Richard Nicholas

Summary

Affiliation: Imperial College Healthcare NHS Trust
Country: UK

Publications

  1. pmc Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)
    Pascal F Durrenberger
    Department of Medicine, Section of Infectious Diseases and Immunity, Commonwealth Building, Hammersmith Campus, Imperial College London, UK
    J Neuroinflammation 9:1. 2012
  2. pmc Development of oral immunomodulatory agents in the management of multiple sclerosis
    Richard Nicholas
    Imperial College Healthcare NHS Trust, London, UK
    Drug Des Devel Ther 5:255-74. 2011
  3. doi request reprint Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: a systematic review and meta-analysis
    Richard Nicholas
    Imperial College Healthcare NHS Trust, London, UK
    Mult Scler 18:1290-6. 2012
  4. doi request reprint Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design
    Richard Nicholas
    Imperial College Healthcare NHS Trust, London, UK
    Mult Scler 17:1211-7. 2011
  5. pmc Hematopoietic mobilization: Potential biomarker of response to natalizumab in multiple sclerosis
    Miriam Mattoscio
    From the Department of Medicine, Division of Brain Sciences, Centre for Neuroscience, Wolfson Neuroscience Laboratories M M, R N, O M, P A M, and the Department of Medicine, Division of Experimental Medicine, Centre for Haematology F D, Imperial College London, UK the Departments of Neurosciences R N, O M and Imaging J S L, A D W, Imperial College Healthcare NHS Trust, London, UK and the Biostatistics Unit, Department of Health Sciences M P S, University of Genoa, Italy
    Neurology 84:1473-82. 2015
  6. doi request reprint In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with (18)F-PBR111 PET
    Alessandro Colasanti
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom Imanova Centre for Imaging Sciences, London, United Kingdom
    J Nucl Med 55:1112-8. 2014
  7. pmc Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome
    Paolo Giannetti
    1 Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Brain 138:110-9. 2015
  8. doi request reprint Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial
    Jeremy Chataway
    National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, University College London, London, UK UCL Institute of Neurology, University College London, London, UK Imperial College Healthcare NHS Trust, London, UK Imperial College, London, UK Electronic address
    Lancet 383:2213-21. 2014
  9. doi request reprint A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
    Jeremy Chataway
    National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK
    Mult Scler 17:81-8. 2011
  10. doi request reprint Bladder symptoms in multiple sclerosis: a review of pathophysiology and management
    Richard Nicholas
    Imperial College Healthcare NHS Trust, Charing Cross Hospital, Department of Neurosciences, London, UK
    Expert Opin Drug Saf 9:905-15. 2010

Collaborators

Detail Information

Publications10

  1. pmc Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1)
    Pascal F Durrenberger
    Department of Medicine, Section of Infectious Diseases and Immunity, Commonwealth Building, Hammersmith Campus, Imperial College London, UK
    J Neuroinflammation 9:1. 2012
    ..In this study, we investigated whether there were differences in NCR1+ cells in the peripheral blood of MS patients and whether NCR1+ cells are present in white matter lesions...
  2. pmc Development of oral immunomodulatory agents in the management of multiple sclerosis
    Richard Nicholas
    Imperial College Healthcare NHS Trust, London, UK
    Drug Des Devel Ther 5:255-74. 2011
    ....
  3. doi request reprint Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: a systematic review and meta-analysis
    Richard Nicholas
    Imperial College Healthcare NHS Trust, London, UK
    Mult Scler 18:1290-6. 2012
    ..Although it is known that the annualized relapse rate (ARR) in patients with multiple sclerosis (MS) changes as disease progresses, in the design and analysis of trials in relapsing multiple sclerosis (RMS) constant ARRs are assumed...
  4. doi request reprint Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design
    Richard Nicholas
    Imperial College Healthcare NHS Trust, London, UK
    Mult Scler 17:1211-7. 2011
    ..Planning a randomized placebo-controlled trial in relapsing-remitting multiple sclerosis (RRMS) requires knowledge of the annualized relapse rate (ARR) in the placebo group...
  5. pmc Hematopoietic mobilization: Potential biomarker of response to natalizumab in multiple sclerosis
    Miriam Mattoscio
    From the Department of Medicine, Division of Brain Sciences, Centre for Neuroscience, Wolfson Neuroscience Laboratories M M, R N, O M, P A M, and the Department of Medicine, Division of Experimental Medicine, Centre for Haematology F D, Imperial College London, UK the Departments of Neurosciences R N, O M and Imaging J S L, A D W, Imperial College Healthcare NHS Trust, London, UK and the Biostatistics Unit, Department of Health Sciences M P S, University of Genoa, Italy
    Neurology 84:1473-82. 2015
    ....
  6. doi request reprint In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with (18)F-PBR111 PET
    Alessandro Colasanti
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom Imanova Centre for Imaging Sciences, London, United Kingdom
    J Nucl Med 55:1112-8. 2014
    ..In this study, we used (18)F-PBR111 PET and MR imaging to measure relative binding in the lesional, perilesional, and surrounding normal-appearing white matter of MS patients, as an index of the innate immune response...
  7. pmc Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome
    Paolo Giannetti
    1 Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Brain 138:110-9. 2015
    ..Our finding, if replicated in a larger study, could be of prognostic value and aid early treatment decisions in clinically isolated syndrome. ..
  8. doi request reprint Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial
    Jeremy Chataway
    National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, University College London, London, UK UCL Institute of Neurology, University College London, London, UK Imperial College Healthcare NHS Trust, London, UK Imperial College, London, UK Electronic address
    Lancet 383:2213-21. 2014
    ....
  9. doi request reprint A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
    Jeremy Chataway
    National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK
    Mult Scler 17:81-8. 2011
    ....
  10. doi request reprint Bladder symptoms in multiple sclerosis: a review of pathophysiology and management
    Richard Nicholas
    Imperial College Healthcare NHS Trust, Charing Cross Hospital, Department of Neurosciences, London, UK
    Expert Opin Drug Saf 9:905-15. 2010
    ....