Jane A Mitchell

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells
    Rekha Badiger
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, London, United Kingdom
    PLoS ONE 7:e46779. 2012
  2. pmc Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test
    Nicholas S Kirkby
    1Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, UK J A M
    FASEB J 27:3938-46. 2013
  3. ncbi request reprint TOLLing away in Brazil
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Nat Immunol 7:675-9. 2006
  4. ncbi request reprint Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    J Endocrinol 193:323-30. 2007
  5. ncbi request reprint Role of pattern-recognition receptors in cardiovascular health and disease
    J A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Imperial College London, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, U K
    Biochem Soc Trans 35:1449-52. 2007
  6. pmc Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells
    Razao Issa
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK
    Respir Res 9:30. 2008
  7. pmc Toll-like receptor 2 is essential for the sensing of oxidants during inflammation
    Mark J Paul-Clark
    Cardiothoracic Pharmacology, Cardiothoracic and Stem Cell Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 179:299-306. 2009
  8. ncbi request reprint Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns
    William R Wright
    Cardiothoracic Pharmacology, Guy Scadding Building, National Heart and Lung Institute, Royal Brompton Campus, Imperial College, London SW3 6LY, UK Electronic address
    Prostaglandins Other Lipid Mediat 107:4-12. 2013
  9. ncbi request reprint Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2
    Timothy D Warner
    The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    FASEB J 20:542-4. 2006
  10. pmc COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma
    Louise S Harrington
    Cardiac Medicine, NHLI, Imperial College, Dovehouse St, London SW3 6LY, UK
    FASEB J 22:4005-10. 2008

Detail Information

Publications72

  1. pmc Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells
    Rekha Badiger
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, London, United Kingdom
    PLoS ONE 7:e46779. 2012
    ..Although rare, these adverse events can be severe and potentially life-threatening, emphasizing the need for simple biomarkers of IFN-induced lung toxicity...
  2. pmc Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test
    Nicholas S Kirkby
    1Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, UK J A M
    FASEB J 27:3938-46. 2013
    ..This important study is the first to demonstrate that while ATL can be measured in tissue, plasma ATL is not a biomarker of vascular COX-2 expression...
  3. ncbi request reprint TOLLing away in Brazil
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Nat Immunol 7:675-9. 2006
  4. ncbi request reprint Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Cardiac Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    J Endocrinol 193:323-30. 2007
    ..The role of pathogen-sensing pathways in disease is also discussed...
  5. ncbi request reprint Role of pattern-recognition receptors in cardiovascular health and disease
    J A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Imperial College London, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, U K
    Biochem Soc Trans 35:1449-52. 2007
    ..We have identified examples of similarities and differences in how cardiovascular tissues and macrophages sense PAMPs. These findings will be discussed together with our interpretation of how this information may lead to new treatments...
  6. pmc Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells
    Razao Issa
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK
    Respir Res 9:30. 2008
    ..We hypothesize that bacteria and bacterial products could induce cytokine/chemokine release from ASMC...
  7. pmc Toll-like receptor 2 is essential for the sensing of oxidants during inflammation
    Mark J Paul-Clark
    Cardiothoracic Pharmacology, Cardiothoracic and Stem Cell Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 179:299-306. 2009
    ..The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood...
  8. ncbi request reprint Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns
    William R Wright
    Cardiothoracic Pharmacology, Guy Scadding Building, National Heart and Lung Institute, Royal Brompton Campus, Imperial College, London SW3 6LY, UK Electronic address
    Prostaglandins Other Lipid Mediat 107:4-12. 2013
    ..Less effect of COX was seen on TLR-induced IP-10 release. In human lung fibroblasts inhibition of COX with diclofenac was associated with increased release of IL-8 and IP-10. Our results may have implications for the treatment of IPF. ..
  9. ncbi request reprint Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2
    Timothy D Warner
    The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    FASEB J 20:542-4. 2006
    ..In particular, selectivity in one body compartment does not demonstrate selectivity in another. Thus, whole-body safety or toxicity cannot be linked to one definitive measure of COX selectivity...
  10. pmc COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma
    Louise S Harrington
    Cardiac Medicine, NHLI, Imperial College, Dovehouse St, London SW3 6LY, UK
    FASEB J 22:4005-10. 2008
    ..These observations show that despite the presence of COX-2, COX-1 is functionally predominant in the airways and explains clinical observations relating to drug specificity in patients with aspirin-sensitive asthma...
  11. pmc Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells
    Gabor Foldes
    National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 5:e10501. 2010
    ..TLR5 levels were similar between differentiated hESC and HAEC, and siRNA knockdown of TLR5 abolished the response to flagellin. These findings have potential implications for survival and function of grafted hESC-derived cells...
  12. pmc LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression
    Nicholas S Kirkby
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 8:e69524. 2013
    ..In doing so, we have identified the thymus, gut, brain and other tissues as target organs for consideration in developing a new understanding of how COX-2 protects the cardiovascular system. ..
  13. ncbi request reprint PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report
    Ferhana Y Ali
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, London, UK
    Arterioscler Thromb Vasc Biol 29:1871-3. 2009
    ..As platelets are anucleated, the effects of PPARbeta/delta agonists on platelets must be nongenomic. Currently, the particular role of PPARbeta/delta receptors and their intracellular signaling pathways in platelets are not known...
  14. pmc Gram-positive and Gram-negative bacteria synergize with oxidants to release CXCL8 from innate immune cells
    Mark J Paul-Clark
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, United Kingdom
    Mol Med 14:238-46. 2008
    ..Thus an oxidant stimulation, possibly via an action on TLR2 or associated transduction pathways, provides a signal that initiates inflammatory responses and sensitizes cells to pathogenic insults...
  15. pmc Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies
    Nicholas S Kirkby
    National Heart and Lung Institute, Imperial College London, UK
    Biochem Biophys Res Commun 438:249-56. 2013
    ..These observations suggest that a COX-2 selective inhibitor, given early in infection, may enhance and/or prolong endogenous interferon responses, and thereby increase anti-viral immunity. ..
  16. ncbi request reprint Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by gram-positive Staphylococcus aureus or gram-negative Escherichia coli
    Neil Cartwright
    Department of Critical Care, National Heart and Lung Institute, Imperial College, London, UK
    Shock 27:40-7. 2007
    ..Our data are the first to establish the definitive roles of specific TLRs in the sensing of Gram-positive and Gram-negative bacteria by vessels and demonstrate that macrophages and blood vessels may differ in their response to pathogens...
  17. ncbi request reprint Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo
    Neil Cartwright
    Department of Critical Care, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 175:595-603. 2007
    ..In animal models, gram-negative septic shock is mimicked by lipopolysaccharide (LPS), which signals through Toll-like receptor 4 (TLR4) and its adaptor MyD88. The role of NLRs in the pathophysiology of septic shock is not known...
  18. ncbi request reprint Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Royal Brompton Hospital, Imperial College School of Medicine, London, UK
    FASEB J 20:2468-75. 2006
    ..The results reported here can offer an explanation for the apparent ability of NSAIDs and COX-2-selective inhibitors to increase the risk of myocardial infarction and stroke...
  19. doi request reprint Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness
    Paul C J Armstrong
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Thromb Haemost 102:772-8. 2009
    ....
  20. doi request reprint Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia
    Beata Wojciak-Stothard
    Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, London, UK
    Circ Res 110:1423-34. 2012
    ..RhoB, a protein homologous to RhoA and activated by hypoxia, regulates neoplastic growth and vasoconstriction but its role in the regulation of pulmonary vascular function is not known...
  21. pmc Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
    Nicholas S Kirkby
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 109:17597-602. 2012
    ....
  22. pmc Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study
    Claire M F Potter
    Cardiothoracic Pharmacology, Pharmacology and Toxicology and Functional Microscopy, Cardiovascular Sciences, National Heart and Lung Institute, London, United Kingdom
    PLoS ONE 7:e31228. 2012
    ....
  23. ncbi request reprint Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia
    Alison S Williams
    Experimental Studies Section, National Heart and Lung Institute, Imperial College London, Dovehouse St, London SW3 6LY, United Kingdom
    J Appl Physiol (1985) 103:1189-95. 2007
    ..Therefore, ozone may induce murine AHR and neutrophilic inflammation through the activation of the Toll-like receptor pathway that may sense noninfectious stimuli such as oxidative stress...
  24. pmc Reduced endothelial dependent vasodilation in vessels from TLR4(-/-) mice is associated with increased superoxide generation
    Louise S Harrington
    Cardiothoracic Pharmacology, NHLI, Imperial College, Dovehouse Street, London, UK
    Biochem Biophys Res Commun 408:511-5. 2011
    ..These data implicate a novel cardio-protective role for TLR4 in vascular homeostasis...
  25. doi request reprint A simple whole blood bioassay detects cytokine responses to anti-CD28SA and anti-CD52 antibodies
    Lucy Bailey
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, London, UK
    J Pharmacol Toxicol Methods 68:231-9. 2013
    ..These types of protocols rely on different donor cells and therefore have limitations as bioassays for pre-clinical testing...
  26. pmc Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse
    Paul C Armstrong
    The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 6:e20062. 2011
    ..Here we have tested the effects of acute inhibition of COX on platelet reactivity using a functional in vivo approach in mice...
  27. pmc Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites
    Stephen J Wort
    Department of Critical Care, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 284:24297-305. 2009
    ..Understanding such mechanisms is crucial in determining the key control points in ET-1 release. This has particular relevance to developing novel treatments targeted at the inflammatory component of pulmonary vascular remodeling...
  28. pmc The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension
    Louise S Harrington
    Cardiothoracic Pharmacology, NHLI, Imperial College London, United Kingdom
    PLoS ONE 5:e9526. 2010
    ..However, none of these provide a cure and the clinical benefits of these drugs individually decline over time. There is, therefore, an urgent need to identify new treatment strategies for pulmonary hypertension...
  29. pmc Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two
    Mark J Paul-Clark
    1Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY
    Br J Pharmacol 148:1067-75. 2006
    ..6. These observations are the first to clearly delineate the role of separately activating TLR2 and TLR4 in the induction of NOSII and TNFalpha genes compared with their coinduction when both receptor pathways are activated...
  30. doi request reprint Antiplatelet actions of statins and fibrates are mediated by PPARs
    Ferhana Y Ali
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Arterioscler Thromb Vasc Biol 29:706-11. 2009
    ..These drugs inhibit platelet function, but the mechanisms by which this pleiotropic effect is exerted are not known...
  31. doi request reprint Viral Toll Like Receptor activation of pulmonary vascular smooth muscle cells results in endothelin-1 generation; relevance to pathogenesis of pulmonary arterial hypertension
    Peter M George
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, United Kingdom
    Biochem Biophys Res Commun 426:486-91. 2012
    ..This may have importance in understanding the association between viruses and the development of PAH...
  32. pmc Stem cell-derived endothelial cells for cardiovascular disease: a therapeutic perspective
    Daniel M Reed
    Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, London, UK
    Br J Clin Pharmacol 75:897-906. 2013
    ..This review discusses these and other issues relating to stem cell-derived endothelial cells in cell therapy for cardiovascular disease...
  33. ncbi request reprint Identification and characterization of a dysfunctional cardiac myocyte phenotype: role of bacteria, Toll-like receptors, and endothelin
    Trupti A Patel
    Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Shock 28:434-40. 2007
    ..Description of the myocyte population, instead of effects only on individual cells, will be more relevant to the prediction of the depression of cardiac function...
  34. pmc COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks
    Nicholas S Kirkby
    National Heart and Lung Institute, Imperial College London, London, United Kingdom The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 9:e98165. 2014
    ....
  35. pmc Evidence for the involvement of type I interferon in pulmonary arterial hypertension
    Peter M George
    From the Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, United Kingdom P M G, D M R, N S K, N A M, S J W, J A M Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom E O, O D D, L Z Service d Anatomie Pathologique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France P D Univ Paris Sud, Faculte de Medecine, Kremlin Bicetre, France P D, F P, F A, M H INSERM UMR S 999, LabEx LERMIT, Hypertension Artérielle Pulmonaire Physiopathologie et Innovation Thérapeutique, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France P D, F P, F A, E F, M H AP HP, DHU Torino, Department of Pharmacology and Toxicology
    Circ Res 114:677-88. 2014
    ..Furthermore, therapeutic use of type I IFN is associated with PAH. This was recognized at the 2013 World Symposium on Pulmonary Hypertension where the urgent need for research into this was highlighted...
  36. pmc Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle
    Rosario Jimenez
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Royal Brompton Hospital, Faculty of Medicine, Imperial College, London SW3 6LY, UK
    Proc Natl Acad Sci U S A 102:4637-42. 2005
    ..These data have important implications for our understanding of the innate immune response in vascular cells and how it may impact vascular disease...
  37. ncbi request reprint COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Royal Brompton Hospital, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Nat Rev Drug Discov 5:75-86. 2006
    ....
  38. pmc Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke
    William R Wright
    Department of Cardiothoracic Pharmacology, Pharmacology and Toxicology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 7:e30120. 2012
    ..The specific cellular mechanisms driving cigarette smoke-induced inflammation and disease are not fully understood, although the innate immune system is involved in the pathology of smoking related diseases...
  39. ncbi request reprint Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Exp Physiol 93:141-7. 2008
    ..The relative contribution of constitutive forms of NOS and COX, as well as interactions between IP, PPAR beta and guanylyl cyclase pathways in vessels and platelets, is discussed...
  40. doi request reprint COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs
    Timothy D Warner
    The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Lancet 371:270-3. 2008
  41. ncbi request reprint Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta
    Ferhana Y Ali
    Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    FASEB J 20:326-8. 2006
    ..Thus, our results identify PPARbeta as a novel antiplatelet target that may mediate some of the effects of prostacyclin in blood...
  42. ncbi request reprint Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance
    Matthew J Walters
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Imperial College London, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Mol Pharmacol 68:1343-53. 2005
    ..These observations add significantly to our understanding of smoke as an inflammatory stimulus that has implications for potential the development of treatments of smoking or related disease...
  43. doi request reprint Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms
    Claire M F Potter
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, UK
    Arterioscler Thromb Vasc Biol 31:384-91. 2011
    ..The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2...
  44. pmc Endothelin-1 as a mediator and potential biomarker for interferon induced pulmonary toxicity
    Peter M George
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, UK
    Pulm Circ 2:501-4. 2012
    ..This hypothesis can be easily tested in IFN-treated patients by measuring serum endothelin-1 levels and cardiopulmonary physiological parameters...
  45. ncbi request reprint Pulmonary endothelium dependent vasodilation emerges after birth in mice
    Renato Faro
    Cardiothoracic Pharmacology, UCCM and Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, SW3 6LY, U K
    Eur J Pharmacol 567:240-4. 2007
    ..This approach can be used with genetically modified mice, which is important to further our understanding of the physiology in this area...
  46. doi request reprint Homeostatic role of Toll-like receptor 4 in the endothelium and heart
    Louise S Harrington
    Cardiac, Vascular, and Inflammation Research, William Harvey Institute, Queen Mary s University of London, Charterhouse Square, London, EC1M 6BQ
    J Cardiovasc Pharmacol Ther 12:322-6. 2007
    ..These observations illustrate a novel role for TLR4 in the homeostatic control of a functional endothelium and, thereby, cardiovascular health...
  47. pmc Transition from placental to air breathing stimulates haem-oxygenase-1 expression without functional consequence for pulmonary vascular adaptation in pigs and mice
    Salome J Stanford
    Cardiothoracic Pharmacology, UCCM, The Royal Brompton and Harefield N H S Trust, Imperial College, National Heart and Lung Institute, Dovehouse Street, Sydney Street, London, UK
    Br J Pharmacol 144:467-76. 2005
    ..These data suggest that HO-1 expression at birth is a redundant response to oxidative stress in the lungs of healthy mammals. However, it remains possible that this pathway protects if complications occur during or after birth...
  48. pmc Pathogen Sensing Pathways in Human Embryonic Stem Cell Derived-Endothelial Cells: Role of NOD1 Receptors
    Daniel M Reed
    Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    PLoS ONE 9:e91119. 2014
    ..Thus, hESC-EC are TLR4 deficient but respond to bacteria via NOD1. This data suggests that hESC-EC may be protected from unwanted TLR4-mediated vascular inflammation, thus offering a potential therapeutic advantage. ..
  49. doi request reprint Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α
    Matthew A Brooke
    Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Gut 63:96-104. 2014
    ..We investigated the genetic basis of this autosomal recessive condition in a pair of affected siblings who have 40-year histories of catastrophic gastrointestinal and extraintestinal disease...
  50. ncbi request reprint The safety and side effects of monoclonal antibodies
    Trevor T Hansel
    Imperial Clinical Respiratory Research Unit, St Mary s Hospital, Paddington, London, UK
    Nat Rev Drug Discov 9:325-38. 2010
    ..Here, we review some of the adverse effects encountered with mAb therapies, and discuss advances in preclinical testing and antibody technology aimed at minimizing the risk of these events...
  51. doi request reprint Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock
    Amar Kapoor
    Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, London, United Kingdom
    Am J Respir Crit Care Med 182:1506-15. 2010
    ..Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown...
  52. ncbi request reprint Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels
    Louise S Harrington
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, The National Heart and Lung Institute, Imperial College, London, United Kingdom
    Am J Physiol Heart Circ Physiol 293:H1682-8. 2007
    ..These data show for the first time that EDHF is released transiently, whereas endothelial-derived NO is released in a sustained manner...
  53. pmc A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses
    Timothy Gatheral
    Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    PLoS ONE 7:e42386. 2012
    ..This data supports the potential utility of NOD1 and RIP2 as therapeutic targets in human disease where vascular inflammation is a clinical feature, such as in sepsis and septic shock...
  54. ncbi request reprint Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts
    Ferhana Y Ali
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Cell Mol Biol 34:242-6. 2006
    ..This study is the first to identify PPARbeta as a potential therapeutic target for the treatment of pulmonary hypertension, which is important because orally active PPARbeta ligands have been developed for the treatment of dyslipidemia...
  55. doi request reprint Pharmacology and therapeutic potential of interferons
    Peter M George
    Cardiothoracic Pharmacology, National Heart and Lung Institute NHLI, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Pharmacol Ther 135:44-53. 2012
    ..Finally, we look to the future of interferon drug treatment, examining the potential for emerging therapies...
  56. doi request reprint Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease
    Nazima Pathan
    Department of Paediatrics, Imperial College London, London, England, UK
    Am J Respir Crit Care Med 184:1261-9. 2011
    ..Children with congenital heart disease are at risk of gut barrier dysfunction and translocation of gut bacterial antigens into the bloodstream. This may contribute to inflammatory activation and organ dysfunction postoperatively...
  57. ncbi request reprint Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries
    Louise S Harrington
    Unit of Critical Care Medicine, Royal Brompton Hospital, The National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY, UK
    Eur J Pharmacol 506:165-8. 2004
    ..These results illustrate an important pharmacological property of this antagonists, which is being increasingly used to study the nature of EDHF...
  58. ncbi request reprint Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension
    Stephen J Wort
    Unit of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, London, United Kingdom
    Mol Pharmacol 62:1147-53. 2002
    ....
  59. ncbi request reprint Type II nitric oxide synthase activity is cardio-protective in experimental sepsis
    Suzanna Price
    Unit of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 472:111-8. 2003
    ..These findings suggest that NOSII is cardio-protective in the heart in sepsis and explain why its inhibition in man led to increased mortality in a subpopulation of patients...
  60. pmc Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle
    Ute Oltmanns
    Experimental Studies National Heart and Lung Institute, Imperial College, London SW36LY, UK
    Respir Res 6:74. 2005
    ..Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. We investigated whether cigarette smoke could directly induce the release of chemokines from HASMC...
  61. ncbi request reprint Cellular mechanisms of acetaminophen: role of cyclo-oxygenase
    Ruth Lucas
    Cardiothoracic Pharmacology, UCCM, Royal Brompton Hospital, NHLI, Imperial College London, UK
    FASEB J 19:635-7. 2005
    ..Specifically, combining active site selectively with actions on enzyme oxidation state would allow for a broader range of tissue selective drugs...
  62. pmc Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells
    Michele Miragoli
    Cardiovascular Science, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    J R Soc Interface 8:913-25. 2011
    ..In conclusion, SICM provides a highly informative multimodal imaging platform for functional analysis of the mechanisms of cardiovascular diseases, which should facilitate identification of novel therapeutic strategies...
  63. pmc Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease
    Maria G Belvisi
    Respiratory Pharmacology Group, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Br J Pharmacol 158:994-1003. 2009
    ..In conclusion, PPARs are novel targets for lung disease and continued work with these ligands may result in a potential new treatment for chronic inflammatory lung diseases...
  64. pmc Novel role for P2X receptor activation in endothelium-dependent vasodilation
    Louise S Harrington
    Unit of Critical Care Medicine, Royal Brompton Hospital, The National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY
    Br J Pharmacol 143:611-7. 2004
    ..These observations have important implications for our understanding of the role of purines in biological responses...
  65. ncbi request reprint Nitric oxide supports atrial function in sepsis: relevance to side effects of inhibitors in shock
    Susanna Price
    Unit of Critical Care Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Eur J Pharmacol 449:279-85. 2002
    ..Our results suggest that myocardial contractility is maintained by NO production and that inhibitors may compromise cardiac output; this may explain the deleterious effects of NOS inhibition on cardiac function in clinical trials...
  66. ncbi request reprint Carbon monoxide inhibits endothelin-1 release by human pulmonary artery smooth muscle cells
    Salome J Stanford
    Unit of Critical Care, The Royal Brompton and Harefield NHS Trust, Imperial College School of Medicine, Sydney Street, London SW3 6NP, UK
    Eur J Pharmacol 486:349-52. 2004
    ..Under certain conditions, carbon monoxide appears to act as an endogenous break on endothelin-1 release...
  67. ncbi request reprint HIF, stretching to get control of VEGF
    Timothy D Warner
    The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Clin Sci (Lond) 105:393-4. 2003
    ....
  68. pmc Endothelium-dependent relaxation and endothelial hyperpolarization by P2Y receptor agonists in rat-isolated mesenteric artery
    Hammit Mistry
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Br J Pharmacol 139:661-71. 2003
    ..The mechanisms for potentiation of relaxation and hyperpolarization by ATPgammaS are unknown, but may indicate interactions between P2Y receptor subtypes...
  69. ncbi request reprint Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy
    Hema J Patel
    Respiratory Pharmacology Group, Department of Cardiothoracic Surgery, Faculty of Medicine, The National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Immunol 170:2663-9. 2003
    ..Hence, PPAR ligands might act as potential treatments in human respiratory diseases...
  70. ncbi request reprint Cyclo-oxygenase-2 inhibitors and cardiovascular events
    Timothy D Warner
    Lancet 360:1700-1. 2002
  71. ncbi request reprint Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery
    Sara Calatayud
    Unidad Mixta de Investigacion, Facultad de Medicina Hospital Clínico Universitario, Universidad de Valencia, Blasco Ibanez 17, 46010, Valencia, Spain
    Eur J Pharmacol 440:71-7. 2002
    ..Specific blockade of cyclooxygenase-1 or cyclooxygenase-2 does not induce any inflammatory event in the rat mesentery and the inflammatory response observed with non-selective NSAIDs seems to be due to the inhibition of both isoenzymes...
  72. ncbi request reprint Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic
    Timothy D Warner
    The William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    FASEB J 18:790-804. 2004
    ..This review will discuss how the latest studies help us understand the roles of COX-1 and COX-2 and what clinically proven benefits the newer generation of COX-2-selective inhibitors offer..