Research Topics
Genomes and GenesSpecies | James Edward PeaseSummaryAffiliation: Imperial College Country: UK Publications
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Publications
Targeting chemokine receptors in allergic diseaseJames E Pease
Leukocyte Biology, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Faculty of Medicine, Imperial College London, London, UK
Biochem J 434:11-24. 2011..In the present review, I detail the roles of chemokines and their receptors in allergic disease and also highlight current progress in the development of relevant chemokine receptor antagonists...
Small molecule antagonists of chemokine receptors--is promiscuity a virtue?James E Pease
Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK
Curr Top Med Chem 10:1351-8. 2010..It may be that a more permissive approach, targeting several chemokine receptors with a single molecule will provide the next generation of anti-inflammatory drugs...- Chemokine receptor antagonists: part 2James E Pease
Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Leukocyte Biology Section, London, UK
Expert Opin Ther Pat 19:199-221. 2009..The first part of this two-part review discussed approaches to generating antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and CCR4... - Chemokine receptor antagonists: Part 1James E Pease
Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Leukocyte Biology Section, South Kensington Campus, London SW7 2AZ, UK
Expert Opin Ther Pat 19:39-58. 2009..Because of their diverse role in autoimmune diseases and AIDS, chemokines and their receptors, which belong to the G-protein-coupled receptor superfamily, have been considered good drug targets by the pharmaceutical industry... 
Tails of the unexpected - an atypical receptor for the chemokine RANTES/CCL5 expressed in brainJ E Pease
Leukocyte Biology Section, Faculty of Medicine, Imperial College London, National Heart and Lung Institute, South Kensington Campus, London, UK
Br J Pharmacol 149:460-2. 2006..Since this peptide is implicated in the pathogenesis of Alzheimer's disease, it may be that exploitation of this signalling pathway presents itself as a future therapeutic treatment...- Chemokines and their receptors in allergic diseaseJames Edward Pease
Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, South Kensington Campus, Imperial College London, Exhibition Road, London SW7 2AZ
J Allergy Clin Immunol 118:305-18; quiz 319-20. 2006..This provides the opportunity for the development of therapeutic compounds designed to suppress the recruitment of particular leukocyte types in allergic reactions... - Asthma, allergy and chemokinesJames E Pease
Leukocyte Biology Section, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ, UK
Curr Drug Targets 7:3-12. 2006..In this review, we will examine recent developments in the field and highlight the roles of other chemokine:chemokine receptor axes implicated in leukocyte recruitment during allergic inflammation... - CCR1 antagonists in clinical developmentJames E Pease
Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK
Expert Opin Investig Drugs 14:785-96. 2005..The developments made in antagonising this receptor and efficacies of these compounds in the clinical setting are also highlighted... - Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?E Wise
Leukocyte Biology Section, NHLI Division, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Biochem Soc Trans 35:755-9. 2007..In this review we discuss these findings and conclude that these small-molecule agonists might be exploited to further our understanding of the molecular mechanisms by which chemokine receptors are activated... - CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11Georgina Xanthou
Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, GB
Eur J Immunol 33:2241-50. 2003..Such interplay may serve to finely tune inflammatory responses in vivo... - Eotaxin and asthmaJ E Pease
Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
Curr Opin Pharmacol 1:248-53. 2001..Such compounds may be developed into orally available drugs aimed at preventing eosinophil recruitment and, hence, the pathogenesis associated with the activation of these cells within the lung tissue... - The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2bR Martinelli
Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College of Science, Technology, and Medicine, South Kensington, London SW7 2AZ, United Kingdom
J Biol Chem 276:42957-64. 2001.... - Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathwaysI Sabroe
Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, South Kensington, London, United Kingdom
J Immunol 162:2946-55. 1999..The observed up-regulation of MIP-1alpha signaling via non-CCR3 pathways may play a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung... - The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart diseaseSarah J Petit
Leukocyte Biology Section, Division, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Exhibition Rd, SW7 2AZ London, United Kingdom
Arterioscler Thromb Vasc Biol 31:914-20. 2011..Here, we examined the effect of the single-nucleotide polymorphisms on CXCL16 function and assessed the association of the mutant allele with coronary heart disease (CHD)... - Roles of chemokines in the regulation of leucocyte recruitmentI Sabroe
Section of Leukocyte Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ, UK
Clin Sci (Lond) 100:359-62. 2001..The story of the eotaxin receptor, CCR3, and its central role in allergic inflammation illustrates that therapeutic antagonism of these pathways is imminently achievable...