M J Morrell

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure
    Simon Freilich
    Clinical and Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Imperial College, London, UK
    Sleep Med 11:87-92. 2010
  2. pmc The impact of ageing and sex on the association between sleepiness and sleep disordered breathing
    Mary J Morrell
    Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
    Eur Respir J 40:386-93. 2012
  3. doi request reprint Changes in brain morphology in patients with obstructive sleep apnoea
    M J Morrell
    National Heart and Lung Institute, Imperial College, London, UK
    Thorax 65:908-14. 2010
  4. pmc The effects of adaptive servo ventilation on cerebral vascular reactivity in patients with congestive heart failure and sleep-disordered breathing
    Mary J Morrell
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, London, UK
    Sleep 30:648-53. 2007
  5. ncbi request reprint Neural consequences of sleep disordered breathing: the role of intermittent hypoxia
    Mary J Morrell
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, Royal Brompton Campus, London, UK
    Adv Exp Med Biol 588:75-88. 2006
  6. ncbi request reprint A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction
    A Vazir
    Academic Unit of Sleep and Breathing, The Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London, United Kingdom
    Eur J Heart Fail 9:243-50. 2007
  7. pmc Unilateral focal lesions in the rostrolateral medulla influence chemosensitivity and breathing measured during wakefulness, sleep, and exercise
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, St Dunstan s Road, London W6 8RP, UK
    J Neurol Neurosurg Psychiatry 67:637-45. 1999
  8. ncbi request reprint Symptom burden of sleep-disordered breathing in mild-to-moderate congestive heart failure patients
    P C Hastings
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, and Cardiac Medicine and Sleep and Ventilation Unit, 2nd Floor, Royal Brompton Hospital, Fulham Road, London, SW3 6NP, UK
    Eur Respir J 27:748-55. 2006
  9. ncbi request reprint Sleep apnoea and daytime function in the elderly--what is the impact of arousal frequency?
    H A K Browne
    Sleep and Ventilation Unit, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, UK
    Respir Med 97:1102-8. 2003
  10. ncbi request reprint Adaptive servo-ventilation and deadspace: effects on central sleep apnoea
    I Szollosi
    Academic Unit of Sleep and Breathing, Royal Brompton and Harefield NHS Trust, London, UK
    J Sleep Res 15:199-205. 2006

Collaborators

Detail Information

Publications40

  1. doi request reprint Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure
    Simon Freilich
    Clinical and Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Imperial College, London, UK
    Sleep Med 11:87-92. 2010
    ....
  2. pmc The impact of ageing and sex on the association between sleepiness and sleep disordered breathing
    Mary J Morrell
    Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
    Eur Respir J 40:386-93. 2012
    ..The age-related reductions in the association between sleepiness and SDB may have clinical implications for the diagnosis and treatment of SDB in older people as sleepiness is often used as a therapeutic target...
  3. doi request reprint Changes in brain morphology in patients with obstructive sleep apnoea
    M J Morrell
    National Heart and Lung Institute, Imperial College, London, UK
    Thorax 65:908-14. 2010
    ....
  4. pmc The effects of adaptive servo ventilation on cerebral vascular reactivity in patients with congestive heart failure and sleep-disordered breathing
    Mary J Morrell
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, London, UK
    Sleep 30:648-53. 2007
    ..We tested the hypothesis that reversal of SDB in CHF patients using adaptive servo ventilation (ASV) would increase morning HCVR...
  5. ncbi request reprint Neural consequences of sleep disordered breathing: the role of intermittent hypoxia
    Mary J Morrell
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, Royal Brompton Campus, London, UK
    Adv Exp Med Biol 588:75-88. 2006
    ....
  6. ncbi request reprint A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction
    A Vazir
    Academic Unit of Sleep and Breathing, The Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London, United Kingdom
    Eur J Heart Fail 9:243-50. 2007
    ..Sleep disordered breathing (SDB) is common in severe chronic heart failure (CHF) and is associated with increased morbidity and mortality. The prevalence of SDB in mild symptomatic CHF is unknown...
  7. pmc Unilateral focal lesions in the rostrolateral medulla influence chemosensitivity and breathing measured during wakefulness, sleep, and exercise
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, St Dunstan s Road, London W6 8RP, UK
    J Neurol Neurosurg Psychiatry 67:637-45. 1999
    ..The aim of this study was to investigate the physiological implications of unilateral lesions in the lower brainstem on the control of breathing...
  8. ncbi request reprint Symptom burden of sleep-disordered breathing in mild-to-moderate congestive heart failure patients
    P C Hastings
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, and Cardiac Medicine and Sleep and Ventilation Unit, 2nd Floor, Royal Brompton Hospital, Fulham Road, London, SW3 6NP, UK
    Eur Respir J 27:748-55. 2006
    ....
  9. ncbi request reprint Sleep apnoea and daytime function in the elderly--what is the impact of arousal frequency?
    H A K Browne
    Sleep and Ventilation Unit, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, UK
    Respir Med 97:1102-8. 2003
    ..We conclude that (1) the effect of sleep apnoea on arousal is no greater in the elderly compared to the young (2) despite similar levels of sleepiness, elderly apneoics perceive a reduced loss of QoL compared to younger patients...
  10. ncbi request reprint Adaptive servo-ventilation and deadspace: effects on central sleep apnoea
    I Szollosi
    Academic Unit of Sleep and Breathing, Royal Brompton and Harefield NHS Trust, London, UK
    J Sleep Res 15:199-205. 2006
    ..We speculate that this effect is likely to be mediated by increased PetCO(2) and respiratory effort associated with DS application...
  11. doi request reprint Autotitrating versus standard noninvasive ventilation: a randomised crossover trial
    J Jaye
    Sleep and Ventilation Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
    Eur Respir J 33:566-71. 2009
    ....
  12. pmc The respiratory response to inspiratory resistive loading during rapid eye movement sleep in humans
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, St Dunstans Road, London W6 8RP, UK
    J Physiol 526:195-202. 2000
    ....
  13. ncbi request reprint Hypercapnic cerebral vascular reactivity is decreased, in humans, during sleep compared with wakefulness
    Guy E Meadows
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, Charing Cross Campus, London, W6 8RP, United Kingdom
    J Appl Physiol 94:2197-202. 2003
    ..1% (P = 0.001). This decrease in hypercapnic cerebral vascular reactivity may, at least in part, explain the stage III-IV NREM sleep-related reduction in cortical blood flow...
  14. ncbi request reprint Central chemosensitivity and breathing asleep in unilateral medullary lesion patients: comparisons to animal data
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, St Dunstan's Road, London, W 6 8RP, UK
    Respir Physiol 129:269-77. 2001
    ..We propose that in humans, dorsal displacement of the RVLM area of chemosensitivity in animals, arises from development of the olive plus the consequences of the evolution of the cerebellum/inferior peduncle...
  15. ncbi request reprint Effect of CO2 inhalation on central sleep apnea and arousals from sleep
    I Szollosi
    Royal Brompton and Harefield NHS Trust, Royal Brompton Hospital, London SW3 6NP, UK
    Respiration 71:493-8. 2004
    ..CO(2) is also a stimulus for cortical arousal, which has been linked to increased sympathetic nerve activity (SNA) and increased mortality in CHF patients with CSA...
  16. doi request reprint Differential effects of waking from non-rapid eye movement versus rapid eye movement sleep on cardiovascular activity
    Elizabeth A Goff
    Clinical and Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Imperial College, Fulham Road, London, UK
    J Sleep Res 19:201-6. 2010
    ....
  17. doi request reprint The influence of age on heart rate variability during morning wakefulness
    Elizabeth Anne Goff
    Clinical and Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Imperial College, Fulham Road, London SW3 6NP, UK
    Clin Auton Res 20:175-82. 2010
    ..This cross-sectional study of healthy men and women (n = 40, 20-30 and >60 years) investigated the effect of age on heart rate variability (HRV) during morning versus evening wakefulness and sleep...
  18. pmc The cardiovascular response to arousal from sleep decreases with age in healthy adults
    Elizabeth A Goff
    Clinical and Academic Unit of Sleep and Ventilation, Royal Brompton Hospital, Imperial College, London, U K
    Sleep 31:1009-17. 2008
    ..To investigate age and gender effects on the acute blood pressure (BP) and heart rate (HR) response to arousal from sleep in healthy adults...
  19. ncbi request reprint CO2 retention in lung disease; could there be a pre-existing difference in respiratory physiology
    Helen M A Dunroy
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, St Dunstans Road, W6 8RP, London, UK
    Respir Physiol Neurobiol 136:179-86. 2003
    ..7, 4.3, 6.2, 8.0 mmHg) and a relatively low HCVR (slope 1.5, 1.7, 1.5, 1.7 L min(-1) mmHg(-1), respectively). We speculate that such individuals, should they develop lung disease, may be predisposed to retain CO(2)...
  20. ncbi request reprint Overnight changes in the cerebral vascular response to isocapnic hypoxia and hypercapnia in healthy humans: protection against stroke
    Guy E Meadows
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, London, UK
    Stroke 36:2367-72. 2005
    ..It is not known if the cerebral vascular response to hypoxia is similarly reduced in the morning, but such a reduction could be considered a further risk factor for cerebral vascular disease...
  21. ncbi request reprint Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans
    Denise M O'Driscoll
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, London, UK
    J Appl Physiol 96:865-70. 2004
    ..70 l/min; P = 0.71). We conclude that combined central and peripheral chemoreceptor stimulation with the use of HH does not interact with the autonomic outflow associated with arousal from sleep to augment the cardiovascular response...
  22. ncbi request reprint Occlusion of the upper airway does not augment the cardiovascular response to arousal from sleep in humans
    Denise M O'Driscoll
    Clinical and Academic Unit of Sleep and Breathing, Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
    J Appl Physiol 98:1349-55. 2005
    ..31). We conclude that stimulation of the respiratory mechanoreceptors by transient upper airway occlusion is unlikely to interact with the arousal-related autonomic outflow to augment the cardiovascular response in healthy young men...
  23. ncbi request reprint Ageing does not influence the sleep-related decrease in the hypercapnic ventilatory response
    H A K Browne
    National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, London, UK
    Eur Respir J 21:523-9. 2003
    ..The authors speculate that age-related changes in the hypercapnic ventilatory response are unlikely to contribute to the increased prevalence of central sleep apnoea in the elderly...
  24. ncbi request reprint Can heart rate variation rule out sleep-disordered breathing in heart failure?
    A Vazir
    Clinical and Academic Unit of Sleep and Breathing, and Department of Cardiology, National Heart and Lung Institute, Imperial College, London, UK
    Eur Respir J 27:571-7. 2006
    ..h-1. In conclusion, these results suggest that spectral analysis of heart rate may be useful as a "rule-out test" for sleep-disordered breathing in patients with mild-to-moderate congestive heart failure...
  25. ncbi request reprint Respiratory muscle activity during REM sleep in patients with diaphragm paralysis
    J R Bennett
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Neurology 62:134-7. 2004
    ..Patients with BDP had a normal quantity of REM sleep (mean +/- SD, 18.6 +/- 7.5% of total sleep time) achieved by inspiratory recruitment of extradiaphragmatic muscles in both tonic and phasic REM, suggesting brainstem reorganization...
  26. ncbi request reprint The interaction between respiratory and autonomic function during sleep-related changes in pharyngeal airway patency
    D M O'Driscoll
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK
    Auton Neurosci 120:18-25. 2005
    ..How these factors interact to cause the acute surges in heart rate and systemic blood pressure that occur at the termination of an apnoea will be reviewed, together with the longer term consequences of pharyngeal occlusion during sleep...
  27. ncbi request reprint Cerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness
    Guy E Meadows
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    J Appl Physiol 97:1343-8. 2004
    ....
  28. ncbi request reprint Ventilation is unstable during drowsiness before sleep onset
    Stuart Thomson
    Department of Respiratory Medicine, Charing Cross Hospital Campus, London, UK
    J Appl Physiol 99:2036-44. 2005
    ..6 Torr (SD 2.3) and on assisted ventilation 38.0 Torr (1.4). We conclude that the ventilatory instability recorded in the present experiments is due to the apneic threshold for CO2 being at or just below that when awake...
  29. ncbi request reprint Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea
    M J Morrell
    National Heart and Lung Institute, Imperial College School of Medicine, Sleep and Ventilation Unit, Royal Brompton Hospital, London, UK
    Eur Respir J 20:451-7. 2002
    ..The authors speculate that surfactant may delay occlusion by reducing the liquid "bridging" within the folded pharyngeal lining...
  30. doi request reprint Variation in severity and type of sleep-disordered breathing throughout 4 nights in patients with heart failure
    Ali Vazir
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College, Sydney Street, London SW3 6NP, UK
    Respir Med 102:831-9. 2008
    ..Currently there is good evidence for treatment of obstructive sleep apnea (OSA) in CHF with continuous positive airway pressure; however, for central sleep apnea (CSA) the treatment is less clear...
  31. ncbi request reprint Changes in brain morphology associated with obstructive sleep apnea
    Mary J Morrell
    National Heart and Lung Institute, Charing Cross Campus, Faculty of Medicine, Imperial College of Science Technology and Medicine, London, UK
    Sleep Med 4:451-4. 2003
    ..We hypothesised that focal loss of cortical gray matter generally within areas associated with memory processing and learning and specifically within the hippocampus would occur in OSA...
  32. pmc Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory
    Gillian L Twigg
    Clinical and Academic Unit of Sleep and Ventilation, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College, London, United Kingdom
    Am J Respir Crit Care Med 182:98-103. 2010
    ..Although cognitive deficits are well documented in patients with sleep apnea, the impact on memory remains unclear...
  33. doi request reprint Adaptive servo-ventilation in heart failure patients with sleep apnea: a real world study
    Peter C Hastings
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Int J Cardiol 139:17-24. 2010
    ..We hypothesized that ASV would be effective at reducing sleep apnea and improving both cardiac status and quality of life...
  34. doi request reprint A quick and easy method of measuring the hypercapnic ventilatory response in patients with COPD
    Annabel H Nickol
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
    Respir Med 103:258-67. 2009
    ..We have tested the hypothesis that end-tidal PCO(2) may be used to test the HCVR in COPD during non-steady-state rebreathing, despite the fact that large (arterial-end-tidal) PCO(2) differences (P(a-et)CO(2)) exist during air breathing...
  35. ncbi request reprint The determinants of therapeutic levels of continuous positive airway pressure in elderly sleep apnea patients
    Konstantinos Kostikas
    Clinical and Academic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London SW3, UK
    Respir Med 100:1216-25. 2006
    ..Ageing may be an important determinant of therapeutic CPAP levels in clinical practice, especially in older sleep apneic patients...
  36. ncbi request reprint Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study
    Annabel H Nickol
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    J Sleep Res 15:445-54. 2006
    ..We conclude that at high altitude temazepam is effective in reducing periodic breathing, and is safe to use, without any adverse effect upon next-day performance...
  37. pmc Cerebral blood flow changes associated with fluctuations in alpha and theta rhythm during sleep onset in humans
    Futoshi Kotajima
    School of Life Sciences, Keele University, Keele, ST5 5BG, UK
    J Physiol 568:305-13. 2005
    ....
  38. ncbi request reprint Apnea and history
    Michael I Polkey
    Chest 125:1587-8. 2004
  39. ncbi request reprint Sleep-disordered breathing in a general heart failure population: relationships to neurohumoral activation and subjective symptoms
    Archana Rao
    Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Sleep Res 15:81-8. 2006
    ..Patients with SDB had higher activation of a neurohumoral marker and more severe HF. Unlike obstructive sleep apnoea, SDB in HF had little discernible effect on sleepiness or quality of life as measured by standard subjective scales...
  40. ncbi request reprint Residual sleepiness in patients with optimally treated sleep apnea: a case for hypoxia-induced oxidative brain injury
    Mary J Morrell
    Sleep 27:186-7. 2004