P Montuschi

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Exhaled carbon monoxide and nitric oxide in COPD
    P Montuschi
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Chest 120:496-501. 2001
  2. ncbi request reprint Validation of leukotriene B4 measurements in exhaled breath condensate
    P Montuschi
    Department of Pharmacology, Catholic University of the Sacred Heart, L go F Vito, 1, Roma, Italy
    Inflamm Res 52:69-73. 2003
  3. ncbi request reprint Analysis of exhaled breath condensate for monitoring airway inflammation
    Paolo Montuschi
    Dept of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy
    Trends Pharmacol Sci 23:232-7. 2002
  4. ncbi request reprint Indirect monitoring of lung inflammation
    Paolo Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito 1 00168, Rome, Italy
    Nat Rev Drug Discov 1:238-42. 2002
  5. ncbi request reprint Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide
    Paolo Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Free Radic Biol Med 33:1403-8. 2002
  6. pmc Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD
    P Montuschi
    Department of Pharmacology, Faculty of Medicine, School of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    Thorax 60:827-33. 2005
  7. ncbi request reprint Anaphylaxis increases 8-iso-prostaglandin F2alpha release from guinea-pig lung in vitro
    P Montuschi
    Institute of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Eur J Pharmacol 365:59-64. 1999
  8. ncbi request reprint Validation of 8-isoprostane and prostaglandin E(2) measurements in exhaled breath condensate
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito, 00168, Rome, Italy
    Inflamm Res 52:502-7. 2003
  9. pmc Exhaled leukotrienes and prostaglandins in COPD
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 58:585-8. 2003
  10. pmc Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma
    S A Kharitonov
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Royal Brompton and Harefield NHS Trust, London SW3 6LY, UK
    Thorax 57:889-96. 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Exhaled carbon monoxide and nitric oxide in COPD
    P Montuschi
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, London, UK
    Chest 120:496-501. 2001
    ..To investigate whether exhaled carbon monoxide (CO) and nitric oxide (NO) could be used as noninvasive in vivo biomarkers of oxidative stress in the lungs of patients with COPD...
  2. ncbi request reprint Validation of leukotriene B4 measurements in exhaled breath condensate
    P Montuschi
    Department of Pharmacology, Catholic University of the Sacred Heart, L go F Vito, 1, Roma, Italy
    Inflamm Res 52:69-73. 2003
    ..To qualitatively validate an enzyme immunoassay to measure leukotriene B4 in exhaled breath condensate. Exhaled breath condensate is a new non-invasive method to monitor airway inflammation...
  3. ncbi request reprint Analysis of exhaled breath condensate for monitoring airway inflammation
    Paolo Montuschi
    Dept of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy
    Trends Pharmacol Sci 23:232-7. 2002
    ..Controlled studies are needed to establish the utility of EBC markers for guiding pharmacological treatment in inflammatory lung diseases...
  4. ncbi request reprint Indirect monitoring of lung inflammation
    Paolo Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito 1 00168, Rome, Italy
    Nat Rev Drug Discov 1:238-42. 2002
    ..Measuring inflammatory markers in exhaled breath condensate is potentially the easiest way to quantify lung inflammation. The clinical applicability of this method could facilitate the practice of respiratory medicine...
  5. ncbi request reprint Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide
    Paolo Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Free Radic Biol Med 33:1403-8. 2002
    ..4 pg/ml, 95% CI -8.9 to 15.7, p =.54). Short-term ozone exposure causes acute increase in lung oxidative stress as reflected by exhaled 8-isoprostane. This increase is resistant to pretreatment with a high dose of inhaled budesonide...
  6. pmc Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD
    P Montuschi
    Department of Pharmacology, Faculty of Medicine, School of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    Thorax 60:827-33. 2005
    ..A study was undertaken to investigate the short term effects of cyclo-oxygenase (COX) inhibition on exhaled LTB4 and PGE2 concentrations in patients with COPD and to identify the COX isoform responsible for exhaled PGE2 production...
  7. ncbi request reprint Anaphylaxis increases 8-iso-prostaglandin F2alpha release from guinea-pig lung in vitro
    P Montuschi
    Institute of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Eur J Pharmacol 365:59-64. 1999
    ..This isoprostane seems to be derived from the cyclooxygenation of arachidonic acid via the constitutive form of cyclooxygenase...
  8. ncbi request reprint Validation of 8-isoprostane and prostaglandin E(2) measurements in exhaled breath condensate
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito, 00168, Rome, Italy
    Inflamm Res 52:502-7. 2003
    ..To qualitatively validate radioimmunoassays for 8-isoprostane and prostaglandin (PG) E(2) in exhaled breath condensate...
  9. pmc Exhaled leukotrienes and prostaglandins in COPD
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 58:585-8. 2003
    ....
  10. pmc Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma
    S A Kharitonov
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Royal Brompton and Harefield NHS Trust, London SW3 6LY, UK
    Thorax 57:889-96. 2002
    ..The anti-inflammatory effect of low dose inhaled budesonide on non-invasive exhaled markers of inflammation and oxidative stress were assessed in patients with mild asthma...
  11. pmc Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung
    G Ciabattoni
    Department of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Br J Pharmacol 109:243-50. 1993
    ..TXA2, on the other hand, strongly enhances neuronal VIP release...
  12. ncbi request reprint Long-acting beta-agonists and their association with inhaled corticosteroids in COPD
    L Fuso
    Department of Internal Medicine and Geriatrics, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Curr Med Chem 20:1477-95. 2013
    ..Dual-pharmacology inhaled muscarinic antagonist-beta(2) agonist (MABA) molecules provide a new approach to the treatment of COPD...
  13. ncbi request reprint Inhaled muscarinic acetylcholine receptor antagonists for treatment of COPD
    P Montuschi
    Department of Internal Medicine and Geriatrics, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Curr Med Chem 20:1464-76. 2013
    ..Dual-pharmacology muscarinic antagonist-beta2 agonist (MABA) molecules present a novel approach to the treatment of COPD by combining muscarinic antagonism and beta2 agonism in a single molecule...
  14. doi request reprint Leukotriene modifiers for asthma treatment
    P Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Clin Exp Allergy 40:1732-41. 2010
    ..This review discusses the role of LTs in asthma and the role of LT modifiers in asthma treatment...
  15. ncbi request reprint Immediate allergic reactions to beta-lactams: diagnosis and therapy
    A Romano
    Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, C I Columbus, Rome, Italy
    Int J Immunopathol Pharmacol 16:19-23. 2003
    ..In addition to adrenaline, corticosteroids and antihistamines should be administered. Histamine H(1) receptor antagonists are the mainstay of the treatment of immediate allergic reactions such as urticaria, rhinitis and conjunctivitis...
  16. ncbi request reprint Increased exhaled 8-isoprostane in childhood asthma
    Eugenio Baraldi
    Department of Pediatrics Drs Baraldi, Ghiro, Piovan, and Carraro, School of Medicine, University of Padova, Padova, Italy
    Chest 124:25-31. 2003
    ....
  17. ncbi request reprint Exhaled leukotrienes and prostaglandins in asthma
    Paolo Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    J Allergy Clin Immunol 109:615-20. 2002
    ..Others have measured eicosanoids in plasma or urine, probably reflecting systemic rather than lung inflammation. Collection of exhaled breath condensate (EBC) is a noninvasive method to collect airway secretions...
  18. ncbi request reprint Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito, 1, 00168 Rome, Italy
    Chest 132:1876-81. 2007
    ..We aimed to study the effect of treatment and withdrawal of montelukast, a LTRA, on airway inflammation as reflected by Feno and lung function in children with asthma...
  19. ncbi request reprint Insights into oxidative stress: the isoprostanes
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    Curr Med Chem 14:703-17. 2007
    ..Measurement of F(2)-IsoPs may provide a uniquely valuable approach to understanding of the clinical pharmacology of antioxidants...
  20. ncbi request reprint Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    J Allergy Clin Immunol 118:347-53. 2006
    ..The effects of leukotriene receptor antagonists (LTRAs) on exhaled leukotriene and prostanoids in children with asthma are unknown...
  21. pmc Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Respir Res 6:119. 2005
    ..We sought to measure LTB4 in EBC in atopic asthmatic children and atopic nonasthmatic children. Exhaled nitric oxide (NO) was measured as an independent marker of airway inflammation...
  22. ncbi request reprint Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma
    Adam Antczak
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Crit Care Med 166:301-6. 2002
    ..Exhaled PGE(2) levels are not reduced, so that it is unlikely that a deficiency of PGE(2) is an important mechanism, whereas exhaled LTB(4) levels are unchanged, indicating an abnormality beyond 5-lipoxygenase...
  23. ncbi request reprint Inflammatory response to sputum induction measured by exhaled markers
    Adam Antczak
    Department of Pneumology and Allergology, Medical University of Lodz, Kopcinskiego Str 22, PL 90 153 Lodz, Poland
    Respiration 72:594-9. 2005
    ..Sputum induction is increasingly used to study both cellular and biochemical composition of the airways. However, there is a significant rise in the percentage of neutrophils at 8 h after inhalation with hypertonic saline...
  24. ncbi request reprint Exhaled breath condensate analysis in patients with COPD
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito, 1, 00168 Rome, Italy
    Clin Chim Acta 356:22-34. 2005
    ..Despite important current limitations, further research in this area is warranted due to the lack of non-invasive methods for assessing lung inflammation which has a central role in the pathophysiology of COPD...
  25. ncbi request reprint Isoprostanes: markers and mediators of oxidative stress
    Paolo Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    FASEB J 18:1791-800. 2004
    ..Products of the isoprostane pathway have been found to exert potent biological actions and therefore may participate as physiological mediators of disease...
  26. ncbi request reprint Ion trap liquid chromatography/tandem mass spectrometry analysis of leukotriene B4 in exhaled breath condensate
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Rapid Commun Mass Spectrom 18:2723-9. 2004
    ..This method is potentially useful for non-invasive assessment of airway inflammation, but the sensitivity of the technique needs to be improved...
  27. ncbi request reprint Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children
    Chiara Mondino
    Department of Immunodermatology, Istituto Dermopatico dell Immacolata, IDI, IRCCS, Rome
    J Allergy Clin Immunol 114:761-7. 2004
    ..Lipid mediators play an important pathophysiologic role in atopic asthmatic children, but their role in the airways of atopic nonasthmatic children is unknown...
  28. ncbi request reprint Chronic obstructive pulmonary disease phenotyping: a possible role for 8-isoprostane measurement in exhaled breath condensate?
    Paolo Montuschi
    Respiration 75:134-5. 2008
  29. doi request reprint Exhaled 8-isoprostane and prostaglandin E(2) in patients with stable and unstable cystic fibrosis
    Vincenzina Lucidi
    Department of Pediatrics, Cystic Fibrosis Unit, Ospedale Pediatrico Bambino Gesu, Rome, Italy
    Free Radic Biol Med 45:913-9. 2008
    ..0 (64.3-81.8) pg/ml, P<0.001) and, to a greater extent, in unstable CF patients [83.0 (74.3-91.3) pg/ml, P<0.001). In patients with CF, exhaled 8-isoprostane and PGE(2) could be a useful marker of disease severity...