David J Nutt

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Rationale for, barriers to, and appropriate medication for the long-term treatment of depression
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e02. 2010
  2. doi request reprint International consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e08. 2010
  3. doi request reprint CNS drug development in Europe--past progress and future challenges
    David J Nutt
    Centre for Neuropsychopharmacology, Imperial College, London, W12 0NN, UK Electronic address
    Neurobiol Dis 61:6-20. 2014
  4. doi request reprint Effects of Schedule I drug laws on neuroscience research and treatment innovation
    David J Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College, London, W12 0NN, UK
    Nat Rev Neurosci 14:577-85. 2013
  5. doi request reprint Addiction: lifestyle choice or medical diagnosis?
    David Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College, London, UK
    J Eval Clin Pract 19:493-6. 2013
  6. doi request reprint Drug harms in the UK: a multicriteria decision analysis
    David J Nutt
    Neuropsychopharmacology Unit, Imperial College, London, UK
    Lancet 376:1558-65. 2010
  7. doi request reprint Antagonist-agonist combinations as therapies for heroin addiction: back to the future?
    David J Nutt
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:141-5. 2010
  8. doi request reprint Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics
    David J Nutt
    Department of Neuropsychopharmacology and Molecular Imaging, Division of Neuroscience and Mental Health, Imperial College London, London, UK
    J Psychopharmacol 24:1601-12. 2010
  9. ncbi request reprint What one hand giveth the other taketh away: some unpredicted effects of enantiomers in psychopharmacology
    David J Nutt
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:1137-41. 2010
  10. ncbi request reprint Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain
    Christine A Parker
    Centre for Neuropsychopharmacology, Hammersmith Hospital, Imperial College London, United Kingdom
    J Nucl Med 55:838-44. 2014

Detail Information

Publications33

  1. doi request reprint Rationale for, barriers to, and appropriate medication for the long-term treatment of depression
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e02. 2010
    ....
  2. doi request reprint International consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e08. 2010
    ....
  3. doi request reprint CNS drug development in Europe--past progress and future challenges
    David J Nutt
    Centre for Neuropsychopharmacology, Imperial College, London, W12 0NN, UK Electronic address
    Neurobiol Dis 61:6-20. 2014
    ..There is a very real risk that without such an integrated approach to policy reforms, innovation in psychotropic medicines will become a 'desert' in the same way that it did for antibiotics in the 1990's. ..
  4. doi request reprint Effects of Schedule I drug laws on neuroscience research and treatment innovation
    David J Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College, London, W12 0NN, UK
    Nat Rev Neurosci 14:577-85. 2013
    ....
  5. doi request reprint Addiction: lifestyle choice or medical diagnosis?
    David Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College, London, UK
    J Eval Clin Pract 19:493-6. 2013
    ..In this paper, I detail these issues and suggest ways to avoid irreparable damage to the current care provisions that are proving effective...
  6. doi request reprint Drug harms in the UK: a multicriteria decision analysis
    David J Nutt
    Neuropsychopharmacology Unit, Imperial College, London, UK
    Lancet 376:1558-65. 2010
    ..Proper assessment of the harms caused by the misuse of drugs can inform policy makers in health, policing, and social care. We aimed to apply multicriteria decision analysis (MCDA) modelling to a range of drug harms in the UK...
  7. doi request reprint Antagonist-agonist combinations as therapies for heroin addiction: back to the future?
    David J Nutt
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:141-5. 2010
    ..These principles, however, can be applied to other disorders as and when other pharmacological approaches become refined in these areas...
  8. doi request reprint Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics
    David J Nutt
    Department of Neuropsychopharmacology and Molecular Imaging, Division of Neuroscience and Mental Health, Imperial College London, London, UK
    J Psychopharmacol 24:1601-12. 2010
    ....
  9. ncbi request reprint What one hand giveth the other taketh away: some unpredicted effects of enantiomers in psychopharmacology
    David J Nutt
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:1137-41. 2010
    ....
  10. ncbi request reprint Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain
    Christine A Parker
    Centre for Neuropsychopharmacology, Hammersmith Hospital, Imperial College London, United Kingdom
    J Nucl Med 55:838-44. 2014
    ....
  11. pmc Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis
    Robin L Carhart-Harris
    To whom correspondence should be addressed Imperial College London, Centre for Neuropsychopharmacology, Burlington Danes Building, 160 Du Cane Rd, London, UK
    Schizophr Bull 39:1343-51. 2013
    ..We suggest that this orthogonality is compromised in early psychosis, explaining similarities between its phenomenology and that of the psychedelic state and supporting the utility of psilocybin as a model of early psychosis. ..
  12. doi request reprint Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008
    Steven Kealey
    Institute of Psychiatry, De Crespigny Park, King s College London, London, United Kingdom
    J Nucl Med 54:139-44. 2013
    ..In this study, BU99008 was radiolabeled with (11)C in order to image the I(2) binding sites in vivo using PET...
  13. doi request reprint History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
    ..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability...
  14. pmc Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, University of Bristol, Bristol BS8 2BN, United Kingdom
    Proc Natl Acad Sci U S A 109:2138-43. 2012
    ..These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition...
  15. ncbi request reprint Broadband cortical desynchronization underlies the human psychedelic state
    Suresh D Muthukumaraswamy
    Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF119BJ, United Kingdom, Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom, Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom, Sir Peter Mansfield Magnetic Resonance Centre, Nottingham University, Nottingham NG7 2RD, United Kingdom, Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom, The Beckley Foundation, Beckley Park, Oxford OX3 9SY, United Kingdom, and Virginia Tech Carilion Research Institute, and Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Roanoke, Virginia 24016
    J Neurosci 33:15171-83. 2013
    ..These findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells...
  16. ncbi request reprint Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients
    Csaba Orban
    Centre for Neuropsychopharmacology, Imperial College London, London, UK
    Am J Drug Alcohol Abuse 39:433-40. 2013
    ..Neurobiological models of anxiety have proposed important roles for amygdala-insula and amygdala-medial prefrontal cortex interactions in the generation and regulation of anxiety states, respectively...
  17. doi request reprint History of cigarette smoking is associated with higher limbic GABAA receptor availability
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neuroimage 69:70-7. 2013
    ....
  18. doi request reprint Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
    Alessandro Colasanti
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom
    Biol Psychiatry 72:371-7. 2012
    ..We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET)...
  19. doi request reprint Sleep and its disorders in translational medicine
    Louise M Paterson
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 25:1226-34. 2011
    ..This review provides examples of how research findings within the sleep field have been translated between animal models, healthy volunteers and patient populations with particular focus on the serotonergic system...
  20. pmc Measuring endogenous 5-HT release by emission tomography: promises and pitfalls
    Louise M Paterson
    Imperial College London, UK
    J Cereb Blood Flow Metab 30:1682-706. 2010
    ....
  21. pmc In vivo imaging of cerebral dopamine D3 receptors in alcoholism
    David Erritzoe
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
    Neuropsychopharmacology 39:1703-12. 2014
    ..This may be relevant to the development of future therapeutic strategies to treat alcohol abuse...
  22. doi request reprint 5-HT radioligands for human brain imaging with PET and SPECT
    Louise M Paterson
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Du Cane Road, London, United Kingdom
    Med Res Rev 33:54-111. 2013
    ....
  23. ncbi request reprint GABAB receptors in addiction and its treatment
    Robin J Tyacke
    Neuropsychopharmacology Unit, Division of Experimental Medicine and Therapeutics, Imperial College London, London, UK
    Adv Pharmacol 58:373-96. 2010
    ..This potential is at present poorly understood or studied and warrants further investigation...
  24. pmc Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking study
    David R Owen
    Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
    J Cereb Blood Flow Metab 34:989-94. 2014
    ..Our estimates of [(11)C]PBR28 VND and hence BPND in the healthy human brain are consistent with in vitro predictions. XBD173 blockade provides a practical means of estimating VND for TSPO targeting radioligands. ..
  25. doi request reprint Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline₂ binding site
    Robin J Tyacke
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, United Kingdom
    Synapse 66:542-51. 2012
    ..This, and the amenability of BU99008 (6) to radiolabeling with a positron-emitting radioisotope, indicates its potential as a PET radioligand for imaging the I₂BS in vivo...
  26. ncbi request reprint The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study
    Andrew J Montgomery
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
    Synapse 61:637-45. 2007
    ..These results support a role for the DA system in nicotine addiction, but reveal a more complex relationship than suggested by studies in animals...
  27. doi request reprint Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?
    David R Owen
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 27:119-22. 2013
    ..In this paper we discuss this issue in relation to psychiatry using a new and interesting example of how genotyping might help rescue an apparently failed novel treatment in anxiety disorders...
  28. doi request reprint Highlights of the international consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 72:e21. 2011
    ....
  29. doi request reprint Gender differences in brain serotonin transporter availability in panic disorder
    Eduard Maron
    Department of Neuropsychopharmacology and Molecular Imaging, Imperial College London, London, UK
    J Psychopharmacol 25:952-9. 2011
    ..Distinctive functioning of the 5-HT system in males and females may underlie certain gender-dependent differences in expressions of PD...
  30. ncbi request reprint Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
  31. doi request reprint The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 25:1562-7. 2011
    ..With appropriate care, this study supports the viability of functional magnetic resonance imaging work with psilocybin...
  32. doi request reprint Harms associated with psychoactive substances: findings of the UK National Drug Survey
    Celia J A Morgan
    Clinical Psychopharmacology Unit, University College London, London, UK
    J Psychopharmacol 24:147-53. 2010
    ..They also suggest that the current UK legal classification system is not acting to inform users of the harms of psychoactive substances...
  33. ncbi request reprint Low sensitivity of the positron emission tomography ligand [11C]diprenorphine to agonist opiates
    Susan P Hume
    Hammersmith Imanet Ltd, Hammersmith Hospital, London, United Kingdom
    J Pharmacol Exp Ther 322:661-7. 2007
    ..Alternative means may be needed to address clinical issues regarding opioid receptor occupancy that are required to optimize treatment strategies...