutr 29:248-54. 2005
    ..We report studies aimed to determine whether there may be synergistic effects of these 2 peptides...
  26. ncbi request reprint Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor gamma ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells--potential for dietary modulation of peroxisome proliferator-activated r
    Rachel Marion-Letellier
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, United Kingdom
    Am J Clin Nutr 87:939-48. 2008
    ..The fatty acid content of defined formula diets may play a role in mediating the antiinflammatory effect, but the mechanism is unclear...
  27. ncbi request reprint Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium
    Matt Butler
    Department of Gastroenterology, Imperial College London Faculty of Medicine, London, UK
    Eur J Immunol 36:864-74. 2006
    ..Thus, polarised epithelial cell monolayers create a 'tolerogenic' environment which modulates the activity of DC. These results highlight the regulatory importance of the epithelial microenvironment at mucosal surfaces...
  28. ncbi request reprint Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Am J Clin Nutr 72:5-14. 2000
    ..We therefore discuss the therapeutic possibilities of using whole colostrum, or individual peptides present in colostrum, for the treatment of various gastrointestinal diseases and the relative merits of the 2 approaches...
  29. ncbi request reprint Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury
    T Marchbank
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Aliment Pharmacol Ther 28:799-804. 2008
    ..A partially hydrolysed and dried product of pacific whiting fish is marketed as a health food supplement supporting 'intestinal health'...
  30. ncbi request reprint Current practice in surveillance strategy for patients with Barrett's oesophagus in the UK
    A Mandal
    Department of Gastroenterology, Leicester General Hospital, Leicester, UK
    Aliment Pharmacol Ther 17:1319-24. 2003
    ..Many guidelines exist regarding the surveillance of patients with Barrett's oesophagus. There are limited data, however, with regard to whether practitioners follow these guidelines...
  31. pmc Human transforming growth factor alpha (TGF-alpha) is digested to a smaller (1-43), less biologically active, form in acidic gastric juice
    T Marchbank
    Imperial College Faculty of Medicine, Department of Gastroenterology, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Gut 51:787-92. 2002
    ..Transforming growth factor alpha (TGF-alpha) is a 50 amino acid peptide with potent proliferative and cytoprotective activity present in gastric mucosa and juice...
  32. ncbi request reprint Does the response of the intestinal epithelium to keratinocyte growth factor vary according to the method of administration?
    R A Goodlad
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    Regul Pept 87:83-90. 2000
    ..However the most efficacious route and method of administration is unclear...
  33. ncbi request reprint Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    Clin Sci (Lond) 100:627-33. 2001
    ..These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans...
  34. pmc Antagonist: endoscopic surveillance of patients with Barrett's oesophagus
    R J Playford
    Gastroenterology Section, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    Gut 51:314-5. 2002
  35. pmc Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damage
    Jorge Berlanga
    Center for Genetic Engineering and Biotechnology, Havana, Cuba
    Am J Pathol 161:373-9. 2002
    ..These studies provide preliminary evidence that EGF is a novel therapy for the early treatment or prevention of intestinal damage and multiorgan failure resulting from mesenteric hypoperfusion...
  36. ncbi request reprint A common CTLA4 haplotype associated with coeliac disease
    Karen A Hunt
    Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Eur J Hum Genet 13:440-4. 2005
    ..Loss of tolerance to dietary antigens in coeliac disease may be mediated in part by heritable variants in co-signalling genes regulating T-cell responses...
  37. ncbi request reprint Surveillance for Barrett's oesophagus: is there light the end of the metaplastic tunnel?
    A C Belo
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, DuCane Road, London, W12 0NN, UK
    Surgeon 1:152-6. 2003
    ..This review highlights some of the areas of controversy and outstanding points that need to be clarified to allow establishment of evidence-based medicine for this condition...
  38. ncbi request reprint Cost analysis of breath test versus endoscopy for dyspepsia
    I Gee
    Department of Gastroenterology, Leicester General Hospital, Leicester, UK
    Digestion 65:207-12. 2002
    ..We aim to perform a cost analysis of a test and treat strategy for Helicobacter pylori versus endoscopy using data based on the breath test service in Leicester...
  39. pmc Homeobox genes: going for growth
    R J Playford
    Gastroenterology Section, Department of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, UK
    Gut 50:447-8. 2002
  40. ncbi request reprint Once you start, you can't stop
    Houman Ashrafian
    Gastroenterology Unit Imperial College School of Medicine, Hammersmith Hospital, W12 OHS, London, UK
    Lancet 359:226. 2002
  41. ncbi request reprint Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis
    Atul Sinha
    Department of Gastroenterology, Leicester Royal Infirmary, Leicester, United Kingdom
    N Engl J Med 349:350-7. 2003
    ..Epidermal growth factor (EGF) is a potent mitogenic peptide produced by salivary glands. We examined whether EGF enemas are an effective treatment for active left-sided ulcerative colitis and ulceration limited to the rectum (proctitis)...
  42. ncbi request reprint Genetic variation in myosin IXB is associated with ulcerative colitis
    Adriaan A van Bodegraven
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    Gastroenterology 131:1768-74. 2006
    ..These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease...
  43. ncbi request reprint Bioactive natural compounds for the treatment of gastrointestinal disorders
    Subrata Ghosh
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Clin Sci (Lond) 104:547-56. 2003
    ....
  44. ncbi request reprint Nitric oxide regulates the release of somatostatin from cultured gastric rabbit primary D-cells
    Naila Arebi
    Department of Gastroenterology, Hammersmith Hospital, Imperial College School of Medicine, London, United Kingdom
    Gastroenterology 123:566-76. 2002
    ..Mucosal somatostatin is diminished in H. pylori gastritis, where production of nitric oxide (NO) is increased. Therefore, we investigated the role of NO in D-cell function and the effects of prolonged exposure of D-cells to NO...