Darlington O Okonko

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
  2. doi request reprint Suppression of erythropoiesis in patients with chronic heart failure and anaemia of unknown origin: evidence of an immune basis
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Int J Cardiol 166:664-71. 2013
  3. ncbi request reprint Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Circulation 117:3020-30. 2008
  4. doi request reprint Impaired heart rate response to exercise in adult patients with a systemic right ventricle or univentricular circulation: prevalence, relation to exercise, and potential therapeutic implications
    Gerhard Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton, Hospital, Sydney Street, London, UK
    Int J Cardiol 134:59-66. 2009
  5. doi request reprint Erythropoietin resistance contributes to anaemia in chronic heart failure and relates to aberrant JAK-STAT signal transduction
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Int J Cardiol 164:359-64. 2013
  6. ncbi request reprint Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival
    Konstantinos Dimopoulos
    Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom
    Circulation 113:2796-802. 2006
  7. doi request reprint Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 58:1241-51. 2011
  8. ncbi request reprint Anemia in chronic heart failure: pathogenetic mechanisms
    Darlington O Okonko
    Imperial College, NHLI, Department of Clinical Cardiology, London, United Kingdom
    J Card Fail 10:S5-9. 2004
  9. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
  10. ncbi request reprint Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure
    Gabor Foldes
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 124:80-5. 2008

Detail Information

Publications15

  1. doi request reprint Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    ..We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency...
  2. doi request reprint Suppression of erythropoiesis in patients with chronic heart failure and anaemia of unknown origin: evidence of an immune basis
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Int J Cardiol 166:664-71. 2013
    ..We tested the hypothesis that unexplained anaemia in CHF might be subsequent to diminished erythropoiesis as a result of an immune-mediated suppression of erythroid colony formation...
  3. ncbi request reprint Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Circulation 117:3020-30. 2008
    ..We speculated that PAH patients are deficient in circulating endothelial progenitor cells (EPCs), potentially contributing to endothelial dysfunction and disease progression...
  4. doi request reprint Impaired heart rate response to exercise in adult patients with a systemic right ventricle or univentricular circulation: prevalence, relation to exercise, and potential therapeutic implications
    Gerhard Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton, Hospital, Sydney Street, London, UK
    Int J Cardiol 134:59-66. 2009
    ..We aimed to investigate the association of CI with exercise capacity, and evaluate whether CI is causally related to exercise intolerance...
  5. doi request reprint Erythropoietin resistance contributes to anaemia in chronic heart failure and relates to aberrant JAK-STAT signal transduction
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Int J Cardiol 164:359-64. 2013
    ..We tested the hypothesis that this might be due to Epo resistance and investigated whether any defects apparent were due to Epo receptor (EpoR) downregulation and/or impaired Epo-induced signal transduction...
  6. ncbi request reprint Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival
    Konstantinos Dimopoulos
    Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom
    Circulation 113:2796-802. 2006
    ..We sought to establish the distribution, relation to cyanosis, and prognostic value of the V(E)/V(CO2) slope across a wide spectrum of ACHD patients...
  7. doi request reprint Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival
    Darlington O Okonko
    Clinical Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 58:1241-51. 2011
    ..The aim of this study was to comprehensively delineate iron metabolism and its implications in patients with chronic heart failure (CHF)...
  8. ncbi request reprint Anemia in chronic heart failure: pathogenetic mechanisms
    Darlington O Okonko
    Imperial College, NHLI, Department of Clinical Cardiology, London, United Kingdom
    J Card Fail 10:S5-9. 2004
    ..Few studies have investigated the mechanisms of anemia in CHF. There is a need for such studies...
  9. ncbi request reprint Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure
    Wolfram Doehner
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Am Coll Cardiol 46:1019-26. 2005
    ..The aim of this study was to determine the significance of insulin resistance as an independent risk factor for impaired prognosis in patients with chronic heart failure (CHF)...
  10. ncbi request reprint Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure
    Gabor Foldes
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Int J Cardiol 124:80-5. 2008
    ..Innate immune activation mediated by myocardial Toll-like receptors (TLRs) is involved in cardiovascular disease. The function and role of TLRs on peripheral leukocytes in human chronic heart failure (CHF) are not known...
  11. ncbi request reprint Blood viscosity and its relationship to iron deficiency, symptoms, and exercise capacity in adults with cyanotic congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Centre, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, England
    J Am Coll Cardiol 48:356-65. 2006
    ..This study sought to determine the relationship between blood viscosity and iron deficiency and their impact on symptoms and exercise function in adults with cyanotic congenital heart disease...
  12. ncbi request reprint Anaemia of chronic disease in chronic heart failure: the emerging evidence
    Darlington O Okonko
    Eur Heart J 26:2213-4. 2005
  13. ncbi request reprint Statins: a treatment option for chronic heart failure?
    Stephan von Haehling
    National Heart and Lung Institute, Department of Clinical Cardiology, Imperial College School of Medicine, London, UK
    Heart Fail Monit 4:90-7. 2004
    ..It is therefore tempting to speculate that low doses of statins still confer pleiotropic effects without lowering plasma cholesterol levels...
  14. ncbi request reprint Vagal nerve stimulation in chronic heart failure: an antiinflammatory intervention?
    Jochen Springer
    Circulation 110:e34; author reply e34. 2004
  15. ncbi request reprint A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy
    Fernando A Botoni
    Postgraduate Course of Tropical Medicine, University Hospital, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Am Heart J 153:544.e1-8. 2007
    ..The objective of this study was to determine the safety and efficacy of renin-angiotensin system (RAS) inhibitors and beta-blockers in chronic Chagas cardiomyopathy...