Affiliation: Imperial College
- Kidney function in the very elderly with hypertension: data from the hypertension in the very elderly (HYVET) trialRuth Peters
Imperial College London, London, UK
Age Ageing 42:253-8. 2013..numerous reports have linked impaired kidney function to a higher risk of cardiovascular events and mortality. There are relatively few data relating to kidney function in the very elderly...
- Impact of transiently elevated diastolic pressure on cause of death: 29-year follow-up from the General Practice Hypertension Study GroupRuth Peters
Imperial College London, London, UK
J Hypertens 31:71-6. 2013..The emphasis has shifted over time from diastolic pressure to systolic pressure and variability in blood pressure. This study examined the impact of transient and sustained diastolic hypertension on later mortality...
- Blood pressure, smoking and alcohol use, association with vascular dementiaRuth Peters
Imperial Clinical Trials Unit, School of Public Health, St Mary s Campus, London W2 1PG, USA
Exp Gerontol 47:865-72. 2012..This review will concentrate on the prevention of dementia and attempt to provide an overview of the evidence relating to vascular related dementia and the potential risk factors of hypertension, alcohol use and smoking behaviour...
- Vascular risk factors and cognitive function among 3763 participants in the Hypertension in the Very Elderly Trial (HYVET): a cross-sectional analysisRuth Peters
Care of the Elderly, Imperial College Faculty of Medicine, London, U K
Int Psychogeriatr 21:359-68. 2009..It is well known that the global population is aging and that those over the age of 80 are the fastest growing part of this expansion. Also known is that prevalence of hypertension and cognitive decline both increase with increasing age...
- The prevention of dementiaRuth Peters
Imperial College Faculty of Medicine, Hammersmith Campus, London, UK
Int J Geriatr Psychiatry 24:452-8. 2009..Dementia is prevalent in older adults and the population is ageing. Many factors have been associated with dementia and anything that may aid the prevention of dementia is of importance...
- Smoking, dementia and cognitive decline in the elderly, a systematic reviewRuth Peters
Experimental Medicine and Toxicology Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, UK
BMC Geriatr 8:36. 2008..Cardiovascular risk factors have been linked to increased risk of dementia. A previous meta-analysis found that current smokers were at higher risk of subsequent dementia, Alzheimer's disease, vascular dementia and cognitive decline...
- Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVETRuth Peters
Care of the Elderly, Faculty of Medicine, Imperial College London, W12 0NN, UK
Age Ageing 38:521-7. 2009..Dementia risk also increases with age and is thought to be higher in hypertensives...
- Hypertension, dementia, and antihypertensive treatment: implications for the very elderlyRuth Peters
Faculty of Medicine, Imperial College London, Exhibition Road, London W120NN, United Kingdom
Curr Hypertens Rep 11:277-82. 2009..Meta-analyses used to explore this area further are inconclusive, and comparative trials are now required...
- Cardiovascular and biochemical risk factors for incident dementia in the Hypertension in the Very Elderly TrialRuth Peters
Care of the Elderly Imperial College, Du Cane Rd London W12 0NN, UK
J Hypertens 27:2055-62. 2009..The aim of these analyses was to examine the impact of baseline cardiovascular and biochemical factors upon incident dementia and cognitive decline in a very elderly hypertensive group...
- Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the Hypertension in the Very Elderly Trial (HYVET)Ruth Peters
Imperial College London, UK
Age Ageing 39:439-45. 2010..depression is common in elderly people and may be associated with increased cardiovascular risk and incident dementia...
- The effect of treatment based on a diuretic (indapamide) +/- ACE inhibitor (perindopril) on fractures in the Hypertension in the Very Elderly Trial (HYVET)Ruth Peters
Imperial College Faculty of Medicine, Hammersmith Campus Du Cane Road, London UK
Age Ageing 39:609-16. 2010..fractures may have serious implications in an elderly individual, and fracture prevention may include a careful choice of medications...
- Modelling cognitive decline in the Hypertension in the Very Elderly Trial [HYVET] and proposed risk tables for population useRuth Peters
Imperial Clinical Trials Unit, Imperial College London, London, United Kingdom
PLoS ONE 5:e11775. 2010..Here, we modelled dynamics of cognition in relation to the treatment of hypertension, to see if treatment effects might better be discerned by a model that included baseline measures of cognition and consequent mortality..
- Predictive value of the Clock Drawing Test. A review of the literatureRuth Peters
Care of the Elderly, Imperial College Faculty of Medicine, Hammersmith Campus, London, UK
Dement Geriatr Cogn Disord 26:351-5. 2008..The Clock Drawing Test (CDT) assesses cognition focusing on executive function and praxis in contrast to the more language-based Mini-Mental State Exam. The CDT may allow early identification of cognitive decline...
- Haemoglobin, anaemia, dementia and cognitive decline in the elderly, a systematic reviewRuth Peters
Experimental Medicine and Toxicology, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
BMC Geriatr 8:18. 2008..The elderly are more at risk of developing dementia and are also more likely to suffer from anaemia, although there is relatively little longitudinal literature addressing this association...
- Ageing and the brainR Peters
Care of the Elderly, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
Postgrad Med J 82:84-8. 2006..A healthy life both physically and mentally may be the best defence against the changes of an ageing brain. Additional measures to prevent cardiovascular disease may also be important...
- A substudy protocol of the hypertension in the Very Elderly Trial assessing cognitive decline and dementia incidence (HYVET-COG) : An ongoing randomised, double-blind, placebo-controlled trialRuth Peters
Imperial College School of Medicine, Section of Elderly Care, Hammersmith Hospital, London, UK
Drugs Aging 23:83-92. 2006..The objective of this protocol is to determine whether treatment of hypertension in this very elderly group affects the incidence of dementia and decline in cognitive function during the period of the HYVET trial...
- Alcohol, dementia and cognitive decline in the elderly: a systematic reviewRuth Peters
Imperial College, London, UK
Age Ageing 37:505-12. 2008..Alcohol has known negative effects in large quantities but may be protective for the cardiovascular system in smaller amounts. Effect of alcohol intake may be greater in the elderly and may impact on cognition...
- Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trialRuth Peters
Care of the Elderly, Imperial College London, London, UK
Lancet Neurol 7:683-9. 2008..The Hypertension in the Very Elderly trial (HYVET) was designed to assess the risks and benefits of treatment of hypertension in elderly patients and included an assessment of cognitive function...
- Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial - HYVETRuth Peters
aImperial College London UK bDepartment of Cardiovascular Diseases, The Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, University of Leuven, Leuven, Belgium cCentre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China dHôpital Broca, Centre de Gerontologie, 54 56 Rue Pascal, 75013 Paris France eLondon School of Hygiene and Tropical Medicine, London, UK
J Hypertens 31:1868-75. 2013..There is some evidence to suggest a potential 'J'-shaped relationship between DBP and risk of cognitive impairment. This was investigated using data from the HYpertension in the Very Elderly Trial (HYVET)...
- Treatment of hypertension in patients 80 years of age or olderNigel S Beckett
Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
N Engl J Med 358:1887-98. 2008..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
- Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET)Christopher John Bulpitt
Imperial College, Hammersmith Hospital, Care of the Elderly, London, UK
Blood Press 18:17-22. 2009..Those with prior cardiovascular disease had an excess of the known cardiovascular risk factors. The baseline characteristics provide a basis for further understanding of the HYVET results, which have been published recently...
- Validity of the Clock-Drawing Test as a screening tool for cognitive impairment in the elderlyYuji Nishiwaki
Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
Am J Epidemiol 160:797-807. 2004..The authors conclude that the CDT may have value as a brief face-to-face screening tool for moderate/severe cognitive impairment in an older community population but is relatively poor at detecting milder cognitive impairment...
- Does white coat hypertension require treatment over age 80?: Results of the hypertension in the very elderly trial ambulatory blood pressure side projectChristopher J Bulpitt
Department of Medicine, Imperial College London, London, United Kingdom
Hypertension 61:89-94. 2013..Because we estimate that 50% had white coat hypertension in the main study, this condition may benefit from treatment in the very elderly...
- Results of the pilot study for the Hypertension in the Very Elderly TrialChristopher J Bulpitt
Faculty of Medicine, Imperial College London, UK
J Hypertens 21:2409-17. 2003..The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction in stroke events of 36% may have to be balanced against a 14% increase in total mortality...
- Rationale and methodology of monitoring ambulatory blood pressure and arterial compliance in the Hypertension in the Very Elderly TrialElisabete Pinto
Faculty of Medicine, Imperial College London, Hammersmith Campus, UK
Blood Press Monit 11:3-8. 2006..This is a side project of the Hypertension in the Very Elderly Trial...
- Subgroup and per-protocol analyses from the Hypertension in the Very Elderly TrialNigel Beckett
aImperial College London, Faculty of Medicine, London, UK bMedical University of Milano, Cardiovascular Rehabilitation and Cardiac Disease Unit, Milan, Italy cMater Hospital, Dublin, Ireland dHypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Belgium eDepartment Hypertension and Diabetology, Meical University of Gdansk, Poland fWhitby Group Practice, Whitby gLondon School of Hygiene and Tropical Medicine, London, UK All committee members and investigators are listed in the On line Supplement
J Hypertens 32:1478-87; discussion 1487. 2014..The results of the Hypertension in the Very Elderly Trial showed positive benefits from blood pressure-lowering treatment in those aged 80 and over...
- Prevalence and covariates of electrocardiographic left ventricular hypertrophy in the Hypertension in the Very Elderly TrialRiitta L Antikainen
Care of the Elderly, Imperial College, London, UK
J Hypertens 31:1224-32. 2013..To estimate the prevalence and covariates of electrocardiographic left ventricular hypertrophy (LVH) in the Hypertension in the Very Elderly Trial...
- Treating hypertension in the very elderly-benefits, risks, and future directions, a focus on the hypertension in the very elderly trialRuth Peters
School of Public Health, Imperial College London, London, UK
Eur Heart J 35:1712-8. 2014..Questions remain as to the level of benefit that would be accrued in the frailer elderly and those at extreme age, for example, over 90...
- Literature review of the Clock Drawing Test as a tool for cognitive screeningElisabete Pinto
Care of the Elderly, Faculty of Medicine, Imperial College London, London, UK
Dement Geriatr Cogn Disord 27:201-13. 2009..This systematic review aims to present and discuss the CDT scoring methods available in the literature, in order to find differences in administration and utility of the CDT...
- Does additional feeding support provided by health care assistants improve nutritional status and outcome in acutely ill older in-patients?--a randomised control trialMary Hickson
Department of Nutrition and Dietetics, Hammersmith Hospitals NHS Trust, Du Cane Road, London W12 0HS, UK
Clin Nutr 23:69-77. 2004..The aim was to examine whether health care assistants, trained to provide additional support with feeding, can improve acutely ill elderly in-patients' clinical outcomes...
- Benefit-risk assessment in a post-market setting: a case study integrating real-life experience into benefit-risk methodologyChristine E Hallgreen
School of Public Health, Imperial College London, London, UK
Pharmacoepidemiol Drug Saf 23:974-83. 2014..This case study investigates this specific situation by applying a formal benefit-risk framework to assess the benefit-risk balance of warfarin for primary prevention of patients with atrial fibrillation...
- A systematic review of calcium channel blocker use and cognitive decline/dementia in the elderlyRuth Peters
aImperial Clinical Trials Unit ICTU, Imperial College London, London bSchool of Health and Related Research ScHARR, University of Sheffield, Sheffield, UK
J Hypertens 32:1945-57; discussion 1957-8. 2014..Either result could have a large impact on a vulnerable population. The aim of this review was to assess the evidence relating CCB use to later cognitive decline or dementia in the very elderly...
- Romanian subjects entered in the hypertension in the very elderly trial (HYVET)D Dumitraşcui
Iuliu Hatieganu University of Medicine and Pharmacy, 3rd Medical Dept, Cluj Napoca, Romania
Rom J Intern Med 44:389-96. 2006..Some of these biochemical differences may reflect different methodologies employed in Romanian laboratories, but we could not confirm this possibility...
- Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control studyMalcolm C Pike
USC Norris Comprehensive Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA
Fertil Steril 82:186-95. 2004..To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer)...
- Galactose-1-phosphate uridyl transferase (GALT) genotype and phenotype, galactose consumption, and the risk of borderline and invasive ovarian cancer (United States)Wendy Cozen
Department of Preventive Medicine, USC Keck School of Medicine, USC Norris Cancer Center, Los Angeles, CA 90033, USA
Cancer Causes Control 13:113-20. 2002..We examined these issues as part of a large case-control study of ovarian cancer conducted in Los Angeles between 1992 and 1998...