James E Pease

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation
    J E Pease
    Krebs Institute, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 273:19972-6. 1998
  2. ncbi request reprint Eotaxin and asthma
    J E Pease
    Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
    Curr Opin Pharmacol 1:248-53. 2001
  3. ncbi request reprint The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy
    James E Pease
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, UK
    Am J Respir Med 1:19-25. 2002
  4. pmc The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor
    Andrea Meiser
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington Campus, London, UK
    J Immunol 180:6713-24. 2008
  5. pmc Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy
    Jonathan M Viney
    Leukocyte Biology Section, Medical Research Council Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Immunol 192:3419-27. 2014
  6. pmc Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation
    Emma L Wise
    Leukocyte Biology Section, National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 282:27935-43. 2007
  7. ncbi request reprint The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner
    Ian Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College London, UK
    Eur J Immunol 35:1301-10. 2005
  8. pmc CCR4 blockade does not inhibit allergic airways inflammation
    Dolores M Conroy
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Leukoc Biol 74:558-63. 2003
  9. ncbi request reprint Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist
    James M Fox
    National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 281:36652-61. 2006
  10. ncbi request reprint Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist
    Filipa Lopes de Mendonça
    Leukocyte Biology, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 280:4808-16. 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation
    J E Pease
    Krebs Institute, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 273:19972-6. 1998
    ..Agents that bind to the N-terminal segments of CCR1 and CCR3 may be useful in blocking receptor function...
  2. ncbi request reprint Eotaxin and asthma
    J E Pease
    Division of Biomedical Sciences, Imperial College School of Medicine, London, UK
    Curr Opin Pharmacol 1:248-53. 2001
    ..Such compounds may be developed into orally available drugs aimed at preventing eosinophil recruitment and, hence, the pathogenesis associated with the activation of these cells within the lung tissue...
  3. ncbi request reprint The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy
    James E Pease
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, UK
    Am J Respir Med 1:19-25. 2002
    ..Clinical trials of such compounds will ultimately provide crucial information currently lacking and will define whether or not IL-8 blockade provides future therapy in pulmonary disease...
  4. pmc The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor
    Andrea Meiser
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington Campus, London, UK
    J Immunol 180:6713-24. 2008
    ....
  5. pmc Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy
    Jonathan M Viney
    Leukocyte Biology Section, Medical Research Council Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Immunol 192:3419-27. 2014
    ..This finding suggests that the selective blockade of CCR4 in allergy may be feasible when one CCR4 ligand dominates, allowing the inhibition of Th2 signaling via one ligand while sparing regulatory T cell recruitment via another. ..
  6. pmc Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation
    Emma L Wise
    Leukocyte Biology Section, National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 282:27935-43. 2007
    ..We conclude that both agonists and antagonists of CCR3 appear to occupy overlapping sites within the transmembrane helical bundle, suggesting a fine line between agonism and antagonism of chemokine receptors...
  7. ncbi request reprint The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner
    Ian Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College London, UK
    Eur J Immunol 35:1301-10. 2005
    ..Thus, the CCR3 C terminus contains distinct domains responsible for the regulation of receptor desensitization and for coupling to chemotactic responses...
  8. pmc CCR4 blockade does not inhibit allergic airways inflammation
    Dolores M Conroy
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, United Kingdom
    J Leukoc Biol 74:558-63. 2003
    ..This study casts doubts on the validity of CCR4 as a therapeutic target in the treatment of asthma...
  9. ncbi request reprint Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist
    James M Fox
    National Heart and Lung Institute Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 281:36652-61. 2006
    ....
  10. ncbi request reprint Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist
    Filipa Lopes de Mendonça
    Leukocyte Biology, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 280:4808-16. 2005
    ..Insights into the mechanism of action of these compounds may facilitate the development of more potent antagonists that show promise as future therapeutic agents in the treatment of inflammatory disease...
  11. doi request reprint Human labour is associated with a decline in myometrial chemokine receptor expression: the role of prostaglandins, oxytocin and cytokines
    Renyi Hua
    Imperial College Parturition Research Group, Academic Department of Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK
    Am J Reprod Immunol 69:21-32. 2013
    ..Myometrial cells also express chemokine receptors, but there is little information about their behaviour or function during pregnancy and labour...
  12. ncbi request reprint Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter
    Rhian M Phillips
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Immunol 170:6190-201. 2003
    ..Identification of a functional CCR1 promoter will facilitate the study of possible genetic determinants underlying this potentially important clinical phenotype...
  13. pmc The attraction of chemokines as a target for specific anti-inflammatory therapy
    James E Pease
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ
    Br J Pharmacol 147:S212-21. 2006
    ..In this article, we will give a short history of the discovery of chemokines and provide examples of the potential for therapeutic targeting of the chemokine network in inflammatory disease...
  14. ncbi request reprint Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines
    Cécile E Duchesnes
    Leukocyte Biology and Section, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
    Mol Immunol 43:1221-31. 2006
    ..Determining how these chemokines interact with their receptor at the molecular level should increase our understanding of the process of chemokine receptor activation...
  15. doi request reprint CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3
    Anja Mueller
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK j
    J Leukoc Biol 83:875-82. 2008
    ..In such a setting, antagonism of the CXCR3/CXCL4 axis may represent a useful, therapeutic intervention...
  16. ncbi request reprint CCR4 in human allergen-induced late responses in the skin and lung
    Kayhan T Nouri-Aria
    Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:1933-8. 2002
    ..CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner...
  17. pmc Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3
    Belinda Nedjai
    Leukocyte Biology Section, NHLI Division, Faculty of Medicine, Imperial College London, UK
    Br J Pharmacol 166:912-23. 2012
    ..Here, we describe the molecular mechanism by which two synthetic small molecule agonists activate CXCR3...
  18. doi request reprint A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane
    Emma L Wise
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 126:150-7.e2. 2010
    ..Non-synonymous single nucleotide polymorphisms (SNPs) within the ccr3 gene have previously been described, with little information regarding their effects on CCR3 function...
  19. doi request reprint The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart disease
    Sarah J Petit
    Leukocyte Biology Section, Division, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Exhibition Rd, SW7 2AZ London, United Kingdom
    Arterioscler Thromb Vasc Biol 31:914-20. 2011
    ..Here, we examined the effect of the single-nucleotide polymorphisms on CXCL16 function and assessed the association of the mutant allele with coronary heart disease (CHD)...
  20. ncbi request reprint Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines
    Fiona J Culley
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, London, GB
    Eur J Immunol 33:1302-10. 2003
    ..This suggests that cell surface proteoglycans are not necessary for signaling via CCR3. However, the GAG context in which chemokines are expressed is likely to represent an important level of regulation of allergic inflammation...
  21. ncbi request reprint Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation
    Georgina Xanthou
    Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London, GB
    Eur J Immunol 33:2927-36. 2003
    ..The development of antagonists targeting the second extracellular loop of CXCR3 should impede receptor activation and aid the treatment of several human inflammatory disorders...
  22. ncbi request reprint Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways
    I Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, South Kensington, London, United Kingdom
    J Immunol 162:2946-55. 1999
    ..The observed up-regulation of MIP-1alpha signaling via non-CCR3 pathways may play a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung...
  23. doi request reprint Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1
    Celine N Parmentier
    King s College London, London, UK
    J Allergy Clin Immunol 129:1136-42. 2012
    ..Recent data have implicated CysLTs in the establishment and amplification of T(H)2 responses in murine models, although the precise mechanisms are unresolved...
  24. ncbi request reprint Small molecule antagonists of chemokine receptors--is promiscuity a virtue?
    James E Pease
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK
    Curr Top Med Chem 10:1351-8. 2010
    ..It may be that a more permissive approach, targeting several chemokine receptors with a single molecule will provide the next generation of anti-inflammatory drugs...
  25. ncbi request reprint Roles of chemokines in the regulation of leucocyte recruitment
    I Sabroe
    Section of Leukocyte Biology, Division of Biomedical Sciences, Imperial College School of Medicine, London SW7 2AZ, UK
    Clin Sci (Lond) 100:359-62. 2001
    ..The story of the eotaxin receptor, CCR3, and its central role in allergic inflammation illustrates that therapeutic antagonism of these pathways is imminently achievable...
  26. ncbi request reprint Asthma, allergy and chemokines
    James E Pease
    Leukocyte Biology Section, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Curr Drug Targets 7:3-12. 2006
    ..In this review, we will examine recent developments in the field and highlight the roles of other chemokine:chemokine receptor axes implicated in leukocyte recruitment during allergic inflammation...
  27. doi request reprint Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16
    Sarah J Petit
    NHLI Division, Leukocyte Biology Section, Faculty of Medicine, Imperial College London, London, UK
    Eur J Immunol 38:2337-50. 2008
    ..Collectively, our data suggest a novel paradigm for the CXCR6:CXCL16 interaction, a finding which may impact the discovery of small-molecule antagonists of CXCR6...
  28. ncbi request reprint Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function
    Hilary Sandig
    Department of Asthma, Allergy and Respiratory Science, King s College London, 5th Floor Thomas Guy House, Guy s Hospital, London, UK
    J Leukoc Biol 81:372-82. 2007
    ..This review is concerned with the diverse responses induced in leukocytes by PGD(2) and its metabolites and the signaling mechanisms which are thought to be responsible for them...
  29. pmc The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo
    Sarah J Collington
    Leukocyte Biology Section, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, South Kensington, London, United Kingdom
    J Immunol 184:6114-23. 2010
    ..These experiments revealed a new function of SCF in chemokine receptor coupling, but they suggest a complex role of the CCL2/CCR2 axis in recruiting MCps during pulmonary inflammation...
  30. ncbi request reprint The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b
    R Martinelli
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College of Science, Technology, and Medicine, South Kensington, London SW7 2AZ, United Kingdom
    J Biol Chem 276:42957-64. 2001
    ....
  31. doi request reprint Stretch and inflammatory cytokines drive myometrial chemokine expression via NF-κB activation
    Renyi Hua
    Imperial College Parturition Research Group, Academic Department of Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Endocrinology 153:481-91. 2012
    ..These data suggest that the modulation of NF-κB activity may be of potential benefit in the management of PTL...
  32. doi request reprint Chemokine receptor antagonists: part 2
    James E Pease
    Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Leukocyte Biology Section, London, UK
    Expert Opin Ther Pat 19:199-221. 2009
    ..The first part of this two-part review discussed approaches to generating antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and CCR4...
  33. doi request reprint Chemokine receptor antagonists: Part 1
    James E Pease
    Faculty of Medicine National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Leukocyte Biology Section, South Kensington Campus, London SW7 2AZ, UK
    Expert Opin Ther Pat 19:39-58. 2009
    ..Because of their diverse role in autoimmune diseases and AIDS, chemokines and their receptors, which belong to the G-protein-coupled receptor superfamily, have been considered good drug targets by the pharmaceutical industry...
  34. doi request reprint Targeting chemokine receptors in allergic disease
    James E Pease
    Leukocyte Biology, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, NHLI Division, Faculty of Medicine, Imperial College London, London, UK
    Biochem J 434:11-24. 2011
    ..In the present review, I detail the roles of chemokines and their receptors in allergic disease and also highlight current progress in the development of relevant chemokine receptor antagonists...
  35. pmc A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG
    J Henry Evans
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Eur J Immunol 41:1924-33. 2011
    ..Thus, HLA-DR expression marks a distinct subset of NK cells, present at low frequency in circulating blood but readily expanded by IL-2, that can play an important role during immune responses to BCG...
  36. pmc Chemokines, innate and adaptive immunity, and respiratory disease
    I Sabroe
    Division of Genomic Medicine, University of Sheffield, UK
    Eur Respir J 19:350-5. 2002
    ..Chemokines are fundamental regulators of leukocyte homeostasis and inflammation, and their antagonism by small molecule chemokine receptor antagonists may be of enormous importance in the future treatment of human respiratory disease...
  37. doi request reprint CCL17/thymus and activation-regulated chemokine induces calcitonin gene-related peptide in human airway epithelial cells through CCR4
    Kandace Bonner
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 132:942-50.e1-3. 2013
    ..Increased airway epithelial cell expression of CGRP, together with increased CCL17 expression, was previously observed in a model of provoked asthma in atopic human subjects...
  38. ncbi request reprint The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody
    Louise A Jopling
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, United Kingdom
    J Biol Chem 277:6864-73. 2002
    ..Subsequent analysis of chimeric chemokine receptors indicated that 10E4, a functional inhibitor of gpCCR4 responses, recognized the amino terminus of CCR4...
  39. ncbi request reprint CCR1 antagonists in clinical development
    James E Pease
    Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK
    Expert Opin Investig Drugs 14:785-96. 2005
    ..The developments made in antagonising this receptor and efficacies of these compounds in the clinical setting are also highlighted...
  40. pmc Tails of the unexpected - an atypical receptor for the chemokine RANTES/CCL5 expressed in brain
    J E Pease
    Leukocyte Biology Section, Faculty of Medicine, Imperial College London, National Heart and Lung Institute, South Kensington Campus, London, UK
    Br J Pharmacol 149:460-2. 2006
    ..Since this peptide is implicated in the pathogenesis of Alzheimer's disease, it may be that exploitation of this signalling pathway presents itself as a future therapeutic treatment...
  41. ncbi request reprint Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?
    E Wise
    Leukocyte Biology Section, NHLI Division, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Biochem Soc Trans 35:755-9. 2007
    ..In this review we discuss these findings and conclude that these small-molecule agonists might be exploited to further our understanding of the molecular mechanisms by which chemokine receptors are activated...