S Patterson

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Analysis of human immunodeficiency virus type 1 (HIV-1) variants and levels of infection in dendritic and T cells from symptomatic HIV-1-infected patients
    S Patterson
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    J Gen Virol 79:247-57. 1998
  2. ncbi request reprint Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1
    S Patterson
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park, Institute for Medical Research, Harrow, Middlesex, UK
    Immunol Lett 66:111-6. 1999
  3. ncbi request reprint Relationship between V3 sequences of HIV type 1 from plasma, T cells, and dendritic cells suggests that plasma virus may arise from different cell sources
    S Patterson
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    AIDS Res Hum Retroviruses 17:179-84. 2001
  4. pmc Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus
    S Patterson
    Department of Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    J Virol 75:6710-3. 2001
  5. pmc Retrovirus-induced immunosuppression via blocking of dendritic cell migration and down-regulation of adhesion molecules
    D I Gabrilovich
    Antigen Presentation Research Group, Clinical Research Centre, Harrow, U K
    Immunology 82:82-7. 1994
  6. ncbi request reprint Murine retrovirus induces defects in the function of dendritic cells at early stages of infection
    D I Gabrilovich
    Antigen Presentation Group, Clinical Research Centre, Harrow, United Kingdom
    Cell Immunol 158:167-81. 1994
  7. ncbi request reprint Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load
    H Donaghy
    Department of Immunology, Imperial College School of Medicine, London, United Kingdom
    Blood 98:2574-6. 2001
  8. ncbi request reprint Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women
    M Prakash
    Department of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    J Reprod Immunol 52:101-11. 2001
  9. ncbi request reprint Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients
    G J Jones
    Imperial College of Science, Technology and Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, UK
    AIDS 15:1657-63. 2001
  10. ncbi request reprint Evaluation of the cervical cytobrush sampling technique for the preparation of CD45+ mononuclear cells from the human cervix
    M Prakash
    Department of Immunology, Imperial College of Science Technology and Medicine at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    J Immunol Methods 258:37-46. 2001

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Analysis of human immunodeficiency virus type 1 (HIV-1) variants and levels of infection in dendritic and T cells from symptomatic HIV-1-infected patients
    S Patterson
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    J Gen Virol 79:247-57. 1998
    ..This may reflect reduced interactions between DC and T cells in infected individuals and for the existence of variants with a stronger tropism for DC, which could play a role in transmission by initiating infection in mucosal DC...
  2. ncbi request reprint Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1
    S Patterson
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park, Institute for Medical Research, Harrow, Middlesex, UK
    Immunol Lett 66:111-6. 1999
    ..This study suggests that there are subpopulations of DC that show differences in susceptibility to infection with some strains of HIV-1...
  3. ncbi request reprint Relationship between V3 sequences of HIV type 1 from plasma, T cells, and dendritic cells suggests that plasma virus may arise from different cell sources
    S Patterson
    Antigen Presentation Research Group, Imperial College School of Medicine at Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    AIDS Res Hum Retroviruses 17:179-84. 2001
    ..However, for one patient there was evidence of differences between plasma virus and virus in the T cell population, with virus in the plasma showing a closer relationship to DC-derived sequences...
  4. pmc Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus
    S Patterson
    Department of Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    J Virol 75:6710-3. 2001
    ..Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC...
  5. pmc Retrovirus-induced immunosuppression via blocking of dendritic cell migration and down-regulation of adhesion molecules
    D I Gabrilovich
    Antigen Presentation Research Group, Clinical Research Centre, Harrow, U K
    Immunology 82:82-7. 1994
    ..A failure of DC migration could be an important immunosuppressive mechanism of RLV infection in mice and we speculate on a similar role for DC in human immunodeficiency virus-1 (HIV-1) infection in humans...
  6. ncbi request reprint Murine retrovirus induces defects in the function of dendritic cells at early stages of infection
    D I Gabrilovich
    Antigen Presentation Group, Clinical Research Centre, Harrow, United Kingdom
    Cell Immunol 158:167-81. 1994
    ..The changes in DC function may have implications for the pathogenesis of retroviral infections including HIV infection...
  7. ncbi request reprint Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load
    H Donaghy
    Department of Immunology, Imperial College School of Medicine, London, United Kingdom
    Blood 98:2574-6. 2001
    ..Both DC populations expressed CD4, CCR5, and CXCR4. The findings suggest that loss of DCs in HIV infection may contribute to disease progression...
  8. ncbi request reprint Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women
    M Prakash
    Department of Immunology, Imperial College of Science Technology and Medicine (ICSTM) at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    J Reprod Immunol 52:101-11. 2001
    ..Thus, the preferential transmission of macrophage tropic strains of HIV-1 following sexual contact cannot be explained solely on the expression of chemokine co-receptors by T lymphocyte subsets...
  9. ncbi request reprint Comparative loss and maturation of peripheral blood dendritic cell subpopulations in African and non-African HIV-1-infected patients
    G J Jones
    Imperial College of Science, Technology and Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, UK
    AIDS 15:1657-63. 2001
    ..There was no selective loss of either DC subpopulation, suggesting that the ability of DC to acquire and present antigens or to produce interferon-alpha may both be impaired in HIV-1 infection...
  10. ncbi request reprint Evaluation of the cervical cytobrush sampling technique for the preparation of CD45+ mononuclear cells from the human cervix
    M Prakash
    Department of Immunology, Imperial College of Science Technology and Medicine at Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    J Immunol Methods 258:37-46. 2001
    ..However, the need to monitor all samples for possible blood contamination was indicated by 4 of 13 samples in which B lymphocytes accounted for 2-8% of the mononuclear cells...
  11. pmc Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy
    A Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 170:212-21. 2012
    ..HAART restored normal expression levels of these receptors...
  12. ncbi request reprint Mechanism for dendritic cell dysfunction in retroviral infection of mice
    D I Gabrilovich
    Antigen Presentation Group, Imperial College of Science, Technology, and Medicine, Middlesex, United Kingdom
    Clin Immunol Immunopathol 80:139-46. 1996
    ..Since reduced stimulation by DC is also seen in HIV-1 infection in humans we speculate that a similar mechanism might operate in retroviral infection in man...
  13. pmc Macrophages are increased in cervical epithelium of women with cervicitis
    M Prakash
    Department of Genito-Urinary/HIV Medicine, ICSTM at Northwick Park and St Mark's Hospitals, Harrow, Middlesex, UK
    Sex Transm Infect 77:366-9. 2001
    ..CONCLUSION: The increased numbers of CE macrophages in women with cervicitis may have important implications for pathogenesis of STIs including human immunodeficiency virus infection...
  14. ncbi request reprint Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations
    J Stebbing
    Departments of Oncology and HIV Medicine, Chelsea and Westminster Hospital, London, UK
    Ann Oncol 14:1660-6. 2003
    ..Cytokines measured included tumour necrosis factor-alpha (TNF-alpha), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and the interleukins IL-2, -6 and -12...
  15. ncbi request reprint Analysis of full-length HIV type 1 env genes indicates differences between the virus infecting T cells and dendritic cells in peripheral blood of infected patients
    R S Daniels
    Virology Division, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    AIDS Res Hum Retroviruses 20:409-13. 2004
    ..These findings suggest that there may be distinct populations of HIV-1 variants infecting blood DC and T cells in patients showing slow and slow/standard disease progression...