Research Topics
| David Mataix-ColsSummaryAffiliation: Imperial College Country: UK Publications
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Detail Information
Publications
Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up studyDavid Mataix-Cols
Department of Psychiatry, Imperial College School of Medicine, London, UK
Am J Psychiatry 159:263-8. 2002..This study systematically investigated the temporal stability of individual symptoms and symptom dimensions of OCD in adult patients who were followed prospectively for 2 years...
Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorderNatalia S Lawrence
Section of Neuroscience and Emotion, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, England
Neuropsychology 20:409-19. 2006..These results help explain previous inconsistent findings in neuropsychological research in OCD and support recent neuroimaging data showing dissociable neural mechanisms involved in mediating the different OCD symptom dimensions...
Neuropsychological performance in medicated vs. unmedicated patients with obsessive-compulsive disorderDavid Mataix-Cols
Department of Psychiatry, Imperial College School of Medicine, Stress Self Help Clinic, 303 North End Road, London W14 9NS, UK
Psychiatry Res 109:255-64. 2002..The interactions between SRIs and benzodiazepines and their effect on cognition in OCD are likely to be complex and deserve further study...
Is the use of the wooden and computerized versions of the Tower of Hanoi puzzle equivalent?David Mataix-Cols
Department of Psychiatry, Imperial College School of Medicine, London, England
Appl Neuropsychol 9:117-20. 2002..It remains to be tested whether age and computer experience affect performance differentially on the computerized and the wooden versions of the TH puzzle and whether these results are replicated in brain-damaged patients...
Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorderDavid Mataix-Cols
Department of Psychological Medicine, Institute of Psychiatry, London, England
Arch Gen Psychiatry 61:564-76. 2004....
Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effectsHeledd Hart
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, England
JAMA Psychiatry 70:185-98. 2013..Furthermore, preliminary evidence suggests that long-term stimulant medication use may be associated with more normal activation in right caudate during the attention domain...
Prevalence and heritability of skin picking in an adult community sample: a twin studyBenedetta Monzani
Department of Psychosis Studies, King s College London, Institute of Psychiatry, London, UK
Am J Med Genet B Neuropsychiatr Genet 159:605-10. 2012..Non-shared environmental factors are also likely to play an important role in its etiology...
Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcomeEriko Nakatani
King s College London, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 52:1261-8. 2011..The present study represents the first investigation into the effect of age at onset of OCD on clinical characteristics and response to treatment in a paediatric sample...
Pragmatic evaluation of computer-aided self-help for anxiety and depressionIsaac M Marks
Department of Psychological Medicine, Charing Cross Campus, Imperial College School of Medicine, London, UK
Br J Psychiatry 183:57-65. 2003..Most anxiety/depression is not effectively treated. Aims Open evaluation of a free clinic giving immediate computer-aided cognitive-behavioural therapy (CBT) self-help plus brief advice from a therapist...
A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorderLisa A Page
King s College London, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Room 3 14, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ, UK
Psychiatry Res 174:202-9. 2009..OCD is associated with task-relevant fronto-striatal dysfunction during motor inhibition and cognitive switching. In addition, parieto-temporal dysfunction was observed during tasks with a higher attentional load...
Stressful life events and material deprivation in hoarding disorderDanielle Landau
King s College London, Institute of Psychiatry, London, England, United Kingdom
J Anxiety Disord 25:192-202. 2011....
Computer-aided self-exposure therapy for phobia/panic disorder: a pilot economic evaluationPaul McCrone
Centre for the Economics of Mental Health, Health Service and Population Research Department, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Cogn Behav Ther 38:91-9. 2009..FF would be less cost-effective if face-to-face therapy was delivered by less qualified professionals. Caution is urged regarding these indicative findings given that these were secondary analyses...
Do patients with hoarding disorder have autistic traits?Alberto Pertusa
Department of Psychosis Studies, King s College London, Institute of Psychiatry, London, England, UK
Depress Anxiety 29:210-8. 2012..In order to further refine the diagnostic boundaries of HD, we examined the presence of autistic traits and theory of mind deficits in individuals with HD and of hoarding behavior in patients with ASD...
Relation of neurological soft signs to nonverbal memory performance in obsessive-compulsive disorderDavid Mataix-Cols
Department of Psychological Medicine, GKT School of Medicine and Institute of Psychiatry, London, UK
J Clin Exp Neuropsychol 25:842-51. 2003..There might be at least two variables independently mediating nonverbal memory deficits in OCD: (1) a cognitive organization and planning component, and (2) a complex motor regulatory component...
Obsessions and compulsions in children with Asperger's syndrome or high-functioning autism: a case-control studyHilary Mack
Maudsley Hospital, London, UK
Aust N Z J Psychiatry 44:1082-8. 2010..To compare the clinical characteristics and symptom severity of children with obsessive disorder (OCD) plus autism spectrum disorders (ASD) with those of children with OCD plus Tourette's syndrome (TS) or OCD alone...
Evidence for a genetic overlap between body dysmorphic concerns and obsessive-compulsive symptoms in an adult female community twin sampleBenedetta Monzani
Institute of Psychiatry, Department of Psychosis Studies, King s College London, London, UK
Am J Med Genet B Neuropsychiatr Genet 159:376-82. 2012..These results support current recommendations to group BDD together with OCD in the same DSM-5 chapter, although comparison with other phenotypes such as somatoform disorders and social phobia is needed...
When hoarding is a symptom of OCD: a case series and implications for DSM-VAlberto Pertusa
Department of Psychosis Studies, King s College London, Institute of Psychiatry, London, England
Behav Res Ther 48:1012-20. 2010..We estimate that this clinical presentation is relatively rare and accounts for a minority of severe hoarding cases. We discuss the unique characteristics of hoarding as a symptom of OCD and the implications for DSM-V...
Refining the diagnostic boundaries of compulsive hoarding: a critical reviewAlberto Pertusa
Division of Psychological Medicine, King s College London, Institute of Psychiatry, London, UK
Clin Psychol Rev 30:371-86. 2010..Growing evidence from epidemiological, phenomenological, neurobiological, and treatment studies suggests that compulsive hoarding may be best classified as a discrete disorder with its own diagnostic criteria...
A multivariate twin study of obsessive-compulsive symptom dimensionsAlessandra C Iervolino
Department of Psychosis Studies, King s College London, London, England
Arch Gen Psychiatry 68:637-44. 2011..Obsessive-compulsive disorder (OCD) is clinically heterogeneous, but it is unclear whether this phenotypic heterogeneity reflects distinct, or partially distinct, etiologic mechanisms...
Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuliDavid Mataix-Cols
King s College London, Institute of Psychiatry, London, UK
Eur J Neurosci 27:3050-8. 2008..The results have implications for disgust-related psychiatric disorders...
Declarative and procedural learning in individuals with subclinical obsessive-compulsive symptomsDavid Mataix-Cols
Division of Psychological Medicine, GKT School of Medicine and Institute of Psychiatry, London, UK
J Clin Exp Neuropsychol 25:830-41. 2003..These results replicate and expand upon previous findings and support a dimensional model of Obsessive-Compulsive Disorder...
Screening people with anxiety/depression for suitability for guided self-helpLina Gega
School of Nursing and Midwifery, King s College, London, UK
Cogn Behav Ther 34:16-21. 2005..In conclusion, by quickly scanning the completed questionnaire, clinicians were able sensitively to detect patients' problem types that were suitable for certain forms of self-help. Some unsuitability items need refining...
Convergent and discriminant validity of the Yale-Brown Obsessive-Compulsive Scale Symptom ChecklistDavid Mataix-Cols
Division of Psychological Medicine, GKT School of Medicine and Institute of Psychiatry, London, UK
Psychother Psychosom 73:190-6. 2004..The factor structure of the Yale-Brown Obsessive-Compulsive Scale Symptom Checklist (Y-BOCS-SC) has been well established, but its convergent and divergent reliability have yet to be studied...
Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcomeGeorgina Krebs
OCD Clinic for Young People, South London and Maudsley NHS Foundation Trust, London, UK
J Child Psychol Psychiatry 54:313-22. 2013....
Brief scheduled phone support from a clinician to enhance computer-aided self-help for obsessive-compulsive disorder: randomized controlled trialMark Kenwright
Institute of Psychiatry, Kings College London and South London and Maudsley Mental Health Trust, London, UK
J Clin Psychol 61:1499-508. 2005..Giving brief support proactively by phone enhanced OCD patients' completion of and improvement with computer-aided self-help...
Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD)Heledd Hart
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
Neurosci Biobehav Rev 36:2248-56. 2012....
Annual research review: hoarding disorder: potential benefits and pitfalls of a new mental disorderDavid Mataix-Cols
Departments of Psychosis Studies and Psychology, King s College London, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 53:608-18. 2012..Given the proposed inclusion of a new hoarding disorder (HD) in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fifth edition), it is pertinent to discuss the potential benefits and pitfalls of such a development...
Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trialDavid Mataix-Cols
Department of Psychiatry, Imperial College School of Medicine, London, UK
Psychother Psychosom 71:255-62. 2002..Existing treatments need to be refined and/or new treatments developed to improve these patients' adherence and response to treatment...
Meta-analysis of gray matter abnormalities in autism spectrum disorder: should Asperger disorder be subsumed under a broader umbrella of autistic spectrum disorder?Esther Via
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, England
Arch Gen Psychiatry 68:409-18. 2011..It is unclear whether the current subtyping of ASD into autistic disorder and Asperger disorder is neurobiologically valid...
Meta-analytic methods for neuroimaging data explainedJoaquim Radua
Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Biol Mood Anxiety Disord 2:6. 2012....
Hoarding versus collecting: where does pathology diverge from play?Ashley E Nordsletten
Department of Psychosis Studies, King s College London, Institute of Psychiatry, London, UK
Clin Psychol Rev 32:165-76. 2012..For a minority of 'extreme' collectors, a diagnosis may potentially be adequate. This review highlights the similarities and differences between hoarding and collecting and offers suggestions for further research in this group...
Patterns of neural response to emotive stimuli distinguish the different symptom dimensions of obsessive-compulsive disorderMary L Phillips
Division of Psychological Medicine, Guy's King's and St. Thomas' School of Medicine and Institute of Psychiatry, London, UK
CNS Spectr 9:275-83. 2004....
Internet-guided self-help with or without exposure therapy for phobic and panic disordersAndreas J Schneider
Department of Psychological Medicine, Imperial College London and Institute of Psychiatry, King's College London, London, UK
Psychother Psychosom 74:154-64. 2005..Analysis is needed of how non-exposure CBT produced its shorter-term effect...
Deconstructing obsessive-compulsive disorder: a multidimensional perspectiveDavid Mataix-Cols
Departments of Psychological Medicine and Psychology, Institute of Psychiatry, King s College London, London, UK
Curr Opin Psychiatry 19:84-9. 2006..e. age of onset, presence of comorbid tics, positive family history) and symptom theme, with particular emphasis on the latter...
Obsessions and compulsions in Asperger syndrome and high-functioning autismAilsa J Russell
Department of Psychology, Institute of Psychiatry, King s College, London, UK
Br J Psychiatry 186:525-8. 2005..Obsessive-compulsive behaviours are common and disabling in autistic-spectrum disorders (ASD) but little is known about how they compare with those experienced by people with obsessive-compulsive disorder (OCD)...
A multidimensional model of obsessive-compulsive disorderDavid Mataix-Cols
Institute of Psychiatry, London
Am J Psychiatry 162:228-38. 2005..The need for a dimensional rating scale and suggestions for future research aimed at reducing the burden of this disorder are discussed...
Structure of obsessive-compulsive symptoms in pediatric OCDDavid Mataix-Cols
King s College London, Institute of Psychiatry, Department of Psychological Medicine, P O Box 69, De Crespigny Park, UK
J Am Acad Child Adolesc Psychiatry 47:773-8. 2008..It is unclear whether the structure of obsessive-compulsive disorder (OCD) symptoms seen in adults is preserved in pediatric samples...
Are there sex differences in neuropsychological functions among patients with obsessive-compulsive disorder?David Mataix-Cols
Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Appl Neuropsychol 13:42-50. 2006..We conclude that sex does not seem to be a major determinant of neuropsychological function in OCD, but the observed cross-sex shifts on some tasks deserve further examination...
Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCDNatalia S Lawrence
Division of Psychological Medicine, Section of Neuroscience and Emotion, King s College London, London, United Kingdom
Biol Psychiatry 61:1072-80. 2007..This study explored neural systems underlying sensitivity to symptom-unrelated disgust and fear in OCD using functional neuroimaging...
Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back taskXavier Caseras
Unitat de Psicologia Mèdica, Institut de Neurociencies, Universitat Autonoma de Barcelona, Barcelona, Spain
Psychosom Med 68:947-55. 2006..However, objective evidence supporting these claims is inconsistent. The present functional magnetic resonance imaging study examined the neural correlates of working memory in patients with CFS compared with controls...
Spanish version of the savings inventory-revised: adaptation, psychometric properties, and relationship to personality variablesMiquel Tortella-Feliu
University Research Institute on Health Sciences
Behav Modif 30:693-712. 2006..The authors conclude that the Spanish SI-R is a promising instrument to measure hoarding symptoms...
Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteersDavid Mataix-Cols
Division of Psychological Medicine, GKT School of Medicine and Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 53:482-93. 2003..Further investigation of the neural basis of OCD symptom dimensions is required...
Psychometric properties of the Spanish version of the Obsessive-Compulsive Inventory--revised in a non-clinical sampleMiquel A Fullana
Department of Psychiatry, Autonomous University of Barcelona, Catalonia, Spain
J Anxiety Disord 19:893-903. 2005..The Spanish version of the OCI-R retains the sound psychometric properties of the original version...
Common and distinct neural correlates of obsessive-compulsive and related disordersDavid Mataix-Cols
Department of Psychological Medicine, King s College London, Institute of Psychiatry, London SE5 8AF, UK
Psychiatr Clin North Am 29:391-410, viii. 2006....
Personality dimensions in obsessive-compulsive disorder: relation to clinical variablesPino Alonso
Obsessive Compulsive Disorder Clinical and Research Unit, Department of Psychiatry, Hospital Universitario de Bellvitge, Barcelona, Spain
Psychiatry Res 157:159-68. 2008....
Perceived parental rearing style in obsessive-compulsive disorder: relation to symptom dimensionsPino Alonso
Obsessive-Compulsive Disorder Clinical and Research Unit, Department of Psychiatry, , Ciudad Sanitaria y Universitaria de Bellvitge, c/ Feixa Llarga s/n 08907, Hospitalet de Llobregat, Barcelona, Spain
Psychiatry Res 127:267-78. 2004..Social/cultural variables such as parental child-rearing patterns, in interaction with biological and genetic factors, may contribute to the expression of the OCD phenotype...
Temporal stability of obsessive-compulsive symptom dimensions in an undergraduate sample: a prospective 2-year follow-up studyMiquel A Fullana
Autonomous University of Barcelona, Catalonia, Spain
Behav Modif 31:815-24. 2007..The results indicate that obsessive-compulsive symptom dimensions tend to be temporally stable in nonclinical participants, replicating similar studies in clinical populations...
Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry studyAndrew R Gilbert
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
J Affect Disord 109:117-26. 2008..Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume...
Compulsive hoarding: OCD symptom, distinct clinical syndrome, or both?Alberto Pertusa
Division of Psychological Medicine, King s College London, Institute of Psychiatry, PO 69, De Crespigny Park Rd, London SE58AF, United Kingdom
Am J Psychiatry 165:1289-98. 2008..Compulsive hoarding is a debilitating problem that is often associated with obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder. However, the precise nosology of compulsive hoarding has yet to be determined...
Reliability and validity of the work and social adjustment scale in phobic disordersDavid Mataix-Cols
Institute of Psychiatry, King s College London, UK
Compr Psychiatry 46:223-8. 2005..The WSAS is a valid, reliable, and change-sensitive measure of work/social and other adjustment in phobic disorders, especially in agoraphobia and social phobia...
Issues for DSM-V: how should obsessive-compulsive and related disorders be classified?David Mataix-Cols
Am J Psychiatry 164:1313-4. 2007
High sensitivity to punishment and low impulsivity in obsessive-compulsive patients with hoarding symptomsMiquel Angel Fullana
Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Barcelona, Catalonia, Spain
Psychiatry Res 129:21-7. 2004..High sensitivity to punishment and low novelty seeking in OCD hoarders might explain their poor compliance and response to conventional treatments, but this question needs to be explored further in a prospective treatment study...
Personality characteristics in obsessive-compulsive disorder and individuals with subclinical obsessive-compulsive problemsMiquel Angel Fullana
Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Spain
Br J Clin Psychol 43:387-98. 2004..CONCLUSION: Healthy participants with high scores on OC measures and OCD patients share various personality traits but can also be distinguished according to the level of extraversion, neuroticism and psychoticism...
Symptom dimensions in obsessive-compulsive disorder: implications for the DSM-VJames F Leckman
Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
CNS Spectr 12:376-87, 400. 2007..Finally, existing assessment methods are inadequate and new dimensional scales are needed to take full advantage of a dimensional approach in clinical and population-based studies...
Self-help with minimal therapist contact for obsessive-compulsive disorder: a reviewDavid Mataix-Cols
Institute of Psychiatry, King s College London, PO Box 69, De Crespigny Park, London SE5 8AF, UK
Eur Psychiatry 21:75-80. 2006..Their dissemination could save resources used by health care providers. We propose a stepped care model for the treatment of OCD...
