M C Pickering

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency
    Marieta M Ruseva
    Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom
    J Am Soc Nephrol 24:43-52. 2013
  2. pmc Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor H-related protein 5 deficiency
    Katherine A Vernon
    Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom
    Am J Kidney Dis 60:121-5. 2012
  3. pmc A hybrid CFHR3-1 gene causes familial C3 glomerulopathy
    Talat H Malik
    Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom
    J Am Soc Nephrol 23:1155-60. 2012
  4. pmc Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase
    Danielle Paixao-Cavalcante
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Mol Immunol 46:1942-50. 2009
  5. pmc Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice
    M C Pickering
    Rheumatology Section and Department of Histopathology, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 103:9649-54. 2006
  6. pmc Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals
    M C Pickering
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Clin Exp Immunol 151:210-30. 2008
  7. pmc Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
    Matthew C Pickering
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London W12 0NN, England, UK
    J Exp Med 204:1249-56. 2007
  8. pmc Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice
    D Paixao-Cavalcante
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Clin Exp Immunol 155:339-47. 2009
  9. ncbi request reprint Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice
    M C Pickering
    Rheumatology Section, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    J Invest Dermatol 117:52-8. 2001
  10. pmc Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant
    K A Vernon
    Centre for Complement and Inflammation Research, Division of Immunology and Inflammation, Faculty of Medicine, Imperial College, London, UK
    Am J Transplant 11:152-5. 2011

Collaborators

Detail Information

Publications23

  1. pmc Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency
    Marieta M Ruseva
    Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom
    J Am Soc Nephrol 24:43-52. 2013
    ..In summary, during uncontrolled activation of C3 driven by complete CFH deficiency, properdin influences the intraglomerular localization of C3, suggesting that therapeutic inhibition of properdin would be detrimental in this setting...
  2. pmc Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor H-related protein 5 deficiency
    Katherine A Vernon
    Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom
    Am J Kidney Dis 60:121-5. 2012
    ..We speculate that this heterozygous CFHR5 sequence variant is a risk factor for the development of chronic kidney disease after streptococcal infection...
  3. pmc A hybrid CFHR3-1 gene causes familial C3 glomerulopathy
    Talat H Malik
    Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom
    J Am Soc Nephrol 23:1155-60. 2012
    ..In addition to identifying an association between these genetic observations and complement-mediated kidney disease, these results provide insight into the protective role of the combined deletion of CFHR3 and CFHR1 in IgA nephropathy...
  4. pmc Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase
    Danielle Paixao-Cavalcante
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Mol Immunol 46:1942-50. 2009
    ..The implication is that successful therapy of DDD is likely to be achieved by therapies that inhibit C3 turnover in plasma...
  5. pmc Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice
    M C Pickering
    Rheumatology Section and Department of Histopathology, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 103:9649-54. 2006
    ....
  6. pmc Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals
    M C Pickering
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Clin Exp Immunol 151:210-30. 2008
    ....
  7. pmc Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
    Matthew C Pickering
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London W12 0NN, England, UK
    J Exp Med 204:1249-56. 2007
    ....
  8. pmc Shiga toxin-2 results in renal tubular injury but not thrombotic microangiopathy in heterozygous factor H-deficient mice
    D Paixao-Cavalcante
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
    Clin Exp Immunol 155:339-47. 2009
    ..In summary, Stx-2 administration did not result in TMA in either Cfh(+/-) or wild-type C57BL/6 mice. Furthermore, haploinsufficiency of factor H did not alter the development of Stx-2-induced renal tubular injury...
  9. ncbi request reprint Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice
    M C Pickering
    Rheumatology Section, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    J Invest Dermatol 117:52-8. 2001
    ..Our findings suggest that C1q does not play a critical role in the physiologic clearance of apoptotic murine keratinocytes in vivo...
  10. pmc Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant
    K A Vernon
    Centre for Complement and Inflammation Research, Division of Immunology and Inflammation, Faculty of Medicine, Imperial College, London, UK
    Am J Transplant 11:152-5. 2011
    ..Strikingly, histological changes of CFHR5 nephropathy were evident in the donor kidney 46 days post-transplantation. This unique case demonstrates that renal-derived CFHR5 protein cannot prevent the development of CFHR5 nephropathy...
  11. doi request reprint Successful renal transplantation in factor H autoantibody associated HUS with CFHR1 and 3 deficiency and CFH variant G2850T
    A M Waters
    Department of Nephro urology, Great Ormond Street Hospital for Children NHS Trust, and Faculty of Medicine, Imperial College, London, UK
    Am J Transplant 10:168-72. 2010
    ..Furthermore, delineation of the functional significance of CFH-autoantibodies is warranted in individual cases...
  12. pmc Complement alternative pathway genetic variation and Dengue infection in the Thai population
    R Kraivong
    Molecular Immunology, Imperial College, London, UK
    Clin Exp Immunol 174:326-34. 2013
    ..We conclude that the complotype does not influence secondary Dengue infection severity in the Thai population. ..
  13. ncbi request reprint Eosinophilic myopathic syndromes
    M C Pickering
    Division of Medicine, Imperial College School of Medicine, London, UK
    Curr Opin Rheumatol 10:504-10. 1998
    ..This report describes the various conditions in which eosinophilic myopathy occurs and reviews the current state of knowledge of eosinophilic myopathy...
  14. ncbi request reprint C1q deficiency and autoimmunity: the effects of genetic background on disease expression
    Daniel A Mitchell
    Rheumatology Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, UK W12 0NN
    J Immunol 168:2538-43. 2002
    ..The work also highlights the potential value of the C1q-deficient MRL/Mp(+/+) strain as a tool with which to dissect further the underlying mechanisms of the autoimmune syndrome associated with C1q deficiency...
  15. ncbi request reprint Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H
    Matthew C Pickering
    Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nat Genet 31:424-8. 2002
    ..Thus, uncontrolled C3 activation in vivo is essential for the development of MPGN associated with deficiency of factor H...
  16. pmc Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
    Kirsten L Rose
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom
    J Clin Invest 118:608-18. 2008
    ....
  17. pmc The development of atypical hemolytic uremic syndrome depends on complement C5
    Elena Goicoechea de Jorge
    Complement and Inflammation Section, Division of Immunology and Inflammation, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Am Soc Nephrol 22:137-45. 2011
    ..This study provides a rationale to investigate therapeutic inhibition of C5 in human aHUS...
  18. pmc Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis
    Daniel P Gale
    Division of Medicine, University College, London, UK
    Lancet 376:794-801. 2010
    ..We aimed to establish the genetic basis for a familial disorder of complement regulation associated with persistent microscopic haematuria, recurrent macroscopic haematuria, glomerulonephritis, and progressive renal failure...
  19. pmc P2X7 deficiency attenuates renal injury in experimental glomerulonephritis
    Simon R J Taylor
    MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
    J Am Soc Nephrol 20:1275-81. 2009
    ..These results support a proinflammatory role for P2X7 in immune-mediated renal injury and suggest that the P2X7 receptor is a potential therapeutic target...
  20. ncbi request reprint New approaches to the treatment of dense deposit disease
    Richard J H Smith
    Department of Internal Medicine and Otolaryngology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    J Am Soc Nephrol 18:2447-56. 2007
    ..As the understanding of DDD increases, novel therapies should be integrated into existing protocols for DDD and evaluated using an open-label Bayesian study design...
  21. ncbi request reprint The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford, GB
    Eur J Immunol 32:1888-96. 2002
    ..These results demonstrate that mAb209, in addition to its role as an FDC marker, is a valuable reagent for the analysis of complement deposition in vivo...
  22. ncbi request reprint Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness
    Jessy J Alexander
    Section of Nephrology, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 16:52-7. 2005
    ..Once deposited in glomeruli, excessive complement activation can lead to glomerular inflammation and the rapid development of a scarring phenotype...
  23. pmc Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction
    Peter J Coffey
    Division of Cellular Therapy, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 104:16651-6. 2007
    ..Collectively, these data show that, in the absence of any specific exogenous challenge to the innate immune system, CFH is critically required for the long-term functional health of the retina...