David R J Owen

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?
    David R Owen
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 27:119-22. 2013
  2. pmc An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
    David R Owen
    Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 32:1-5. 2012
  3. doi Inflammation within carotid atherosclerotic plaque: assessment with late-phase contrast-enhanced US
    David R Owen
    Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, England
    Radiology 255:638-44. 2010
  4. pmc Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation
    David R Owen
    Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 30:1608-18. 2010
  5. pmc Mixed-affinity binding in humans with 18-kDa translocator protein ligands
    David R J Owen
    Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 52:24-32. 2011
  6. doi Imaging of atherosclerosis
    D R J Owen
    Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Annu Rev Med 62:25-40. 2011
  7. doi Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography
    Oliver Gaemperli
    Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, UK
    Eur Heart J 33:1902-10. 2012
  8. doi Late-phase contrast-enhanced ultrasound reflects biological features of instability in human carotid atherosclerosis
    Joseph Shalhoub
    Academic Section of Vascular Surgery, Department of Experimental Medicine, Imperial College London, and Charing Cross Hospital, London W6 8RF, UK
    Stroke 42:3634-6. 2011
  9. doi Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands
    David R J Owen
    Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Int Rev Neurobiol 101:19-39. 2011
  10. doi Identification and assessment of plasma lysozyme as a putative biomarker of atherosclerosis
    Vahitha B Abdul-Salam
    Experimental Medicine, Imperial College London, Du Cane Road, London W12 0NN, England
    Arterioscler Thromb Vasc Biol 30:1027-33. 2010

Detail Information

Publications12

  1. doi Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?
    David R Owen
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 27:119-22. 2013
    ..In this paper we discuss this issue in relation to psychiatry using a new and interesting example of how genotyping might help rescue an apparently failed novel treatment in anxiety disorders...
  2. pmc An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
    David R Owen
    Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 32:1-5. 2012
    ....
  3. doi Inflammation within carotid atherosclerotic plaque: assessment with late-phase contrast-enhanced US
    David R Owen
    Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, England
    Radiology 255:638-44. 2010
    ..To determine if the number of nontargeted microbubbles retained in human carotid plaque is sufficient to be detected with ultrasonography (US)...
  4. pmc Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation
    David R Owen
    Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 30:1608-18. 2010
    ..The functional significance of differences in binding characteristics warrants further investigation...
  5. pmc Mixed-affinity binding in humans with 18-kDa translocator protein ligands
    David R J Owen
    Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 52:24-32. 2011
    ....
  6. doi Imaging of atherosclerosis
    D R J Owen
    Department of Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Annu Rev Med 62:25-40. 2011
    ..Each technique has its own strengths and drawbacks. In this article, we review the various imaging modalities used for the evaluation and quantification of atherosclerosis...
  7. doi Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography
    Oliver Gaemperli
    Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Hammersmith Hospital, Imperial College, London, UK
    Eur Heart J 33:1902-10. 2012
    ....
  8. doi Late-phase contrast-enhanced ultrasound reflects biological features of instability in human carotid atherosclerosis
    Joseph Shalhoub
    Academic Section of Vascular Surgery, Department of Experimental Medicine, Imperial College London, and Charing Cross Hospital, London W6 8RF, UK
    Stroke 42:3634-6. 2011
    ..We hypothesized that microbubbles are retained in areas of plaque inflammation, aiming to examine whether LP-CEUS signal reflects plaque biology...
  9. doi Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands
    David R J Owen
    Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Int Rev Neurobiol 101:19-39. 2011
    ..This review describes the principles of PET imaging, the rationale and challenges in targeting the TSPO as means of quantifying microglial activation in vivo, and disease applications that have been studied with TSPO-PET hitherto...
  10. doi Identification and assessment of plasma lysozyme as a putative biomarker of atherosclerosis
    Vahitha B Abdul-Salam
    Experimental Medicine, Imperial College London, Du Cane Road, London W12 0NN, England
    Arterioscler Thromb Vasc Biol 30:1027-33. 2010
    ..To identify a plasma biomarker of atheromatous disease...
  11. doi Motion-sensitized driven equilibrium for blood-suppressed T2* mapping
    Rexford D Newbould
    GSK Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    J Magn Reson Imaging 34:702-9. 2011
    ..To combine a motion-sensitized driven equilibrium (MSDE) preparation with a multi-echo spoiled gradient-echo sequence (SPGR) to suppress the blood signal intensity in T2* mapping of carotid plaques and liver...
  12. doi Towards molecular imaging of multiple sclerosis
    David R J Owen
    Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, UK
    Mult Scler 17:262-72. 2011
    ..In the future, molecular imaging could assist clinical decision-making with patient stratification for optimization of treatment selection...