R J Playford

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Am J Clin Nutr 72:5-14. 2000
  2. ncbi request reprint Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    Clin Sci (Lond) 100:627-33. 2001
  3. pmc Homeobox genes: going for growth
    R J Playford
    Gastroenterology Section, Department of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, UK
    Gut 50:447-8. 2002
  4. pmc Antagonist: endoscopic surveillance of patients with Barrett's oesophagus
    R J Playford
    Gastroenterology Section, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    Gut 51:314-5. 2002
  5. pmc Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
    A Mahmood
    Department of Gastroenterology, Imperial College London, UK
    Gut 56:168-75. 2007
  6. ncbi request reprint Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury
    T Marchbank
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Aliment Pharmacol Ther 28:799-804. 2008
  7. ncbi request reprint Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Peptides 25:793-801. 2004
  8. pmc Reparative properties of a commercial fish protein hydrolysate preparation
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 54:775-81. 2005
  9. pmc Gastroprotective effects of oral nucleotide administration
    A Belo
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:165-71. 2006
  10. ncbi request reprint Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis
    A Mahmood
    Department of Gastroenterology, Imperial College, Hammersmith Hospital Campus, London, UK
    Aliment Pharmacol Ther 21:1357-64. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Am J Clin Nutr 72:5-14. 2000
    ..We therefore discuss the therapeutic possibilities of using whole colostrum, or individual peptides present in colostrum, for the treatment of various gastrointestinal diseases and the relative merits of the 2 approaches...
  2. ncbi request reprint Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability
    R J Playford
    Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    Clin Sci (Lond) 100:627-33. 2001
    ..These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans...
  3. pmc Homeobox genes: going for growth
    R J Playford
    Gastroenterology Section, Department of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, UK
    Gut 50:447-8. 2002
  4. pmc Antagonist: endoscopic surveillance of patients with Barrett's oesophagus
    R J Playford
    Gastroenterology Section, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN, UK
    Gut 51:314-5. 2002
  5. pmc Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
    A Mahmood
    Department of Gastroenterology, Imperial College London, UK
    Gut 56:168-75. 2007
    ..Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited...
  6. ncbi request reprint Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury
    T Marchbank
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Aliment Pharmacol Ther 28:799-804. 2008
    ..A partially hydrolysed and dried product of pacific whiting fish is marketed as a health food supplement supporting 'intestinal health'...
  7. ncbi request reprint Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    Peptides 25:793-801. 2004
    ....
  8. pmc Reparative properties of a commercial fish protein hydrolysate preparation
    A J Fitzgerald
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 54:775-81. 2005
    ..A partially hydrolysed and dried product of pacific whiting fish is currently marketed as a health food supplement to support "intestinal health". However, there has been only limited scientific study regarding its true biological activity...
  9. pmc Gastroprotective effects of oral nucleotide administration
    A Belo
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:165-71. 2006
    ..However, there has been only limited scientific study regarding the true biological activity of orally administered nucleotides. We therefore tested their efficacy in a variety of models of epithelial injury and repair...
  10. ncbi request reprint Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis
    A Mahmood
    Department of Gastroenterology, Imperial College, Hammersmith Hospital Campus, London, UK
    Aliment Pharmacol Ther 21:1357-64. 2005
    ..Current treatment of ulcerative colitis is imperfect. Trefoil peptides are known to stimulate repair in many models of injury, including animal models of colitis...
  11. ncbi request reprint Cytokines and growth factor modulators in intestinal inflammation and repair
    R J Playford
    Imperial College, London, UK
    J Pathol 205:417-25. 2005
    ..This review summarizes current thoughts on the use of these factors in general, but with particular emphasis on inflammatory bowel disease...
  12. ncbi request reprint Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice
    O Bashir
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Clin Sci (Lond) 105:323-30. 2003
    ..EGF did not initiate polyp formation in control or Min mice. However, as polyp size is an important determinant for subsequent risk of malignant change in human colon cancer, further studies appear justified...
  13. ncbi request reprint Dietary microparticles implicated in Crohn's disease can impair macrophage phagocytic activity and act as adjuvants in the presence of bacterial stimuli
    M Butler
    Department of Gastroenterology, Imperial College London, Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Inflamm Res 56:353-61. 2007
    ..These are taken up by M cells, accumulate in gut macrophages, and may influence the aetiology of inflammatory bowel diseases (IBD)...
  14. ncbi request reprint Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice
    T Marchbank
    Department of Gastroenterology, Hammersmith Hospital, Imperial College School of Medicine, London W12 0NN, United Kingdom
    J Biol Chem 276:24088-96. 2001
    ..01). Overexpression of TFF3 stabilizes the mucosa against noxious agents, supporting its role in mucosal protection/repair. It may therefore provide a novel approach to the prevention and/or treatment of intestinal ulceration...
  15. ncbi request reprint Does the response of the intestinal epithelium to keratinocyte growth factor vary according to the method of administration?
    R A Goodlad
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    Regul Pept 87:83-90. 2000
    ..However the most efficacious route and method of administration is unclear...
  16. pmc New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett's oesophagus
    R J Playford
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:442. 2006
  17. pmc Is thiopurine therapy in ulcerative colitis as effective as in Crohn's disease?
    S Ghosh
    Imperial College London, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:6-8. 2006
  18. pmc Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
    D A van Heel
    Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Gut 54:1553-7. 2005
    ..TLR9 is functional in the intestinal epithelium where it is most strongly expressed in Paneth cells...
  19. ncbi request reprint Surveillance for Barrett's oesophagus: is there light the end of the metaplastic tunnel?
    A C Belo
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, DuCane Road, London, W12 0NN, UK
    Surgeon 1:152-6. 2003
    ..This review highlights some of the areas of controversy and outstanding points that need to be clarified to allow establishment of evidence-based medicine for this condition...
  20. pmc Effects of growth factors and receptor blockade on gastrointestinal cancer
    R J Playford
    Gastroenterology Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Gut 53:1059-63. 2004
    ..Similarly, peptide and non-peptide antagonists of growth factor receptors show great potential as novel antichemotherapy agents. However, their actual place in clinical practice has yet to be established...
  21. ncbi request reprint Current practice in surveillance strategy for patients with Barrett's oesophagus in the UK
    A Mandal
    Department of Gastroenterology, Leicester General Hospital, Leicester, UK
    Aliment Pharmacol Ther 17:1319-24. 2003
    ..Many guidelines exist regarding the surveillance of patients with Barrett's oesophagus. There are limited data, however, with regard to whether practitioners follow these guidelines...
  22. pmc Human transforming growth factor alpha (TGF-alpha) is digested to a smaller (1-43), less biologically active, form in acidic gastric juice
    T Marchbank
    Imperial College Faculty of Medicine, Department of Gastroenterology, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Gut 51:787-92. 2002
    ..Transforming growth factor alpha (TGF-alpha) is a 50 amino acid peptide with potent proliferative and cytoprotective activity present in gastric mucosa and juice...
  23. pmc Probiotics in inflammatory bowel disease: is it all gut flora modulation?
    S Ghosh
    Gastroentrology Section, Division of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Gut 53:620-2. 2004
  24. pmc Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
    F Beck
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne 3052, Australia
    Proc Natl Acad Sci U S A 96:7318-23. 1999
    ..This intercalary growth in a restricted space results in the formation of the polypoid lesions observed...