Sandra M Newton

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Paediatric tuberculosis
    Sandra M Newton
    Department of Paediatrics, Imperial College London, London, UK
    Lancet Infect Dis 8:498-510. 2008
  2. pmc Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis
    Katalin A Wilkinson
    National Institute for Medical Research, Mill Hill, London, UK
    BMC Microbiol 9:93. 2009
  3. pmc Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis
    Graham R Stewart
    Center for Molecular Microbiology and Infection and Wellcome Trust Center for Research in Clinical Tropical Medicine, Imperial College London, UK
    Infect Immun 73:6831-7. 2005
  4. ncbi request reprint Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine and Department of Pediatric Infectious Diseases, Faculty of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Immunol 174:4237-43. 2005
  5. ncbi request reprint Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing
    Suzanne T Anderson
    M B B S, Department of Pediatrics, Division of Medicine, Wright Fleming Institute, Imperial College London, London W2 1PG, UK
    Am J Respir Crit Care Med 173:1038-42. 2006
  6. ncbi request reprint Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Infect Dis 193:354-9. 2006
  7. pmc Neutrophil-mediated innate immune resistance to mycobacteria
    Adrian R Martineau
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
    J Clin Invest 117:1988-94. 2007
  8. pmc 1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection
    Anna Coussens
    Division of Mycobacterial Research, National Institute for Medical Research, London, UK
    Immunology 127:539-48. 2009
  9. ncbi request reprint The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis
    Graham R Stewart
    Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, South Kensington, London SW7 2AZ, UK
    Mol Microbiol 55:1127-37. 2005

Detail Information

Publications9

  1. pmc Paediatric tuberculosis
    Sandra M Newton
    Department of Paediatrics, Imperial College London, London, UK
    Lancet Infect Dis 8:498-510. 2008
    ..Advances in our understanding of tuberculosis in children would provide insights and opportunities to enhance efforts to control this disease...
  2. pmc Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis
    Katalin A Wilkinson
    National Institute for Medical Research, Mill Hill, London, UK
    BMC Microbiol 9:93. 2009
    ..We also reintroduced the 19 kDa gene in two modified forms that lacked motifs for acylation (Delta19::19NA) and O-glycosylation (Delta19::19NOG)...
  3. pmc Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosis
    Graham R Stewart
    Center for Molecular Microbiology and Infection and Wellcome Trust Center for Research in Clinical Tropical Medicine, Imperial College London, UK
    Infect Immun 73:6831-7. 2005
    ..tuberculosis with phagocytes. However, this analysis indicates that in the context of the whole bacillus, the 19-kDa lipoprotein is only one of a number of molecules that mediate the innate response to M. tuberculosis...
  4. ncbi request reprint Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine and Department of Pediatric Infectious Diseases, Faculty of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Immunol 174:4237-43. 2005
    ..The demonstration that there is infection stage-specific immunity to tuberculosis has implications for vaccine design...
  5. ncbi request reprint Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing
    Suzanne T Anderson
    M B B S, Department of Pediatrics, Division of Medicine, Wright Fleming Institute, Imperial College London, London W2 1PG, UK
    Am J Respir Crit Care Med 173:1038-42. 2006
    ..The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors...
  6. ncbi request reprint Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens
    Katalin A Wilkinson
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Imperial College London, Wright Fleming Institute, UK
    J Infect Dis 193:354-9. 2006
    ..These results suggest that the integrity of the bacterial cell wall is important for M. tuberculosis in avoiding immune recognition by T cells and favor a dynamic model of LTBI...
  7. pmc Neutrophil-mediated innate immune resistance to mycobacteria
    Adrian R Martineau
    Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
    J Clin Invest 117:1988-94. 2007
    ..Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB...
  8. pmc 1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection
    Anna Coussens
    Division of Mycobacterial Research, National Institute for Medical Research, London, UK
    Immunology 127:539-48. 2009
    ..1alpha,25(OH)(2)D(3) also induced secretion of IL-10 and PGE(2) from M. tuberculosis-infected PBMC. These findings represent a novel immunomodulatory role for 1alpha,25(OH)(2)D(3) in M. tuberculosis infection...
  9. ncbi request reprint The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis
    Graham R Stewart
    Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, South Kensington, London SW7 2AZ, UK
    Mol Microbiol 55:1127-37. 2005
    ..These findings demonstrate that both alpha-crystallins contribute to persistent infection with M. tuberculosis and suggest that manipulation of acr expression can influence the host response to infection...