David J Nutt

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Rationale for, barriers to, and appropriate medication for the long-term treatment of depression
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e02. 2010
  2. ncbi International consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e08. 2010
  3. ncbi Drug harms in the UK: a multicriteria decision analysis
    David J Nutt
    Neuropsychopharmacology Unit, Imperial College, London, UK
    Lancet 376:1558-65. 2010
  4. ncbi What one hand giveth the other taketh away: some unpredicted effects of enantiomers in psychopharmacology
    David J Nutt
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:1137-41. 2010
  5. ncbi Antagonist-agonist combinations as therapies for heroin addiction: back to the future?
    David J Nutt
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:141-5. 2010
  6. ncbi Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics
    David J Nutt
    Department of Neuropsychopharmacology and Molecular Imaging, Division of Neuroscience and Mental Health, Imperial College London, London, UK
    J Psychopharmacol 24:1601-12. 2010
  7. ncbi Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008
    Steven Kealey
    Institute of Psychiatry, De Crespigny Park, King s College London, London, United Kingdom
    J Nucl Med 54:139-44. 2013
  8. ncbi History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
  9. ncbi Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, University of Bristol, Bristol BS8 2BN, United Kingdom
    Proc Natl Acad Sci U S A 109:2138-43. 2012
  10. ncbi Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
    Alessandro Colasanti
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom
    Biol Psychiatry 72:371-7. 2012

Detail Information

Publications23

  1. ncbi Rationale for, barriers to, and appropriate medication for the long-term treatment of depression
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e02. 2010
    ....
  2. ncbi International consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e08. 2010
    ....
  3. ncbi Drug harms in the UK: a multicriteria decision analysis
    David J Nutt
    Neuropsychopharmacology Unit, Imperial College, London, UK
    Lancet 376:1558-65. 2010
    ..Proper assessment of the harms caused by the misuse of drugs can inform policy makers in health, policing, and social care. We aimed to apply multicriteria decision analysis (MCDA) modelling to a range of drug harms in the UK...
  4. ncbi What one hand giveth the other taketh away: some unpredicted effects of enantiomers in psychopharmacology
    David J Nutt
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:1137-41. 2010
    ....
  5. ncbi Antagonist-agonist combinations as therapies for heroin addiction: back to the future?
    David J Nutt
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:141-5. 2010
    ..These principles, however, can be applied to other disorders as and when other pharmacological approaches become refined in these areas...
  6. ncbi Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics
    David J Nutt
    Department of Neuropsychopharmacology and Molecular Imaging, Division of Neuroscience and Mental Health, Imperial College London, London, UK
    J Psychopharmacol 24:1601-12. 2010
    ....
  7. ncbi Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008
    Steven Kealey
    Institute of Psychiatry, De Crespigny Park, King s College London, London, United Kingdom
    J Nucl Med 54:139-44. 2013
    ..In this study, BU99008 was radiolabeled with (11)C in order to image the I(2) binding sites in vivo using PET...
  8. ncbi History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
    ..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability...
  9. ncbi Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, University of Bristol, Bristol BS8 2BN, United Kingdom
    Proc Natl Acad Sci U S A 109:2138-43. 2012
    ..These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition...
  10. ncbi Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
    Alessandro Colasanti
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom
    Biol Psychiatry 72:371-7. 2012
    ..We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET)...
  11. ncbi Sleep and its disorders in translational medicine
    Louise M Paterson
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 25:1226-34. 2011
    ..This review provides examples of how research findings within the sleep field have been translated between animal models, healthy volunteers and patient populations with particular focus on the serotonergic system...
  12. ncbi Measuring endogenous 5-HT release by emission tomography: promises and pitfalls
    Louise M Paterson
    Imperial College London, UK
    J Cereb Blood Flow Metab 30:1682-706. 2010
    ....
  13. ncbi History of cigarette smoking is associated with higher limbic GABAA receptor availability
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neuroimage 69:70-7. 2013
    ....
  14. ncbi GABAB receptors in addiction and its treatment
    Robin J Tyacke
    Neuropsychopharmacology Unit, Division of Experimental Medicine and Therapeutics, Imperial College London, London, UK
    Adv Pharmacol 58:373-96. 2010
    ..This potential is at present poorly understood or studied and warrants further investigation...
  15. ncbi Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline₂ binding site
    Robin J Tyacke
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, United Kingdom
    Synapse 66:542-51. 2012
    ..This, and the amenability of BU99008 (6) to radiolabeling with a positron-emitting radioisotope, indicates its potential as a PET radioligand for imaging the I₂BS in vivo...
  16. ncbi The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study
    Andrew J Montgomery
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
    Synapse 61:637-45. 2007
    ..These results support a role for the DA system in nicotine addiction, but reveal a more complex relationship than suggested by studies in animals...
  17. ncbi 5-HT radioligands for human brain imaging with PET and SPECT
    Louise M Paterson
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Du Cane Road, London, United Kingdom
    Med Res Rev 33:54-111. 2013
    ....
  18. ncbi Harms associated with psychoactive substances: findings of the UK National Drug Survey
    Celia J A Morgan
    Clinical Psychopharmacology Unit, University College London, London, UK
    J Psychopharmacol 24:147-53. 2010
    ..They also suggest that the current UK legal classification system is not acting to inform users of the harms of psychoactive substances...
  19. ncbi The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 25:1562-7. 2011
    ..With appropriate care, this study supports the viability of functional magnetic resonance imaging work with psilocybin...
  20. ncbi Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
  21. ncbi Highlights of the international consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 72:e21. 2011
    ....
  22. ncbi Gender differences in brain serotonin transporter availability in panic disorder
    Eduard Maron
    Department of Neuropsychopharmacology and Molecular Imaging, Imperial College London, London, UK
    J Psychopharmacol 25:952-9. 2011
    ..Distinctive functioning of the 5-HT system in males and females may underlie certain gender-dependent differences in expressions of PD...
  23. ncbi Low sensitivity of the positron emission tomography ligand [11C]diprenorphine to agonist opiates
    Susan P Hume
    Hammersmith Imanet Ltd, Hammersmith Hospital, London, United Kingdom
    J Pharmacol Exp Ther 322:661-7. 2007
    ..Alternative means may be needed to address clinical issues regarding opioid receptor occupancy that are required to optimize treatment strategies...