R Motterlini

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Biochem Biophys Res Commun 225:167-72. 1996
  2. ncbi request reprint Regulation of heme oxygenase-1 by redox signals involving nitric oxide
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Antioxid Redox Signal 4:615-24. 2002
  3. ncbi request reprint Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 83:568-77. 1998
  4. ncbi request reprint Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 275:13613-20. 2000
  5. ncbi request reprint Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
    Free Radic Biol Med 28:1303-12. 2000
  6. ncbi request reprint Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 90:E17-24. 2002
  7. pmc Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 339:729-36. 1999
  8. ncbi request reprint Involvement of the heme oxygenase-carbon monoxide pathway in keratinocyte proliferation
    J E Clark
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Biochem Biophys Res Commun 241:215-20. 1997
  9. pmc Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart
    M D Musameh
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Br J Pharmacol 149:1104-12. 2006
  10. ncbi request reprint Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H1976-84. 2001

Collaborators

Detail Information

Publications60

  1. ncbi request reprint A precursor of the nitric oxide donor SIN-1 modulates the stress protein heme oxygenase-1 in rat liver
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Biochem Biophys Res Commun 225:167-72. 1996
    ..These results indicate a possible role for locally generated NO in the modulation of hepatic stress response in vivo suggesting that NO mediates cell adaptation to stress by activation of endogenous defensive mechanisms...
  2. ncbi request reprint Regulation of heme oxygenase-1 by redox signals involving nitric oxide
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Antioxid Redox Signal 4:615-24. 2002
    ....
  3. ncbi request reprint Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 83:568-77. 1998
    ..These results provide evidence for a crucial role of the heme oxygenase/CO pathway in the regulation of blood pressure under stress conditions in vivo...
  4. ncbi request reprint Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 275:13613-20. 2000
    ....
  5. ncbi request reprint Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
    Free Radic Biol Med 28:1303-12. 2000
    ..These data indicate that curcumin is a potent inducer of HO-1 in vascular endothelial cells and that increased heme oxygenase activity is an important component in curcumin-mediated cytoprotection against oxidative stress...
  6. ncbi request reprint Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 90:E17-24. 2002
    ..In the long term, transition metal carbonyls could be utilized for the therapeutic delivery of CO to alleviate vascular- and immuno-related dysfunctions. The full text of this article is available at http://www.circresaha.org...
  7. pmc Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 339:729-36. 1999
    ..These results indicate the ability of ONOO- to modulate the expression of the stress protein HO-1 and suggest that the haem oxygenase pathway contributes to protection against the cytotoxic action of ONOO-...
  8. ncbi request reprint Involvement of the heme oxygenase-carbon monoxide pathway in keratinocyte proliferation
    J E Clark
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Biochem Biophys Res Commun 241:215-20. 1997
    ..These results suggest that the heme oxygenase pathway is involved in keratinocyte proliferation mediated by NO...
  9. pmc Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart
    M D Musameh
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Br J Pharmacol 149:1104-12. 2006
    ..Here, we investigated whether CO liberated from two water soluble carbon monoxide-releasing molecules (CO-RMs) exerts inotropic effects on the myocardium...
  10. ncbi request reprint Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H1976-84. 2001
    ..These results indicate that the HO-1-bilirubin pathway can effectively defend hypoxic cardiomyocytes against reoxygenation injury and highlight the issue of heme availability in the cytoprotective action afforded by HO-1...
  11. ncbi request reprint Reviewing the use of carbon monoxide-releasing molecules (CO-RMs) in biology: implications in endotoxin-mediated vascular dysfunction
    R Foresti
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 51:409-23. 2005
    ..Thus, it emerges that CO-RMs could exert important biological actions in the context of endotoxic-mediated dysfunction...
  12. ncbi request reprint Homocysteine attenuates endothelial haem oxygenase-1 induction by nitric oxide (NO) and hypoxia
    P Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    FEBS Lett 508:403-6. 2001
    ..These novel findings indicate that hyperhomocysteinemia interferes with crucial signaling pathways required by cells to respond and adapt to stressful conditions...
  13. ncbi request reprint Carbon monoxide-releasing molecules (CO-RMs) modulate respiration in isolated mitochondria
    A Sandouka
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 51:425-32. 2005
    ..In summary, the results indicate that HO-1 induction and enhanced CO decrease renal oxygen consumption and alter mitochondrial function suggesting that CO could be a physiological regulator of mitochondrial oxidative phosphorylation...
  14. ncbi request reprint Interaction of heme with nitroxyl or nitric oxide amplifies heme oxygenase-1 induction: involvement of the transcription factor Nrf2
    P Naughton
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 48:885-94. 2002
    ....
  15. ncbi request reprint Treatment with CO-RMs during cold storage improves renal function at reperfusion
    A Sandouka
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Kidney Int 69:239-47. 2006
    ..CO-RMs are effective therapeutic agents that deliver CO during kidney cold preservation and can be used to ameliorate vascular activity, energy metabolism and renal function at reperfusion...
  16. ncbi request reprint Cyclophilins are induced by hypoxia and heat stress in myogenic cells
    L Andreeva
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Biochem Biophys Res Commun 237:6-9. 1997
    ....
  17. ncbi request reprint Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, U K
    Biochem Soc Trans 35:1142-6. 2007
    ....
  18. ncbi request reprint Heme oxygenase-1: a key step in counteracting cellular dysfunction
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 51:343-6. 2005
  19. ncbi request reprint The interaction of nitric oxide with distinct hemoglobins differentially amplifies endothelial heme uptake and heme oxygenase-1 expression
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Harrow, Middlesex, HA1 3UJ, UK
    J Pharmacol Exp Ther 317:1125-33. 2006
    ..In conclusion, our data indicate a novel role for NO in the modulation of heme transport and HO-1 induction in endothelial cells, which may be relevant for hematological disorders characterized by disruption of the heme-NO equilibrium...
  20. ncbi request reprint Bioactive properties of iron-containing carbon monoxide-releasing molecules
    Philip Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    J Pharmacol Exp Ther 318:403-10. 2006
    ..Thus, iron-based carbonyls mediate pharmacological responses that are achieved through liberation of CO and the nature of the substituents in the organic ligand have a profound effect on both the rate of CO release and cytotoxicity...
  21. ncbi request reprint Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase
    Stefan Chlopicki
    Department of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University Medical College, 31 531 Krakow 16 Grzegorzecka, Poland
    Cardiovasc Res 71:393-401. 2006
    ..Here we investigated the possible involvement of soluble guanylate cyclase in the anti-aggregatory effect of micromolar concentrations of CO released by a novel, water-soluble, CO releasing molecule (CORM) in human platelets...
  22. ncbi request reprint Heme oxygenase-1 mediates the anti-inflammatory actions of 2'-hydroxychalcone in RAW 264.7 murine macrophages
    Hadil Abuarqoub
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Rd, Harrow, Middlesex, HA1 3UJ, UK
    Am J Physiol Cell Physiol 290:C1092-9. 2006
    ..These findings strongly suggest that 2-HC exerts anti-inflammatory actions via activation of the HO-1 pathway and help to elucidate the mechanisms underlying the potential therapeutic value of chalcones...
  23. ncbi request reprint Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3
    Mohamed G Bani-Hani
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    J Pharmacol Exp Ther 318:1315-22. 2006
    ..These results suggest that the anti-inflammatory activity of CORM-3 could be exploited to mitigate microglia activity in stroke and other neuroinflammatory diseases...
  24. ncbi request reprint Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery
    Judit Varadi
    Department of Pharmacology, Health Science Center, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary
    Life Sci 80:1619-26. 2007
    ..In conclusion, CORM-3 exerts beneficial effects against ischemia/reperfusion-induced injury through its abilities to release CO which mediates a cardioprotective action by regulating tissue Na(+), K(+), and Ca(2+) levels...
  25. ncbi request reprint A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia
    Mohamed G Bani-Hani
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, United Kingdom
    Pharmacol Rep 58:132-44. 2006
    ..These results suggest that the anti-inflammatory action of CORM-3 could be exploited to mitigate microglia activation in neuro-inflammatory diseases...
  26. ncbi request reprint Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells
    Robert T Kinobe
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON K7L 3N5, Canada
    J Pharmacol Exp Ther 323:763-70. 2007
    ..These data demonstrate a protective role of both HO-1 and HO-2 against gliotoxin/TNF-alpha-induced cytotoxicity in LLC-PK1 cells. The novel imidazole-dioxolane compounds can be used as effective inhibitors of HO activity in cell culture...
  27. ncbi request reprint Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats
    Massimo Bolognesi
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    J Pharmacol Exp Ther 321:187-94. 2007
    ....
  28. ncbi request reprint Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3)
    Muntaser D Musameh
    Department of Surgery, Royal Free and University College London Medical School, Hampstead, London, UK
    J Heart Lung Transplant 26:1192-8. 2007
    ..We investigated the cardioprotective role of carbon monoxide (CO) released from CORM-3 against cold ischemia-mediated injury in the heart and evaluated its potential application in the clinical setting of cardiac transplantation...
  29. doi request reprint Use of carbon monoxide as a therapeutic agent: promises and challenges
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, HA1 3UJ, Harrow, Middlesex, UK
    Intensive Care Med 34:649-58. 2008
    ....
  30. ncbi request reprint Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation
    Maria José Alcaraz
    Department of Pharmacology, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Curr Pharm Des 14:465-72. 2008
    ....
  31. doi request reprint A carbon monoxide-releasing molecule (CORM-3) abrogates polymorphonuclear granulocyte-induced activation of endothelial cells and mast cells
    Emanuela Masini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139, Florence, Italy
    FASEB J 22:3380-8. 2008
    ....
  32. ncbi request reprint Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)
    Ian J S Fairlamb
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    Bioorg Med Chem Lett 16:995-8. 2006
    ....
  33. ncbi request reprint Therapeutic applications of carbon monoxide-releasing molecules
    Roberto Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Expert Opin Investig Drugs 14:1305-18. 2005
    ....
  34. ncbi request reprint Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    James E Clark
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Circ Res 93:e2-8. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  35. ncbi request reprint Heme oxygenase is expressed in human pulmonary artery smooth muscle where carbon monoxide has an anti-proliferative role
    Salome J Stanford
    Unit of Critical Care, The Royal Brompton and Harefield N H S Trust, Imperial College School of Medicine, Sydney Street, London SW3 6NP, UK
    Eur J Pharmacol 473:135-41. 2003
    ..Our observations support the growing evidence that the heme oxygenase/carbon monoxide system may play a role in the pathology of pulmonary hypertension...
  36. ncbi request reprint Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    Alicja Jozkowicz
    Department of Vascular Surgery, University of Vienna, Austria
    Antioxid Redox Signal 5:155-62. 2003
    ..Thus, HO activity up-regulates VEGF production and augments the capability of endothelial cells to respond to exogenous stimulation...
  37. pmc Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 372:381-90. 2003
    ....
  38. ncbi request reprint Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy
    Biochem Pharmacol 66:2355-63. 2003
    ..Taken together, these data suggest that BR should not be considered only as an endogenous antioxidant but also as a molecule with the potential ability to counteract intracellular nitrosative stress reactions...
  39. pmc Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 142:453-60. 2004
    ....
  40. ncbi request reprint Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    J Pharmacol Exp Ther 312:686-93. 2005
    ..Thus, this study identified novel plant constituents that highly induce HO-1 in endothelial cells and investigated some of the mechanisms involved in this effect...
  41. ncbi request reprint CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    FASEB J 19:284-6. 2005
    ....
  42. ncbi request reprint Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
    Jozef Dulak
    Division of Cardiology, Innsbruck University, Innsbruck, Austria
    Antioxid Redox Signal 4:229-40. 2002
    ..As CO and iron, respectively the inducer and the inhibitor of VEGF synthesis, are concomitantly produced during the degradation of heme, these data indicate that HO by-products may differentially modulate VEGF production...
  43. ncbi request reprint Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats
    Sophie Lanone
    INSERM U 700 and U 683, Faculte de Medecine Xavier Bichat, Universite Paris VII, Paris, France
    FASEB J 19:1890-2. 2005
    ..These findings indicate that bilirubin can act as an effective agent to reduce mortality and counteract hypotension elicited by endotoxin through mechanisms involving a decreased NOS2 induction secondary to inhibition of NAD(P)H oxidase...
  44. pmc Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
    Philip Sawle
    Department of Surgical Research, Vascular Biology Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 145:800-10. 2005
    ....
  45. ncbi request reprint Induction of heme oxygenase 1 by nitrosative stress. A role for nitroxyl anion
    Patrick Naughton
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 277:40666-74. 2002
    ..These findings indicate that heme oxygenase can act both as a sensor to and target of redox-based mechanisms involving NO and extend our knowledge on the biological function of HO-1 in response to nitrosative stress...
  46. ncbi request reprint Interaction of bilirubin and biliverdin with reactive nitrogen species
    Harparkash Kaur
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Y Block, Middlesex HA1 3UJ, Harrow, UK
    FEBS Lett 543:113-9. 2003
    ....
  47. doi request reprint Structure-activity relationships of methoxychalcones as inducers of heme oxygenase-1
    Philip Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Chem Res Toxicol 21:1484-94. 2008
    ..This study provides additional information on the structural features that methoxychalcones and natural antioxidants need to possess to be considered as therapeutic agents for maximizing HO-1 expression and activity...
  48. pmc Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    Elisabeth Balogun
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 371:887-95. 2003
    ..Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway...
  49. ncbi request reprint Mitochondrial and cellular heme-dependent proteins as targets for the bioactive function of the heme oxygenase/carbon monoxide system
    Mathieu Desmard
    INSERM, U700 Université Paris 7, Faculte de Medicine, Site Xavier Bichat, Assistance Publique Hopitaux de Paris, Hopital Bichat, Paris, France
    Antioxid Redox Signal 9:2139-55. 2007
    ....
  50. ncbi request reprint A cytoprotective role for the heme oxygenase-1/CO pathway during neural differentiation of human mesenchymal stem cells
    Ignazio Barbagallo
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    J Neurosci Res 86:1927-35. 2008
    ..Thus, overexpression of HO-1 and CO-releasing molecules could provide a possible therapeutic strategy to improve cell viability during neural differentiation in applications that use stem cell technology...
  51. ncbi request reprint Curcumin reduces cold storage-induced damage in human cardiac myoblasts
    Hadil Abuarqoub
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Exp Mol Med 39:139-48. 2007
    ..Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold-storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms...
  52. ncbi request reprint Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule
    Yasin Tayem
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Am J Physiol Renal Physiol 290:F789-94. 2006
    ..Our data demonstrate that CORM-3 can be used as an effective therapeutic adjuvant in the treatment of CP-induced nephrotoxicity...
  53. ncbi request reprint Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle
    Camille Taillé
    INSERM Unité 700 and Unité 683, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Biol Chem 280:25350-60. 2005
    ..This study provides a new mechanism to explain redox signaling by CO...
  54. pmc Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
    Yiru Guo
    Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Physiol Heart Circ Physiol 286:H1649-53. 2004
    ..8% (n = 14), P < 0.05]. CORM-3 did not increase carboxyhemoglobin levels in the blood. These results suggest that a novel class of drugs, CO-releasing molecules, can be useful to limit myocardial ischemia-reperfusion injury in vivo...
  55. pmc Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction
    Adam B Stein
    Division of Cardiology, The Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    J Mol Cell Cardiol 38:127-34. 2005
    ..In addition, this study provides the first evidence that the cardioprotective actions of ischemic PC persist for 72 h in the mouse...
  56. ncbi request reprint CO-metal interaction: Vital signaling from a lethal gas
    Jorge Boczkowski
    INSERM, U700, Universite Paris 7, Faculte de Medecine, Site Xavier Bichat, Asistance Publique Hopitaux de Paris, CIC 07, Hopital Bichat, 75018 Paris, France
    Trends Biochem Sci 31:614-21. 2006
    ..Thus, exploring how CO binding to metal complexes is translated into a cytoprotective function is a challenging task and might open up opportunities for therapeutic applications based on CO delivery...
  57. ncbi request reprint Bioactivity and pharmacological actions of carbon monoxide-releasing molecules
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Curr Pharm Des 9:2525-39. 2003
    ....
  58. ncbi request reprint Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells
    Elizabeth Balogun
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem Biophys Res Commun 308:950-5. 2003
    ..These findings highlight the feasibility of modulating HO-1 expression during hypothermic storage to confer tissues a better protection to counteract the damage characteristic of organ transplantation...
  59. ncbi request reprint Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow
    Paula Urquhart
    William Harvey Research Institute, London, UK
    J Pharmacol Exp Ther 321:656-62. 2007
    ..In conclusion, we have reported that CORM-3 possesses acute anti-inflammatory effects in vivo and that these are probably the result of targeting PMN activation and rolling upon the endothelium...
  60. ncbi request reprint cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 28:8568-76. 2008
    ..Together, our results provide evidence that NO-GC is crucially involved in the central sensitization of pain pathways during inflammatory and neuropathic pain...