Jeremy K Nicholson

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Metabolic phenotyping in clinical and surgical environments
    Jeremy K Nicholson
    Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Nature 491:384-92. 2012
  2. ncbi Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations
    Steven L Robinette
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Genome Med 4:30. 2012
  3. ncbi Host-gut microbiota metabolic interactions
    Jeremy K Nicholson
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Science 336:1262-7. 2012
  4. ncbi Piecewise multivariate modelling of sequential metabolic profiling data
    Mattias Rantalainen
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Umea, S 901 87, Sweden
    BMC Bioinformatics 9:105. 2008
  5. ncbi K-OPLS package: kernel-based orthogonal projections to latent structures for prediction and interpretation in feature space
    Max Bylesjo
    Research Group for Chemometrics, Department of Chemistry, Umea University, Umea, SE 901 87, Sweden
    BMC Bioinformatics 9:106. 2008
  6. ncbi Gut microorganisms, mammalian metabolism and personalized health care
    Jeremy K Nicholson
    Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 3:431-8. 2005
  7. ncbi Gut microbiome-host interactions in health and disease
    James M Kinross
    Section of Bimolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, The Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Genome Med 3:14. 2011
  8. ncbi Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy
    Jeremy K Nicholson
    Imperial College London, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Expert Opin Drug Metab Toxicol 8:135-9. 2012
  9. ncbi The challenges of modeling mammalian biocomplexity
    Jeremy K Nicholson
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Nat Biotechnol 22:1268-74. 2004
  10. ncbi Pharmacometabonomics as an effector for personalized medicine
    Jeremy K Nicholson
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Pharmacogenomics 12:103-11. 2011

Detail Information

Publications117 found, 100 shown here

  1. ncbi Metabolic phenotyping in clinical and surgical environments
    Jeremy K Nicholson
    Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Nature 491:384-92. 2012
    ..There have been many reports of direct applications of metabolic phenotyping in a clinical setting...
  2. ncbi Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations
    Steven L Robinette
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Genome Med 4:30. 2012
    ..These new data-fusion techniques will have important consequences in functional genomics, microbial metagenomics and disease modeling, the early results and implications of which are reviewed...
  3. ncbi Host-gut microbiota metabolic interactions
    Jeremy K Nicholson
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Science 336:1262-7. 2012
    ..A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health...
  4. ncbi Piecewise multivariate modelling of sequential metabolic profiling data
    Mattias Rantalainen
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Umea, S 901 87, Sweden
    BMC Bioinformatics 9:105. 2008
    ..In metabolic profiling studies, the sampling rate and number of sampling points are often restricted due to experimental and biological constraints...
  5. ncbi K-OPLS package: kernel-based orthogonal projections to latent structures for prediction and interpretation in feature space
    Max Bylesjo
    Research Group for Chemometrics, Department of Chemistry, Umea University, Umea, SE 901 87, Sweden
    BMC Bioinformatics 9:106. 2008
    ....
  6. ncbi Gut microorganisms, mammalian metabolism and personalized health care
    Jeremy K Nicholson
    Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 3:431-8. 2005
    ....
  7. ncbi Gut microbiome-host interactions in health and disease
    James M Kinross
    Section of Bimolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, The Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Genome Med 3:14. 2011
    ..We also describe possible avenues of research in this rapidly growing field with respect to future personalized healthcare strategies...
  8. ncbi Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy
    Jeremy K Nicholson
    Imperial College London, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Expert Opin Drug Metab Toxicol 8:135-9. 2012
    ..It is anticipated that as metabonomics analytical and statistical technologies continue to develop, more applications will be realised and these should find use in real clinical situations, even monitoring patients in real time...
  9. ncbi The challenges of modeling mammalian biocomplexity
    Jeremy K Nicholson
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Nat Biotechnol 22:1268-74. 2004
    ..We now need novel approaches to measure and model metabolic compartments in interacting cell types and genomes that are connected by cometabolic processes in symbiotic mammalian systems...
  10. ncbi Pharmacometabonomics as an effector for personalized medicine
    Jeremy K Nicholson
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Pharmacogenomics 12:103-11. 2011
    ..It could also find application in population-wide large cohort studies and in studies of nutrition where it would allow the elucidation of health risk factors and provide easily measured surrogate biomarkers...
  11. ncbi Experimental metabonomic model of dietary variation and stress interactions
    Yulan Wang
    Biological Chemistry, Biomedical Sciences Division, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom
    J Proteome Res 5:1535-42. 2006
    ..This work indicates that the different stressor types resulted in some common systemic metabolic responses that involve changes in energy and muscle metabolism, but that they are not reversible by dietary intervention...
  12. ncbi Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model
    Francois Pierre J Martin
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, UK
    Mol Syst Biol 4:157. 2008
    ....
  13. ncbi Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain
    Jasmina Saric
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Mol Syst Biol 6:396. 2010
    ....
  14. ncbi An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate
    Ivan K S Yap
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ United Kingdom
    J Proteome Res 5:2675-84. 2006
    ..This suggests disruption in lipid transport from the liver to plasma, which could arise through impaired apolipoprotein synthesis, as with ethionine...
  15. ncbi Human metabolic phenotype diversity and its association with diet and blood pressure
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Nature 453:396-400. 2008
    ..Metabolic phenotyping applied to high-quality epidemiological data offers the potential to develop an area of aetiopathogenetic knowledge involving discovery of novel biomarkers related to cardiovascular disease risk...
  16. ncbi Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model
    Francois Pierre J Martin
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, London, UK
    Mol Syst Biol 4:205. 2008
    ..These results provide evidence for the potential use of prebiotics for beneficially modifying the gut microbial balance as well as host energy and lipid homeostasis...
  17. ncbi Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents
    Alison Waldram
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington SW7 2AZ, United Kingdom
    J Proteome Res 8:2361-75. 2009
    ....
  18. ncbi Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents
    Jasmina Saric
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 9:2255-64. 2010
    ....
  19. ncbi Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
    Sandrine P Claus
    SORA Division, Department of Biomolecular Medicine, Imperial College London, London, UK
    Mol Syst Biol 4:219. 2008
    ....
  20. ncbi Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues
    Yulan Wang
    Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, SW7 2AZ London, UK
    Anal Biochem 323:26-32. 2003
    ..We have shown that subtle changes in the metabolic profiles can be selectively amplified using a metabonomics approach based on the different NMR spectral editing techniques in conjunction with PCA...
  21. ncbi A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
    Francois Pierre J Martin
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Mol Syst Biol 3:112. 2007
    ..These data indicate that the microbiome modulates absorption, storage and the energy harvest from the diet at the systems level...
  22. ncbi Stability and robustness of human metabolic phenotypes in response to sequential food challenges
    Silke S Heinzmann
    Biomolecular Medicine, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom
    J Proteome Res 11:643-55. 2012
    ....
  23. ncbi Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy
    Francois Pierre J Martin
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    J Proteome Res 6:1471-81. 2007
    ..These signals acted as reference profiles with which to compare changes in response to gut microbiota manipulation at the tissue level as demonstrated by ingestion of a bacterial probiotic...
  24. ncbi Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom
    J Proteome Res 8:5175-87. 2009
    ..This systems level metabonomic approach has provided new mechanistic insights into differential response to galN and is widely applicable to the study of interindividual variation in metabolism for any xenobiotic intervention...
  25. ncbi Hepatotoxin-induced hypertyrosinemia and its toxicological significance
    T Andrew Clayton
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Arch Toxicol 81:201-10. 2007
    ..This analysis may have implications for the interpretation of clinical measures of liver status such as Fischer's ratio and the branched-chain tyrosine ratio (BTR)...
  26. ncbi Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status
    T Andrew Clayton
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, London, UK
    Arch Toxicol 78:86-96. 2004
    ..The ethionine and ANIT data suggest that fatty liver (steatosis) and cholestatic damage may not be associated with hypercreatinaemia and hypercreatinuria...
  27. ncbi Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies
    Olivier Cloarec
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Anal Chem 77:517-26. 2005
    ....
  28. ncbi System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster
    Yulan Wang
    Biological Chemistry, Biomedical Sciences Division, Faculty of Life Science, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Mol Biochem Parasitol 146:1-9. 2006
    ..The major distinguishing consequence of a S. japonicum infection in the hamster was the inhibition of manufacture or utilization of short-chain fatty acids, when compared to a S. mansoni infection in the mouse...
  29. ncbi Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach
    Timothy M D Ebbels
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, United Kingdom
    J Proteome Res 6:4407-22. 2007
    ..This study constitutes the largest validation to date of the metabonomic approach to preclinical toxicology assessment, confirming that the methodology offers practical utility for rapid in vivo drug toxicity screening...
  30. ncbi High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
    Olaf Beckonert
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Nat Protoc 5:1019-32. 2010
    ....
  31. ncbi Understanding the role of gut microbiome-host metabolic signal disruption in health and disease
    Elaine Holmes
    Department of Surgery and Cancer, Imperial College London, London, UK
    Trends Microbiol 19:349-59. 2011
    ....
  32. ncbi Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma
    Anthony D Maher
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, London, UK
    Clin Chem 54:2063-6. 2008
    ..Although studies have revealed decreased sperm motility, the quantitative biochemical changes that underlie the infertility mechanism remain poorly understood...
  33. ncbi Pharmaco-metabonomic phenotyping and personalized drug treatment
    T Andrew Clayton
    Biological Chemistry, Biomedical Sciences Division, Faculty of Natural Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UK
    Nature 440:1073-7. 2006
    ..We show pre-dose prediction of an aspect of the urinary drug metabolite profile and an association between pre-dose urinary composition and the extent of liver damage sustained after paracetamol administration...
  34. ncbi Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice
    Claire L Gavaghan McKee
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, United Kingdom
    J Proteome Res 5:378-84. 2006
    ....
  35. ncbi Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    Marc-Emmanuel Dumas
    Department of Biological Chemistry, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 103:12511-6. 2006
    ..These data also indicate that gut microbiota may play an active role in the development of insulin resistance...
  36. ncbi A metabolic entropy approach for measurements of systemic metabolic disruptions in patho-physiological States
    Kirill A Veselkov
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, London SW7 2AZ, United Kingdom
    J Proteome Res 9:3537-44. 2010
    ....
  37. ncbi Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles
    Hector C Keun
    Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, United Kingdom
    Chem Res Toxicol 17:579-87. 2004
    ....
  38. ncbi Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies
    Elizabeth J Want
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK
    Anal Chem 82:5282-9. 2010
    ..The UPLC-MS approach to BA analysis offers a sensitive and reproducible tool that will be of great value in exploring both markers and mechanisms of hepatotoxicity and can readily be extended to clinical studies of liver damage...
  39. ncbi Summary recommendations for standardization and reporting of metabolic analyses
    John C Lindon
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Nat Biotechnol 23:833-8. 2005
  40. ncbi Biofluid 1H NMR-based metabonomic techniques in nutrition research - metabolic effects of dietary isoflavones in humans
    Kirty S Solanky
    Biological Chemistry, Faculty of Medicine, Imperial College of Science, Technology and Medicine, University of London, South Kensington, SW7 2AZ London, UK
    J Nutr Biochem 16:236-44. 2005
    ....
  41. ncbi Comparative metabonomics of differential hydrazine toxicity in the rat and mouse
    Mary E Bollard
    Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UK
    Toxicol Appl Pharmacol 204:135-51. 2005
    ..The greater magnitude of metabolic effects observed in the rat was supported by the more pronounced effect on liver pathology in the rat when compared with the mouse...
  42. ncbi Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption
    Silke S Heinzmann
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
    Am J Clin Nutr 92:436-43. 2010
    ..New food biomarkers are needed to objectively evaluate the effect of diet on health and to check adherence to dietary recommendations and healthy eating patterns...
  43. ncbi Analysis of time-related metabolic fluctuations induced by ethionine in the rat
    Eleni Skordi
    Biomolecular Medicine, Imperial College London, Sir Alexander Fleming Building, Imperial College Road, South Kensington, London, SW7 2AZ, UK
    J Proteome Res 6:4572-81. 2007
    ..These studies have given new insights into mechanisms of ethionine-induced toxicity and show the value of multisystem level data integration in the understanding of experimental models of toxicity or disease...
  44. ncbi NMR-based metabolic profiling identifies biomarkers of liver regeneration following partial hepatectomy in the rat
    Mary E Bollard
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 9:59-69. 2010
    ..Biofluid (1)H NMR-based metabolic profiling provides new insight into the role of metabolism of liver regeneration, and suggests putative biomarkers for the noninvasive monitoring of the regeneration process...
  45. ncbi Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse
    Ivan K S Yap
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Proteome Res 7:3718-28. 2008
    ....
  46. ncbi Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls
    Ivan K S Yap
    Biomolecular Medicine, Division of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, United Kingdom
    J Proteome Res 9:2996-3004. 2010
    ....
  47. ncbi Metabonomics techniques and applications to pharmaceutical research & development
    John C Lindon
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Pharm Res 23:1075-88. 2006
    ..Some discussion is given on the strengths and weaknesses, opportunities of, and threats to metabonomics...
  48. ncbi Global metabolic phenotyping in an experimental laparotomy model of surgical trauma
    James M Kinross
    Section of Biosurgery and Surgical Technology, St Mary s Hospital, London, UK
    J Proteome Res 10:277-87. 2011
    ..Metabonomic profiling provides a global overview of surgical trauma that has the potential to provide novel biomarkers for personalized surgical optimization and outcome prediction...
  49. ncbi Scaling and normalization effects in NMR spectroscopic metabonomic data sets
    Andrew Craig
    Biological Chemistry, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ U.K
    Anal Chem 78:2262-7. 2006
    ..e., transcriptomics or proteomics) and for integrated studies with "fused" data sets. It is concluded that data preprocessing is context dependent and there can be no single method for general use...
  50. ncbi Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study
    Ivan K S Yap
    Department of Surgery and Cancer, Faculty of Medicine, School of Public Health, Imperial College London, United Kingdom
    J Proteome Res 9:6647-54. 2010
    ..These findings indicate the importance of environmental influences (e.g., diet), endogenous metabolism, and mammalian-gut microbial cometabolism, which may help explain north-south China differences in cardiovascular disease risk...
  51. ncbi Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology
    Magda Bictash
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    J Clin Epidemiol 63:970-9. 2010
    ....
  52. ncbi Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs
    Selena E Richards
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington London, SW7 2AZ, UK
    Anal Chem 80:4876-85. 2008
    ..Hence SMCR is a useful addition to the chemometric "toolbox" for metabolic analysis and should have diverse applications within other biomedical conditions characterized by subtle time-dependent changes...
  53. ncbi Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat
    Sarah Garrod
    Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 18:115-22. 2005
    ..By 168 h postdose, NMR spectral profiles of treated rats appeared similar to those of matched controls for all tissue types indicative of recovery from toxic insult...
  54. ncbi Gut microbiota modulate the metabolism of brown adipose tissue in mice
    Renaud Mestdagh
    Division of Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ, London, UK
    J Proteome Res 11:620-30. 2012
    ..We also demonstrated that (1)H NMR metabolic profiles of BAT were excellent predictors of BW and TBFC, indicating the potential of BAT to fight against obesity...
  55. ncbi Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection
    Jia V Li
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 7:3948-56. 2008
    ..berghei infection. Hence, metabolic profiling may provide a sensitive diagnostic tool of Plasmodium infection and the control of malaria more generally...
  56. ncbi Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies
    Yulan Wang
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, UK
    Anal Chem 80:1058-66. 2008
    ..This approach could be extended to allow the detection of altered distributions within metabolic subcompartments as well as conventional metabonomics concentration-based diagnostics...
  57. ncbi High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study
    Richard H Barton
    Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Int J Epidemiol 37:i31-40. 2008
    ....
  58. ncbi Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009
    ..The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling...
  59. ncbi Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples
    Leon M Smith
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    Anal Chem 79:5682-9. 2007
    ..Both methods either alone or in combination have the potential for general applications to any complex mixture analysis where the sample contains compounds with a range of diffusion coefficients...
  60. ncbi Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation
    Leon M Smith
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Anal Chem 81:4847-56. 2009
    ....
  61. ncbi HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies
    Konstantina Spagou
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Anal Chem 83:382-90. 2011
    ....
  62. ncbi Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
    Jonathan R Swann
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 108:4523-30. 2011
    ....
  63. ncbi Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity
    Young Shick Hong
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Magn Reson Chem 47:S47-53. 2009
    ..Finally, the chemical shift difference between that of the anomeric H1 proton of alpha-glucose and residual water is confirmed as a suitable internal temperature calibration method...
  64. ncbi Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    T Andrew Clayton
    SORA Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington, London, United Kingdom
    Proc Natl Acad Sci U S A 106:14728-33. 2009
    ..Furthermore, we envisage that gut bacterial populations might be deliberately manipulated to improve drug efficacy and to reduce adverse drug reactions...
  65. ncbi NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
    Mary E Bollard
    Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK
    NMR Biomed 18:143-62. 2005
    ..Thus metabonomic approaches based on information-rich spectroscopic data sets can be used to evaluate normal physiological variation and for investigation of drug safety issues...
  66. ncbi Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity
    Nigel J Waters
    Biological Chemistry, Division of Biomedical Sciences, Sir Alexander Fleming Building, Imperial College, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 18:639-54. 2005
    ....
  67. ncbi An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy
    Muireann Coen
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 16:295-303. 2003
    ..These findings could indicate a mitochondrial inability to use pyruvate in the citric acid cycle and also reveal the impairment of fatty acid beta-oxidation in liver mitochondria of such treated mice...
  68. ncbi Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk
    Jia V Li
    Section of Biomolecular, Imperial College London, South Kensington, London SW7 2AZ, UK
    Gut 60:1214-23. 2011
    ..Understanding surgical weight loss mechanisms and metabolic modulation is required to enhance patient benefits and operative outcomes...
  69. ncbi Susceptibility of human metabolic phenotypes to dietary modulation
    Cinzia Stella
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA, Faculty of Medicine, Imperial College London, and MRC Dunn Human Nutrition Unit, Addenbrookes Hospital, Cambridge, United Kingdom
    J Proteome Res 5:2780-8. 2006
    ..This work shows the potential for the routine use of metabonomics in nutritional and epidemiological studies, in characterizing and predicting the metabolic effects and the influence of diet on human metabotypes...
  70. ncbi Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation
    Francois-Pierre J Martin
    Biological Chemistry, Biomedical Sciences Division, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 5:2185-93. 2006
    ..The work presented here suggests that probiotics may be beneficial in patients with IBS...
  71. ncbi Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity
    Muireann Coen
    Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, U K
    Anal Chem 79:8956-66. 2007
    ..This approach is generic and can be applied to correlate the covarying signals for any spin-active nuclei where there is parallel or serial collection of data...
  72. ncbi Panorganismal gut microbiome-host metabolic crosstalk
    Francois Pierre J Martin
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 8:2090-105. 2009
    ..These studies show the breadth and the depth of gut microbiome modulations of host biochemistry and reveal that major mammalian metabolic processes are under symbiotic homeostatic control...
  73. ncbi Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington SW7 2AZ, United Kingdom
    Anal Chem 80:7354-62. 2008
    ....
  74. ncbi Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions
    Caroline H Johnson
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW7 2AZ, UK
    Anal Chem 80:4886-95. 2008
    ..JRES-STOCSY is also of potential use as a method for recovering spectroscopic information in highly overlapped NMR signals and spin systems in other types of complex mixture analysis...
  75. ncbi Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition
    Yulan Wang
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    J Pharm Biomed Anal 40:375-81. 2006
    ..1H HRMAS NMR profiles of individual animals correlated well with conventional clinical chemistry and histology confirming the reproducibility of the technology and generating complementary molecular pathway information...
  76. ncbi Environmental metabonomics: applying combination biomarker analysis in earthworms at a metal contaminated site
    Jacob G Bundy
    Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, London SW7 2AZ, UK
    Ecotoxicology 13:797-806. 2004
    ..terrestris. This study demonstrates the utility of NMR spectroscopy in detecting previously unknown potential biomarkers for ecotoxicity testing and identified maltose as a potential biomarker compound deserving of further study...
  77. ncbi The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements
    John C Lindon
    Imperial College London, Biological Chemistry, Biomedical Sciences Division, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK. j.lindon @imperial.ac.uk
    Pharmacogenomics 6:691-9. 2005
    ....
  78. ncbi Analytical reproducibility in (1)H NMR-based metabonomic urinalysis
    Hector C Keun
    Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK
    Chem Res Toxicol 15:1380-6. 2002
    ..These results have implications for the quantitative interpretation of metabonomic data, and the establishment of quality control criteria for both regulatory agencies and for integrating data obtained at different sites...
  79. ncbi NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology
    Muireann Coen
    Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK
    Chem Res Toxicol 21:9-27. 2008
    ..The use of biological fluids as a source of whole organism metabolic information enhances the use of this approach in minimally invasive longitudinal studies...
  80. ncbi An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria
    T Andrew Clayton
    Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, London, UK
    Arch Toxicol 77:208-17. 2003
    ..A related hypothesis is now presented that would explain the selective hypercreatinuria in terms of increased cysteine synthesis...
  81. ncbi Evaluation of metabolic variation in normal rat strains from a statistical analysis of 1H NMR spectra of urine
    Timothy M D Ebbels
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington, London SW72AZ, UK
    J Pharm Biomed Anal 36:823-33. 2004
    ....
  82. ncbi NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats
    Andrew W Nicholls
    Biological Chemistry, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 16:1395-404. 2003
    ..Such effects are likely to be observed particularly in the area of preclinical investigation where the data from these studies are of particular relevance...
  83. ncbi Metabonomics: a platform for studying drug toxicity and gene function
    Jeremy K Nicholson
    Biological Chemistry Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, UK
    Nat Rev Drug Discov 1:153-61. 2002
    ..Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process...
  84. ncbi Metabolic profiling of the effects of D-galactosamine in liver spheroids using (1)H NMR and MAS-NMR spectroscopy
    Mary E Bollard
    Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology, and Medicine, University of London, Sir Alexander Fleming Building, South Kensington, UK
    Chem Res Toxicol 15:1351-9. 2002
    ....
  85. ncbi Colonization-induced host-gut microbial metabolic interaction
    Sandrine P Claus
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
    MBio 2:e00271-10. 2011
    ..This work will also contribute to developing novel strategies in the alteration of host-gut microbiota relationships which can in turn beneficially modulate the host metabolism...
  86. ncbi Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification
    Yulan Wang
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, England
    Proc Natl Acad Sci U S A 101:12676-81. 2004
    ..It also holds promise as a basis for novel diagnostic tests with high sensitivity and specificity and for improved disease surveillance and control...
  87. ncbi Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    John C Lindon
    Biological Chemistry, Biomedical Sciences, Division, Faculty of Medicine, Imperial College London, UK
    Biomarkers 9:1-31. 2004
    ..Transcriptomic and metabonomic data is currently being further integrated into a holistic understanding of systems biology. An assessment of the possible future role and impact of metabonomics is presented...
  88. ncbi Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma
    Huiru Tang
    Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, London, UK
    Anal Biochem 325:260-72. 2004
    ..Both pulse sequences and experimental results are discussed for T(1)-, T(1rho)-, and T(2)-filtered COSY, T(2)-filtered phase-sensitive DQF-COSY, and T(1), T(1rho)-, and T(2)-filtered TOCSY NMR...
  89. ncbi Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse
    Muireann Coen
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    J Pharm Biomed Anal 35:93-105. 2004
    ....
  90. ncbi Metabonomics and its role in drug development and disease diagnosis
    John C Lindon
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Expert Rev Mol Diagn 4:189-99. 2004
    ....
  91. ncbi ¹H NMR-based metabonomics for investigating diabetes
    Anthony D Maher
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington SW72AZ, UK
    Future Med Chem 1:737-47. 2009
    ..Continuing technological improvements will expand our knowledge of the causes and progression of this disease, and enhance treatment options for individuals...
  92. ncbi 1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies
    Derek J Crockford
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Medicine and Anaesthetics, Sir Alexander Fleming Building, Imperial College London, UK
    Anal Chem 80:6835-44. 2008
    ..This approach is of great potential value in the description of population xenometabolomes and in population pharmacology studies, and indeed for drug metabolism studies in general...
  93. ncbi Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington SW7 2AZ, United Kingdom
    Anal Chem 79:5204-11. 2007
    ....
  94. ncbi Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation
    Hector C Keun
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, U K
    Anal Chem 80:1073-9. 2008
    ..g., 13C, 15N, 31P) label present...
  95. ncbi Metabonomic investigations of aging and caloric restriction in a life-long dog study
    Yulan Wang
    Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    J Proteome Res 6:1846-54. 2007
    ....
  96. ncbi Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study
    Marc Emmanuel Dumas
    Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London UK
    Anal Chem 78:2199-208. 2006
    ..These cross-population differences in urinary metabolites could be related to genetic, dietary, and gut microbial factors...
  97. ncbi Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy
    Anthony D Maher
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington, SW7 2AZ, United Kingdom
    Anal Chem 81:288-95. 2009
    ..The novel approach adopted here has the potential to capture dynamic information in any complex mixture of reacting chemicals including other biofluids or cell extracts...
  98. ncbi Genetic algorithms for simultaneous variable and sample selection in metabonomics
    Rachel Cavill
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Bioinformatics 25:112-8. 2009
    ..Here, we develop a GA approach which simultaneously selects sets of samples and spectral regions from the COMET database to build robust, predictive classifiers of liver and kidney toxicity...
  99. ncbi Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis
    Yulan Wang
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7, 2AZ, United Kingdom
    J Proteome Res 4:1324-9. 2005
    ..This study will provide a metabolic reference for further studies assessing the metabolic consequences of nutrition, stress and gut microbiota on intestinal composition...
  100. ncbi The comparison of plasma deproteinization methods for the detection of low-molecular-weight metabolites by (1)H nuclear magnetic resonance spectroscopy
    Clare A Daykin
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Anal Biochem 304:220-30. 2002
    ....
  101. ncbi Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
    Marc Emmanuel Dumas
    Imperial College London, Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Genet 39:666-72. 2007
    ....