C J Mathias

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Abnormal suppression of arginine-vasopressin by clonidine in multiple system atrophy
    J Kimber
    Division of Neuroscience and Psychological Medicine, Imperial College Medical School at St Mary s Hospital, London, United Kingdom
    Clin Auton Res 9:271-4. 1999
  2. ncbi request reprint L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure
    C J Mathias
    Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College of Science, Technology, and Medicine at St Mary s, London, UK
    Clin Auton Res 11:235-42. 2001
  3. ncbi request reprint Neurodegeneration, parkinsonian syndromes and autonomic failure
    Christopher J Mathias
    University Department of Clinical Neurology, National Hospital for Neurology, University College London, UK
    Auton Neurosci 96:50-8. 2002
  4. ncbi request reprint To stand on one's own legs
    Christopher J Mathias
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College of Science, Technology and Medicine at St Mary s Hospital, London
    Clin Med 2:237-45. 2002
  5. ncbi request reprint Observations on recurrent syncope and presyncope in 641 patients
    C J Mathias
    Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine at St Mary s, London, UK
    Lancet 357:348-53. 2001
  6. ncbi request reprint Cardiovascular autonomic dysfunction in parkinsonian patients
    C J Mathias
    Neurovascular Medicine Unit Pickering Unit, St Mary s Hospital Imperial College School of Medicine, London, UK
    Clin Neurosci 5:153-66. 1998
  7. ncbi request reprint Familial vasovagal syncope and pseudosyncope: observations in a case with both natural and adopted siblings
    C J Mathias
    University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, and the Institute of Neurology, University College London, United Kingdom
    Clin Auton Res 10:43-5. 2000
  8. ncbi request reprint Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophy
    C J Mathias
    Neurovascular Medicine Unit, Division of Neurosience and Psychological Medicine, Imperial College School of Medicine at St Mary s Hospital, Praed Street, London W2 INY, UK
    J Neurol 246:893-8. 1999
  9. ncbi request reprint Postural hypotension: causes, clinical features, investigation, and management
    C J Mathias
    Neurovascular Medicine Unit, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Annu Rev Med 50:317-36. 1999
  10. ncbi request reprint Skin vasomotor reflex responses in two contrasting groups of autonomic failure: multiple system atrophy and pure autonomic failure
    T M Young
    Autonomic Unit, National Hospital for Neurology and Neurosurgery University College London, London, UK
    J Neurol 253:846-50. 2006

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Abnormal suppression of arginine-vasopressin by clonidine in multiple system atrophy
    J Kimber
    Division of Neuroscience and Psychological Medicine, Imperial College Medical School at St Mary s Hospital, London, United Kingdom
    Clin Auton Res 9:271-4. 1999
    ..In conclusion, there is an abnormal AVP response to clonidine in MSA, which probably represents loss of functional noradrenergic innervation of the supraoptic nucleus...
  2. ncbi request reprint L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure
    C J Mathias
    Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College of Science, Technology, and Medicine at St Mary s, London, UK
    Clin Auton Res 11:235-42. 2001
    ..In conclusion, L-threo-DOPS (100, 200, and 300 mg, twice daily) was well tolerated. The dosage of 300 mg twice daily L-threo-DOPS seemed to offer the most effective control of symptomatic orthostatic hypotension in MSA and PAF...
  3. ncbi request reprint Neurodegeneration, parkinsonian syndromes and autonomic failure
    Christopher J Mathias
    University Department of Clinical Neurology, National Hospital for Neurology, University College London, UK
    Auton Neurosci 96:50-8. 2002
  4. ncbi request reprint To stand on one's own legs
    Christopher J Mathias
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College of Science, Technology and Medicine at St Mary s Hospital, London
    Clin Med 2:237-45. 2002
    ..New techniques are helping to unravel the functional anatomy of cerebral autonomic centres and their pathways in the causation of orthostatic intolerance...
  5. ncbi request reprint Observations on recurrent syncope and presyncope in 641 patients
    C J Mathias
    Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine at St Mary s, London, UK
    Lancet 357:348-53. 2001
    ..The object was to find out whether autonomic investigation helped diagnosis...
  6. ncbi request reprint Cardiovascular autonomic dysfunction in parkinsonian patients
    C J Mathias
    Neurovascular Medicine Unit Pickering Unit, St Mary s Hospital Imperial College School of Medicine, London, UK
    Clin Neurosci 5:153-66. 1998
    ..Clinical features and evaluation are described, together with abnormalities in different parkinsonian disorders and the principles of management...
  7. ncbi request reprint Familial vasovagal syncope and pseudosyncope: observations in a case with both natural and adopted siblings
    C J Mathias
    University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, and the Institute of Neurology, University College London, United Kingdom
    Clin Auton Res 10:43-5. 2000
    ..A psychological origin was sought, found, and in part rectified. The separation of vasovagal syncope from pseudosyncope, in the context of the family history, is discussed...
  8. ncbi request reprint Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophy
    C J Mathias
    Neurovascular Medicine Unit, Division of Neurosience and Psychological Medicine, Imperial College School of Medicine at St Mary s Hospital, Praed Street, London W2 INY, UK
    J Neurol 246:893-8. 1999
    ..Lack of these features does not exclude the need to assess and investigate orthostatic hypotension and possible autonomic failure...
  9. ncbi request reprint Postural hypotension: causes, clinical features, investigation, and management
    C J Mathias
    Neurovascular Medicine Unit, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Annu Rev Med 50:317-36. 1999
    ..Treatment of the causative disorder is often curative when there are non-neurogenic causes. A combination of nonpharmacological and pharmacological measures is needed in the management of neurogenic postural hypotension...
  10. ncbi request reprint Skin vasomotor reflex responses in two contrasting groups of autonomic failure: multiple system atrophy and pure autonomic failure
    T M Young
    Autonomic Unit, National Hospital for Neurology and Neurosurgery University College London, London, UK
    J Neurol 253:846-50. 2006
    ..We evaluated the SkVR in response to various stimuli in MSA and PAF, to determine differences in skin vasomotor involvement between these two patient groups...
  11. ncbi request reprint Contribution of nitric oxide to exercise-induced hypotension in human sympathetic denervation
    A B Akinola
    University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, Institute of Neurology, University College London, United Kingdom
    Clin Auton Res 9:263-9. 1999
    ..This study suggests that circulating changes in NOx levels do not exert a major role in exercise-induced hypotension in subjects with sympathetic denervation...
  12. ncbi request reprint Heat-provoked skin vasodilatation in innervated and denervated trunk dermatomes in human spinal cord injury
    A Nicotra
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, London, UK
    Spinal Cord 44:222-6. 2006
    ..Cross-sectional, observational, controlled study...
  13. ncbi request reprint Age- and gender-related growth hormone responses to intravenous clonidine in healthy adults
    J Kimber
    Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine at St Mary's Hospital, London, UK
    Growth Horm IGF Res 11:128-35. 2001
    ..The results overall suggest that i.v. clonidine-GH testing provides a reliable method for investigation of central alpha(2)-adrenergic function in adult humans...
  14. pmc Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans
    H D Critchley
    Wellcome Department of Cognitive Neurology, Institute of Neurology and Autonomic Unit, National Hospital for Neurology and Neurosurgery, Institute of Neurology, University College London, Queen Square, London, UK
    J Physiol 523:259-70. 2000
    ....
  15. ncbi request reprint Cardiovascular and hormonal responses to food ingestion in humans with spinal cord transection
    R R Baliga
    Department of Medicine, St Mary s Hospital Imperial College School of Medicine, University of London, UK
    Clin Auton Res 7:137-41. 1997
    ....
  16. ncbi request reprint Separation of peripheral and central cardiovascular actions of angiotensin II
    J S Kooner
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Am J Physiol 273:H2620-6. 1997
    ..Our results separate, in conscious rabbits, the direct vascular effects of ANG II from its indirect vascular actions, which are mediated by central sympathetic stimulation in the brain...
  17. ncbi request reprint Brain activity during biofeedback relaxation: a functional neuroimaging investigation
    H D Critchley
    Wellcome Department of Cognitive Neurology, Institute of Neurology, UCL, London, UK
    Brain 124:1003-12. 2001
    ..The findings have potential implications for a mechanistic account of how therapeutic interventions, such as relaxation training in stress-related disorders, mediate their effects...
  18. ncbi request reprint Cardiovascular and neurohormonal responses to i. v. l-arginine in two groups with primary autonomic failure
    J Kimber
    National Hospital for Neurology and Neurosurgery, University Department of Neurology, Institute of Neurology, University College London, UK
    J Neurol 248:1036-41. 2001
    ..These studies suggest that reducing NO levels, as with NOS inhibitors, may be of benefit in the treatment of postural hypotension and possibly post-prandial hypotension in chronic primary AF...
  19. pmc The effects of water ingestion on orthostatic hypotension in two groups of chronic autonomic failure: multiple system atrophy and pure autonomic failure
    T M Young
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 75:1737-41. 2004
    ....
  20. ncbi request reprint Characteristics of habituation of the sympathetic skin response to repeated electrical stimuli in man
    P Cariga
    Department of Sensorimotor Systems, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
    Clin Neurophysiol 112:1875-80. 2001
    ..To study the effect of repeating electrical peripheral nerve stimulation on latency, duration and amplitude of the sympathetic skin response (SSR)...
  21. ncbi request reprint High beta-adrenoceptor density on peripheral blood mononuclear cells in progressive multiple sclerosis: a manifestation of autonomic dysfunction?
    Y Zoukos
    Multiple Sclerosis Laboratory, National Hospital for Neurology and Neurosurgery, London, England
    Acta Neurol Scand 90:382-7. 1994
    ....
  22. doi request reprint Effects of water drinking on cardiovascular responses to supine exercise and on orthostatic hypotension after exercise in pure autonomic failure
    A M Humm
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 79:1160-4. 2008
    ..This study assessed the pressor effect of water on the cardiovascular responses to supine exercise and on OH after exercise...
  23. ncbi request reprint Abnormal cardiovascular responses to carotid sinus massage also occur in vasovagal syncope - implications for diagnosis and treatment
    A M Humm
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital and Institute of Neurology, University College London, London, UK
    Eur J Neurol 17:1061-7. 2010
    ..However, CSM itself could provoke classical vasovagal syncope (VVS) in pre disposed subjects...
  24. ncbi request reprint The metabolic, catecholamine and cardiovascular effects of exercise in human sympathetic denervation
    A B Akinola
    Autonomic Unit, University Department of Clinical Neurology, University College London, UK
    Clin Auton Res 11:251-7. 2001
    ..A role for lactate-induced vasodilatation, not compensated for by sympathetic vasoconstriction, remains speculative...
  25. ncbi request reprint Progression of cardiovascular autonomic dysfunction in Holmes-Adie syndrome
    P Guaraldi
    Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square and Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1046-9. 2011
    ..This has a number of implications, including those relating to aetiology and prognosis. The authors recommend regular clinical and laboratory follow-up, especially of cardiovascular autonomic function, in patients with HAS...
  26. pmc Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension
    I F Hussain
    Uro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:371-4. 2001
    ..Furthermore, such patients should be made aware of seeking medical advice if they develop symptoms on treatment suggestive of orthostatic hypotension...
  27. ncbi request reprint Haemodynamics of the pressor effect of oral water in human sympathetic denervation due to autonomic failure
    P Cariga
    Neurovascular Medicine Unit, Imperial College School of Medicine at St Mary s Hospital, Praed Street, London W2 1NY, U K
    Clin Sci (Lond) 101:313-9. 2001
    ....
  28. ncbi request reprint Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome
    C J Mathias
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    Eur J Neurol 11:613-9. 2004
    ....
  29. ncbi request reprint Management of hypertension by reduction in sympathetic activity
    C J Mathias
    Department of Medicine, St Mary s Hospital Medical School Imperial College, London, UK
    Hypertension 17:III69-74. 1991
    ..The role of reducing sympathetic activity in the current management of hypertension and its complications is considered in this overview...
  30. ncbi request reprint The prevalence and association of neck (coat-hanger) pain and orthostatic (postural) hypotension in human spinal cord injury
    P Cariga
    Neurovascular Medicine Unit, Imperial College at St Mary s Hospital, London, UK
    Spinal Cord 40:77-82. 2002
    ..To investigate the prevalence of orthostatic (postural) hypotension (OH) and neck pain in a 'coat-hanger' occipito-cervical distribution in subjects with spinal cord injury (SCI), and their association...
  31. ncbi request reprint Cardiovascular autonomic function in systemic lupus erythematosus
    M B Hogarth
    Rheumatology Unit, Imperial College School of Medicine, St Mary s Hospital, London, UK
    Lupus 11:308-12. 2002
    ..To determine whether cardiovascular autonomic function is impaired in systemic lupus erythematosus (SLE)...
  32. doi request reprint Development of quantitative and sensitive assessments of physiological and functional outcome during recovery from spinal cord injury: a clinical initiative
    P H Ellaway
    Department of Clinical Neuroscience, Imperial College, London, UK
    Brain Res Bull 84:343-57. 2011
    ....
  33. ncbi request reprint Neuroanatomical basis for first- and second-order representations of bodily states
    H D Critchley
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 4:207-12. 2001
    ..Our findings provide empirical support for a theory proposing a hierarchical representation of bodily states...
  34. ncbi request reprint Skin vasodilator response to local heating in human chronic spinal cord injury
    A Nicotra
    Neurovascular Medicine Unit, St Mary s Hospital, Imperial College London, London, UK
    Eur J Neurol 11:835-7. 2004
    ..This test, that evaluates localized sympathetic vasomotor dysfunction, may be a useful non-invasive technique to detect completeness of autonomic disruption after SCI...
  35. ncbi request reprint Neural activity in the human brain relating to uncertainty and arousal during anticipation
    H D Critchley
    Wellcome Department of Cognitive Neurology, 12 Queen Square, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
    Neuron 29:537-45. 2001
    ..Our findings highlight distinct contributions of cognitive uncertainty and autonomic arousal to anticipatory neural activity in prefrontal cortex...
  36. pmc Unexplained syncope--is screening for carotid sinus hypersensitivity indicated in all patients aged >40 years?
    A M Humm
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 77:1267-70. 2006
    ..To determine the frequency, age distribution and clinical presentation of carotid sinus hypersensitivity (CSH) among 373 patients (age range 15-92 years) referred to two autonomic referral centres during a 10-year period...
  37. ncbi request reprint [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
    A Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurology 61:686-9. 2003
    ..Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA...
  38. ncbi request reprint Social and motivational functioning is not critically dependent on feedback of autonomic responses: neuropsychological evidence from patients with pure autonomic failure
    H C Heims
    Department of Neuropsychology, National Hospital for Neurology and Neurosurgery, Box 37, Queen Square, London WC1N 3BG, UK
    Neuropsychologia 42:1979-88. 2004
    ....
  39. ncbi request reprint Do published criteria improve clinical diagnostic accuracy in multiple system atrophy?
    Y Osaki
    National Hospital for Neurology and Nuerosurgery, London, UK
    Neurology 59:1486-91. 2002
    ..To assess the accuracy of a clinical diagnosis of multiple system atrophy (MSA) and compare it to the Quinn and Consensus criteria for MSA using neuropathologically examined cases from the Queen Square Brain Bank for Neurological Disorders...
  40. pmc Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction
    J Kimber
    Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 65:583-6. 1998
    ..The cough may be related to involvement of afferent or efferent pathways in the vagus. Chronic cough may be an accompaniment in the Holmes-Adie syndrome, like other forms of autonomic dysfunction...
  41. pmc Organisation of the sympathetic skin response in spinal cord injury
    P Cariga
    Department of Sensorimotor Systems, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine at Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    J Neurol Neurosurg Psychiatry 72:356-60. 2002
    ..This study investigated the capacity of the isolated spinal cord to generate an SSR, and determined the relation between SSR, levels of spinal cord lesion, and supraspinal connections...
  42. ncbi request reprint Postural variation in intraocular pressure in primary chronic autonomic failure
    Martin J Dumskyj
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, Cranmer Terrace, London, UK, SW17 ORE
    J Neurol 249:712-8. 2002
    ..These data show that patients with autonomic failure are subject to large posture-related changes in IOP. These appear to be related to the large posture-induced changes in systemic blood pressure which occur in these patients...
  43. ncbi request reprint Skin vasodilator response to local heating in multiple system atrophy
    Yoshitaka Yamanaka
    Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
    Mov Disord 22:2405-8. 2007
    ..The P1 phase is thought to be mediated by a sensory-axon reflex modulated by sympathetic nerve activity. These findings are indicative of the skin sympathetic vasomotor dysfunction in MSA...
  44. ncbi request reprint Differences in overshoot of blood pressure after head-up tilt in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy
    Masato Asahina
    Department of Neurology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    J Neurol 252:72-7. 2005
    ..In conclusion, BP overshoot was prominent in the PAF group but not in the MSA group. The phenomenon of BP overshoot while supine, especially in PAF, may have implications for long term cardiac and vascular damage in such patients...
  45. ncbi request reprint Haemodynamic responses during head-up tilt and tilt reversal in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy
    Margaret P Chandler
    Neurovascular Medicine Unite, Pickering Unit, Imperial College School of Medicine at St Mary s, London, UK
    J Neurol 249:542-8. 2002
    ..These haemodynamic observations may aid therapeutic strategies to reduce orthostatic hypotension and prevent supine hypertension...
  46. doi request reprint L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experience
    Christopher J Mathias
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Clin Auton Res 18:25-9. 2008
    ..It also addresses the issue of whether addition of dopa decarboxylase inhibitors, when combined with l-dopa in the treatment of the motor deficit in Parkinson's disease, impairs the pressor efficacy of Droxidopa...
  47. ncbi request reprint Cognitive functioning in orthostatic hypotension due to pure autonomic failure
    Hannah C Heims
    Dept of Neuropsychology, Box 37, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Clin Auton Res 16:113-20. 2006
    ..However, a failure in integrated bodily arousal responses during cognitive behaviours may also contribute to some of the observed deficits...
  48. ncbi request reprint Pure autonomic failure followed by amyotrophy
    Sarosh R Irani
    Autonomic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Neurology 68:792-3. 2007
  49. ncbi request reprint Vagal and sympathetic heart rate and blood pressure control in adult onset PHOX2B mutation-confirmed congenital central hypoventilation syndrome
    Andre Diedrich
    Dept of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Auton Res 17:177-85. 2007
    ....
  50. pmc Autonomic diseases: management
    Christopher J Mathias
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 74:iii42-7. 2003
  51. doi request reprint Autonomic contributions to empathy: evidence from patients with primary autonomic failure
    Bina Chauhan
    Royal Free and University College London Medical School UCL, Gower Street London WC1E 6BT, United Kingdom
    Auton Neurosci 140:96-100. 2008
    ..These early observations provide preliminary evidence for a direct contribution of autonomic responsivity to the 'higher-order' social cognitive process of empathy, and may inform the dynamics of supportive care...
  52. ncbi request reprint Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy
    Hugo D Critchley
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, Institute of Neurology and Institute of Cognitive Neuroscience, UCL, WC1N 3BG, London, United Kingdom
    Neuron 33:653-63. 2002
    ..The findings indicate that the expression of conditioning-related neural activity is modulated by both awareness and representations of bodily states of autonomic arousal...
  53. ncbi request reprint Rate of change in cerebral oxygenation and blood pressure in response to passive changes in posture: a comparison between pure autonomic failure patients and controls
    Ilias Tachtsidis
    Adv Exp Med Biol 566:187-93. 2005
    ..05). MBP slope magnitudes showed significant differences for phases 2 (P < .01) and 5 (P < .01). These differences in the rate of change suggest differences in blood vessel resistance related to sympathetic activation...
  54. ncbi request reprint The ability of physiological stimuli to generate the sympathetic skin response in human chronic spinal cord injury
    Alessia Nicotra
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, Praed Street, London W2 1NY, UK
    Restor Neurol Neurosci 23:331-9. 2005
    ..Sympathetic sudomotor function in chronic spinal cord injury (SCI) has been evaluated to determine if recording the sympathetic skin response (SSR) provides evidence of integrity of the spinal component of the sympathetic pathways...
  55. pmc Autonomic diseases: clinical features and laboratory evaluation
    Christopher J Mathias
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 74:iii31-41. 2003
  56. ncbi request reprint Pressor effect of water instilled via a gastrostomy tube in pure autonomic failure
    Tim M Young
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London W2 1NY, UK
    Auton Neurosci 113:79-81. 2004
    ..We therefore assessed the haemodynamic effects of water instilled directly into the stomach via a gastrostomy tube in pure autonomic failure (PAF)...
  57. ncbi request reprint Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence
    Hugo D Critchley
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Brain 126:2139-52. 2003
    ..Thus, converging neuroimaging and clinical findings suggest that ACC function mediates context-driven modulation of bodily arousal states...
  58. ncbi request reprint Changes in cerebral morphology consequent to peripheral autonomic denervation
    Hugo D Critchley
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 18:908-16. 2003
    ....
  59. ncbi request reprint Role of autonomic evaluation in the diagnosis and management of syncope
    Christopher J Mathias
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, 2nd Floor, Queen Elizabeth the Queen, Mother Wing, Praed Street, London W2 1NY, UK
    Clin Auton Res 14:45-54. 2004
    ..This has dual purposes; to aid the diagnosis and cause of syncope, and furthermore to provide information to understand the pathophysiological basis of syncope and thus improve management of such disorders...
  60. ncbi request reprint Plugging the leak--benefits of the vasopressin-2 agonist, desmopressin in autonomic failure
    Christopher J Mathias
    Clin Auton Res 13:85-7. 2003
  61. ncbi request reprint Unconscious confusion--a literature search for definitions of syncope and related disorders
    Roland D Thijs
    Dept of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, 9600, 2300 RC Leiden, The Netherlands
    Clin Auton Res 15:35-9. 2005
    ..Imprecise definitions of syncope and related conditions appear common in the medical literature. To investigate the scope of the problem we systematically searched for definitions in high-ranking medical journals...
  62. ncbi request reprint Orthostatic hypotension and paroxysmal hypertension in humans with high spinal cord injury
    Christopher J Mathias
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, London W2 1NY, UK
    Prog Brain Res 152:231-43. 2006
    ..Conditions promoting these abnormalities in blood pressure will be elaborated. Possible mechanisms for the hypo- and hypertension will be discussed, as will strategies for managing these problems...
  63. ncbi request reprint Volitional control of autonomic arousal: a functional magnetic resonance study
    Hugo D Critchley
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, ION, UCL, London WC1N 3BG, United Kingdom
    Neuroimage 16:909-19. 2002
    ..These findings identify neural substrates that support integration of perceptual processing, interoception, and intentional modulation of bodily states of arousal...
  64. ncbi request reprint Hemodynamic effects of clonidine in two contrasting models of autonomic failure: multiple system atrophy and pure autonomic failure
    Tim M Young
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, London, United Kingdom
    Mov Disord 21:609-15. 2006
    ..These BP differences, thus, may reflect the underlying lesion site in MSA and PAF, and the hemodynamic data after clonidine infusion may help differentiate these conditions...
  65. ncbi request reprint Neuroendocrine and behavioural responses to CO2 inhalation in central versus peripheral autonomic failure
    Joey M Kaye
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Clin Auton Res 16:121-9. 2006
    ..A central autonomic lesion, however, also appears to be associated with blunting of both cortisol and emotional responses to this stress paradigm...
  66. pmc Emotional and autonomic consequences of spinal cord injury explored using functional brain imaging
    Alessia Nicotra
    Autonomic Unit, National Hospital for Neurology and Neurosurgery, and Institute of Neurology, UCL, London, UK
    Brain 129:718-28. 2006
    ..Together these observations may account for motivational and affective sequelae of SCI in some individuals...